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Contents
Volume 70 Issue 1 | THORAX January 2015
Editorials
Critical care
1
41
Dysregulated fibulin-5 expression and
elastogenesis in COPD lungs: pyromaniac
or fire fighter?
G Brusselle
Journal of the British Thoracic Society
Impact Factor: 8.562
Traffic-related air pollution: an avoidable
exposure to improve respiratory health
Editors-in-Chief
P D Sly
A Bush (UK)
I Pavord (UK)
3
5
Deputy Editors
P Cullinan (UK)
C Lloyd (UK)
T P Hellyer, A C Morris, D F McAuley,
T S Walsh, N H Anderson, S Singh, P Dark,
A I Roy, S V Baudouin, S E Wright, G D Perkins,
K Kefala, M Jeffels, R McMullan, C M O’Kane,
C Spencer, S Laha, N Robin, S Gossain, K Gould,
M-H Ruchaud-Sparagano, J Scott, E M Browne,
J G MacFarlane, S Wiscombe, J D Widdrington,
I Dimmick, I F Laurenson, F Nauwelaers,
A J Simpson
Biomarkers to exclude the diagnosis
of ventilator-associated pneumonia
M A Matthay
Associate Editors
R Beasley (New Zealand)
A Custovic (UK)
P Gibson (Australia)
J Grigg (UK)
D Halpin (UK)
ML Han (USA)
A Jones (UK)
E Lim (UK)
N Maskell (UK)
Diagnostic accuracy of pulmonary host
inflammatory mediators in the exclusion
of ventilator-acquired pneumonia
S Nathan (USA)
JL Pepin (France)
T Sethi (UK)
D Sin (Canada)
M Steiner (UK)
D Thickett (UK)
A Torres (Spain)
Z Udwadia (India)
H Zar (South Africa)
7
Not all wheeze is asthma: time for patients
to exercise their rights
9
T Fardon (UK)
Statistical Editors
G Jenkins
Online Associate Editor
Statistician
11
A Millar
D J DePianto, S Chandriani, A R Abbas,
G Jia, E N N’Diaye, P Caplazi, S E Kauder,
S Biswas, S K Karnik, C Ha, Z Modrusan,
M A Matthay, J Kukreja, H R Collard, J G Egen,
P J Wolters, J R Arron
Respiratory epidemiology
57
Journal club Editor
President, British Thoracic Society
Bronchiectasis
12
Editorial Office
Thorax, BMA House, Tavistock Square,
London WC1H 9JR, UK
T: +44 (0)20 7383 6373
E: [email protected]
Heterogeneous gene expression signatures
correspond to distinct lung pathologies and
biomarkers of disease severity in idiopathic
pulmonary fibrosis
Thorax: the lean and slippered Pantaloon years
A Bush, I Pavord
L Szatkowski (UK)
J Quint (UK)
48
J H Hull
Endotyping idiopathic pulmonary fibrosis
should improve outcomes for all patients
with progressive fibrotic lung disease
J Gibson (UK)
T McKeever (UK)
Interstitial lung disease
Quality of Life Questionnaire-Bronchiectasis:
final psychometric analyses and determination
of minimal important difference scores
Prevalence of exercise-induced
bronchoconstriction and exercise-induced
laryngeal obstruction in a general adolescent
population
H Johansson, K Norlander, L Berglund, C Janson,
A Malinovschi, L Nordvall, L Nordang, M Emtner
A L Quittner, A E O’Donnell, M A Salathe,
S A Lewis, X Li, A B Montgomery,
T G O’Riordan, A F Barker
Twitter: @ThoraxBMJ
ISSN: 0040-6376 (print)
ISSN: 1468-3296 (online)
Disclaimer: Thorax is owned and published by the
British Thoracic Society and BMJ Publishing Group
Ltd, a wholly owned subsidiary of the British Medical
Association. The owners grant editorial freedom to
the Editor of Thorax.
Chronic obstructive pulmonary disease
21
C-A Brandsma, M van den Berge, D S Postma,
M R Jonker, S Brouwer, P D Paré, D D Sin,
Y Bossé, M Laviolette, J Karjalainen,
R S N Fehrmann, D C Nickle, K Hao,
A I R Spanjer, W Timens, L Franke
Thorax follows guidelines on editorial
independence produced by the World Association
of Medical Editors and the code on good
publication practice of the Committee on
Publication Ethics.
Thorax is intended for medical professionals and is
provided without warranty, express or implied.
Statements in the Journal are there sponsibility of
their authors and advertisers and not authors’
institutions, the BMJ Publishing Group Ltd, the
British Thoracic Society or theBMAunless otherwise
specified or determined by law. Acceptance of
advertising does not imply endorsement.
To the fullest extent permitted by law, the BMJ
Publishing Group Ltd shall not be liable for any loss,
injury or damage resulting from the use of Thorax
or any information in it whether based on contract,
tort or otherwise. Readers are advised to verify any
information they choose to rely on.
Copyright: © 2014 BMJ Publishing Group Ltd and
the British Thoracic Society. All rights reserved; no
part of this publication may be reproduced, stored
in a retrieval system or transmitted in any form or
by any means, electronic, mechanical, photocopying,
recording or otherwise without the prior permission
of Thorax.
A large lung gene expression study
identifying fibulin-5 as a novel player
in tissue repair in COPD
33
MORE CONTENTS 䉴
Cover caption: Bronchoscopic view of the tracheal web
(see Nanzer AM, et al., page 101).
Statin use and exacerbations in individuals
with chronic obstructive pulmonary disease
This article has been chosen by the Editor to be of special interest
or importance and is freely available online.
T S Ingebrigtsen, J L Marott, B G Nordestgaard,
P Lange, J Hallas, J Vestbo
OPEN ACCESS
This article has been made freely available online under the BMJ
Journals Open Access scheme.
See http://thorax.bmj.com/site/about/guidelines.xhtml#open
This journal is a member of and subscribes to the principles of the
Committee on Publication Ethics
http://publicationethics.org/
Thorax is published by BMJ Publishing Group
Ltd, typeset by Techset and printed in the UK on
acid-free paper.
Thorax (ISSN No: 0040–6376) is published
monthly by BMJ Publishing Group and distributed
in the USA by Air Business Ltd. Periodicals postage
paid at Jamaica NY 11431. POSTMASTER: send
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Contents
64
Intrauterine and early postnatal exposure
to outdoor air pollution and lung function
at preschool age
E Morales, R Garcia-Esteban,
O Asensio de la Cruz, M Basterrechea,
A Lertxundi, M D M L de Dicastillo,
C Zabaleta, J Sunyer
Volume 70 Issue 1 | THORAX January 2015
Pulmonary puzzles
93
Respiratory microbiota: addressing clinical
questions, informing clinical practice
OPEN ACCESS
G B Rogers, D Shaw, R L Marsh, M P Carroll,
D J Serisier, K D Bruce
Case based discussions
95
98
Decreased glutathione and low catalase
activity contribute to oxidative stress in
children with α-1 antitrypsin deficiency
A Escribano, M Amor, S Pastor, S Castillo, F Sanz,
P Codoñer-Franch, F Dasí
Images in thorax
Intrapulmonary vascular shunt pathways
in alveolar capillary dysplasia with
misalignment of pulmonary veins
C Galambos, S Sims-Lucas, N Ali, J Gien,
M K Dishop, S H Abman
An adolescent with persistent cough,
abdominal pain and refusal to walk
from Salesi Children’s Hospital
S Angeloni, I Carloni, P Osimani, L Amici,
C Lanza, F M de Benedictis
101
84
Lesson of the month: rowing-induced
laryngeal obstruction: a novel cause of
exertional dyspnoea: characterised
by direct laryngoscopy
B Panchasara, C Nelson, R Niven, S Ward,
J H Hull
Research letters
82
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J Hutton, C McBrien, Z Sardelis, G McGann
Review
74
A rapid change in a patient’s chest radiograph
appearances
A deadly web
A M Nanzer, S Jordan, S Padley,
M Griffiths, M Hind
Journal club summaries
102
What’s hot that the other lot got
C Lee
PostScript
86
Correspondence
Chest clinic
Audit, research and guideline update
88
Which intravenous bronchodilators are being
administered to children presenting with acute
severe wheeze in the UK and Ireland?
I Morris, M D Lyttle, R O’Sullivan, N Sargant,
I J M Doull, C V E Powell, on behalf of the PERUKI
network
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