Curriculum Vitae Uğur ÖZBEK, M.D., Ph.D. [email protected] Present Position: Director Professor, Member-Genetics Department, Institute of Experimental Medicine (DETAE), Istanbul University, Turkey Undergraduate Education: Graduate Education: 1979-1981 Anittepe High School, Ankara, Turkey Preclinic, Cerrahpasa Medical Faculty, Istanbul University 1981-1986 Clinical Cerrahpasa Medical Faculty, Istanbul University Helsinki University Medical Faculty, Finland 04.31.1986 Doctor of Medicine (diploma nr.: 3717, Turkey) Postgraduate Education and Positions: 1989-1995 Ph.D. student, Basic Oncology Department, Oncology Institute, Istanbul University 1991 Laboratory rotation (6 months) Prenatal Diagnosis Center (PRETAM), Istanbul University Faculty of Medicine, 1991-1992 Laboratory rotation (8 months) Molecular Genetics Lab., Biology Dept., Bogazici University, Istanbul 1994 Visiting Researcher, (6 months) G. Gaslini Institute, Oncology Research Lab., Genoa, Italy (fellowship from Italian Government) 1994-1996 Research Assistant Genetics Department, Institute of Experimental Medicine, Istanbul University 1995 PhD. degree in Cancer Genetics Oncology Institute, Istanbul University 1996 Visiting Researcher, Tettamanti Leukemia Research Lab., University of Milan, Italy 1996-97 Assistant Professor in Genetics Genetics Department, Institute of Experimental Medicine, Istanbul University 2.11.1997 Associate Professor in Basic Oncology 1998-2000 Research Associate, Genetics Department, St. Jude’s Children Research Hospital, Memphis, USA 2002- 2007 2003 2003 2006-2007 2008 2009- Chairman Genetics Department, Institute of Experimental Medicine, Istanbul University Clinical Observer, Cancer Genetics Section, Royal Marsden Hospital, Surrey Sutton, England Full Professor, Genetics Department, Institute of Experimental Medicine, Istanbul University, Turkey Querido Chair, Visiting Professor Erasmus University Medical Center Rotterdam-the Netherlands Specialist in Medical Genetics, Istanbul University Director, Institute of Experimental Medicine, Istanbul University Ongoing International/National Projects-Partnerships: 1. Core Partner. EPICURE. Functional Genomics and Neurobiology of Epilepsy: a basis for new therapeutic strategies. Integrated Project. EC contract number LSH-CT-2006-037315 (EPICURE) FP6 - Thematic priority LIFESCIHEALTH (http://www.epicureproject.eu/) 2. National Node representative: BBMRI Consortium. http://bbmri.eu/images/ammap/world.htm 3. Partner. MedGeNet. Euro-Mediterranean Network for Genetic Services. FP6-2004INCO-MPC-3. (031968) (http://medgenet.tredueuno.it/) 4. Partner. PHGEN. Public Health Genetics European Network. OJ2005/C11 (http://www.phgen.eu) 5. Partner. ELN-European LeukemiaNet. (LSH-2002-2.2.0-3). Strengthen and develop scientific and technological excellence in research and therapy of leukemia (http://www.leukemia-net.org) 6. Partner. ORPHANET-European Orphan Disease Network. DG Public Health ( EC Contract no. 2006 119) (www.orpha.net) 7. Partner. Bilateral collaborative agreement. Istanbul University-Ludwig Institute for Cancer Research- New York Branch James Kerr programme (http://www.licr.org/F_sites/f4_kerr.php) 8. Project coordinator. (2010-2013). TUBITAK-SBAG-109S2128. Intensified Cooperation (IntenC): Promotion of German-Turkish Higher Education Research. Project name: Genome-wide integrated methylome analyses in idiopathic generalized epilepsies 9. Project coordinator. (2010-2013). TUBITAK-SBAG-109S295. Project name: Genome wide expression array analysis in T cell acute lymphoblastic leukemia. PUBLICATIONS 1. Møller RS, Weber YG, Klitten LL, Trucks H, Muhle H, Kunz WS, Mefford HC, Franke A, Kautza M, Wolf P, Dennig D, Schreiber S, Rückert IM, Wichmann HE, Ernst JP, Schurmann C, Grabe HJ, Tommerup N, Stephani U, Lerche H, Hjalgrim H, Helbig I, Sander T; EPICURE Consortium.Zimprich F, Mörzinger M, Feucht M, Suls A, Weckhuysen S, Claes L, Deprez L, Smets K, Van Dyck T, Deconinck T, De Jonghe P, Velizarova R, Dimova P, Radionova M, Tournev I, Kancheva D, Kaneva R, Jordanova A, Kolonivej D, Møller RS, Kjelgaard DB, Hjalgrim H, Helsinki B, Lehesjoki AE, Siren A, Baulac S, Leguern E, Campus K, Helbig I, Muhle H, von Spiczak S, Ostertag P, Stephani U, Leber M, Leu C, Sander T, Toliat MR, Trucks H, Nürnberg P, Hempelmann A, Rüschendorf F, Sander T, Elger CE, Kleefuß-Lie AA, Kunz W, Surges R, Gaus V, Janz D, Sander T, Schmitz B, Klein KM, Reif PS, Oertel WH, Hamer HM, Rosenow F, Becker F, Weber Y, Lerche H, Marini C, Guerrini R, Mei D, Norci V, Zara F, Striano P, Robbiano A, Pezzella M, Bianchi A, Gambardella A, Tinuper P, La Neve A, Capovilla G, Vigliano P, Crichiutti G, Vanadia F, Vignoli A, Coppola A, Striano S, Giallonardo EM, Franceschetti S, Belcastro V, Benna P, Coppola G, De Palo A, Ferlazzo E, Vecchi M, Martinelli V, Bisulli F, Beccaria F, Del Giudice E, Mancardi M, Stranci G, Scabar A, Gobbi G, Giordano I, Koeleman BP, de Kovel C, Lindhout D, de Haan GJ, Ozbek U, Bebek N, Baykan B, Ozdemir O, Ugur S, Kocasoy-Orhan E, Yücesan E, Cine N, Gokyigit A, Gurses C, Gul G, Yapici Z, Ozkara C, Caglayan H, Yalcin O, Yapici Z, Yalcin D, Turkdogan D, Ozkara C, Dizdarer G. Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy. Epilepsia. 2013 Feb;54(2):256-64. doi: 10.1111/epi.12078. Epub 2013 Jan 7. 2. Zorba OU, Sirma S, Ozgon G, Salabas E, Ozbek U, Kadioglu A. Comparison of apoptotic gene expression profiles between Peyronie's disease plaque and tunica albuginea. Comparison of apoptotic gene expression profiles between Peyronie's disease plaque and tunica albuginea. Adv Clin Exp Med. 2012 Sep-Oct;21(5):607-14. 3. Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS Biol. 2012 Nov;10(11):e1001430. doi: 10.1371 4. Uz B, Tatonyan SC, Sayitoglu M, Erbilgin Y, Ng OH, Buyukasik Y, Sayinalp N, Aksu S, Goker H, Ozcebe OI, Ozbek U, Haznedaroglu IC. Local hematopoietic renin-angiotensin system in myeloid versus lymphoid hematological neoplastic disorders. J Renin Angiotensin Aldosterone Syst. 2012 Nov 6. [Epub ahead of print] 5. Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C, Akpinar B, Ozbek U, Buyukdevrim S, Yazici Z. The role of mediastinal adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. Cardiovasc Diabetol. 2012 Sep 25;11(1):115. 6. Atalar F, Vural B, Ciftci C, Demirkan A, Akan G, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS. 11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Genet Mol Res. 2012 Aug 31;11(3):3122-32. 7. Consortium E, Consortium E, Steffens M, Leu C, Ruppert AK, Zara F, Striano P, Robbiano A, Capovilla G, Tinuper P, Gambardella A, Bianchi A, La Neve A, Crichiutti G, de Kovel CG, Kasteleijn-Nolst Trenité D, de Haan GJ, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Steinhoff BJ, Kleefuß-Lie AA, Kunz WS, Surges R, Elger CE, Muhle H, von Spiczak S, Ostertag P, Helbig I, Stephani U, Møller RS, Hjalgrim H, Dibbens LM, Bellows S, Oliver K, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. Guerrini R, Lehesjoki AE, Siren A, Guipponi M, Malafosse A, Thomas P, Nabbout R, Baulac S, Leguern E, Guerrero R, Serratosa JM, Reif PS, Rosenow F, Mörzinger M, Feucht M, Zimprich F, Kapser C, Schankin CJ, Suls A, Smets K, De Jonghe P, Jordanova A, Caglayan H, Yapici Z, Yalcin DA, Baykan B, Bebek N, Ozbek U, Gieger C, Wichmann HE, Balschun T, Ellinghaus D, Franke A, Meesters C, Becker T, Wienker TF, Hempelmann A, Schulz H, Rüschendorf F, Leber M, Pauck SM, Trucks H, Toliat MR, Nürnberg P, Avanzini G, Koeleman BP, Sander T. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. Hum Mol Genet. 2012 Oct 2. [Epub ahead of print] Atalar F, Gormez S, Caynak B, Akan G, Tanriverdi G, Bilgic-Gazioglu S, Gunay D, Duran C, Akpinar B, Ozbek U, Buyukdevrim AS, Yazıcı Z. Mediastinal adipose tissue expresses a pathogenic profile of 11 β-hydroxysteroid dehydrogenase Type 1, glucocorticoid receptor, and CD68 in patients with coronary artery disease. Cardiovasc Pathol. 2012 Sep 3. [Epub ahead of print] Hannon MM, Lohan F, Erbilgin Y, Sayitoglu M, O'Hagan K, Mills K, Ozbek U, Keeshan K. Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL. Br J Haematol. 2012 Sep;158(5):626-34 Yavuz EN, Ozdemir O, Catal S, Bebek N, Ozbek U, Baykan B. Bromodomain-containing protein 2 gene in photosensitive epilepsy. Seizure. 2012 Oct;21(8):646-8 Sirma Ekmekci S, G Ekmekci C, Kandilci A, Gulec C, Akbiyik M, Emrence Z, Abaci N, Karakas Z, Agaoglu L, Unuvar A, Anak S, Devecioglu O, Ustek D, Grosveld G, Ozbek U. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. SET oncogene is upregulated in pediatric acute lymphoblastic leukemia. Vural B, Yakar F, Derin D, Saip P, Yakar A, Demirkan A, Karabulut A, Ugurel E, Cine N, Kilicaslan Z, Tüzün E, Ozbek U. Evaluation of glutathione S-transferase P1 polymorphisms (Ile105Val and Ala114Val) in patients with small cell lung cancer. Genet Test Mol Biomarkers. 2012 Jul;16(7):701-6. EPICURE Consortium, Leu C, de Kovel CG, Zara F, Striano P, Pezzella M, Robbiano A, Bianchi A, Bisulli F, Coppola A, Giallonardo AT, Beccaria F, Trenité DK, Lindhout D, Gaus V, Schmitz B, Janz D, Weber YG, Becker F, Lerche H, Kleefuß-Lie AA, Hallman K, Kunz WS, Elger CE, Muhle H, Stephani U, Møller RS, Hjalgrim H, Mullen S, Scheffer IE, Berkovic SF, Everett KV, Gardiner MR, Marini C, Guerrini R, Lehesjoki AE, Siren A, Nabbout R, Baulac S, Leguern E, Serratosa JM, Rosenow F, Feucht M, Unterberger I, Covanis A, Suls A, Weckhuysen S, Kaneva R, Caglayan H, Turkdogan D, Baykan B, Bebek N, Ozbek U, Hempelmann A, Schulz H, Rüschendorf F, Trucks H, Nürnberg P, Avanzini G, Koeleman BP, Sander T. Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies. Epilepsia. 2012 Feb;53(2):308-318 Gialluisi A, Pippucci T, Anikster Y, Ozbek U, Medlej-Hashim M, Mégarbané A, Romeo G. Estimating the Allele Frequency of Autosomal Recessive Disorders through Mutational Records and Consanguinity: The Homozygosity Index (HI). Ann Hum Genet. 2011 Dec 21. doi: 10.1111/j.1469-1809.2011 Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, Ozbek U, Nalcaci M, Cefle K. Investigation of Arg399Gln and Arg194Trp Polymorphisms of the XRCC1 (X-Ray CrossComplementing Group 1) Gene and Its Correlation to Sister Chromatid Exchange Frequency in Patients with Chronic Lymphocytic Leukemia. Genet Test Mol Biomarkers. 2011 Nov 22. [Epub ahead of print] Erbilgin Y, Ng OH, Mavi N, Ozbek U, Sayitoglu M. Genetic alterations in members of the Wnt pathway in acute leukemia. Leuk Lymphoma. 2011 Oct 24. [Epub ahead of print] Vural B, Uğurel E, Tüzün E, Kürtüncü M, Zuliani L, Cavuş F, Içöz S, Erdağ E, Gül A, Güre AO, Vincent A, Ozbek U, Eraksoy M, Akman-Demir G. Anti-neuronal and stress-induced- 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. phosphoprotein 1 antibodies in neuro-Behçet's disease. J Neuroimmunol. 2011 Oct 28;239(1-2):91-7. Epub 2011 Aug 27. Saip R, Sen F, Vural B, Ugurel E, Demirkan A, Derin D, Eralp Y, Camlica H, Ustuner Z, Ozbek U. Glutathione S-transferase P1 polymorphisms are associated with time to tumor progression in small cell lung cancer patients. J BUON. 2011 Apr-Jun;16(2):241-6. Firtina S, Sayitoglu M, Hatirnaz O, Erbilgin Y, Oztunc C, Cinar S, Yildiz I, Celkan T, Anak S, Unuvar A, Devecioglu O, Timur C, Aydogan G, Akcay A, Atay D, Turkkan E, Karaman S, Orhaner B, Sarper N, Deniz G, Ozbek U. Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia. Leuk Res. 2012 Jan;36(1):87-92. Epub 2011 Aug 2. Eskazan AE, Soysal T, Erbilgin Y, Ozbek U, Ferhanoglu B. Chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation are resistant to dasatinib: is that true for all the patients? Leuk Res. 2011 Sep;35(9):e145-6. Epub 2011 May 24 Gormez S, Demirkan A, Atalar F, Caynak B, Erdim R, Sozer V, Gunay D, Akpinar B, Ozbek U, Buyukdevrim AS. Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-α and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease. Intern Med. 2011;50(8):805-10. Epub 2011 Apr 15. Ostergaard M, Nyvold CG, Jovanovic JV, Andersen MT, Kairisto V, Morgan YG, Tobal K, Pallisgaard N, Ozbek U, Pfeifer H, Schnittger S, Grubach L, Larsen JK, Grimwade D, Hokland P. Development of standardized approaches to reporting of minimal residual disease data using a reporting software package designed within the European LeukemiaNet. Leukemia. 2011 Apr 15 Bahat G, Saka B, Erten N, Ozbek U, Coskunpinar E, Yildiz S, Sahinkaya T, Karan MA. BsmI polymorphism in the vitamin D receptor gene is associated with leg extensor muscle strength in elderly men. Aging Clin Exp Res. 2010 Jun;22(3):198-205 Erbilgin Y, Sayitoglu M, Hatirnaz O, Dogru O, Akcay A, Tuysuz G, Celkan T, Aydogan G, Salcioglu Z, Timur C, Yuksel-Soycan L, Ure U , Anak S, Agaogl S, Devecioglu O, Yildiz I, Ozbek U, Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL. Disease Markers 28 (2010) 1–8 Atalar F, Tevfik Acuner T, Cine N, Oncu F, Yesilbursa D, Ozbek U, Turkcan S.Two fourmarker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study. Behav Brain Funct. 2010 May 28;6(1):27 Vural B, Demirkan A, Ugurel E, Kalaylioglu-Wheeler Z, Esen BA, Gure AO, Gül A, Ozbek U. Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Behçet's disease. Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S67-72. Palanduz S, Bayrak A, Sirma S, Vural B, Cefle K, Ucur A, Ozturk S, Yenerel MN, Besisik SK, Yavuz S, Diz-Kucukkaya R, Sargin D, Nalcaci M, Pekcelen Y, Ozbek U. Comparison of the cytogenetic and molecular analyses in the assessment of imatinib response in chronic myelocytic leukemia. Genet Test Mol Biomarkers. 2009 Oct;13(5):599-602. Baccarani M, Rosti G, Castagnetti F, Haznedaroglu I, Porkka K, Abruzzese E, Alimena G, Ehrencrona H, Hjorth-Hansen H, Kairisto V, Levato L, Martinelli G, Nagler A, Nielsen JL, Ozbek U, Palandri F, Palmieri F, Pane F, Rege-Cambrin G, Russo D, Specchia G, Testoni N, Weiss-Bjerrum O, Saglio G, Simonsson B. A comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of patients with high risk, Philadelphia-positive, chronic myeloid leukaemia: a European LeukemiaNet study. Blood. 2009 May 7;113(19):4497504 Vural B, Atalar F, Ciftci C, Demirkan A, Susleyici-Duman B, Gunay D, Akpinar B, Sagbas E, Ozbek U, Buyukdevrim AS. Presence of fatty-acid-binding protein 4 expression in human 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. epicardial adipose tissue in metabolic syndrome. Cardiovasc Pathol. 2008 NovDec;17(6):392-8. Ustuner Z, Saip P, Yasasever V, Vural B, Yazar A, Bal C, Ozturk B, Ozbek U, Topuz E. Prognostic and predictive value of vascular endothelial growth factor and its soluble receptors, VEGFR-1 and VEGFR-2 levels in the sera of small cell lung cancer patients. Med Oncol. 2008 ;25(4):394-9. Chtcheglova LA, Atalar F, Ozbek U, Wildling L, Ebner A, Hinterdorfer P. Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging. Pflugers Arch. 2008 Apr;456(1):247-54. Ince AT, Hatırnaz O, Ovünc O, Ozbek U. 1007fs, G908R, R702W Mutations and P268S, IVS8(+158) Polymorphisms of the CARD15 Gene in Turkish Inflammatory Bowel Disease Patients and Their Relationship with Disease-Related Surgery. Dig Dis Sci. 2008 Jun;53(6):1683-92. Sayitoğlu M, Ar MC, Hatırnaz O, Ongören S, Ure U, Başlar Z, Sırma,S Aydın Y, Özbek U, Ferhanoğlu B. Minimal Residual Disease (MRD) Detection with Translocations and T-Cell Receptor and Immunoglobulin Gene Rearrangements in Adult Acute Lymphoblastic Leukaemia Patients: A Pilot Study. Turkish Journal of Hematology. 2008 25 (3): 124-132. Ustek D, Sırma S, Cakiris A, Cosan F, Oku B, Ozbek U. Cloning of chimerical translocations as positive control for molecular genetic diagnosis of leukemia. Turkish Journal of Hematology. 2008 25 (1):20-23 Gazioglu NM, Erensoy N, Kadioglu P, Sayitoglu MA, Ersoy IH, Hatirnaz O, Kisacik B, Oz B, Sar M, Ozbek U, Ciplak N, Cagatay P. Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas. Med Sci Monit. 2007 Oct;13(10):CR457-63. Kadioglu P, Oral G, Sayitoglu M, Erensoy N, Senel B, Gazioglu N, Sav A, Cetin G, Ozbek U. Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary. 2008;11(1):29-35. Olcay A, Nişanci Y, Ekmekçi CG, Ozbek U, Sezer M, Umman B, Buğra Z. Angiotensinogen M235T polymorphism and left ventricular indices in treated hypertensive patients with normal coronary arteries. Anadolu Kardiyol Derg. 2007 Sep;7(3):257-61. Ozbek U, Kandilci A, Van Baal S, Bonten J, Boyd K, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and proliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-666. Yonal O, Hatirnaz O, Akyuz F, Ozbek U, Demir K, Kaymakoglu S, Okten A, Mungan Z. HFE Gene Mutation, Chronic Liver Disease, and Iron Overload In Turkey.Dig Dis Sci. 2007 Nov;52(11):3298-302. Hatirnaz O, Ure U, Ar C, Akyerli C, Soysal T, Ferhanoglu B, Ozcelik T, Ozbek U. The SOCS1 gene methylation in chronic myeloid leukemia patients. Am J Hematol. 2007 Aug;82(8):729-30. Kalayoglu-Besisik S, Ozturk GB, Caliskan Y, Nalcaci M, Gurses N, Cin N, Ozbek U, Sargin D.. Autologous stem cells collected after debulking by high dose chemotherapy in late phase chronic myeloid leukemia may improve Imatinib efficacy. Transfus Apher Sci. 2007 Feb;36(1):91-4. Ustek D, Ekmekci CG, Selcukbiricik F, Cakiris A, Oku B, Vural B, Yanar H, Taviloglu K, Ozbek U, Gul A. Association between reduced levels of MEFV messenger RNA in peripheral blood leukocytes and acute inflammation. Arthritis Rheum. 2007 Jan;56(1):345-50. Olcay A, Ekmekci CG, Ozbek U, Sezer M, Barcin C, Arslan E, Boztosun B, Nisanci Y.. Negative association of endothelial nitric oxide gene polymorphism with hypertension in 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy. Cardiovasc Ultrasound. 2006 Aug 21;4:33. Aydin-Sayitoglu M, Hatirnaz O, Erensoy N, Ozbek U. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1 and GSTM1 Genes in the Susceptibility to Acute Leukemias. Am J Hemat, 2006 Feb 21;81(3):162-170 Olcay A, Nisanci Y, Ekmekci CG, Umman B, Bugra Z, Sezer M, Acar RD, Ozbek U. Aldosterone synthase -344C/T and angiotensin-converting enzyme I/D polymorphisms in Turkish hypertensive patients with normal coronary arteries. Acta Cardiol. 2006 Feb;61(1):29-34 Erkan E, Muslumanoglu AY, Oktar T, Sanli O, Ozbek U, Kadioglu A. Polymorphism of endothelial nitric oxide synthase gene in patients with erectile dysfunction. J Sex Med. 2006 Jan;3(1):69-75. Chan, AO, Soliman AS, Zhang, Q, Rashid A, Bedeir A, Houlihan PC, Mokhtar N, Al-Masri N, Ozbek U, Yaghan R, Kandilci A, Omar S, Kapran Y, Dizdaroglu F, Bondy ML, Amos CI, Issa JP, Levin B, Hamilton SR. Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries. Clin Cancer Res. 2005 Dec 1;11(23):8281-7. Einav U, Tabach Y, Get G, Yitzhaky A, Ozbek U, Amariglio N, Izraeli S Rechavi and , Domany E. Gene expression analysis reveals a strong signature of an interferon induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer. Oncogene. 2005 Sep 22;24(42):6367-75. Vural B, Chen L, Saip P.3, Chen Y , Ustuner Z.3, Gonen M, Jager E, Simpson AJ; Old LJ, Ozbek U, Gure AO. Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish SCLC patients and their correlation with clinical parameters. Cancer, 2005, May; 103 (12):2575-2583 Cardone M, Kandilci A, Carella C, Nilsson JA, Brennan JA, Sirma S, Ozbek U, Boyd K, Cleveland JL, Grosveld GC. The Novel ETS Factor TEL2 Cooperates with Myc in B Lymphomagenesis. Mol and Cell Biol. 2005 Mar; 25(6): 2395–2405 Aydin-Sayitoglu M, Yildiz I, Hatirnaz O, Ozbek U. Common Cytochrome p4503A (CYP3A4 and CYP3A5) and thiopurine S-methyl transferase (TPMT) polymorphisms in Turkish population. Turk J Med Sci, 2005 35:1-5 Bebek N, Cine N, Oner GO, Eskazan E, Ozbek U. Genotype and allele frequencies of MDR1 C3435T polymorphism in Turkish population. Journal of Neurological Sciences 2005;22(3): 261-266 Akyerli CA, Beksac M, Holko M,d, Frevel M, Dalva K, Ozbek U, Soydan E, Ozcan M, Ozet G, Ilhan O, Gurman G, Akan H, Williams BRG, Ozcelik T. Expression of IFITM1 in chronic myeloid leukemia patients. Leukemia Research 29 (2005) 283–286 Aşıcıoğlu F, Oğuz-Savran F, Ozbek U. Mutation rate at commonly used forensic STR loci: paternity testing experience. Disease Markers 2004, 20(6): 313-315. Aydin M, Hatirnaz O, Erensoy N, Ozbek U. CYP2D6 and CYP1A1 mutations in the Turkish population. Cell Biochem Funct. 2005 Jan 13; 23(2):133-135 Ekmekci CG, Gutierrez MI, Siraj AK, Ozbek U, Bhatia K. Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia. Am J Hematol. 2004 Oct 19;77(3):233-240 Sirma S, Agaoglu L, Yildiz I, Cayli D, Horgusluoglu E, Anak S, Yuksel L, Unuvar A, Celkan T, Apak H, Karakas Z, Devecioglu O, Ozbek U. NAD(P)H:quinone oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia. Pediatr Blood Cancer. 2004 Oct;43(5):568-70. 58. Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Salcioglu Z, Sarper N, Ozbek U. Real-Time PCR analysis of af4 and dek genes expression in acute promyelocytic leukemia t(15;17) patients. Exp Mol Med. 2004 Jun 30;36(3):279-82. 59. Savlı H, Sırma S, Nagy B, Aktan M, Dinçol G, Salcioglu Z, Ozbek U. Expression analysis of DEK, AF4 and FLI1 genes in all-trans-retioic acid (ATRA) treated acute promyelocytic leukemia t(15;17) patients by quantitative real-time PCR. Turk J Med Sci. 2004, 34: 8560. Duymaz-Tozkir J, Gul A, Uyar FA, Ozbek U, Saruhan-Direskeneli G. Tumour necrosis factor-alpha gene promoter region -308 and -376 G-->A polymorphisms in Behcet's disease. Clin Exp Rheumatol. 2003 Jul-Aug;21(4 Suppl 30):S15-8. 61. Kalayoglu-Besisik S, Caliskan Y, Sargin D, Gurses N, Ozbek U. Methylenetetrahydrofolate reductase C677T polymorphism and toxicity in allogeneic hematopoietic cell transplantation. Transplantation. 2003, 27;76(12):1775-7. 62. Savlı H, Sırma S, Aktan M, Dinçol G, Özbek U. Quantification of all-trans-retinoic acid dependent expression of CXCR4 gene in acute ptomyelocytic leukaemia. Turk J Haematol 2003, 20(3): 153-159. 63. Savlı H, Sırma S, Ozbek U. Identification of the FLI-1 gene expression by real-time quantitative RT-PCR. Turk J Med Sci 2003, 33:21-25. 64. Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Ozbek U. Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Exp Mol Med. 2003, 31;35(5):454-9. 65. Gutierrez MI, Siraj AK, Bhargava M, Ozbek U, Banavali S, Chaudhary MA, El Solh H, Bhatia K. Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup. Leukemia. 2003, 17(9):1845-50. 66. Akyerli CB, Ozbek U, Aydin-Sayitoglu M, Sirma S, Ozcelik T. Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias. J Cancer Res Clin Oncol. 2003, 129(10):604-5 67. H. Savlı, A. Karadenizli, F. Kolaylı, S. Gündes, U. Ozbek, H. Vahaboglu. Expression stability of six housekeeping genes: a proposal for resistance gene quantification studies of Pseudomonas aeruginosa by real-time quantitative RT-PCR. Journal of Medical Microbiology, 2003, 52: 1-6. 68. U. Özbek, Sırma S, Ağaoğlu L, Yüksel L, Anak S, Yıldız I, Devecioğlu O, Timur Ç, Meral A, Gedikoğlu G. Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey. J Pediatr Hematol/Oncol, 2003, March; 25(3): 204208. 69. Onay UV, Kavakli K, Kilinc Y, Gurgey A, Aktuglu G, Kemahlı S, Ozbek U, Caglayan SH.Molecular pathology of haemophilia B in Turkish patients: identification of a large deletion and 33 independent point mutations. Br J Haematol. 2003 Feb;120(4):656-659 70. Siraj A.K., Ozbek U., Sazawal S., Sırma S., Timson G., Al-Nasser A., Bhargava M., El Solh H., Bhatia K., Gutierrez M.I. Preclinical validation of a monochrome real-time multiplex assay for translocations in childhood acute lymphoblastic leukemia. Clinical Cancer Research, 2002, Dec;8(12):3832-40. 71. Asicioglu F, Akyuz F, Cetinkaya U., Yılmaz S., Koluacık S., Vural B., Ozbek U. Turkish population data on nine short tandem repeat loci: HumCSF1PO, HumTHO1, HumTPOX, HumFES/FPS, HumF13B, HumVWA, D3S1358, D7S820, D16S539. Forensic Sci Int 126(3):252-253, 2002 72. Asicioglu F, Akyuz F, Cetinkaya U, Ozbek U. Allele distribution data of nine short tandem repeat loci for Turkish population: WS1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820. Forensic Sci Int 129 (1): 75-77 2002 73. B. Ömer, U. Özbek, A.Akköse, G. Kılıç. Genetic polymorphism of cytochrome p450 2E1 in the Turkish polulation. Cell Biochem Function 2001, 19(4):273-275 74. Günay, A. Öztürk, T.Budak, U. Özbek, N. Üskent. Activated protein C resistance in polycythemia vera. Turk J Haematol 2001;18(3):157-164 75. U.Özgen, S. Anak, U. Özbek, Nazan Sarper, E. Eryilmaz, L. Agaoglu, Ö. Devecioglu, N. Yalman, G. Gedikoglu: Prognostic significance of Wilms tumor 1 gene in childhood acute lymphoblastic leukemia. Turk J Haematol 2000, 17(4):183-188. 76. N. Sarper, U. Ozbek, L. Agaoglu, U. Ozgen A. Kandilci, S. Sirma, S. Anak, N. Yalman, E. Eryilmaz, O. Devecioglu, G. Gedikoglu. Detection of BCR/ABL trascripts by reverse transcriptase polymerase chain reaction in pediatric acute lymphoblastic leukemia: Incidence and clinical features. Turk J Haematol 2000, 17(4):197-206. 77. Sarper N, Özbek U, Agaoglu L, Ozgen U, Eryilmaz E, Yalman N, Anak S, Devecioglu O, Gedikoglu GIs AML1/ETO gene expression a good prognostic factor in pediatric acute myeloblastic leukemia? Pediatr Hematol Oncol. 2000 Oct-Nov;17(7):577-83. 78. Özgen U, Anak S, Özbek U, Sarper N, Eryilmaz E, Agaoglu L, Devecioglu O, Yalman N, Gedikoglu G. WT1 gene expression in childhood acute leukemias. Acta Haematol. 2000;103(4):229-30. 79. Sarper N, Özbek U, Agaoglu L, Ozgen U, Devecioglu O, Kandilci A., Sırma S., Karakas Z., Yalman N, Anak S, , Gedikoglu. Clinical outcome of children with ALL-AF4 positive acute lymphoblastik leukemia. Haema. 2000; 3(2): 102-106. 80. F. Yesim, K. Demirci, D.B. Guney, K. Akarcay, N. Kir, U. Ozbek, S. Sirma, N. Unaltuna, E. Ongor. Revalence of factor V Leiden in patients with retinal vein occlusion.Acta Ophthalmol Scand. 1999 Dec;77(6):631-3. 81. Elter K, Erel CT, Cine N, Ozbek U, Hacihanefioglu B, Ertungealp E. Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Fertil Steril. 1999 Mar;71(3):425-30. 82. Dincol G, Nalcaci M, Yavuz AS, Keskin H, Aktan M, Dogan O, Agan M, Ozbek U, Dincol K.Case of hepatosplenic gammadelta T-cell lymphoma presenting with severe hypersplenism.. Am J Hematol 1999 Apr; 60(4):313-4. 83. U. Özbek, B. Vural, S. Kalayoglu, T. Soysal, S. Anak, D. Sargýn, G. Gedikoglu, T. Akoglu, B. Ferhanoglu, Y. Tangün, T. Özçelik: Evaluation of chimerism with DNA polymorphisms in bone marrow transplantation. Turk J Pediatr. 1997 Jul; 39(3): 303-311. 84. U. Özbek, Y. Tangün: Frequency of factor V Leiden (Arg506Gln) in Turkey. Br J Haematol. 1997 May; 97(2): 504-505. 85. A. Gul, U. Özbek, C. Oztürk, M. Inanç, M. Konice, T. Ozçelik: Coagulation factor V gene mutation increases the risk of venous thrombosis in behcet's disease. Br J Rheumatol. 1996 Nov; 35(11): 1178-1180. 86. H. Yazici, M. Müslümanoglu, D. Güzey, V. Yasasever, U. Özbek, N. Dalay: Amplification in tumors and benign tissue of breast cancer patients. Cancer Lett. 1996 Oct 22; 107(2): 235-239. 87. U. Özbek, Y. Tangün: Frequency of factor V Leiden in Turkey. Int J Hematol. 1996 Oct; 64(3-4): 291-292. 88. G. Ogur, Z. Sengün, G. Arel-Kiliç, C. De Busscher, S. Basaran, U. Özbek, I. Ayan, E. Sariban, E. Vamos: Clinical and cytogenetic studies of two cases of Klinefelter syndrome with hereditary retinoblastoma and rhabdomyosarcoma. Cancer Genet Cytogenet. 1996 Jul 1; 89(1): 77-81. 89. S. Savasan, B. Zulfikar, A. Ozgeneci, U. Özbek, Z. Sengun: Monosomy 7 myeloproliferative disease associated with neurofibromatosis type I: a case report. JChemother.1996 Jun; 8(3): 243-246. 90. G. Ogur, Z. Sengün, H. Onat, U. Özbek, G. Erseven, I. Ayan, S. Kurul, R. Kebudi, S. Inanç: Correlation of chromosomal changes with morphological classification in non-Hodgkin’s lymphoma. Turkish Journal of Oncology, 10(4):56-62 (1995). PROFESSIONAL MEMBERSHIPS: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. The Human Genome Organization (HUGO) American Society of Human Genetics (ASHG) American Association for Cancer Research (AACR) American Society of Hematology (ASH) European Hematology Association (EHA) European Society of Human Genetics (ESHG). PPLC committee member Turkish Society of Hematology (THD). Board member-Treasurer. 2001-2005 Turkish Society of Genetics (TGD). Board member 2007-2009 Turkish Oncology Foundation (TOV) Turkish Society of Epilepsy
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