Email: [email protected] Liyan He Liyan He, Ph. D. 396 Lake Victoria Cir. Melbourne, FL 32940 Tel: (321) 394-1640 Email: [email protected] Education Ph.D. M.S. M.S. B.S. Biophysical Chemistry, University of Rochester, Rochester, NY. 1994 Biophysical Chemistry, University of Rochester, Rochester, NY. 1990 Chemistry, Zhongshan University, Guangzhou, China, 1988 Chemistry, Zhongshan University, Guangzhou, China. 1985 Language Fluent in English and Chinese (Mandarin and Cantonese) Employment History July, 2013 – Present On disability leave Mar. 2008 – July, 2013 Sr. TCLO, Center for Technology Enterprise and Commercialization, Cornell University Responsible for managing a portfolio of inventions focusing on gene and cell therapies, biomaterials & biomedical engineering and research tools generated at Weill Cornell Medical College (WCMC).  Intellectual Property (IP) Portfolio Management Review, analyze and evaluate new disclosures for their technical development, patentability, commercial potential and practical utilities. Develop strategy for portfolio management. Work with outside patent attorneys to file and prosecute patent applications. Currently Manage over 200 dockets.  Liaison and Services to Faculty Members and Research Staff Assist faculty and researchers to disclose their inventions according to Cornell policy. Help inventors crystallize any valuable IP from their work, including inventions, tangible research materials, and copyrightable materials. Actively participate in Cornell-wide educational program to increase the general awareness of IP issues. Coordinate with the appropriate staff to plan and implement outreach and economic development activities. Current portfolio contains inventions from more than 80 inventors.  Intellectual Property Licensing Interact with the technology businesses and investment communities to promote utilization of Cornell IPs for economic development. Actively transfer IPs generated at WCMC to industry partners so that they can be developed into useful products for the public to advance the university's missions. Activities include preparing marketing material for each docket available for licensing in my portfolio; marketing IPs to potential licensees; drafting and negotiating license agreement with potential licensees; and maintaining good rapport with existing and potential industry partners at all time. In the past three years, I successfully negotiated 15 licenses including 3 startup licenses. Jun. 2005 – Sept. 2007 VP of Technology Evaluation, XL TechGroup, Melbourne, FL Responsible for discovering and evaluating technologies for potential business opportunities. Defining the path forward and business requirement for the selected technologies. Develop and implement technical plans. 1 Email: [email protected] Liyan He  Screened broad spectrum of technologies in the areas of Bio-Tech, Eco-Tech and Med-Tech to select technologies that match with the potential business opportunities. Worked with business development team to evaluate the commercialization potentials of the technologies. Participated in the creation of two portfolio companies.  Created extra value for the company by inventing new applications using the existing technologies. Resulted in two provisional patent applications.  Built and maintained relationships with technology partners such as universities, R&D laboratories and companies. Worked with inventors to develop sponsored research plans.  Provided technical consulting for portfolio companies. Nov. 2002 – Jun. 2005 Research Professor Associate, Arizona State University, Tempe, AZ Participated in the preparation of a DRAPA (Defense Advanced Research Projects Agency) phase I research proposal, which was granted with over $1 Million to develop a single-molecule DNA sensor. Developed and implemented the strategy to meet the milestones set by DARPA. Prepared quarterly reports, presentations and the phase II research proposal. Invented novel DNA detection methods that yielded two patent applications. Supervised a team of graduate students, postdocs, and technicians. Oct. 2001 – July, 2002 Staff Scientist, Motorola Life Sciences, Tempe, AZ Responsible for developing technologies to increase the accuracy and decrease the cost of CodeLinkTM SNP Bioarrays. Invented a novel method to rescue failed assay and eliminated the need for outside licensing. Enabled one provisional patent application. Evaluated a broad range of technologies related to nucleic acid testing. Managed relationships with external collaborators. Supervised a team of two scientists. May 1998-Oct. 2001 Senior Scientist, Sequenom Inc., San Diego, CA Responsible for advanced DNA genotyping technology development. Invented novel DNA multiplex genotyping assays and sample preparation methods that resulted in >50% assay cost reduction and enabled Sequenom to lunch flagship homogeneous MassEXTENDTM assay. Co-inventor of several patents and patent applications. Built and maintained relationships with internal and external collaborators, and with vendors. Evaluated a broad range of technologies for potential licensing opportunities. Introduced MassArrayTM technology to China creating opportunity for market penetration. Supervised a team of three scientists. Jul. 1995-May 1998 Senior Scientist, Chromagen Inc., San Diego, CA Responsible for establishing and managing the chemistry program. Invented and developed Chromagen’s flagship commercial product StarBrightTM series fluorescent labels and substrates. Established and managed multi-functional teams of new fluorescent dye development and DNA probe design, synthesis, and screening. Developed research plans and worked closely with the senior management and other department heads to implement plans and meet timelines for the development of commercial product HPSATM series gene expression assays. Presented Chromagen’s technologies to investors and collaborators for evaluation and due diligence. Established and maintained relationships with internal and external collaborators, vendors and patent attorneys. Recruited and supervised a group of seven scientists. Aug. 1994-Jul. 1995 Postdoctoral Fellow, ICN Pharmaceuticals, Costa Mesa, CA Responsible for screening modified oligonucleotides as potential antisense drugs. Synthesized and screened 2 Email: [email protected] Liyan He modified oligonucleotides as potential antisense drugs. 1993-1994 Postdoctoral Fellow, University of Colorado at Boulder, CO 1988-1993 Graduate Student, University of Rochester, Rochester, NY 1986-1988 Research Associate, The University of Hong Kong, Hong Kong Patents and Patent Applications 1. “Fluorogenic Substrates” US Patent No. 6,949,632 and foreign equivalents. 2. “Fluorogenic Substrates and their use” US Patent No. 6,635,435 and foreign equivalents. 3. “Methods for generating databases and databases for identifying polymorphic genetic markers” US Patent No. 7,668,658 and foreign equivalents. 4. “Methods for generating databases and databases for identifying polymorphic genetic markers” US Patent No. 8,229,677and foreign equivalents. 5. “Single Molecule Detection Using Molecular Motors” US application 20090035751. 6. “Methods for generating databases and databases for identifying polymorphic genetic markers” US application 20120301882. 7. “Methods for generating databases and databases for identifying polymorphic genetic markers” US application 20100292930. 8. “Nucleic Acid Indexing” US application 20040224330. 9. “Surface Plasmon Resonance Sensor for Detecting Changes in Polynucleotide Mass” US application 20090035751. Publications Available upon request Professional Affiliations Association of University Technology Managers Licensing Executives Society Citizenship US citizen References Available upon request 3