1. No category

Publications with Seahorse XF Data
October 2, 2013
Aging
Overexpression of Atg5 in mice activates autophagy and extends lifespan
Pyo J O, Yoo S M, Ahn H H, Nah J, Hong S H, Kam T I, Jung S and Jung Y K
Nat Commun. 2013 Aug 13; [Epub ahead of print].
Protective role of Psoralea corylifolia L. seed extract against hepatic mitochondrial dysfunction
induced by oxidative stress or aging
Seo E, Oh Y-S, Kim D, Lee M Y, Chae S and Jun H
Evidence-Based Complementary and Alternative Medicine. 2013 Jul 16; [Epub ahead of print].
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and
FOXO Signaling
Mouchiroud L, Houtkooper R H, Moullan N, Katsyuba E, Ryu D, Canto C, Mottis A, Jo Y S,
Viswanathan M, Schoonjans K, Guarente L and Auwerx J
Cell; 2013 Jul 18. 154 (2):430-441.
Age-dependent mitochondrial energy dynamics in the mice heart: Role of superoxide
dismutase-2
Das K C and Muniyappa H
Exp Gerontol; 2013 Jun 24. 48 (9):947-59.
Mitonuclear protein imbalance as a conserved longevity mechanism
Houtkooper R H, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams R W and Auwerx J
Nature; 2013 May 23. 497 (7450):451-457.
Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice
Jackson K C, Wohlers L M, Lovering R M, Schuh R A, Maher A C, Bonen A, Koves T R, Ilkayeva O,
Thomson D M, Muoio D M and Spangenburg E E
Am J Physiol Regul Integr Comp Physiol; 2013 Feb 1.
Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging
Horan M P, Pichaud N and Ballard J W
J Gerontol A Biol Sci Med Sci; 2012 Oct 1. 67 (10):1022-35.
GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor
(TGF) beta1-induced senescence
Byun H O, Jung H J, Seo Y H, Lee Y K, Hwang S C, Seong Hwang E and Yoon G
Exp Cell Res; 2012 Sep 10. 318 (15):1808-19.
ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with
Kufor-Rakeb syndrome
Grunewald A, Arns B, Seibler P, Rakovic A, Munchau A, Ramirez A, Sue C M and Klein C
Neurobiol Aging; 2012 Aug 1. 33 (8):1843.e.1-7.
Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A
Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular
Diseases in Suburban Areas of Northern Taiwan
Hung C-L, Wu Y-J, Liu C-C, Chi B-C, Chang S-S, Wang L-Y, Yeh H-I and Wei Y-H
International Journal of Gerontology; 2012 Jun 8. 6 (2):122-126.
Short-term calorie restriction enhances skeletal muscle stem cell function
Cerletti M, Jang Y C, Finley L W, Haigis M C and Wagers A J
Cell Stem Cell; 2012 May 4. 10 (5):515-519.
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
Quijano C, Cao L, Fergusson M M, Romero H, Liu J, Gutkind S, Rovira, II, Mohney R P, Karoly E D and
Finkel T
Cell Cycle; 2012 Apr 1. 11 (7):1383-1392.
Ethanol withdrawal hastens the aging of cytochrome c oxidase
Jung M E, Ju X, Metzger D B and Simpkins J W
Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP
phosphodiesterases
Park S J, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown A L, Kim
M K, Beaven M A, Burgin A B, Manganiello V and Chung J H
Cell; 2012 Feb 3. 148 (3):421-433.
The role of nuclear lamin B1 in cell proliferation and senescence
Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S
T, Chandel N S and Goldman R D
Genes Dev; 2011 Dec 15. 25 (24):2579-2593.
Identification and characterization of a functional mitochondrial angiotensin system
Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D,
Fedarko N S, Carey R M, O'Rourke B and Walston J D
Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.
Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3
Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E
J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.
Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes
Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D
J Neurosci; 2011 Mar 23. 31 (12):4524-4534.
Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in
mouse embryonic fibroblasts
Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H
Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial
rhomboid protease PARL
Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C,
Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith
S R and Ravussin E
Cell Metab; 2010 May 5. 11 (5):412-426.
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Liu J, Cao L, Chen J, Song S, Lee I H, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L Y, Ahn B H,
Kumar N G, Rovira, II, Xu X L, van Lohuizen M, Motoyama N, Deng C X and Finkel T
Nature; 2009 May 21. 459 (7245):387-392.
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced
by the disruption of autophagy
Wu J J, Quijano C, Chen E, Liu H, Cao L, Fergusson M M, Rovira, II, Gutkind S, Daniels M P, Komatsu
M and Finkel T
Aging (Albany NY); 2009 Apr 1. 1 (4):425-437.
Cancer
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining
mitochondrial homeostasis and promoting tumor growth
Sohn Y S, Tamir S, Song L, Michaeli D, Matouk I, Conlan A R, Harir Y, Holt S H, Shulaev V, Paddock M L,
Hochberg A, Cabanchick I Z, Onuchic J N, Jennings P A, Nechushtai R and Mittler R
Proc Natl Acad Sci U S A; 2013 Sep 3. 110 (36):14676-14681.
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null
cells from hereditary leiomyomatosis renal cell carcinoma
Yang Y, Lane A N, Ricketts C J, Sourbier C, Wei M H, Shuch B, Pike L, Wu M, Rouault T A, Boros L G,
Fan T W and Linehan W M
PloS one; 2013 Aug 15. 8 (8):e72179.
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Dorr J R, Yu Y, Milanovic M, Beuster G, Zasada C, Dabritz J H, Lisec J, Lenze D, Gerhardt A, Schleicher
K, Kratzat S, Purfurst B, Walenta S, Mueller-Klieser W, Graler M, Hummel M, Keller U, Buck A K, Dorken
B, Willmitzer L, Reimann M, Kempa S, Lee S and Schmitt C A
Nature. 2013 Aug 14; [Epub ahead of print].
Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E-Driven
Lung Tumors
Strohecker A M, Guo J Y, Karsli-Uzunbas G, Price S M, Chen G J, Mathew R, McMahon M and White E
Cancer Discov. 2013 Aug 24; [Epub ahead of print].
Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL
Zou H, Lai Y, Zhao X, Yan G, Ma D, Cardenes N, Shiva S, Liu Y, Bai X and Jiang Y
J Biol Chem. 2013 Aug 19; [Epub ahead of print].
Design and discovery of novel quinazolinedione-based redox modulators as therapies for
pancreatic cancer
Pathania D, Sechi M, Palomba M, Sanna V, Berrettini F, Sias A, Taheri L and Neamati N
Biochim Biophys Acta; 2013 Aug 15. pii: S0304-4165 (13):00349-8.
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells
on reductive glutamine metabolism
Fendt S M, Bell E L, Keibler M A, Davidson S M, Wirth G J, Fiske B, Mayers J R, Schwab M, Bellinger G,
Csibi A, Patnaik A, Blouin M J, Cantley L C, Guarente L, Blenis J, Pollak M N, Olumi A F, Vander Heiden
M G and Stephanopoulos G
Cancer res; 2013 Jul 15. 73 (14):4429-4438.
Cetuximab reverses the Warburg effect by inhibiting HIF-1-regulated LDH-A
Lu H, Li X, Luo Z, Liu J and Fan Z
Mol Cancer Ther. 2013 Aug 6; [Epub ahead of print].
Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR
Signaling
Rico-Bautista E, Zhu W, Kitada S, Ganapathy S, Lau E, Krajewski S, Ramirez J, Bush J A, Yuan Z and
Wolf D A
Oncotarget; 2013 Jul 14.
Contributions of AMPK and p53 dependent signaling to radiation response in the presence of
metformin
Muaddi H, Chowdhury S, Vellanki R, Zamiara P and Koritzinsky M
Radiother Oncol.. 2013 Jul 25; [Epub ahead of print].
Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma
cells: Altered metabolic phenotype associated with reactive oxygen species, nitric oxide and
SXR target genes involved in cholesterol and lipid metabolism
Fredericks W J, Yin H, Lal P, Puthiyaveettil R, Malkowicz S B, Fredericks N J, Tomaszewski J and
Rauscher F J, 3rd
Int J Oncol; 2013 Aug 1. 43 (2):638-652.
Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates
bioenergetics, cell proliferation, and angiogenesis in colon cancer
Szabo C, Coletta C, Chao C, Modis K, Szczesny B, Papapetropoulos A and Hellmich M R
Proc Natl Acad Sci U S A; 2013 Jul 23. 110 (30):12474-12479.
Induction of a Tumor-Associated Activating Mutation in Protein Tyrosine Phosphatase Ptpn11
(Shp2) Enhances Mitochondrial Metabolism, Leading to Oxidative Stress and Senescence
Zheng H, Li S, Hsu P and Qu C K
J Biol Chem. 2013 Jul 24; [Epub ahead of print].
Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines:
Effects on Cell Survival and Mitochondrial Oxidative Metabolism
Richter S, Morrison S, Connor T, Su J, Print C G, Ronimus R S, McGee S L and Wilson W R
PloS one; 2013 Jun 27. 8 (6):e65267.
Tumor necrosis factor alpha increases aerobic glycolysis and reduces oxidative metabolism in
prostate epithelial cells
Vaughan R A, Garcia-Smith R, Trujillo K A and Bisoffi M
Prostate. 2013 Jul 1; [Epub ahead of print].
The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and
stimulates mitochondrial respiration
Kumar P, Sharoyko V V, Spegel P, Gullberg U, Mulder H, Olsson I and Ajore R
PloS one; 2013 Jul 11. 8 (7):e68502.
Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes
in Oxygen Tension: Effects of HIF-1alpha
Diers A R, Vayalil P K, Oliva C R, Griguer C E, Darley-Usmar V, Hurst D R, Welch D R and Landar A
PloS one; 2013 Jun 28. 8 (6):e68348.
Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of
Pten-deficient preneoplastic thyroid cells
Antico Arciuch V G, Russo M A, Kang K S and Di Cristofano A
Cancer Res. 2013 Aug 3; [Epub ahead of print].
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced
senescence
Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov V A, Mackay G, van der Burg S H, Verdegaal E M,
Cascante M, Shlomi T, Gottlieb E and Peeper D S
Nature; 2013 May 19. 498 (7452):109-12.
Decreased mitochondrial OGG1 expression is linked to mitochondrial defects and delayed
hepatoma cell growth
Lee Y K, Youn H G, Wang H J and Yoon G
Mol Cells; 2013 Jun 1. 35 (6):489-97.
Tumor necrosis factor alpha induced warburg-like metabolism and is reversed by
anti-inflammatory curcumin in breast epithelial cells
Vaughan R A, Garcia-Smith R, Dorsey J, Griffith J K, Bisoffi M and Trujillo K A
Int J Cancer. 2013 May 10; [Epub ahead of print].
Activating mutations in protein tyrosine phosphatase ptpn11 (shp2) enhance reactive oxygen
species production that contributes to myeloproliferative disorder
Xu D, Zheng H, Yu W M and Qu C K
PloS one; 2013 May 16. 8 (5):e63152.
Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in
Breast Cancer
Dennison J B, Molina J R, Mitra S, Gonzalez-Angulo A M, Balko J M, Kuba M G, Sanders M E, Pinto J A,
Gomez H L, Arteaga C L, Brown R E and Mills G B
Clin Cancer Res; 2013 Jul 1. 19 (13):3703-3713.
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from
lysophospholipids
Kamphorst J J, Cross J R, Fan J, de Stanchina E, Mathew R, White E P, Thompson C B and Rabinowitz
JD
Proc Natl Acad Sci U S A; 2013 May 28. 110 (22):8882-8887.
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
Sullivan L B, Garcia-Martinez E, Nguyen H, Mullen A R, Dufour E, Sudarshan S, Licht J D, Deberardinis
R J and Chandel N S
Mol Cell; 2013 Jun 25. 51 (2):236-48.
Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo
and in vitro
Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N,
Yamamoto T, Fukuda R, Saya H, Suematsu M and Minamishima Y A
Mol Cancer Res; 2013 Sep 1. 11 (9):973-85.
KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of
Parthenolide in Normal and Cancer Cells
Xu Y, Fang F, Miriyala S, Crooks P A, Oberley T D, Chaiswing L, Noel T, Holley A K, Zhao Y, Kiningham
K K, St Clair D K and St Clair W H
Cancer research; 2013 Jul 15. 73 (14):4406-17.
Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor
of Mitochondrial Electron Transport Chain Complex I
Thomas S, Sharma N, Gonzalez R, Pao P W, Hofman F M, Chen T C, Louie S G, Pirrung M C and
Schonthal A H
PloS one; 2013 Jun 12. 8 (6):e65695.
Posttranscriptional control of T cell effector function by aerobic glycolysis
Chang C H, Curtis J D, Maggi L B, Jr., Faubert B, Villarino A V, O'Sullivan D, Huang S C, van der Windt
G J, Blagih J, Qiu J, Weber J D, Pearce E J, Jones R G and Pearce E L
Cell; 2013 Jun 6. 153 (6):1239-1251.
Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated
mitochondrial fission
Sarin M, Wang Y, Zhang F, Rothermund K, Zhang Y, Lu J, Sims-Lucas S, Beer-Stolz D, Van Houten B E,
Vockley J, Goetzman E S, Anthony Graves J and Prochownik E V
Cell Death Dis; 2013 Jun 13. 4:e670.
The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and
regulation of energy metabolism
Chu K, Boley K M, Moraes R, Barsky S H and Robertson F M
Oncotarget; 2013 Mar 1. 4 (3):446-462.
Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS
Production, and DNA Damage in Human Gastric Cancer Cells
Strickertsson J A, Desler C, Martin-Bertelsen T, Machado A M, Wadstrom T, Winther O, Rasmussen L J
and Friis-Hansen L
PloS one; 2013 Apr 30. 8 (4):e63147.
Arsenic exposure induces the Warburg effect in cultured human cells
Zhao F, Severson P, Pacheco S, Futscher B W and Klimecki W T
Toxicol Appl Pharmacol; 2013 Aug 15. 271 (1):72-7.
Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to
glycolysis driven by the V600EBRAF oncogene
Hall A, Meyle K D, Lange M K, Klima M, Sanderhoff M, Dahl C, Abildgaard C, Thorup K, Moghimi S M,
Jensen P B, Bartek J, Guldberg P and Christensen C
Oncotarget; 2013 Apr 1. 4 (4):584-599.
p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsasser H
P and Stiewe T
Cell reports; 2013 May 30. 3 (5):1512-25.
The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating
mitochondrial bioenergetics
Kang R, Tang D, Schapiro N E, Loux T, Livesey K M, Billiar T R, Wang H, Van Houten B, Lotze M T and
Zeh H J
Oncogene. 2013 Jan 14; [Epub ahead of print].
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell
lines
Grosso S, Doyen J, Parks S K, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noel A,
Pouyssegur J, Barbry P, Mazure N M and Mari B
Cell Death Dis; 2013 Mar 14. 4 (e544):2013.
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1alpha and MITF
Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe G C, Frederick D T, Hurley A D,
Nellore A, Kung A L, Wargo J A, Song J S, Fisher D E, Arany Z and Widlund H R
Cancer Cell; 2013 Mar 18. 23 (3):302-315.
Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid
leukemia cells
Jhas B, Sriskanthadevan S, Skrtic M, Sukhai M A, Voisin V, Jitkova Y, Gronda M, Hurren R, Laister R C,
Bader G D, Minden M D and Schimmer A D
PLoS One; 2013 Mar 8. 8 (3):e58367.
Metabolic Changes During Ovarian Cancer Progression as Targets for Sphingosine Treatment
Anderson A S, Roberts P C, Frisard M I, McMillan R P, Brown T J, Lawless M H, Hulver M W and
Schmelz E M
Exp Cell Res; 2013 Mar 19.
Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic
Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation
Shen Y-A, Hung P-H, Chi W-H, Wang C-Y, Hsieh Y-T, Wei Y H and Chen Y-J
Evid Based Complement Alternat Med; 2013 Mar 16. 2013 (2013):590393.
Mitochondria-Targeted Nitroxide, Mito-CP, Suppresses Medullary Thyroid Carcinoma Cell
Survival in Vitro and in Vivo
Starenki D and Park J I
J Clin Endocrinol Metab; 2013 Apr 1. 98 (4):1529-40.
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration
and aerobic glycolysis
Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee M J, Lee S, Vartholomaiou E, Tatokoro M, Beebe
K, Miyajima N, Mohney R P, Chen Y, Hasumi H, Xu W, Fukushima H, Nakamura K, Koga F, Kihara K,
Trepel J, Picard D and Neckers L
Proc Natl Acad Sci U S A; 2013 Apr 23. 110 (17):E1604-12.
Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to
bortezomib
Sanchez W Y, McGee S L, Connor T, Mottram B, Wilkinson A, Whitehead J P, Vuckovic S and Catley L
Br J Cancer; 2013 Apr 30. 108 (8):1624-33.
Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple
Myeloma Activity
Jeso V, Yang C, Cameron M D, Cleveland J L and Micalizio G C
ACS Chem Biol. 2013 Apr 2; [Epub ahead of print].
Rab27B-Mediated Metabolic Reprogramming Induces Secretome Acidification and
Chemoresistance in Breast Cancer Cells
Hendrix A, Ciccone C, Gespach C, Bracke M, Wever O D and Westbroek W
Exosomes and Microvesicles; 2013 Mar 18.
Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing
Cancer Cell Death
Palorini R, Simonetto T, Cirulli C and Chiaradonna F
International Journal of Cell Biology. 2013 Feb 28; [Epub ahead of print].
Involvement of estrogen receptor beta5 in the progression of glioma
Li W, Winters A, Poteet E, Ryou M G, Lin S, Hao S, Wu Z, Yuan F, Hatanpaa K J, Simpkins J W and
Yang S H
Brain Res; 2013 Mar 29. 1503:97-107.
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the
PI3-kinase inhibitor BKM120 in hepatocellular carcinoma
Kirstein M M, Boukouris A E, Pothiraju D, Buitrago-Molina L E, Marhenke S, Schütt J, Orlik J, Kühnel F,
Hegermann J, Manns M P and Vogel A
Liver International; 2013 Mar 15. 33 (3)
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels
Parks S K, Mazure N M, Counillon L and Pouyssegur J
J Cell Physiol; 2013 Sep 1. 228 (9):1854-62.
Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active
Mitochondria
Suchorolski M T, Paulson T G, Sanchez C A, Hockenbery D and Reid B J
PLoS One; 2013 Feb 27. 8 (2):e56884.
The TBC1D15 Oncoprotein Controls Stem Cell Self-Renewal through Destabilization of the
Numb-p53 Complex
Feldman D E, Chen C, Punj V and Machida K
PLoS One; 2013 Feb 27. 8 (2):e57312.
Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast
Cancer
Dong C, Yuan T, Wu Y, Wang Y, Fan T W, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D,
Hung M C, Evers B M and Zhou B P
Cancer Cell; 2013 Mar 18. 23 (3):316-31.
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from
lipotoxicity
Williams K J, Argus J P, Zhu Y, Wilks M Q, Marbois B N, York A G, Kidani Y, Pourzia A L, Akhavan D,
Lisiero D N, Komisopoulou E, Henkin A H, Soto H, Chamberlain B T, Vergnes L, Jung M E, Torres J Z,
Liau L M, Christofk H R, Prins R M, Mischel P S, Reue K, Graeber T G and Bensinger S
Cancer Res; 2013 Feb 25.
Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells
Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q
and Zhu D
Cell Death Dis; 2013 Feb 14. 4 (e494):2013.
Reversing the Warburg Effect as a Treatment for Glioblastoma
Poteet E, Choudhury G R, Winters A, Li W, Ryou M G, Liu R, Tang L, Ghorpade A, Wen Y, Yuan F, Keir S
T, Yan H, Bigner D D, Simpkins J W and Yang S H
J Biol Chem; 2013 Mar 29. 288 (13):9153-64.
PGC1alpha Expression Defines a Subset of Human Melanoma Tumors with Increased
Mitochondrial Capacity and Resistance to Oxidative Stress
Vazquez F, Lim J H, Chim H, Bhalla K, Girnun G, Pierce K, Clish C B, Granter S R, Widlund H R,
Spiegelman B M and Puigserver P
Cancer Cell; 2013 Mar 18. 18 (23):287-301.
LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the
Metabolism Drug Phenformin
Shackelford D B, Abt E, Gerken L, Vasquez D S, Seki A, Leblanc M, Wei L, Fishbein M C, Czernin J,
Mischel P S and Shaw R J
Cancer Cell; 2013 Feb 11. 23 (2):143-58.
Tracking metastasis and tricking cancer
Marx V
Nature; 2013 Feb 7. 494 (7435):133-136.
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in
glioblastoma stem cells
Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli
F, Brandner S, Campanella M, Grose R, Jones C and Salomoni P
Oncogene; 2013 Feb 7. 32 (6):699-712.
Metabolic changes in cancer cells upon suppression of MYC
Anso E, Mullen A, Felsher D, Mates J, DeBerardinis R and Chandel N
Cancer Metab; 2013 Feb 4. 1 (1):7.
Role of p90RSK in regulating the Crabtree effect: implications for cancer
Redman E K, Brookes P S and Karcz M K
Biochem Soc Trans; 2013 Feb 1. 41 (1):124-126.
Control of glutamine metabolism by the tumor suppressor Rb
Reynolds M R, Lane A N, Robertson B, Kemp S, Liu Y, Hill B G, Dean D C and Clem B F
Oncogene. 2013 Jan 28; [Epub ahead of print].
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Maddocks O D, Berkers C R, Mason S M, Zheng L, Blyth K, Gottlieb E and Vousden K H
Nature; 2013 Jan 24.
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell
survival and tumor growth
Griffiths B, Lewis C, Bensaad K, Ros S, Zhang Q, Ferber E, Konisti S, Peck B, Miess H, East P,
Wakelam M, Harris A and Schulze A
Cancer Metab; 2013 Jan 21. 1 (3)
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent
Human Leukemia Stem Cells
Lagadinou E D, Sach A, Callahan K, Rossi R M, Neering S J, Minhajuddin M, Ashton J M, Pei S, Grose
V, O'Dwyer K M, Liesveld J L, Brookes P S, Becker M W and Jordan C T
Cell Stem Cell; 2013 Mar 7. 12 (3):329-41.
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Faubert B, Boily G, Izreig S, Griss T, Samborska B, Dong Z, Dupuy F, Chambers C, Fuerth B J, Viollet B,
Mamer O A, Avizonis D, Deberardinis R J, Siegel P M and Jones R G
Cell Metab; 2013 Jan 8. 17 (1):113-124.
Acidity generated by the tumor microenvironment drives local invasion
Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell H H, Ibrahim-Hashim A, Bailey K, Balagurunathan Y,
Rothberg J M, Sloane B F, Johnson J, Gatenby R A and Gillies R J
Cancer Res; 2013 Mar 1. 73 (5):1524-35.
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Mutations in COX7B Cause Microphthalmia with Linear Skin Lesions, an Unconventional
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Obesity, Diabetes & Metabolic Disorders
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Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea
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Metabolism of Xenobiotic Carboxylic Acids: Focus on Coenzyme A Conjugation, Reactivity, and
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A systematic study of mitochondrial toxicity of environmental chemicals using quantitative high
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Olanzapine Activates Hepatic Mammalian Target of Rapamycin (mTOR): New mechanistic insight
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Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and
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High-Throughput Screening Assays to Evaluate the Cardiotoxic Potential of Drugs
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Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on
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Disordered purinergic signaling and abnormal cellular metabolism are associated with
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An indole-derivative protects against acetaminophen-induced liver injury by directly binding to
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Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long
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Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid
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Ethanol Suppresses Ureagenesis in Rat Hepatocytes: Role of Acetaldehyde
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Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
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Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo
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A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number
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High-Throughput Screening Assays to Evaluate the Cardiotoxic Potential of Drugs
Mandenius C-F and Meyer T
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Enhanced tissue production through redox control in stem cell-laden hydrogels
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Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier
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Heuck A P, Ferrick D A, Henry R R, McDonald W G, Colca J R, Simon M I, Ciaraldi T P and Murphy A N
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Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and
neutrophils, and the oxidative burst from human blood
Chacko B K, Kramer P A, Ravi S, Johnson M S, Hardy R W, Ballinger S W and Darley-Usmar V M
Lab Invest; 2013 Jun 1. 93 (9):690-700.
Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice
Jackson K C, Wohlers L M, Lovering R M, Schuh R A, Maher A C, Bonen A, Koves T R, Ilkayeva O,
Thomson D M, Muoio D M and Spangenburg E E
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Cellular Bioenergetics is an Important Determinant of the Molecular Imaging Signal Derived
from Luciferase and the Sodium-Iodide Symporter
Chang C, Chan A, Lin X, Higuchi T, Terrovitis J, Afzal J M, Rittenbach A, Sun D, Vakrou S,
Woldemichael K, O'Rourke B, Wahl R, Pomper M, Tsui B and Abraham M R
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Glycolysis-respiration relationships in a neuroblastoma cell line
Swerdlow R H, Lezi E, Aires D and Lu J
Biochim Biophys Acta; 2013 Jan 10. 1830 (4):2891-2898.
An Interval of the Obesity QTL Nob3.38 within a QTL Hotspot on Chromosome 1 Modulates
Behavioral Phenotypes
Vogel H, Montag D, Kanzleiter T, Jonas W, Matzke D, Scherneck S, Chadt A, Tole J, Kluge R, Joost H
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PLoS One; 2013 Jan 4. 8 (1):e53025.
Determination of Oxidoreductase Activity Using a High Throughput Microplate Respiratory
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Hommes G, Gasser C A, Ammann E M and Corvini P F
Anal Chem; 2013 Jan 2. 85 (1):283-91.
Inhibitors of bacterial tubulin target bacterial membranes in vivo
Foss M H, Eun Y-J, Grove C I, Pauw D A, Sorto N A, Rensvold J W, Pagliarini D J, Shaw J T and
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Standardized Bioenergetic Profiling of Adult Mouse Cardiomyocytes
Readnower R D, Brainard R E, Hill B G and Jones S P
Physiol Genomics; 2012 Dec 18. 44 (24):1208-13.
Comprehensive method for culturing embryonic dorsal root ganglion neurons for Seahorse
Extracellular Flux XF24 Analysis
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Frontiers in Neurology; 2012 Dec 14. 3 (175)
The impact of mitochondrial and thermal stress on the bioenergetics and reserve respiratory
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Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Hill B G, Benavides G A, Lancaster J R, Ballinger S, Dell'italia L, Zhang J and Darley-Usmar V M
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Transferring isolated mitochondria into tissue culture cells
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Nucleic Acids Res; 2012 Oct 1. 40 (19):e148.
Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based
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Measuring energy metabolism in cultured cells, including human pluripotent stem cells and
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Measurement of mitochondrial respiration in trophoblast culture
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Investigation of Mitochondrial Dysfunction by Sequential Microplate-Based Respiration
Measurements from Intact and Permeabilized Neurons
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Measuring mitochondrial respiration in intact single muscle fibers
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Adaptation of microplate-based respirometry for hippocampal slices and analysis of
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Assessing bioenergetic function in response to oxidative stress by metabolic profiling
Dranka B P, Benavides G A, Diers A R, Giordano S, Zelickson B R, Reily C, Zou L, Chatham J C, Hill B
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High throughput microplate respiratory measurements using minimal quantities of isolated
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Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells
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Assessing mitochondrial dysfunction in cells
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Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial
inhibition utilizing a microplate based system
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Assays Based on Integrated Cell System Properties
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A microfabricated reservoir-type oxygen sensor for measuring the real-time cellular oxygen
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Quantitative microplate-based respirometry with correction for oxygen diffusion
Gerencser A A, Neilson A, Choi S W, Edman U, Yadava N, Oh R J, Ferrick D A, Nicholls D G and
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Advances in measuring cellular bioenergetics using extracellular flux
Ferrick D A, Neilson A and Beeson C
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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial
bioenergetic function and enhanced glycolysis dependency in human tumor cells
Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J,
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Review Articles
Regulation of Mitochondrial Bioenergetic Function by Hydrogen Sulfide. Part I. Biochemical and
Physiological Mechanisms
Szabo C, Ransy C, Modis K, Andriamihaja M, Murghes B, Coletta C, Olah G, Yanagi K and Bouillaud F
Br J Pharmacol. 2013 Sep 2; [Epub ahead of print].
Regulation
of
Mitochondrial
Bioenergetic
Function
by
Hydrogen
Sulfide.
Part
II.
Pathophysiological and Therapeutic Aspects
Modis K, Bos E M, Calzia E, van Goor H, Coletta C, Papapetropoulos A, Hellmich M R, Radermacher P,
Bouillaud F and Szabo C
Br J Pharmacol. 2013 Sep 2; [Epub ahead of print].
Metabolism of Xenobiotic Carboxylic Acids: Focus on Coenzyme A Conjugation, Reactivity, and
Interference with Lipid Metabolism
Darnell M and Weidolf L
Chem Res Toxicol; 2013 Aug 19. 26 (8):1139-55.
Methods for assessing mitochondrial function in diabetes
Perry C G, Kane D A, Lanza I R and Neufer P D
Diabetes; 2013 Apr 1. 62 (4):1041-1053.
The role of CSA and CSB protein in the oxidative stress response
D'Errico M, Pascucci B, Lorio E, Van Houten B and Dogliotti E
Mech Ageing Dev; 2013 May 1. 134 (6-May):261-9.
The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells
Hockenbery D, Tom M, Abikoff C and Margineantu D
Cell Death Signaling in Cancer Biology and Treatment; 2013 Jan 1. 1 (2):35-51.
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Hill B G, Benavides G A, Lancaster J R, Ballinger S, Dell'italia L, Zhang J and Darley-Usmar V M
Biol Chem; 2012 Nov 1. 393 (12):1485-1512.
Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging
Horan M P, Pichaud N and Ballard J W
J Gerontol A Biol Sci Med Sci; 2012 Oct 1. 67 (10):1022-35.
The impact of assay technology as applied to safety assessment in reducing compound attrition
in drug discovery
Thomas C E and Will Y
Expert Opin Drug Discov; 2012 Feb 1. 7 (2):109-122.
Mitochondria: isolation, structure and function
Picard M, Taivassalo T, Gouspillou G and Hepple R T
J Physiol; 2011 Sep 15. 589 (Pt 18):4413-4421.
Uncoupling proteins and the control of mitochondrial reactive oxygen species production
Mailloux R J and Harper M E
Free Radic Biol Med; 2011 Sep 15. 51 (6):1106-1115.
To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease
Gusdon A M and Chu C T
Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.
Assessing mitochondrial dysfunction in cells
Brand M D and Nicholls D
Biochem J; 2011 Mar 29. 435 (1):297-312.