Direct thrombin inhibitors (DTIs) block both circulating and clot-bound thrombin Thrombin generation
Direct thrombin inhibitors (DTIs) block both circulating and clot-bound thrombin Thrombin generation Antithrombin DTIs: dabigatran etexilate Heparin Conversion of fibrinogen to fibrin Amplification DTIs: dabigatran etexilate Blood clot Clot-bound thrombin Adapted from Eikelboom J et al. J Am Coll Cardiol 2003;41:70S–8S
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