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Program
Monday September 14
th
13.00 – 16.00 Arrival at Sinatur Hotel Storebælt, Nyborg (DK)
16.00 – 16.15 Welcome (Pernille B.L. Hansen)
Chair: Jo De Mey
16.15– 17.15
Keynote lecture / 2nd Tudor Griffith lecture
Hiroaki Shimokawa (Sendai, Japan): Endothelium-dependent hyperpolarizations in health
and disease. Crucial roles of endothelium-derived reactive oxygen species / endotheliumdependent hyperpolarization. 37
18.00 – 19.00 Reception at Nyborg Castle
19.30
Dinner at Hotel Storebælt
Tuesday September 15th
7.00 – 8.30
Mounting of posters (on display during the entire meeting)
Chairs: Cor de Wit and Ulf Simonsen
8.30
Christian Aalkjær (Aarhus, DK): EDH and vasomotion. 1
9.00
Kim Dora (Oxford, GB): EDH and conducted vasodilation. 14
9.30
Shigeo Godo et al. (Sendai, Japan): Excessive Endothelium-Derived Nitric Oxide Impairs
Cardiovascular Homeostasis by Suppressing Endothelium-dependent HyperpolarizationMediated Relaxation in Mice. 17
9.45
Hatice Yorulmaz et al. (Marmara, Turkey): Protective effect of simvastatin on trace minerals
in intestinal tissue during early phase of sepsis. 48
10.00
Ulf Simonsen et al. (Aarhus, DK): Genetic deficit of KCa3.1 channels protects against
pulmonary circulatory collapse induced by TRPV4 channel activation. 39
10.15
Thomas Leurgans et al. (Odense, DK): Effects of nitric oxide and hydrogen peroxide in
resistance arteries from cardiovascular disease patients depend on vasoconstrictor
conditions. 26, 27*
10.30 – 11.00 Coffee break and poster viewing
EDH2015 Fyn, Denmark, Sept. 14 – 17
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Chairs: Kim Dora and Brant Isakson
11.00
Pernille B.L. Hansen (Odense, DK): T-type calcium channels and endothelial function. 24
11.30
Cor de Wit (Lübeck, D): EDH, are gap junctions and connexins the answer? 46
12.00
Maria Bloksgaard et al. (Odense, DK): Microarchitecture of the internal elastic lamina (IEL)
in human resistance arteries from different vascular beds. 4*
12.15
Kasper Møller Rasmussen et al. (Copenhagen, DK): Influence of K+-channels and gap
junctions on endothelium derived hyperpolarization-induced renal vasodilation in rats. 30
12.30 – 13.30 Lunch
Chairs: Ingrid Fleming and Niels Henrik Holstein Rathlou
13.30
Christoffer Garland (Oxford, GB): EDH and evolving recognition of a role for endothelial
signaling microdomains. 16
14.00
Brant Isakson (Charlottesville, USA): Contact-dependency for EDH. 22
14.30
Hiroki Saito et al. (Sendai, Japan): Important roles of endothelial caveolin-1/eNOS complex
in maintaining microvascular homeostasis through EDH-mediated mechanism. 35
14.45
Elise Røge Hedegaard et al. (Aarhus, DK): Involvement of K channels and calciumindependent mechanisms in hydrogen sulfide relaxation of rat mesenteric small arteries. 34
15.00
Rainer Windler and Cor de Wit (Lübeck, D): The coronary murine vascular bed relies on NO
and prostaglandins during reactive hyperemia and ACh induced dilation. 45
15.15
Sarah Brøgger Kristiansen et al. (Copenhagen, DK): Calcium signaling in coronary artery
after reperfusion damage in rat model of acute myocardial infarct. 7
15.30 – 16.00 Coffee break and poster viewing
Chairs: Christoffer Garland and Christian Aalkjær
16.00
Jenny Nystrøm (Gothenburg, S): The role of the glomerular endothelium in kidney function.
31
16.30
Niels Henrik Holstein-Rathlou (Copenhagen, DK): Vascular conducted responses and
regulation of kidney blood flow.
17.00
J. Christian Brasen et al. (Copenhagen, DK): Endothelial derived hyperpolarization in renal
interlobar arteries. 6
17.15
Kasper Bostlund Assersen et al. (Odense, DK): Exaggerated natriuresis in essential
hypertension is not due to Increase in Renal Medullary Blood Flow. 5*
18.30
Dinner at Hotel Storebælt
EDH2015 Fyn, Denmark, Sept. 14 – 17
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20.00
Guided poster tours
Wednesday September 16th
Chairs: Bill Campbell and Jo De Mey
8.30
Susan Leung (Hong Kong, PRC): EDH: age, gender and high blood pressure. Does it matter?
25
9.00
Anne-Sofie Grell et al. (Copenhagen, DK): Cerebrovascular responses in spontaneously
hypertensive rats after ischemic stroke. 18
9.15
Kristina Lyngsø et al. (Odense, DK): Chronic aldosterone exposure inhibits nitric oxidedependent dilatation in human and mouse intracerebral arterioles. 28*
9.30
Cheng-Ming Tsao et al. (Taipei, Taiwan): Modulating effects of perivascular adipose tissue
in mesenteric artery of spontaneously hypertensive rat. 44
9.45
Atlanta Elie et al. (Odense, DK): Human pericardial adipose tissue can contract and relax
pericardial resistance arteries. 15*
10.00
Katrine Dueholm Nissen et al. (Odense, DK): Adiponectin mimetic causes full relaxation in
pericardial resistance arteries from cardiac and vascular disease patients independent of
NO production. 13*
10.15
Chin-Chen Wu et al. (Taipei, Taiwan): Hydrogen Sulfide and Perivascular Adipose Tissue
Regulate Resistant Mesenteric Arterial Tone in Endotoxaemic Rats. 47
10.30 – 11.00
Coffee break and poster viewing
Chairs: Lars Edvinsson and Huang Yu
11.00
Bill Campbell (Milwaukee, USA): EETs, from EDHFs to anti-hypertensive drugs. 8
11.30
Kristian Agmund Haanes et al. (Glostrup, DK): Different roles for P2Y2 and P2Y6 receptors in
large and smaller coronary arteries. 19*
11.45
Simon Comerma et al. (Aarhus, DK): Effects of an opener of small and intermediate
calcium-activated K+ channels NS309 on cardiac rhythm and erectile function in rats. 10
12.00
Stine Spray et al. (Glostrup, DK): Increased ET-1 reactivity of intraparenchymal arterioles
after transient global cerebral ischemia in rat - new mechanistic insights into the
development of delayed cerebral hypoperfusion. 40*
12.15
Lei Zhao et al. (Hong Kong, China): Enhanced autophagy ameliorates endothelial
dysfunction in diabetic mice. 50
EDH2015 Fyn, Denmark, Sept. 14 – 17
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12.30 – 13.30 Lunch
Chairs: Boye Jensen, in collaboration with the Danish Hypertension Society
13.30
Ebbe Boedtkjer (Aarhus, DK): Transport and sensing of HCO3- and H+ modify endothelial
function, blood pressure and metabolic autoregulation. 49
13.55
Jesper Nørgaard Bech (Aarhus, DK): Effects of systemic NO-inhibition on renal
hemodynamics and sodium excretion in healthy subjects and in patients with disturbed
sodium-water balance due to hypertension, renal disease, heart disease or liver disease. 3
14.20
Rozh Husain Al-Mashhadi (Aarhus, DK): In vivo high resolution isotropic 3D MRI of coronary
atherosclerosis in hypertensive hypercholesterolemic minipigs. 2
14.45
Jane Stubbe et al. (Odense, DK): The water channel AQP1 is associated with human
atherosclerotic vascular lesions and attenuates vascular injury in murine models of
atherosclerosis independent of blood pressure. 42
15.00 – 15.30
Coffee break and poster viewing
Chairs: Chris Triggle, in collaboration with the Danish Hypertension Society
15.30
Carmine Cardillo (Rome, I): Hyperpolarization and vascular function in cardiovascular risk
conditions. 9
16.00
Nanna Borup Johansen (Copenhagen, DK): Dysglycaemia and arterial stiffness. 23
16.20
Simon Comerma-Steffensen et al. (Aarhus, DK): Role of SK3 channels in erectile function in
mice. 11*
16.35
Aino Siltari et al. (Helsinki, FIN): Effects of bioactive tripeptides on vascular effects of
bradykinin in young and old SHRs. 38*
16.50
Stefan Mortensen (Odense, DK): The effect of lifelong physical activity on vascular function
and blood flow in the ageing human leg. 29
17.30
To the busses
18.00
Reception, dinner etc. at Broholm Castle
Thursday September 17th
Chairs: Carmine Cardillo and Pernille Hansen
8.30
Jo De Mey (Odense, DK): Endothelin-1 mediates and promotes patient pericardial
resistance artery relaxing responses to insulin. 12
9.00
Chris Triggle (Qatar). Metformin, more than just an oral anti-hyperglycaemic drug. 43
EDH2015 Fyn, Denmark, Sept. 14 – 17
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9.30
Holger Schneider et al. (Munich, D): AMPK relaxes vascular smooth muscle of resistance
arteries by dual action on BKCa channels and SERCA. 36
9.45
Nelson Orie et al. (Qatar): Reduced EDH but not NO per se is responsible for attenuated
microvascular endothelium-dependent relaxation to Ach in morbid obesity. 32
10.00
Jiong Hu et al. (Frankfurt, D): Pharmacologic inhibition of the soluble epoxide hydrolase
attenuates diabetic retinopathy in Ins2 Akita mice. 20
10.15
Wei Ning Hu et al. (Hong Kong, PRC): Bone morphogenic protein-4-induced up-regulation of
platelet-derived growth factor AA impairs endothelial function. 21*
10.30
Janina Steck et al. (Frankfurt, D): Inhibition of eNOS phosphorylation on tyrosine656 in mice
protects from atherosclerotic plaque formation. 41
10.45
Aneta Radziwon-Balicka et al. (Glostrup, DK): A novel multicolor flow-cytometry application
for detection of different tissue cell types. 33
11.00 – 11.30
Coffee break and poster viewing
Chair: Paul M. Vanhoutte
11.30 – 12.00
Young investigator awards
12.00 – 12.30
Michel Feletou (Suresnes, F): EDH quo vadis? Highlights of EDH2015.
12.30
Box lunch and departure
*Participants in young investigators’ competition.
EDH2015 Fyn, Denmark, Sept. 14 – 17
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