Charles E. Thirkill, Ph.D. Clinical/Research Interests Autoimmune reactions within the eye develop in association with a variety of different cancers, and in patients for whom there is no immediate explanation for their continuing loss of vision. The Ocular Immunology laboratory provides the means to detect abnormal antibody activity with a collection of ten ocular antigens described in the published literature as having an immunologic connection with vision loss. In doing so, the lab provides the clinician with insight into a possible explanation for the patient’s problem, and guidance towards the appropriate medical intervention. Title: Professor Address: Surge III Suite 1220 Davis, CA 95616 Phone: (530) 752 7845 Education: Yale University New Haven, Connecticut Post-Doc 1984 University of Oklahoma College of Medicine Oklahoma City, Oklahoma Ph.D. 1979 University of Washington Seattle, Washington M.Ph. 1974 Professional Memberships: American Society for Microbiology American Uveitis Society Association for Research in Vision and Ophthalmology British Journal of Biomed Science, Editorial Board Member Honors and Awards Member of the U.C. Davis Ophthalmology department team that received the 1992 U.C. Davis Oettinger Award for cancer research. Member of the team that received second place prize at the Annual Meeting of the German Dermatologic Society held in Berlin, 2001. Research project entitled 'The Identification of Antibodies in the Serum of Patients with Melanoma Associated retinopathy (MAR)'. Member of the team that received First Prize as 'Best Scientific Contribution' at the 8th World Congress on 'Cancers of the Skin' held in Zurich, Switzerland, 2001. Research project entitled 'The Identification of Antibodies in the Serum of Patients with Melanoma Associated retinopathy (MAR) Patents: The molecularly cloned cDNA equivalent of the human 23 kd CAR antigen ‘recoverion’. U.S. patent number 5,786,451, Licensed by the University of California to Athena Diagnostics. Select Recent Publications: Paraneoplastic Optic Neuropathy Associated with Colon Adenocarcinoma. Diana Chao, Wei-Chung Chen, Charles E. Thirkill, Andrew G. Lee. Canadian Journal of Ophthalmology. In Press. 2013 Paraneoplastic Retinopathy Associated with Systemic Follicular Cell Lymphoma Kavita V. Bhavsar, Elias Reichel, Thomas Hedges, Charles E. Thirkill. JAMA Ophthalmology. In press. 2013 47 kD (presumed α-enolase) Positive Autoimmune Related Retinopathy and Optic Neuropathy(ARRON).Wonchon Lin, , Derrick D. Pau,2, Charles E. Thirkill Andrew G. Lee, J. NeuroOphthalmology. 2012 Pancreatic Neuroendocrine Paraneoplastic Optic Neuropathy: Confirmation with Antibody to Optic Nerve and Hepatic Metastasis. Slamovits TL, Posner JB, Reidy DL, Thirkill CE, Keltner JL. J Neuroophthalmol. 2012 Unusual Paraneoplastic Cause of Vision Loss: Combined Paraneoplastic cone Dystrophy and Optic Neuropathy. Finger ML, Borruat F, Thirkill CE, Archives of Ophthalmology; 130(5):660-662, 2012 Outer Retinal Structure in Patients With Acute Zonal Occult Outer Retinopathy.Mkrtchyan M, Lujan BJ, Merino D, Thirkill CE, Roorda A, Duncan JL. Am J Ophthalmol. ;153(4):757-68. ! &n bsp; 2011 Hyperautofluorescent Ring in Autoimmune Retinopathy. Luiz H. Lima,, Jonathan Greenberg, Vivienne C. Greenstein,, Juliana M. F. Sallum,, R. T. Smith, Charles Thirkill, Lawrence A. Yannuzzi, Stephen H. Tsang, ‘Retina’; 32(7):1385-1394. 2011 Cancer-associated retinopathy with retinal periphlebitis in a patient with ovarian cancer. Kim SJ, Toma HS, Thirkill CE, Dunn JP Jr. Ocul Immunol Inflamm;18(2):107-9, 2010 2010 Cancer-associated retinopathy with retinal periphlebitis in a patient with ovarian cancer. Kim SJ, Toma HS, Thirkill CE, Dunn JP Jr. Ocul Immunol Inflamm;18(2):107-9, 2010 Espandar L, O'Brien S, Thirkill CE, Lubecki LA. Esmaeli B. Successful treatment of Cancer-Associated Retinopathy with Alemtuzumab. J. Neuro-Oncology. 83(3):295-302. 2007 Thirkill CE. Immune-Mediated Paraneoplasia. Brit J. Med Sci 63(4) 185-195. 2006 Parc CE, Azan E. Bonnel S, Sahel JA, Kaplan J, Thirkill CEo Cone Dysfunction as a Paraneoplastic Syndrome Associated with Retinal Antigens Approximating 40 kd. Ophthalmic Genet. 27(2):57-61. 2006 Sharan S, Thirkill CE, Grigg JR. Autoimmune retinopathy associated with intravesical BCG therapy. Br J Ophthalmol. 89(7):927-8. 2005 G Ladewig, U Reinhold, C E. Thirkill, A Kerber, W Tilgen,C Pfohler. Incidence of anti-retinal antibodies in Melanoma:screening of 77 AJCC stage I-IV patients. Brit J. Dermatol. 152(5):931-8. 2005 Thirkill CEo Cancer-Induced, Immune-Mediated Ocular Degenerations. Ocular Immunol Inflamm. 13:119-131. 2005