PREFACE
This thesis is submitted for a PhD degree at the Faculty of Science, University of Copenhagen.
The PhD project was carried out at the Department of Nutrition, Exercise and Sports, Faculty of
Science, University of Copenhagen from April 2012 until August 2016 under the supervision of
Associate Professor Lesli Hingstrup Larsen. MSc, PhD and Professor Arne Astrup, MD, PhD.
The work was centered on a randomized, controlled crossover trial and three completed human
intervention trials. The project was a part of the FIAF consortium and was funded by the The
Danish Strategic Council for Research, The Danish Dairy Association and Arla Foods amba.
The thesis is structured as a critical review on the role of Angiopoietin-like protein 4 in obesity and
obesity-related diseases intended for submission to an international peer-reviewed journal. The
review has a focus on the potential for dietary modulation in humans and is based on the available
literature along with results from the four intervention trials included in the three papers.
The following papers are included in the thesis:
Paper I. The Role of the Angiopoietin-like Protein 4 in obesity – A randomized controlled trial.
Blædel T, Holm JB, Sundekilde UK, Schmedes MS, Hess AL, Lorenzen JK, Kristiansen K,
Dalsgaard TK, Astrup A and Larsen LH. Accepted, Journal of Nutritional Science.
Paper II. The association between Angiopoietin-like protein 4 and lipid metabolism during weight
management. Blædel T, Kjølbæk L, Lorenzen JK, Hess AL, Kersten S, Astrup A and Larsen LH.
Draft.
Paper III. Genetic variants and expression of Angiopoietin-like Protein 4 in obesity: The
DiOGenes study. Blædel T, Valsesia A, Viguerie N, Di Cara A, Hess AL, Armenise C, Lefebvre G,
Charon C, Astrup A, Langin D, Hager J, Saris W, Larsen LH. Draft.
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