JAC The Journal of Antimicrobial Chemotherapy Volume 69 Number 12 December 2014 Contents Systematic reviews Virological efficacy of abacavir: systematic review and meta-analysis Mario Cruciani, Carlo Mengoli, Marina Malena, Giovanni Serpelloni, Saverio G. Parisi, Graeme Moyle and Oliviero Bosco Efficacy and safety of daptomycin for the treatment of infectious disease: a meta-analysis based on randomized controlled trials Wenqiang He, Yawei Zhang, Hongbin Chen, Chunjiang Zhao and Hui Wang 3169 3181 Original research Generation of a vancomycin-intermediate Staphylococcus aureus (VISA) strain by two amino acid exchanges in VraS 3190 Anne Berscheid, Patrice Franc¸ois, Axel Strittmatter, Gerhard Gottschalk, Jacques Schrenzel, Peter Sass and Gabriele Bierbaum Kinetics of recA and recX induction in drug-susceptible and MDR clinical strains of Mycobacterium tuberculosis Purva Bhatter, Anirvan Chatterjee and Nerges Mistry 3199 Interplay between plasmid-mediated and chromosomal-mediated fluoroquinolone resistance and bacterial fitness in Escherichia coli 3203 Jesu´s Machuca, Alejandra Briales, Gema Labrador, Paula Dı´az-de-Alba, Rafael Lo´pez-Rojas, Fernando Docobo-Pe´rez, Luis Martı´nez-Martı´nez, Jesu´s Rodrı´guez-Ban˜o, Maria Eugenia Pacho´n, A´lvaro Pascual and Jose´-Manuel Rodrı´guez-Martı´nez Proteus genomic island 1 (PGI1), a new resistance genomic island from two Proteus mirabilis French clinical isolates 3216 Eliane Siebor and Catherine Neuwirth MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation 3221 Yi-Tsung Lin, Yi-Wei Huang, Rung-Shiuan Liou, Yi-Chih Chang and Tsuey-Ching Yang Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics Muhammad Malik, Liping Li, Xilin Zhao, Robert J. Kerns, James M. Berger and Karl Drlica 3227 Activity of the type I signal peptidase inhibitor MD3 against multidrug-resistant Gram-negative bacteria alone and in combination with colistin Yoann Personne, Michael A. Curtis, David W. Wareham and Richard D. Waite 3236 Aspergillus fumigatus harbouring the sole Y121F mutation shows decreased susceptibility to voriconazole but maintained susceptibility to itraconazole and posaconazole J. Lescar, I. Meyer, K. Akshita, K. Srinivasaraghavan, C. Verma, M. Palous, D. Mazier, A. Datry and A. Fekkar 3244 Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19 Rosalba Perrone, Elena Butovskaya, Dirk Daelemans, Giorgio Palu`, Christophe Pannecouque and Sara N. Richter Nitrofurantoin retains antimicrobial activity against multidrug-resistant urinary Escherichia coli from US outpatients G. V. Sanchez, A. M. G. Baird, J. A. Karlowsky, R. N. Master and J. M. Bordon 3248 3259 Comparison of ML8-X10 (a prototype oil-in-water micro-emulsion based on a novel free fatty acid), taurolidine/citrate/heparin and vancomycin/heparin antimicrobial lock solutions in the eradication of biofilm-producing staphylococci from central venous catheters Megan K. Luther, Leonard A. Mermel and Kerry L. LaPlante Efficacy of low doses of amphotericin B plus allicin against experimental visceral leishmaniasis M. Jesu´s Corral, Dolores R. Serrano, Inmaculada Moreno, J. J. Torrado, Mercedes Domı´nguez and Jose´ M. Alunda 3263 3268 A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication Darren M. Moss, Paul Curley, Alison Shone, Marco Siccardi and Andrew Owen 3275 Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection Gita N. Shankar and Carsten Alt 3282 3294 Pharmacokinetics of caspofungin in ICU patients E. W. Muilwijk, J. A. Schouten, H. J. van Leeuwen, A. R. H. van Zanten, D. W. de Lange, A. Colbers, P. E. Verweij, D. M. Burger, P. Pickkers and R. J. M. Bru¨ggemann Sex differences in atazanavir pharmacokinetics and associations with time to clinical events: AIDS Clinical Trials Group Study A5202 Charles S. Venuto, Katie Mollan, Qing Ma, Eric S. Daar, Paul E. Sax, Margaret Fischl, Ann C. Collier, Kimberly Y. Smith, Camlin Tierney and Gene D. Morse on behalf of the AIDS Clinical Trials Group Study A5202 Team Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4b-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment E. Ngaimisi, O. Minzi, S. Mugusi, P. Sasi, K.-D. Riedel, A. Suda, N. Ueda, M. Bakari, M. Janabi, F. Mugusi, L. Bertilsson, J. Burhenne, E. Aklillu and U. Diczfalusy Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-30 untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study Takeshi Nishijima, Kiyoto Tsuchiya, Noriko Tanaka, Akane Joya, Yohei Hamada, Daisuke Mizushima, Takahiro Aoki, Koji Watanabe, Ei Kinai, Haruhito Honda, Hirohisa Yazaki, Junko Tanuma, Kunihisa Tsukada, Katsuji Teruya, Yoshimi Kikuchi, Shinichi Oka and Hiroyuki Gatanaga CYP2B6 c.983T.C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations Daniel F. Carr, Mas Chaponda, Elena M. Cornejo Castro, Andrea L. Jorgensen, Saye Khoo, Joep J. Van Oosterhout, Collet Dandara, Elizabeth Kampira, Francis Ssali, Paula Munderi, David G. Lalloo, Robert S. Heyderman and Munir Pirmohamed Initiation of rilpivirine, tenofovir and emtricitabine (RPV/TDF/FTC) regimen in 363 patients with virological vigilance assessment in ‘real life’ Corinne Amiel, Veronique Schneider, Sabine Guessant, Mohammed Hamidi, Khadijah Kherallah, Marie-Gisele Lebrette, Julie Chas, Catherine Lependeven and Gilles Pialoux Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length gag – protease genes Katherine A. Sutherland, Jean L. Mbisa, Jade Ghosn, Marie-Laure Chaix, Isabelle Cohen-Codar, Stephane Hue, Jean-Francois Delfraissy, Constance Delaugerre and Ravindra K. Gupta Cost-efficient HIV-1 drug resistance surveillance using multiplexed high-throughput amplicon sequencing: implications for use in low- and middle-income countries Halime Ekici, Shwetha D. Rao, Anders So¨nnerborg, Vedam L. Ramprasad, Ravi Gupta and Ujjwal Neogi 3300 3311 3320 3329 3335 3340 3349 Rapid plasma viral suppression in naive HIV-infected patients with high CD4 cells and low viraemia initiating a dual nucleoside reverse transcriptase inhibitor strategy: a proof-of-concept study 3356 S. Seang, S. Fourati, Y. Keita, C. Blanc, R. Tubiana, L. Schneider, M. A. Valantin, F. Caby, R. Calin, S. Lambert-Niclot, A.-G. Marcelin, V. Calvez, D. Costagliola and C. Katlama Inaccuracy of haemoglobin A1c among HIV-infected men: effects of CD4 cell count, antiretroviral therapies and haematological parameters 3360 Laurence Slama, Frank J. Palella Jr, Alison G. Abraham, Xiuhong Li, Corinne Vigouroux, Gilles Pialoux, Lawrence Kingsley, Jordan E. Lake and Todd T. Brown on behalf of the Multicenter AIDS Cohort Study (MACS) Improvement in bone mineral density after switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: two-centre randomized pilot study (OsteoTDF study) Euge`nia Negredo, Pere Domingo, Nu´ria Pe´rez-A´lvarez, Mar Gutie´rrez, Gracia Mateo, Jordi Puig, Roser Escrig, Patricia Echeverrı´a, Anna Bonjoch and Bonaventura Clotet Antibiotic prophylaxis for transrectal prostate biopsy—a new strategy Valeria Antsupova, Nis Nørgaard, Rasmus Bisbjerg, Jette Nygaard Jensen, Jonas Boel, Jens Otto Jarløv and Magnus Arpi Ertapenem prophylaxis of surgical site infections in elective colorectal surgery in China: a multicentre, randomized, double-blind, active-controlled study Xi-sheng Leng, Yong-jie Zhao, Hui-zhong Qiu, Yong-kuan Cao, Wei-hua Zhu, Ju-fang Shen, Amanda Paschke, Wei-min Dai, Nicole Caldwell and Jue Wang A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in high-risk patients with haematological malignancies Maria J. G. T. Vehreschild, Axel Hamprecht, Lisa Peterson, So¨ren Schubert, Maik Ha¨ntschel, Silke Peter, Philippe Schafhausen, Holger Rohde, Marie v. Lilienfeld-Toal, Isabelle Bekeredjian-Ding, Johannes Libam, Martin Hellmich, Jo¨rg J. Vehreschild, Oliver A. Cornely and Harald Seifert 3368 3372 3379 3387 Emergence of quinolone resistance in the microbiota of hospitalized patients treated or not with a fluoroquinolone Victoire de Lastours, Franc¸oise Chau, Carine Roy, Beatrice Larroque and Bruno Fantin 3393 Does universal active MRSA surveillance influence anti-MRSA antibiotic use? A retrospective analysis of the treatment of patients admitted with suspicion of infection at Veterans Affairs Medical Centers between 2005 and 2010 Makoto Jones, Benedikt Huttner, Molly Leecaster, Angela Huttner, Kavitha Damal, Windy Tanner, Christopher Nielson, Michael A. Rubin, Matthew Bidwell Goetz, Karl Madaras-Kelly and Matthew H. Samore 3401 Homogeneity of antimicrobial policy, yet heterogeneity of antimicrobial resistance: antimicrobial non-susceptibility among 108 717 clinical isolates from primary, secondary and tertiary care patients in London Luke S. P. Moore, Rachel Freeman, Mark J. Gilchrist, Myriam Gharbi, Eimear T. Brannigan, Hugo Donaldson, David M. Livermore and Alison H. Holmes 3409 Trends in antibiotic prescribing in primary care for clinical syndromes subject to national recommendations to reduce antibiotic resistance, UK 1995 – 2011: analysis of a large database of primary care consultations Jeremy I. Hawker, Sue Smith, Gillian E. Smith, Roger Morbey, Alan P. Johnson, Douglas M. Fleming, Laura Shallcross and Andrew C. Hayward 3423 Research letters A survey of metallo-b-lactamase sequence accuracy before the data deluge Katinka I. Apagyi and Matthew J. Ellington 3431 Amikacin resistance plasmids in extensively antibiotic-resistant GC2 Acinetobacter baumannii from two Australian hospitals Steven J. Nigro and Ruth M. Hall 3435 Molecular characterization of NDM-1-producing Acinetobacter pittii isolated from Turkey in 2006 Ignasi Roca, Noraida Mosqueda, Belgin Altun, Paula Espinal, Murat Akova and Jordi Vila 3437 New case of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in Belgium Isabel Montesinos, Magali Dodemont, Katrien Lagrou, Frederique Jacobs, Isabelle Etienne and Olivier Denis 3439 Combination testing of colistin with telavancin and daptomycin K. E. Milne and I. M. Gould 3440 Pharmacokinetics of oral isavuconazole in a patient after Roux-en-Y gastric bypass surgery Bettina M. Knoll 3441 Letters to the Editor Comment on: Effects of selective digestive decontamination (SDD) on the gut resistome J. Hatcher, A. Myers, H. Donaldson, A. C. Gordon, R. Meacher and J. Baruah 3444 Comment on: Measurement units for antibiotic consumption in outpatients Samuel Coenen, Robin Bruyndonckx, Niel Hens, Marc Aerts and Herman Goossens 3445 Acknowledgement to referees 3447