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Friday, November 28, 2014 10:00-‐11:00 Session 1 Development, Differentiation, Ageing and Tissue Regeneration 1 The role of the oncoprotein SET in zebrafish embryonic development Iliana Serifi1, Eleni Tzima1, Zoe Karetsou1, Thomais Papamarcaki1, 2 Laboratory of Biological Chemistry, Medical School, University of Ioannina, Ioannina, Greece Division of Biomedical Research, Foundation for Research and Technology-‐Hellas, Institute of Molecular Biology and Biotechnology, Ιοannina, Greece 1
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2 Rac1 and 3 is necessary in cycling progenitors and postmitotic cells destined to become GABAergic cortical interneurons Simona Tivodar1,2, Kostas Theodorakis1, Katerina Kalemaki1,2, Zouzana Kounoupa1,2, Marina Vidaki1,2,#,, Myrto Denaxa3, Vassilis Pachnis 3, and Domna Karagogeos1,2,* 1: Institute of Molecular Biology & Biotechnology (IMBB, FORTH), Heraklion, Greece, 2: Department of Basic Science, Faculty of Medicine, University of Crete, Heraklion, Greece, 3: Division of Molecular Neurobiology, Medical Research Council, National Institute for Medical Research, London, UK. # Current address: Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. 3 The ablation of Geminin favours the gliogenic fate of the adult neural stem cells Maria-‐Eleni Lalioti1, Christina Kyrousi1, Konstantina Kaplani1, Zoi Lygerou2, Stavros Taraviras1 1. 2. Department of Physiology, Medical School, University of Patras, Greece Department of General Biology, Medical School, University of Patras, Greece
4 Molecular and cellular analysis of the mechanisms coordinating growth arrest and myogenesis in adult muscle stem cells Despoina MADEMTZOGLOU, Sonia ALONSO-‐MARTIN, Frédéric AURADE, Bernadette DRAYTON, Ted CHANG, Philippos MOURIKIS, Frédéric RELAIX* 1 Center of Research in Myology, UMRS974 INSERM – UPMC Paris VI -‐ AIM, F-‐75013 Paris, France. *e-‐mail: [email protected] 5 Implications of proteasome in ageing of human mesenchymal stem cells Marianna Kapetanou *1,2, Niki Chondrogianni 1and Stathis Gonos 1. 1: National Hellenic Research Foundation, Institute of Biological Research & Biotechnology, Athens, 2: Dept of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece 11:00-‐11:30 11:30-‐12:00 Lecture: Mitochondrial turnover and homeostasis during ageing Nektarios Tavernarakis Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-‐Hellas, Heraklion, Greece & Medical School, University of Crete, Heraklion, Crete, Greece Lecture: Immunogenetics of the lymphoid malignancies Kostas Stamatopoulos Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece & Hematology Department and HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece 12:00 -‐12:30 Coffee BREAK -‐ Poster viewing 1 Friday, November 28, 2014 12:30-‐13:30 Session 2 Molecular and Cellular Basis of Human Disease 6 ERα mediates epithelial to mesenchymal transition and expression of specific matrix effectors in breast cancer cells Panagiotis Bouris1, Spyros S. Skandalis1, Zoi Piperigkou1, Dimitra Manou1, Aristidis Moustakas2, Achilleas D. Theocharis1, Nikos K. Karamanos1 1
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Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece. Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Sweden. 7 MiR24-‐Mediated HNF4α Silencing Induced Epithelial-‐to-‐Mesenchymal transition (EMT) in 3D models of Liver Cancer Through Notch and TGFβ Signalling Pathways Olga Maria Ntina, Elisavet Lioulia, Ioanna Vallianou, Dimitra Dafou*, Margarita Hadzopoulou-‐Cladaras Laboratory of Developmental Biology, Department of Genetics, Development and Molecular Biology, School of Biology, Faculty of Sciences, Aristotle University of Thessaloniki, Thessaloniki 54 124, Greece 8 Thiols abrogate free heme cytotoxicity: Analysis of the mechanism and implications in therapy of hemolytic disorders Sofia K. Georgiou & Asterios S. Tsiftsoglou Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece 9 Insulin resistance in macrophages controls M1/M2 polarization and shapes gut microbiota Eleftheria Ieronymaki1, Manolis Theodorakis1, Marina Aznaourova1, Katerina Vaporidi2, Andrew Margioris1, Aristides Eliopoulos3 and Christos Tsatsanis1 Dept of Clinical Chemistry, 2 Dept of Intensive Care Medicine and 3Dept of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece 1 10 Estrogen anti-‐inflammatory activity on human monocytes is mediated through estrogen receptor ERα36 Alexandra Deli1, Vasiliki Pelekanou1,2, Marilena Kampa1, Foteini Kiagiadaki1, Panayiotis Theodoropoulos3, George Agrogiannis4, Efstratios Patsouris4, Andreas Tsapis1,5,6, Elias Castanas1, George Notas1,* Laboratories of Experimental Endocrinology (1),Pathology (2) and Biochemistry (3) University of Crete School of Medicine, Heraklion, Crete, Greece; 1st Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens Greece (4); INSERM U976, Hôpital Saint Louis, Paris, France (5) and University Paris Diderot, Paris, France (6). 13:30-‐14:00 Lecture: Global, in vivo assessment of canonical TGFβ superfamily signaling with the aid of mouse transgenic reporter lines Paschalis Sideras Centre for Immunology and Transplantations, Biomedical Research Foundation Academy of Athens, Athens, Greece 14:00-‐14:30 Lecture sponsored by Antisel From exome to transcriptome to genome to metagenome: An integrated approach using massively parallel semiconductor sequencing Constantinos Lilakos, Application Specialist Antisel 14:30-‐16:00 Poster viewing (Session 1) 2 Friday, November 28, 2014 16:00-‐16:30 Lecture: The multifunctional protein SAFB: A multifaceted approach Eleni Georgatsou Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Larissa, Greece 16:30-‐18:00 Session 3 Molecular and Cellular Basis of Human Disease & Functional Genomics/Proteomics 11 Next-‐generation sequencing of the primary ciliary dyskinesia UK10K cohort identifies novel disease causing genes Alexandros Onoufriadis1*, UK10K2, Hannah Mitchison3 Dept of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK, 2 uk10k.org, 3Genetics and Genomic Medicine Programme, University College London (UCL) Institute of Child Health, London, UK 1
12 Genetic association signal near NTN4 in Tourette syndrome Iordanis Karagiannidis1*, Fotis Tsetsos1, GGRI Consortium2, Peristera Paschou1 Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece, 2 The Gilles de la Tourette Syndrome Genome-‐wide Association Study Replication Initiative 1 13 Osteoimmunological interactions in transgenic mice overexpressing human RANKL Maria Papadaki1,2, Vagelis Rinotas1,2, George Kollias2, Eleni Douni1,2,* Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, , Athens, 2Division of Immunology, B.S.R.C. “Alexander Fleming”, Vari 1
14 Homeobox transcription factor MEIS1 induces CD8+ T-‐lymphocyte recruitment in early stage ovarian cancer Athanasios Karapetsas, Christos Evangelou, Raphael Sandaltzopoulos Department of Molecular Biology & Genetics, School of Health Sciences, Democritus University of Thrace, Alexandroupolis, Greece 15 New insights into Doubly Uniparental Inheritance of mitochondrial DNA: a protein binding site in the M genome of Mytilus is responsible for its paternal transmission Kyriakou Eleni1, Kravariti Lara1, Zouros Eleftherios2 and Rodakis George C.1 Dept of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 157 01 Athens, 2Dept of Biology, University of Crete, 714 09, Heraklion, Crete 1
16 Understanding the physiological role of DNAJC11 through identification of its interactors Foteini Violitzi1,2, Martina Samiotaki3, Fotis Ioakeimidis1, Marios Boyongo1,2, George Panayotou3, Eleni Douni1,2,* Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens 11855, Greece, 2Division of Immunology, Biomedical Sciences Research Center “Alexander Fleming”, Vari 16672, Greece , 3Division of Molecular Oncology, Biomedical Sciences Research Center “Alexander Fleming”, Vari 16672, Greece 1
18:00-‐18:30 Coffee BREAK-‐ Poster viewing 18:30–19:00 Lecture: Cell cycle regulation and DNA damage response in mammalian female meiosis Petros Marangos Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece 19:00-‐19:30 Opening Ceremonies 19:30–20:30 Honorary Lecture / FEBS LECTURE: Perturbation of TGF-‐β receptor signaling pathways in breast cancer Peter ten Dijke Dept. Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands 3 Saturday, November 29, 2014 10:00-‐11:00 Session 4 Cell Organization and Function 1 17 Functional characterization and evolution of human Glutamate Dehydrogenase mitochondrial presequence Ester Kalef-‐Ezra1, Dimitra Kotzamani2, Ioannis Zaganas2, Andreas Plaitakis2, Kostas Tokatlidis3,4 Department of Biology, 2Department of Neurology, School of Medicine, 3Department of Materials Science & Technology, University of Crete, Heraklion, Greece, 4Institute of Molecular Biology and Biotechnology-‐Foundation for Research and Technology (IMBB-‐FORTH), Heraklion, Greece 1
18 Oligomerization of the UapA purine transporter is critical for ER-‐exit and sorting into plasma membrane microdomains Olga Martzoukou1, Mayia Karachaliou1, Sotiris Amillis1, Vassilis Giallelis1, Minos Evangelinos1, James Leung2, Bernadette Byrne2 & George Diallinas1* 1
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Faculty of Biology, University of Athens, Panepistimioupolis, Athens, Greece Division of Molecular Biology, Imperial College, London, SW7 2AZ, UK 19 A novel experimental system to directly visualize FGF2 secretion Eleni Dimou*, Sabine Wegehingel, Walter Nickel, Biochemistry Institute Heidelberg (BZH), Heidelberg, Germany 20 Overexpression of Thioredoxin and Glutaredoxin in human cells offers protection against DNA damage, and inhibits apoptosis, after exposure to oxidative stress Efthymios Poulios1*, Nefeli Lagopati1, Vasiliki Roupaka1, Dimitrios Galaris1 and Giannis Spyrou2 1 Laboratory of Biological Chemistry, School of Medicine, University of Ioannina, Ioannina, Greece., 2Basic Research Center, Biomedical Research Foundation of the Academy of Athens , Athens, Greece. 11:00-‐11:30 Lecture: Investigation of proximal membrane signaling using Surface Plasmon Resonance biosensors: The paradigm of PI3Kα Paul (Bogos) Agianian Dept of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece 11:30-‐12:00 Coffee BREAK-‐ Poster viewing 4 Saturday, November 29, 2014 12:00-‐13:00 Session 5 Cell Organization and Function 21 ALDH3A1 expression in corneal epithelial cells results in reduced apoptosis and oxidative DNA damage accompanied by altered expression of DNA damage response and apoptosis related genes Georgia-‐Persephoni Voulgaridou1, Christos Tolkas1, Persephoni Zioga1, Eleni Panagiotidou1, Theodora Mantso2, Mihalis Panayiotidis2, Aglaia Pappa1* 1Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, 2
School of Life Sciences, Heriot Watt University, Edinburgh, Scotland 22 Malaria parasite gametogenesis as a target for intervention strategies Inga Siden-‐Kiamos1*, Maria Andreadaki1,2, Chiara Curra1, Evangelia Morou2, Lefteris Spanos1 and Elena Deligianni1 Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology – Hellas, Heraklion, Greece,2 Department of Biology, University of Crete, Heraklion, Greece 1 23 The role of miR-‐29a in bladder cancer progression Marika Mokou1,2, Vasiliki Bitsika3, Manousos Makridakis3, Evangelos Marinos1, Nicholaos Anagnou1,2, Antonia Vlahou3, Maria G. Roubelakis1* Laboratory of Biology, School of Medicine, University of Athens, Athens,Greece. Cell and Gene Therapy Laboratory, & 3 Biotechnology Laboratory, Centre of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. 1
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24 Transcriptomic analysis sheds light on new transporters regulating the osmotic adaptive response of nucleus pulposus intervertebral disc cells Eleni Mavrogonatou1, Konstantinos Papadimitriou2, Jill P. Urban3, Vassilios Papadopoulos4 and Dimitris Kletsas1* Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research "Demokritos", Athens, Greece, 2 Dept of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece, 3 Dept of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK, 4 The Research Institute of the McGill University Health Centre, Dept of Medicine, McGill University, Montreal, Quebec, Canada 1 13:00-‐13:30 Lecture: Tuftsin and its Receptor Neuropilin-‐1 in a model of Multiple Sclerosis Stella A. Tsirka Department of Pharmacological Sciences, Stony Brook University, NY, USA 13:30-‐14:15 14:15-‐16:00 Lectures sponsoredby LabSupplies -‐Novel engineered enzymes for QPCR and NGS application Dr Juergen Luenzer, Nippon Genetics -‐Safe DNA stains and high-‐sensitivity detection of nucleic acids using broad excitation spectrum LED technology Dr. Marcelo Lanz, Nippon Genetics
Poster viewing (Session 2) 5 Saturday, November 29, 2014 16:00-‐17:15 Session 6 Cell Communication and Signaling 25 Characterization of TRAF-‐interacting proteins Despina Kerselidou 1, Hadweh Paul1, Aphrodite Sivropoulou1, Elliott Kieff2 , George Mosialos1 , Eudoxia Ηatzivassiliou3* Department of Genetics, Developmental and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2 Department of Medicine and Microbiology and Molecular Genetics, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA, 3 Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece 1
26 Loss of Rassf1α deregulates Hippo pathway signalling in tumourigenesis and development Angelos Papaspyropoulos1, Louise van der Weyden2, Chuen Yan Leung3, Magdalena Zernicka-‐Goetz3, Eric O'Neill1 CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK, 2 Wellcome Trust Sanger Institute, University of Cambridge, UK, 3 The Gurdon Institute, University of Cambridge, UK 1
27 Crosstalk mechanism between AP-‐1 transcription factors and AKT (PKB) in ALK+ Anaplastic Large Cell Lymphoma (ALK+ ALCL) Vassilios Atsaves1, 2, Vicky Leventaki3, Francois .X Claret1, 4 , George Z. Rassidakis5,6 * Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Thorax Foundation, Athens, Greece, 3 Saint Jude Children’s Hospital, Memphis, TN, USA, 4Experimental Therapeutics Academic Program and Cancer Biology Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA,5First Department of Pathology, National and Kapodistrian University of Athens, Athens, Greece, 6Department of Pathology and Cytology, Karolinska University Hospital & Karolinska Institute, Stockholm, Sweden 1
28 RGS4 a new regulator of STAT5-‐mediated gene transcription P.Pallaki, I.M Georganta, A.Agalou, V.Papanikolaou, A.Tserga, S.Koutloglou, I. Serafimidis# and Z. Georgoussi* Laboratory of Cellular Signaling & Molecular Pharmacology, Institute of Biosciences and Applications National Centre for Scientific Research “Demokritos” #Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens 29 Regulation of TGF-‐β and BMP signaling pathways by Poly(ADP-‐ribose) polymerases and Poly(ADP-‐ribose) glycohydrolase Panagiotis Papoutsoglou1*, Yukihide Watanabe1,2, Varun Maturi1, Carl-‐Henrik Heldin1, Aristidis Moustakas1,3* Ludwig Cancer Research, Science for Life Laboratory, Uppsala University, Uppsala, Sweden Laboratory of Experimental Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan 3 Dept. Of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden 1 2 17:15-‐18:15 SEKERIS LECTURE: The regulation of lymphocyte development and activation by microRNAs and RNA binding proteins Martin Turner Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK 18:15-‐18:30 Coffee BREAK-‐ Poster viewing 18:30-‐21:15 EMBL SECTION 18:30-‐18:35 18:35-‐18:55 Introduction The EMBL Alumni Association and the Local Chapter Anastasia Politou, Member of EAA Board and Organizer of the Local Chapter, University of Ioannina, Ioannina, Greece EMBL Lecture 1 Reiner Pepperkok, Head of Core Facilities, Head of Advanced Light Microscopy Core Facility, Team Leader at EMBL EMBL Lecture 2 Nasos Typas, Team Leader in EMBL’s Genome Biology Department Teaching Life Scinces to High school students Vassiliki Kioupi, EMBL Learning Labs Round table with members of HSBMB and EMBL alumni in Greece on Greece's participation in and collaboration with EMBL 18:55-‐19:35 19:35-‐20:15 20:15-‐20:30 20:30-‐21:15 6 Sunday, November 30, 2014 10:00-‐11:00 Session 7 Structure and Function of Macromolecules 1 30 Odorant Binding Protein 1: A potential target for the structure–based design of novel insect repellents Christina E. Drakou1, Katerina E. Tsitsanou1, Spyros E. Zographos1* 1 31 Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Greece Characterization of trans-‐cellular tau propagation using a Drosophila neuronal cell culture system Taxiarchis Katsinelos1*, Thomas R. Jahn1 Schaller Research Group at the University of Heidelberg and the DKFZ, Proteostasis in Neurodegenerative Disease, German Cancer Research Center, Heidelberg, Germany 1 32 First X-‐ray crystal structures of a neuronal nicotinic receptor extracellular domain Marios Zouridakis1, Petros Giastas1, Eleftherios Zarkadas1,2, Dafni Chroni-‐Tzartou1,3, Piotr Bregestovski4, Cornelia Poulopoulou3 and Socrates Tzartos1,2* Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece, 2 Department of Pharmacy, University of Patras, Rio, Patras, Greece, 3 Laboratory of Experimental Neurophysiology, Eginition Hospital, Athens, Greece, 4 Brain Dynamics Institute, University Aix-‐Marseille, Marseille, France 1 33 Disulfide bond requirements for activity and nuclear localization of SRPK1 Maria Koutroumani1, Giorgos Papadopoulos2, Eleni Nikolakaki1, Thomas Giannakouros1* Department of Chemistry, Aristotelian University, Thessaloniki, Greece Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece 1 2
11:00-‐11:30 Lecture: HDL quality and functionality as a novel pharmacological target for atherosclerosis and beyond Kyriakos E. Kypreos Department of Pharmacology, University of Patras, School of Medicine, Rio Achaias, Greece 11:30-‐12:00 Lecture: Nucleotide Excision Repair: in Development and Disease George Garinis Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-‐Hellas, Heraklion, Crete, Greece & Department of Biology, University of Crete, Heraklion, Crete, Greece
12:00-‐13:15 Coffee BREAK -‐ Poster viewing (Session 3) 13:15-‐13:45 Lecture: Molecular mechanisms of Cellular Reprogramming Dimitris Thanos Biomedical Research Foundation, Academy of Athens, Athens, Greece 7 Sunday, November 30, 2014 13:45-‐14:45 Session 8 Structure and Function of Macromolecules 2 34 “Truncated” ribosomes translate faster: A nano technological verification resulted by single molecule investigation A. Katranidis1*, A. Tsagkalia2*, F. Tsitouroudi 2*, K. Nierhaus 3, D. Kalpaxis 4, G. Papadopoulos 5 and T. Choli-‐Papadopoulou 2 1. Forschungszentrum Jülich · Molecular Biophysics , 2.Aristotle University of Thessaloniki, School of Chemistry, Laboratory of Biochemistry, 3 Institute for Medical Physics and Biophysics , Charite-‐University, Berlin, 4. University of Patras, School of Medicine ,Laboratory of Biological Chemistry and 5. University of Thessaly Department of Biochemistry and Biotechnology *These authors contributed equally 35 Monitoring eIF4A conformational dynamics: dissecting the effects of RNA and translation initiation factors eIF4G and eIF4B Alexandra Andreou, Ulf Harms, Dagmar Klostermeier* 1 36 Institute for Physical Chemistry, University of Muenster, Muenster, Germany A central role of RF2 in translational quality control Alexandros D. Petropoulos, Megan E. McDonald, Hani S. Zaher and Rachel Green Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 37 Selective tRNAGly isoacceptor binding to a single glyS T-‐Box riboswitch regulates translation and cell wall formation in Staphylococcus aureus Maria Apostolidi1, Dimitrios Anastasakis1, Parthena Konstantinidou1, Nizaar Saad2, Jonathan L. Huot2, Hubert D. Becker2 and Constantinos Stathopoulos1* 1
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14:45-‐15:15 Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece. Unité Mixte de Recherche 7156 Génétique Moléculaire, Génomique, Microbiologie, CNRS, Université de Strasbourg 67084, Strasbourg, France Honorary Lecture – EVANGELOPOULOS LECTURE: From perception to chromatin remodeling Vardis Ntoukakis School of Life Sciences , University of Warwick, Coventry, UK 15:15-‐15:30 Closing Ceremony – Prize Awards 8