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Ekstrakcija, izolovanje, sinteza i biološka aktivnost sekundarnih metabolita biljnih vrsta
roda Hypericum
dr Andrija Šmelcerović, vanredni profesor Medicinskog fakulteta u Nišu
Rod Hypericum L. (Hypericaceae/Guttiferae) obuhvata oko 484 biljnih vrsta, rasprostranjenih širom
sveta. Biljne vrste roda Hypericum se tradicionalno koriste u narodnoj medicine. Broj naučnih publikacija
o biljnim vrstama ovog roda je značajno porastao usled farmakološkog značaja sekundarnih metabolita
kantariona (Hypericum perforatum L.). Najznačajniji biokativni sastojci ovog roda su: (i) naftodiantroni,
od kojih su najpoznatiji hipericin i pseudohipericin, (ii) derivati floroglucinola, pre svih hiperforin i
adhiperforin, i (iii) flavonoidi, hiperozid, rutin, kvercetin i drugi. Hipericin i pseudohipericin deluju kao
antivirotici, hiperforin je jedan od nosilaca antidepresivnog dejstva ekstrakata biljnih vrsta roda
Hypericum, dok flavonoidi pokazuju antioksidatvnu aktivnost.
U ovom predavanju biće predstavljeni rezultati istarživanja o ekstrakciji, izolovanju, sintezi i biološkoj
aktivnosti sekundarnih metabolita biljnih vrsta roda Hypericum.
Selektovani radovi Andrije Šmelcerovića o bioaktivnim sastojcima Hypericum vrsta
1.
Stojanović, G., Đorđević, A., Šmelcerović, A. (2013) Do other Hypericum species have medical potential
as St. John’s Wort (Hypericum perforatum)? Current Medicinal Chemistry 20, 2273-2295.
2. Đorđević, A., Lazarević, J., Šmelcerović, A., Stojanović, G. (2013) The case of Hypericum rochelii Griseb.
& Schenk and Hypericum umbellatum A. Kern. essential oils: Chemical composition and antimicrobial
activity. Journal of Pharmaceutical and Biomedical Analysis 77, 145-148.
3. Košuth, J., Smelcerovic, A., Borsch, Th., Zuehlke, S., Karppinen, K., Spiteller, M., Hohtola, A., Čellárová,
E. (2011) The hyp-1 gene is not a limiting for hypericin biosynthesis in the genus Hypericum. Functional
Plant Biology 38, 35-43.
4. Komarovská H., Košuth J., Giovannini A., Smelcerovic, A., Zhuelke S., Čellárová E. (2010) Effect of
number of rol genes integration on phenotypic variation in hairy root-derived Hypericum perforatum L.
plants. Zeitschrift für Naturforschung C 65c, 701-712.
5. Bonkanka, C.X., Smelcerovic, A., Zuehlke, S., Rabanal, R.M., Spiteller, M., Sánchez-Mateo, C.C. (2008)
HPLC-MS analysis and anti-oedematogenic activity of Hypericum grandifolium Choisy (Hypericaceae).
Planta Medica 74, 719-725.
6. Glisic, S., Smelcerovic, A., Zuehlke, S., Spiteller, M., Skala, D. (2008) Extraction of hyperforin and
adhyperforin from St. John’s Wort (Hypericum perforatum L.) by supercritical carbon dioxide. Journal of
Supercritical Fluids 45, 332-337.
7. Radulović, N., Stankov-Jovanović, V., Stojanović, G., Šmelcerović, A., Spiteller, M., Asakawa, Y. (2007)
Screening of in vitro antimicrobial and antioxidant activity of nine Hypericum species from the Balkans.
Food Chemistry 103, 15-21.
8. Smelcerovic, A., Verma, V., Spiteller, M., Ahmad, S.M., Puri, S.C., Qazi, G.N. (2006) Phytochemical
analysis and genetic characterisation of six Hypericum species from Serbia. Phytochemistry 67, 171-177.
9. Smelcerovic, A., Spiteller, M. (2006) Phytochemical analysis of nine Hypericum L. species from Serbia
and the F.Y.R. Macedonia. Pharmazie 61, 251-252.
10. Smelcerovic, A., Spiteller, M., Zuehlke, S. (2006) Comparison of methods for the exhaustive extraction of
hypericins, flavonoids, and hyperforin from Hypericum perforatum L. Journal of Agricultural and Food
Chemistry 54, 2750-2753.
11. Lackner, B., Popova, Y., Etzlstorfer, Ch., Smelcerovic, A.A., Klampfl, Ch., Falk, H. (2005) Synthesis and
properties of two heterocyclically substituted hypericin derivatives: 10, 11-dibenzothiazolyl-10,11didesmethylhypericin and 10, 11-dibenzoxazolyl-10,11-didesmethylhypericin. Monatshefte für Chemie
(Chemical Monthly) 136, 777-793.
12. Smelcerovic, A., Laatsch, H., Lepojevic, Z., Djordjevic, S. (2002) The separation of hypericine and
pseudohypericine from Hypericum perforatum L. Pharmazie 57, 178-180.