BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Berkin Bilgic Postdoctoral Research Fellow eRA COMMONS USER NAME (credential, e.g., agency login) BBILGIC EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Bogazici University, Turkey B.S. 06/08 Electrical and Electronics Engineering Bogazici University, Turkey B.S. 06/08 Physics Massachusetts Institute of Technology, MA S.M. 02/10 Electrical Engineering and Computer Science Massachusetts Institute of Technology, MA Ph.D. 02/13 Electrical Engineering and Computer Science Postdoctoral 02/13 to date Massachusetts General Hospital, MA Medical Imaging/ Neuroscience A. Personal Statement My research focuses on the development of novel data acquisition and reconstruction methods that increase the efficiency of MRI through the combination of MR physics, signal processing, and numerical optimization. By fully harnessing the hardware capabilities of MR scanners, I aim to develop accelerated protocols that will help us study the human physiology in finer detail than previously possible. I am pursuing this goal on two fronts: 1) Develop WAVE-CAPI acquisition/reconstruction for highly accelerated imaging. Modern MR scanners are equipped with multiple receivers that are sensitive to signals arising from their vicinity. Such difference in sensitivity can be used for reconstructing images from sub-sampled acquisitions, thereby reducing the scan time. Due to physical limits of multi-channel receivers, pushing the acceleration factor beyond 3 through conventional methods degrades the image quality. I am developing the Wave-CAIPI technique that enables 10-fold acceleration with low image artifact and noise amplification penalties. Wave-CAIPI has already been incorporated into the 3D gradient echo (GRE) acquisition sequence, which is the main protocol used for Quantitative Susceptibility Mapping (QSM) and Susceptibility Weighted Imaging (SWI). These modalities allow investigation of the magnetic susceptibility of the brain tissue, and facilitate monitoring neurodegenerative diseases. Wave-CAIPI allows full-brain imaging at 1 mm isotropic voxel size in two minutes with retained SNR values close to 100%. Since it requires no additional hardware, I will be able to disseminate this method to any scan site by distributing the software. 2) Investigate white matter connectivity at high resolution through tissue susceptibility anisotropy. The observed susceptibility of the brain tissue depends on the orientation of the head relative to the main magnetic field. If susceptibility distribution is modeled as a tensor, it can be estimated by acquiring GRE data at multiple orientations by rotating the head. This modality is termed Susceptibility Tensor Imaging (STI), and requires data collected at 12 or more head positions. I aim to optimize a 1-minute whole-brain GRE exam at 1.5 mm isotropic resolution through Wave-CAIPI acceleration, thereby enabling a 12-minute STI exam. This will render STI clinically feasible for the first time, which has been limited to research studies so far. B. Research and/or Professional Experience: Employment 02/07 – 06/07 Student Assistant, Bogazici University, Turkey Supervisor: Prof. Taylan Akdogan 06/07 – 08/07 01/09 – 01/10 02/10 – 06/10 02/10 – 02/13 02/13 to date Research Intern, Institute for Quantum Optics & Quantum Information (IQOQI), Austria Supervisor: Prof. Anton Zeilinger Research Assistant, Massachusetts Institute of Technology, Cambridge, MA Supervisor: Prof. Berthold K. P. Horn Teaching Assistant, Massachusetts Institute of Technology, Cambridge, MA Supervisor: Prof. William T. Freeman Research Assistant, Massachusetts Institute of Technology, Cambridge, MA Supervisor: Prof. Elfar Adalsteinsson Research Fellow, A. A. Martinos Center for Biomedical Imaging, Charlestown, MA Supervisor: Prof. Kawin Setsompop Honors 2004 2004 2004-2008 2008 2008 2008-2009 2011-2012 2012 2012-2013 2013 2013 2014 2014 Ranked 1st among Class of 2004, Izmir Science High School Ranked 56th out of 1.8 million candidates in the University Entrance Exam, Turkey Prime Ministry Scholarship, Turkey Ranked 1st in the Faculty of Engineering among Class of 2008, Bogazici University Ranked 1st in the double major program among Class of 2008, Bogazici University DuPont – MIT Presidential Fellowship CIMIT – MIT Medical Engineering Fellowship MICCAI Young Scientist Award Finalist ISMRM Educational Stipend ISMRM Magna Cum Laude Merit Award ISMRM Summa Cum Laude Merit Award ISMRM Power Poster Award for top 2% conference abstracts ISMRM Summa Cum Laude Merit Awards for two abstracts Professional Societies and Public Advisory Committees Membership: International Society of Magnetic Resonance in Medicine (ISMRM) Medical Image Computing and Computer Assisted Intervention (MICCAI) Society Reviewer: Journals: NeuroImage, Magnetic Resonance in Medicine, Frontiers in Human Neuroscience, American Journal of Neuroradiology, Journal of American Aging Association, IEEE Transactions on Image Processing, IEEE Signal Processing Letters Conferences: ISMRM 2012, MICCAI 2012 and 2013, International Workshop on MRI Phase Contrast & Quantitative Susceptibility Mapping 2013, IEEE Conference on Intelligent Transportation Systems 2010 and 2011 C. Journal Publications 1. B. Bilgic, V.K. Goyal, E. Adalsteinsson; Multi-contrast Reconstruction with Bayesian Compressed Sensing; Magnetic Resonance in Medicine 66.6 (2011): 1601-1615. 2. B. Bilgic, A. Pfefferbaum, T. Rohlfing, E.V. Sullivan, E. Adalsteinsson; MRI Estimates of Brain Iron Concentration in Normal Aging Using Quantitative Susceptibility Mapping; NeuroImage 59.3 (2012): 26252635. 3. B. Bilgic, K. Setsompop, J. Cohen-Adad, A. Yendiki, L.L. Wald, E. Adalsteinsson;Accelerated Diffusion Spectrum Imaging with Compressed Sensing using Adaptive Dictionaries; Magnetic Resonance in Medicine 68.6 (2012): 1747-1754. 4. B. Bilgic, B. Gagoski, T. Kok, E. Adalsteinsson; Lipid Suppression in CSI with Spatial Priors and Highly Undersampled Peripheral k-space; Magnetic Resonance in Medicine 69.6 (2013): 1501-1511 5. B. Bilgic, I. Chatnuntawech, K. Setsompop, S.F. Cauley, L.L. Wald, E. Adalsteinsson; Fast Diffusion Spectrum Imaging Reconstruction with Trained Dictionaries; IEEE Transactions on Medical Imaging 32.11 (2013): 2022-2033 6. B. Bilgic, I. Chatnuntawech, A.P. Fan, K. Setsompop, S.F. Cauley, L.L. Wald, E. Adalsteinsson; Fast Image Reconstruction with L2-Regularization; Journal of Magnetic Resonance Imaging, DOI: 10.1002/jmri.24365 7. A.P. Fan, B. Bilgic, L. Gagnon, T. Witzel, H. Bhat, B.R. Rosen, E. Adalsteinsson; Quantitative Oxygenation Venography from MRI Phase; Magnetic Resonance in Medicine, DOI: 10.1002/mrm.24918 8. B. Bilgic, A.P. Fan, J.R. Polimeni, S.F. Cauley, M. Bianciardi, E. Adalsteinsson, L.L. Wald, K. Setsompop; Fast Quantitative Susceptibility Mapping with L1-Regularization and Automatic Parameter Selection; Magnetic Resonance in Medicine, DOI: 10.1002/mrm.25029 9. I. Chatnuntawech, B. Gagoski, B. Bilgic, S.F. Cauley, K. Setsompop, E. Adalsteinsson; Accelerated MRSI Using Randomly Undersampled Spiral-Based k-Space Trajectories; submitted to Magnetic Resonance in Medicine 10. S.F. Cauley, Y. Xi, B. Bilgic, J. Xia, E. Adalsteinsson, V.R. Balakrishnan, L. L. Wald, K. Setsompop; Fast Reconstruction for Multi-channel Compressed Sensing Using a Hierarchically Semiseparable Solver; Magnetic Resonance in Medicine, DOI: 10.1002/mrm.25222 11. B. Bilgic, B. Gagoski, S.F. Cauley, A.P. Fan, J.R. Polimeni, P.E. Grant, L.L. Wald, K. Setsompop; WaveCAIPI for Highly Accelerated 3D Imaging; accepted for publication in Magnetic Resonance in Medicine D. Selected Conference Contributions (out of 32) 1. B. Bilgic, A.P. Fan, E. Adalsteinsson; Quantitative Susceptibility Map Reconstruction with Magnitude Prior; International Society for Magnetic Resonance in Medicine 19th Scientific Meeting, Montreal, Canada, 2011, p. 746. Oral Presentation 2. B. Bilgic, V.K. Goyal, E. Adalsteinsson; Joint Bayesian Compressed Sensing for Multi-contrast Reconstruction; International Society for Magnetic Resonance in Medicine 19th Scientific Meeting, Montreal, Canada, 2011, p. 71. Oral Presentation 3. B. Bilgic, B. Gagoski E. Adalsteinsson; Lipid Suppression in CSI with Highly-Undersampled Peripheral kspace and Spatial Priors; International Society for Magnetic Resonance in Medicine 20th Scientific Meeting, Melbourne, Australia, 2012, p. 4455. Poster Presentation 4. B. Bilgic, E. Adalsteinsson; Joint Bayesian Compressed Sensing with Prior Estimate; International Society for Magnetic Resonance in Medicine 20th Meeting, Melbourne, Australia, 2012, p. 75. Oral Presentation 5. B. Bilgic, K. Setsompop, J. Cohen-Adad, V. Wedeen, L. Wald, E. Adalsteinsson; Accelerated Diffusion Spectrum Imaging with Compressed Sensing using Adaptive Dictionaries; 15th International Conference on Medical Image Computing and Computer Assisted Intervention, 2012; LNCS 7512:1-9. Oral Presentation 6. B. Bilgic, I. Chatnuntawech, A.P. Fan, E. Adalsteinsson; Regularized QSM in Seconds; International Society for Magnetic Resonance in Medicine 21st Scientific Meeting, Salt Lake City, Utah, USA, 2013, p. 168. Oral Presentation 7. B. Bilgic, I. Chatnuntawech, K. Setsompop, S.F. Cauley, L.L. Wald, E. Adalsteinsson; Fast DSI Reconstruction with Trained Dictionaries; International Society for Magnetic Resonance in Medicine 21st Scientific Meeting, Salt Lake City, Utah, USA, 2013, p. 58. Oral Presentation 8. B. Bilgic, I. Chatnuntawech, K. Setsompop, S.F. Cauley, L.L. Wald, E. Adalsteinsson; Fast Regularized Reconstruction Tools for QSM and DSI; ISMRM Workshop on Data Sampling & Image Reconstruction, Sedona, Arizona USA, 2013. Oral Presentation 9. B. Bilgic, A.P. Fan, C. Eichner, J.R. Polimeni, M. Bianciardi, E. Adalsteinsson, L.L. Wald, K. Setsompop; Fast Reconstruction for Regularized Quantitative Susceptibility Mapping; accepted to International Society for Magnetic Resonance in Medicine 22nd Scientific Meeting, Milan, Italy. Oral Presentation 10. B. Bilgic, B. Gagoski, S.F. Cauley, A.P. Fan, J.R. Polimeni, P.E. Grant, L.L. Wald, K. Setsompop; Rapid QSM Acquisition with Wave-CAIPI; accepted to International Society for Magnetic Resonance in Medicine 22nd Scientific Meeting, Milan, Italy. Power Poster Presentation E. Research Support Current Support N/A Completed Support N/A
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