M AP OF THE CAMPUS
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CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
SCIENTIFIC PROGRAM
Tuesday, 18th November 2014
Opening of the Cilia 2014 Conference
Tuesday, 18th November 2014
CIS auditorium
14:00 - 15:45
14:00 Welcome and registration in the CIS. Tea/coffee will be available.
14:30 Installation of posters 58-135
15:30 Official opening in the CIS
1 Cilia: the journey from obscurity to the heart of development
15:45 Martina Brueckner
Yale University School of Medicine, United States
1 - Ciliopathies I (kidney)
Tuesday, 18th November 2014
Chair:
Hannah Mitchison, University College London
CIS auditorium
16:35 - 17:45
2 Ciliary and non-ciliary functions of NPHP and IFT subunits altered in
16:35 pathophysiological mechanisms of Nephronophthisis and related syndromes
Sophie Saunier
Necker Hospital, France
Invited speaker, *Student
3 Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis
17:00 and epithelial-to-mesenchymal transition in the kidney
Gisela Slaats*
University Medical Center Utrecht, The Netherlands
4 PI3K-C2α regulates Polycystin-2 ciliary entry to prevent kidney cyst formation
17:15 Jean Piero Margaria*
University of Turin, Italy
5 Cilia here, cilia there, cilia everywhere
17:30 Phil Beales
UCL Institute of Child Health, United Kingdom
CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
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2 - Exchanges patients-clinicians-scientists
Tuesday, 18th November 2014
CIS auditorium/Centre François Jacob
18:00 - 19:30
18:00 (French and English versions)
Programme will be updated according to the number of registered patients.
One session will be held in the CIS and the other one in the François Jacob
Auditorium.
19:30 Welcome cocktail - buffet
Wednesday, 19th November 2014
3 - Molecular and Cellular Biology of Cilia I (basal body and centrioles)
Wednesday, 19th November 2014
Chair:
Alexandre Benmerah, INSERM U1163 - Institut Imagine
CIS auditorium
08:45 - 10:20
6 SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans
08:45 Pierre Gönczy
École Polytechnique Fédérale de Lausanne, Switzerland
7 Centrosomes and centriolar satellites associate with negative regulators of innate
09:10 immune signaling
Jens Andersen
University of Southern Denmark, Denmark
8 Molecular Basis of Ciliogenesis Control by Actin Remodeling Factors
09:25 Joon Kim
Korean Advanced Institute of Science and Technology (KAIST), South Korea
9 Kinesin-3 motor protein KIF13B localizes to centrosomes and primary cilia and
09:40 regulates ciliary length and signaling
Kenneth B. Schou
University of Copenhagen, Denmark
10 Control of initial steps of ciliogenesis by protein kinases
09:55 Gislene Pereira
German Cancer Research Centre (DKFZ), Germany
Invited speaker
10:20 Coffee break and Poster Session A (odd numbers 59, 61, ...)
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CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
4 - Cilia and Flagella in infectious eukaryotes
Wednesday, 19th November 2014
Chair:
Philippe Bastin, Institut Pasteur
CIS auditorium
11:25 - 13:00
11 Motility and more: the flagellum of African trypanosomes
11:25 Kent Hill
University of California, Los Angeles (UCLA), United States
12 Identification of constituents of the flagella connector, a flagellar tip complex
11:50 of Trypanosoma brucei, by an immunoprecipitation-based approach
Vladimir Varga
University of Oxford, United Kingdom
13 9+2 to 9+0 axoneme conversion in Leishmania
12:05 Richard Wheeler
University of Oxford, United Kingdom
14 Similarities and discrepancies between SAS-6 and RSP9 depletion in Plasmodium
12:20 berghei flagellum assembly and fertilization
Sara Marques
Imperial College of London, United Kingdom
15 Asymmetries in the biogenesis of basal body duplication, reorientation and
12:35 segregation
Sue Vaughan
Oxford Brookes University, United Kingdom
13:00 Lunch and Poster Viewing
5 - Development 1
Wednesday, 19th November 2014
Chair:
Sigolène Meilhac, Institut Pasteur
CIS auditorium
14:30 - 16:05
16 TGFβ/BMP networking at the primary cilium
14:30 Søren Christensen
University of Copenhagen, Denmark
CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
Invited speaker
17 Mouse RFX2 is a major transcriptional regulator of spermiogenesis
14:55 Marie Paschaki
University Claude Bernard Lyon1, France
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18 Ciliary dysfunction impairs pancreatic insulin secretion and promotes
15:10 development of type 2 diabetes in rodents
Jantje Gerdes
Helmholtz Zentrum München, Germany
19 Primary cilia elongation and associated IGF-receptor trafficking into the cilium
15:25 are required for adipogenic differentiation of human mesenchymal stem cells
Melis Dalbay*
Queen Mary University of London, United Kingdom
20 The regulation of mechanosensory motile cilium formation
15:40 Andrew Jarman
University of Edinburgh, United Kingdom
16:05 Coffee break and Poster Session A II (even numbers 58, 60, ...)
6 - Molecular and Cellular Biology of Cilia II
(Cilia formation and trafficking)
Wednesday, 19th November 2014
Chair:
Peter Swoboda, Karolinska Institute
CIS auditorium
17:20 - 19:15
21 Cilium-autonomous Regulation of Tubulin Transport by IFT
17:20 Karl Lechtreck
University of Georgia, United States
22 Multisystem functional characterisation of motile ciliopathy
17:45 genes HEATR2 and ZMYND10
Girish Mali*
University of Edinburgh, United Kingdom
Invited speaker, *Student
23 Functional Analysis of the Outer Arm Dynein Assembly Factor CCDC103
18:00 Stephen King
University of Connecticut Health Center, United States
24 Cilia-mediated Hedgehog signaling in Drosophila
18:15 Mattias Alenius
Linköping university, Sweden
25 The ciliary gene, EFHC1, implicated in human epilepsy, modulates dopamine
18:30 signalling in C. elegans
Catrina Loucks*
Simon Fraser University, Canada
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CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
26 Regulating entry into the ciliary compartment
18:45 Kristen Verhey
University of Michigan Medical School, United States
19:10 Removal of posters 58-135
19:15 Business meeting - Meeting room BIME 28-01-01A
Thursday, 20th November 2014
7 - Ciliopathies II
Thursday, 20th November 2014
Chair:
Tess Harris, Ciliopathy Alliance
CIS auditorium
08:30 - 10:35
08:30 Installation of posters 136-212
27 Gene Therapy Clinical Trials for Childhood Blindness and its Applications for
09:00 Ocular, Auditory and Renal Ciliopathies
Daniel Chung
University of Pennsylvania, United States
28 Murine Joubert syndrome reveals Hedgehog signaling defects as a potential
09:25 therapeutic target for nephronophthisis
Rachel Giles
University Medical Center Utrecht, The Netherlands
30 Mutations in a novel dynein-2 light chain, TCTEX1D2, cause Jeune Asphyxiating
09:55 Thoracic Dystrophy (JATD) with incomplete penetrance
Miriam Schmidts*
Institute of Child Health, United Kingdom
31 Round-trip from pediatrics to extreme ciliopathies
10:10 Tania Attié-Bitach
Necker Hospital, France
10:35 Coffee break and Poster Session B (odd numbers 137, 139, ...)
CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
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Invited speaker, *Student
29 Cyclin O (Ccno) functions in deuterosome-mediated centriole amplification of
09:40 multiciliated cells
Sebastian Arnold
University of Freiburg, Germany
8 - Systems Biology of Cilia and Flagella
Thursday, 20th November 2014
Chair:
Ronald Roepman, Radboud University Medical Center
CIS auditorium
11:40 - 13:00
32 Determining the ciliome and its modules from genomics data
11:40 Martijn Huynen
University of Nijmegen, Radboud University Medical Center, The Netherlands
33 A high-throughput genome-wide siRNA screen for ciliogenesis identifies new
12:05 ciliary functional components and ciliopathy genes
Katarzyna Szymanska*
University of Leeds, United Kingdom
34 The architectural landscape of diverse ciliary functions
12:20 Monica Bettencourt-Dias
Instituto Gulbenkian de Ciencia, Portugal
35 A systems view on the basics of vision-molecular dissection and multi-scale
12:35 integration of functional protein networks in mammalian photoreceptors
Marius Ueffing
University of Tuebingen, Germany
13:00 Lunch and Poster Viewing
9 - Development 2
Thursday, 20th November 2014
Chair:
Christine Laclef, Université Pierre et Marie Curie
CIS auditorium
14:30 - 16:05
36 Signalling and cilia in immune cells
14:30 Gillian Griffiths
Cambridge Institute for Medical Research, United Kingdom
Invited speaker, *Student
37 A dual function of the Zebrafish ESCRT complex in the formation and function of
14:55 ciliated organs
Thomas Juan*
Institut de Biologie Valrose, France
38 A novel form of PCD that impacts nodal, but not tracheal Cilia
15:10 Jennifer Keynton
MRC Harwell, United Kingdom
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CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
39 Unexpectedly fragile architecture of nodal cilia that determine left-right
15:25 asymmetry in the mouse embryo
Kyosuke Shinohara
Osaka University, Japan
40 The Role of ARL13B in Joubert Pathogenesis
15:40 Tamara Caspary
Emory University, United States
16:05 Coffee break and Poster Session B II (even numbers 136, 138, ...)
10 - Molecular and Cellular Biology III
(Intraflagellar transport and cilium assembly)
Thursday, 20th November 2014
Chair:
Lotte Pedersen, University of Copenhagen
CIS auditorium
17:20 - 18:55
41 Ultrastructural studies of Intraflagellar Transport trains in Chlamydomonas
17:20 reinhardtii suggest a revision of the current model for IFT trafficking in the
flagellar compartment
Pietro Lupetti
University of Siena, Italy
42 Uncoupling flagellum formation and maintenance
17:45 Cécile Fort
Institut Pasteur, France
43 Proteomic and functional studies on the role of D1bLIC in IFT
18:00 Mary Porter
University of Minnesota, United States
45 The Intraflagellar Transport Protein IFT27 promotes BBSome exit from cilia
18:30 through the GTPase ARL6/BBS3
Gerald Liew*
Stanford University, United States
46 Structural studies of ciliogenesis complexes
18:45 Esben Lorentzen
Max Planck Institute of Biochemistry, Germany
20:30 Gala Dinner on the River Seine - the boat will be open from 8:30 pm and will leave
at 8:50 pm sharp, make sure you are on time!
CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
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Invited speaker, *Student
44 Whole-organism developmental expression profiling identifies novel ciliary
18:15 components. including Wdr60. whose properties reveal a new model for the
regulation of retrograde intraflagellar transport
Victor Jensen
Simon Fraser University, Canada
Friday, 21st November 2014
11 - Ciliopathies III
Friday, 21st November 2014
Chair:
Rachel Giles, University Medical Center Utrecht
CIS auditorium
09:00 - 11:00
47 What’s in the “omes” in Kouncil?
09:00 Nine Knoers
University Medical Centre Utrecht, The Netherlands
48 The centrosomal OFD1 protein interacts with the PreInitiation Complex of
09:25 translation and regulates the synthesis of specific targets in the kidney
Daniela Iaconis
Telethon Institute of Genetics and Medicine (TIGEM), Italy
49 Developing Stem Cell Therapy for Retinal Dystrophies
09:40 Jane Sowden
University College London (UCL) Institute of Child Health, United Kingdom
50 Treating retinal degeneration in the Bardet-Biedl syndrome ciliopathy
10:05 Xiangxiang Yu
University of Strasbourg, France
51 TMEM107 is a ciliopathy protein that recruits ciliopathy TMEMs to anchored ring10:20 like domains of the C. elegans ciliary transition zone membrane.
Oliver Blacque
University College Dublin, Ireland
52 Treatment-resistant schizophrenia due to loss of function mutations in PCM1 and
10:45 Defective trafficking of GPCRs to the cilium
Ed Oh
Duke University, United States
11:00 Coffee break
Invited speaker
11:00 Removal of posters 136-212
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CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
12 - Molecular and Cellular Biology IV Motile Cilia
Friday, 21st November 2014
Chair:
Bénédicte Durand, Université de Lyon 1
CIS auditorium
11:25 - 13:10
53 Cilia in the pathogenesis of congenital heart disease
11:25 Cécilia Lo
University of Pittsburgh School of Medicine, United States
54 Centriole amplification by mother and daughter centrioles differs in multiciliated
11:50 cells
Alice Meunier
Ecole Normale Supérieure, France
55 MCIDAS acts upstream of CCNO in the deuterosome – mediated centriole
12:05 assembly pathway
Julia Wallmeier
University Hospital Münster, Germany
56 The CDC20B/miR-449 locus controls vertebrate multiciliogenesis
12:20 Laure-Emmanuelle Zaragosi
Institut de Pharmacologie Moléculaire et Cellulaire, France
57 Cilia mediated hydrodynamics in the left-right organizer of zebrafish
12:35 Julien Vermot
Institut de Génétique de Biologie Moléculaire et Cellulaire, France
13:00 Conclusions, announcement of poster/talk awards
13:10 Meeting ends
Invited speaker
14:00 Free guided tour of the Pasteur Museum (in French or in English).
Also available at 15:00 and 16:00.
CILIA 2014, November 18th – 21st, Institut Pasteur, Paris, France
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