M AP OF THE CAMPUS 10 CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France SCIENTIFIC PROGRAM Tuesday, 18th November 2014 Opening of the Cilia 2014 Conference Tuesday, 18th November 2014 CIS auditorium 14:00 - 15:45 14:00 Welcome and registration in the CIS. Tea/coffee will be available. 14:30 Installation of posters 58-135 15:30 Official opening in the CIS 1 Cilia: the journey from obscurity to the heart of development 15:45 Martina Brueckner Yale University School of Medicine, United States 1 - Ciliopathies I (kidney) Tuesday, 18th November 2014 Chair: Hannah Mitchison, University College London CIS auditorium 16:35 - 17:45 2 Ciliary and non-ciliary functions of NPHP and IFT subunits altered in 16:35 pathophysiological mechanisms of Nephronophthisis and related syndromes Sophie Saunier Necker Hospital, France Invited speaker, *Student 3 Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis 17:00 and epithelial-to-mesenchymal transition in the kidney Gisela Slaats* University Medical Center Utrecht, The Netherlands 4 PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation 17:15 Jean Piero Margaria* University of Turin, Italy 5 Cilia here, cilia there, cilia everywhere 17:30 Phil Beales UCL Institute of Child Health, United Kingdom CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 11 2 - Exchanges patients-clinicians-scientists Tuesday, 18th November 2014 CIS auditorium/Centre François Jacob 18:00 - 19:30 18:00 (French and English versions) Programme will be updated according to the number of registered patients. One session will be held in the CIS and the other one in the François Jacob Auditorium. 19:30 Welcome cocktail - buffet Wednesday, 19th November 2014 3 - Molecular and Cellular Biology of Cilia I (basal body and centrioles) Wednesday, 19th November 2014 Chair: Alexandre Benmerah, INSERM U1163 - Institut Imagine CIS auditorium 08:45 - 10:20 6 SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans 08:45 Pierre Gönczy École Polytechnique Fédérale de Lausanne, Switzerland 7 Centrosomes and centriolar satellites associate with negative regulators of innate 09:10 immune signaling Jens Andersen University of Southern Denmark, Denmark 8 Molecular Basis of Ciliogenesis Control by Actin Remodeling Factors 09:25 Joon Kim Korean Advanced Institute of Science and Technology (KAIST), South Korea 9 Kinesin-3 motor protein KIF13B localizes to centrosomes and primary cilia and 09:40 regulates ciliary length and signaling Kenneth B. Schou University of Copenhagen, Denmark 10 Control of initial steps of ciliogenesis by protein kinases 09:55 Gislene Pereira German Cancer Research Centre (DKFZ), Germany Invited speaker 10:20 Coffee break and Poster Session A (odd numbers 59, 61, ...) 12 CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 4 - Cilia and Flagella in infectious eukaryotes Wednesday, 19th November 2014 Chair: Philippe Bastin, Institut Pasteur CIS auditorium 11:25 - 13:00 11 Motility and more: the flagellum of African trypanosomes 11:25 Kent Hill University of California, Los Angeles (UCLA), United States 12 Identification of constituents of the flagella connector, a flagellar tip complex 11:50 of Trypanosoma brucei, by an immunoprecipitation-based approach Vladimir Varga University of Oxford, United Kingdom 13 9+2 to 9+0 axoneme conversion in Leishmania 12:05 Richard Wheeler University of Oxford, United Kingdom 14 Similarities and discrepancies between SAS-6 and RSP9 depletion in Plasmodium 12:20 berghei flagellum assembly and fertilization Sara Marques Imperial College of London, United Kingdom 15 Asymmetries in the biogenesis of basal body duplication, reorientation and 12:35 segregation Sue Vaughan Oxford Brookes University, United Kingdom 13:00 Lunch and Poster Viewing 5 - Development 1 Wednesday, 19th November 2014 Chair: Sigolène Meilhac, Institut Pasteur CIS auditorium 14:30 - 16:05 16 TGFβ/BMP networking at the primary cilium 14:30 Søren Christensen University of Copenhagen, Denmark CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France Invited speaker 17 Mouse RFX2 is a major transcriptional regulator of spermiogenesis 14:55 Marie Paschaki University Claude Bernard Lyon1, France 13 18 Ciliary dysfunction impairs pancreatic insulin secretion and promotes 15:10 development of type 2 diabetes in rodents Jantje Gerdes Helmholtz Zentrum München, Germany 19 Primary cilia elongation and associated IGF-receptor trafficking into the cilium 15:25 are required for adipogenic differentiation of human mesenchymal stem cells Melis Dalbay* Queen Mary University of London, United Kingdom 20 The regulation of mechanosensory motile cilium formation 15:40 Andrew Jarman University of Edinburgh, United Kingdom 16:05 Coffee break and Poster Session A II (even numbers 58, 60, ...) 6 - Molecular and Cellular Biology of Cilia II (Cilia formation and trafficking) Wednesday, 19th November 2014 Chair: Peter Swoboda, Karolinska Institute CIS auditorium 17:20 - 19:15 21 Cilium-autonomous Regulation of Tubulin Transport by IFT 17:20 Karl Lechtreck University of Georgia, United States 22 Multisystem functional characterisation of motile ciliopathy 17:45 genes HEATR2 and ZMYND10 Girish Mali* University of Edinburgh, United Kingdom Invited speaker, *Student 23 Functional Analysis of the Outer Arm Dynein Assembly Factor CCDC103 18:00 Stephen King University of Connecticut Health Center, United States 24 Cilia-mediated Hedgehog signaling in Drosophila 18:15 Mattias Alenius Linköping university, Sweden 25 The ciliary gene, EFHC1, implicated in human epilepsy, modulates dopamine 18:30 signalling in C. elegans Catrina Loucks* Simon Fraser University, Canada 14 CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 26 Regulating entry into the ciliary compartment 18:45 Kristen Verhey University of Michigan Medical School, United States 19:10 Removal of posters 58-135 19:15 Business meeting - Meeting room BIME 28-01-01A Thursday, 20th November 2014 7 - Ciliopathies II Thursday, 20th November 2014 Chair: Tess Harris, Ciliopathy Alliance CIS auditorium 08:30 - 10:35 08:30 Installation of posters 136-212 27 Gene Therapy Clinical Trials for Childhood Blindness and its Applications for 09:00 Ocular, Auditory and Renal Ciliopathies Daniel Chung University of Pennsylvania, United States 28 Murine Joubert syndrome reveals Hedgehog signaling defects as a potential 09:25 therapeutic target for nephronophthisis Rachel Giles University Medical Center Utrecht, The Netherlands 30 Mutations in a novel dynein-2 light chain, TCTEX1D2, cause Jeune Asphyxiating 09:55 Thoracic Dystrophy (JATD) with incomplete penetrance Miriam Schmidts* Institute of Child Health, United Kingdom 31 Round-trip from pediatrics to extreme ciliopathies 10:10 Tania Attié-Bitach Necker Hospital, France 10:35 Coffee break and Poster Session B (odd numbers 137, 139, ...) CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 15 Invited speaker, *Student 29 Cyclin O (Ccno) functions in deuterosome-mediated centriole amplification of 09:40 multiciliated cells Sebastian Arnold University of Freiburg, Germany 8 - Systems Biology of Cilia and Flagella Thursday, 20th November 2014 Chair: Ronald Roepman, Radboud University Medical Center CIS auditorium 11:40 - 13:00 32 Determining the ciliome and its modules from genomics data 11:40 Martijn Huynen University of Nijmegen, Radboud University Medical Center, The Netherlands 33 A high-throughput genome-wide siRNA screen for ciliogenesis identifies new 12:05 ciliary functional components and ciliopathy genes Katarzyna Szymanska* University of Leeds, United Kingdom 34 The architectural landscape of diverse ciliary functions 12:20 Monica Bettencourt-Dias Instituto Gulbenkian de Ciencia, Portugal 35 A systems view on the basics of vision-molecular dissection and multi-scale 12:35 integration of functional protein networks in mammalian photoreceptors Marius Ueffing University of Tuebingen, Germany 13:00 Lunch and Poster Viewing 9 - Development 2 Thursday, 20th November 2014 Chair: Christine Laclef, Université Pierre et Marie Curie CIS auditorium 14:30 - 16:05 36 Signalling and cilia in immune cells 14:30 Gillian Griffiths Cambridge Institute for Medical Research, United Kingdom Invited speaker, *Student 37 A dual function of the Zebrafish ESCRT complex in the formation and function of 14:55 ciliated organs Thomas Juan* Institut de Biologie Valrose, France 38 A novel form of PCD that impacts nodal, but not tracheal Cilia 15:10 Jennifer Keynton MRC Harwell, United Kingdom 16 CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 39 Unexpectedly fragile architecture of nodal cilia that determine left-right 15:25 asymmetry in the mouse embryo Kyosuke Shinohara Osaka University, Japan 40 The Role of ARL13B in Joubert Pathogenesis 15:40 Tamara Caspary Emory University, United States 16:05 Coffee break and Poster Session B II (even numbers 136, 138, ...) 10 - Molecular and Cellular Biology III (Intraflagellar transport and cilium assembly) Thursday, 20th November 2014 Chair: Lotte Pedersen, University of Copenhagen CIS auditorium 17:20 - 18:55 41 Ultrastructural studies of Intraflagellar Transport trains in Chlamydomonas 17:20 reinhardtii suggest a revision of the current model for IFT trafficking in the flagellar compartment Pietro Lupetti University of Siena, Italy 42 Uncoupling flagellum formation and maintenance 17:45 Cécile Fort Institut Pasteur, France 43 Proteomic and functional studies on the role of D1bLIC in IFT 18:00 Mary Porter University of Minnesota, United States 45 The Intraflagellar Transport Protein IFT27 promotes BBSome exit from cilia 18:30 through the GTPase ARL6/BBS3 Gerald Liew* Stanford University, United States 46 Structural studies of ciliogenesis complexes 18:45 Esben Lorentzen Max Planck Institute of Biochemistry, Germany 20:30 Gala Dinner on the River Seine - the boat will be open from 8:30 pm and will leave at 8:50 pm sharp, make sure you are on time! CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 17 Invited speaker, *Student 44 Whole-organism developmental expression profiling identifies novel ciliary 18:15 components. including Wdr60. whose properties reveal a new model for the regulation of retrograde intraflagellar transport Victor Jensen Simon Fraser University, Canada Friday, 21st November 2014 11 - Ciliopathies III Friday, 21st November 2014 Chair: Rachel Giles, University Medical Center Utrecht CIS auditorium 09:00 - 11:00 47 What’s in the “omes” in Kouncil? 09:00 Nine Knoers University Medical Centre Utrecht, The Netherlands 48 The centrosomal OFD1 protein interacts with the PreInitiation Complex of 09:25 translation and regulates the synthesis of specific targets in the kidney Daniela Iaconis Telethon Institute of Genetics and Medicine (TIGEM), Italy 49 Developing Stem Cell Therapy for Retinal Dystrophies 09:40 Jane Sowden University College London (UCL) Institute of Child Health, United Kingdom 50 Treating retinal degeneration in the Bardet-Biedl syndrome ciliopathy 10:05 Xiangxiang Yu University of Strasbourg, France 51 TMEM107 is a ciliopathy protein that recruits ciliopathy TMEMs to anchored ring10:20 like domains of the C. elegans ciliary transition zone membrane. Oliver Blacque University College Dublin, Ireland 52 Treatment-resistant schizophrenia due to loss of function mutations in PCM1 and 10:45 Defective trafficking of GPCRs to the cilium Ed Oh Duke University, United States 11:00 Coffee break Invited speaker 11:00 Removal of posters 136-212 18 CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 12 - Molecular and Cellular Biology IV Motile Cilia Friday, 21st November 2014 Chair: Bénédicte Durand, Université de Lyon 1 CIS auditorium 11:25 - 13:10 53 Cilia in the pathogenesis of congenital heart disease 11:25 Cécilia Lo University of Pittsburgh School of Medicine, United States 54 Centriole amplification by mother and daughter centrioles differs in multiciliated 11:50 cells Alice Meunier Ecole Normale Supérieure, France 55 MCIDAS acts upstream of CCNO in the deuterosome – mediated centriole 12:05 assembly pathway Julia Wallmeier University Hospital Münster, Germany 56 The CDC20B/miR-449 locus controls vertebrate multiciliogenesis 12:20 Laure-Emmanuelle Zaragosi Institut de Pharmacologie Moléculaire et Cellulaire, France 57 Cilia mediated hydrodynamics in the left-right organizer of zebrafish 12:35 Julien Vermot Institut de Génétique de Biologie Moléculaire et Cellulaire, France 13:00 Conclusions, announcement of poster/talk awards 13:10 Meeting ends Invited speaker 14:00 Free guided tour of the Pasteur Museum (in French or in English). Also available at 15:00 and 16:00. CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France 19
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