Yuqian Shi 220 Mt Evans Dr, Durham, NC 27705 Phone: (919) 381-2399 E-mail: [email protected] EDUCATION Sep 2011 – present Duke University, Durham, NC PhD candidate in Biochemistry Areas of Interest: Human DNA Repair and Drug Design Current GPA: 3.93 Sep 2007 – Aug 2011 The Hong Kong University of Science and Technology (HKUST), Hong Kong First Class Honors Bachelor of Science in Biochemistry Minors: Biotechnology, Biology and Mathematics Areas of Interest: Immune System Development and Regulation Sep 2004 – Jun 2007 Beijing Huiwen High School (Peking Academy), Beijing, China China College Entrance Exam Score: 654/750 (Top 0.1%) PUBLICATIONS Shi, Y., Mao, L., Kumar, S., Beese, L. (2014). The complex structure of human exonuclease 1 C-terminal region with PCNA reveals a new PIP-box interaction conformation. (paper in preparation) Mabanglo, M., Shi, Y., Hast, M., Lubock, N., Beese, L. (2014). 3-D structure and steady-state kinetics of Candida albicans protein farnesyltransferase reveal strategies for designing dual prenyltransferase inhibitors with fungal enzyme selectivity. (paper in preparation) Li, L., Yan, B., Shi, Y., Zhang, W., Wen, Z. (2012). Live imaging reveals differing roles of macrophages and neutrophils during zebrafish tail fin regeneration. J Bio Chem, 287(30): 25353-60. doi: 10.1074/jbc.M112.34912 Li, L., Jin, H., Xu, J., Shi, Y., Wen, Z. (2011). Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis. Blood, 117(4):1359-69 TALKS, PRESENTATIONS, POSTERS, and PROCEEDINGS Shi, Y. (2014). Molecular Mechanism of Human Exonuclease 1. Talk at Duke Biochemistry Retreat 2014, Wilmington, NC. Shi, Y., McSweeny, E., Beese, L. (2014). Structural Investigation of Human Exonuclease 1. Duke Biochemistry Retreat 2014 Wilmington, NC. Mao, L., Shi, Y., Wu, Q., Zhou, P., Beese, L. (2014). Biochemical and Biophysical Characterization of Human Exonuclease 1 Regulatory C-terminal Domain. Duke Biochemistry Retreat 2014, Wilmington, NC. Shi, Y., McSweeny, E., Mao, L., Beese, L. (2014). Structural Invesstigation of Human Exonuclease 1 (hExo1). 44th Mid-Atlantic Macromolecular Crystallography Meeting (MAMCM) and 11th SER-CAT Symposium, Maryland, MA. Shi, Y., McSweeny, E., Mao, L., Beese, L. (2014). Structural Invesstigation of Human Exonuclease 1 (hExo1). Duke Biochemistry Symposium 2014, Durham, NC. Mao, L., Shi, Y., McSweeny, E., Beese, L. (2014). Mapping Mismatch Repair Protein Interactions to the Regulatory C-terminal Tail of Human Exonuclease 1. Duke Biochemistry Symposium 2014, Durham, NC. Shi, Y., McSweeny, E., Mao, L., Kumar, S., Beese, L. (2014). Characterization of Human Exonuclease 1(hExo1) C-terminal Protein-protein Interactions. 13th The Structural Cell Biology of DNA Repair Machines Meeting (SBDR), Berkeley, CA. McSweeny, E., Shi, Y., Beese, L. (2013). Ensemble of Human Exonuclease 1 Complexes with DNA Provides -1- Yuqian Shi 220 Mt Evans Dr, Durham, NC 27705 Phone: (919) 381-2399 E-mail: [email protected] Novel Insights into Mechanism. 43th Mid-Atlantic Macromolecular Crystallography Meeting (MAMCM), Durham, NC. Shi, Y., McSweeny, E., Beese, L. (2012). Structure Analysis of Human Exonuclease 1 R92A Mutant Complexes. Duke Biochemistry Retreat 2012, Wilmington, NC. Shi, Y. (2011). The Certification of Coronin 1a Transgenic Zebrafish. HKUST UROP Proceedings 2010, 7. Shi, Y. (2010). The Effect of Pu.1 or/and Runx1 Mutation on Zebrafish Primitive Hematopoiesis. HKUST UROP Proceedings 2009, 6. GRANTS, HONORS and AWARDS 2014 Cover Image, 2014 Duke Biochemistry Retreat, Wilmington, NC. 2014 Design Award, Duke Biochemistry Tee design Contest, Durham, NC 2014 Best Poster Presentation Award (HKL Award, 2%), 44th Mid-Atlantic Macromolecular Crystallography Meeting (MAMCM) and 11th SER-CAT Symposium, Maryland, MA. 2010 – 2011 HKUST Scholarship for UG Students, reorganization and honor for students with outstanding academic performance. 2009 – 2010 HKUST Undergraduate Research Opportunities Program Grant (twice), HKUST, Hong Kong 2008 – 2010 Dean’s List (Continuous 4 times), HKUST honor for outstanding students RESEARCH EXPERIENCES 2012 – present Lorena Beese Laboratory, Duke University Medical Center, Durham, NC Graduate Research Assistant - Investigation of molecular mechanisms of human DNA mismatch repair (MMR) proteins using Structural and Biochemical approaches. 2009 – 2011 in silico and in vitro drug design for fungi farnesyltransferase. State Key Developmental Biology Laboratory of Zilong Wen, HKUST, Hong Kong Research Assistant 2007 – 2008 - Generated specifically labeled zebrafish transgenic lines. - Studied macrophage and neutrophil development and behavior. Costal Marine Biology Laboratory of Peiyuan Qian, HKUST, Hong Kong Student Helper Leader - Designed and improved microbial fuel cells. - Coordinate eight other student helpers in the lab. TEACHING EXPERIENCES 2012 BIOCHEM 301- Introduction to Biochemistry I, Duke University, Durham, NC Teaching Assistant - One of the four teaching assistants on this class with more than 300 students. - Preparing tutorials and TA sessions with other teaching assistants. -2- Yuqian Shi 220 Mt Evans Dr, Durham, NC 27705 Phone: (919) 381-2399 E-mail: [email protected] LEADERSHIP and TEAM EXPERIENCES 2013 – present American Area Manager, Shanghai Tanxin Trading Co.,Ltd, Shanghai, China (The largest longbow manufacturer in China) 2011 – present - Lead and coordinate sales in North America. - Communicate with Chinese manufacturer about company strategy. - Design and manage online shops. Senior Saints, Duke Christian on Campus, Durham, NC - Lead and coordinated the local church development with other saints, the number of active saints increased from less than ten to over forty. - Designed and organized series of gospel activities on campus and in neighborhood, got over two hundred people baptized 2008 – 2011 Communicated and visited more than ten churches in the USA with other saints. Internal Secretary, Students’ Karate Club, HKUST, Hong Kong - In charge of daily management of club internal affairs including training, membership and dojo maintenance. - Coordinated on-campus activities with other secretaries including competition, promotion and performance. 2008 – 2009 Promotion Secretary, Film Society, HKUST, Hong Kong - Directed and organized series of promotional activities with other committee members, recruited more than 150 members. 2008 Designed and prepared stands, panels, posters, booklets for these activities. Organizer, Peer-Counselor Program, HKUST, Hong Kong - Coordinated with 12 junior undergraduate students and arranged activates to help them get adjusted to college life. 2007 – 2008 Art Editor, The Sishuiliunian Magazine, Hong Kong - Prepared layout of pages and picked necessary graphics and photographs to assist stories. - Coordinated with journalists and editorial staff and discussed ideas to be incorporated in magazines. 2007 Established a style for publications and ensured compliance in every issue. Interpreters, JIE Holding Group, Hangzhou, - Translate for five foreign engineers. COMPUTER SKILLS Coding: Python, Wolfram Mathematica, Matlab, HTML, CSS, PHP Editing and Art: Microsoft Office, Adobe Photoshop, Adobe Illustrator, Adobe InDesign, Adobe Dreamweaver, Adobe Fireworks Analysis: JMP, Origin, Graphpad Prism, Kaleidagraph, ImageJ -3- Yuqian Shi 220 Mt Evans Dr, Durham, NC 27705 Phone: (919) 381-2399 E-mail: [email protected] Biological and Chemical: Schrödinger Suite, PHENIX Suite, DNASTAR Lasergene Suite, CCP4 Suite, XDS, CNS Suite, ChemBioOffice Suite, PyMOL, Chimera, Coot, KiNG, Scatter, Scaffold, Autodock, iMosflm, HKL, etc LANGUAGES English: Proficient Chinese: Native Cantonese: Fluent, level 1 certificate Japanese: Speak, read and write with basic competence MEMBERSHIPS America Mensa Member Hong Kong Mensa Member, SIG Xuanzhuo Hong Kong St. John Ambulance ACTIVITIES Member of North Carolina Bowhunter Association, BABINC certified, BCRS certified Bowhunter Member of HKUST Karate Team, 2nd runner-up of Hong Kong Karate University Cup Member of HKUST Judo Team Member of HKUST Kendo Team Member of HKUST Climbing Team -4-
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