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PhD fellowship 2. Structural aspects of hydrates
Project description:
This project will focus on using miniaturized sensors for understanding complex solid phase
transformations. Specific interest is to increase our current knowledge of hydrates, and especially,
investigate the hydrate formation and dehydration (the loss of water of crystallization). All these
phenomena can have detrimental consequences for the final drug product. Uncontrolled solid
phase transformations have been shown to be a root-cause of many product withdrawals with
several consequences for patients. Understanding the nature of hydrate-anhydrate
transformations can be used as a part of novel pharmaceutical product design enabling robust
production at a full manufacturing scale. Successful applicant has some understanding of
crystallography and related analytical techniques. Main analytical techniques will be non-invasive
spectroscopic methods (especially Raman) and diffraction based methods, as well as the related
multivariate data analytical methods. Several prototype nanosensors developed at DTU Nanotech
will be utilized for small scale analysis of these systems. Specific interest in this project will be on
the mechanistic insight into the hydrate-anhydrate transformations.
Preferred qualifications
We are looking for highly motivated, mathematically oriented, individuals with a strong
background in/experience with solid dosage forms and some experience with solid state
characterization of small organic molecules.
Principal supervisor is Professor Jukka Rantanen, Department of Pharmacy.
E-mail: [email protected] Direct Phone: +45 35 33 65 85
How to apply? Please see advertisement for further information and online application: