Curriculum Vitae
Patrik Christen
Date of Birth: 31 March 1982
Nationality: Swiss
E-Mail: [email protected]
Postdoctoral Training
Oct 2014 – current
Postdoctoral Fellow
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
Jun 2014 – Sep 2014
Senior Research Associate
Animal Flight Group, Department of Zoology, University of Oxford,
Oxford, United Kingdom
Sep 2013 – Mai 2014
Postdoctoral Research Assistant
Animal Flight Group, Department of Zoology, University of Oxford,
Oxford, United Kingdom
Mar 2013 – Aug 2013
Postdoctoral Fellow
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
Education
Mar 2009 – Feb 2013
PhD Biomechanics
Orthopaedic Biomechanics, Eindhoven University of Technology,
Eindhoven, The Netherlands
Oct 2006 – Jan 2009
MSc Biomedical Engineering (insigni cum laude)
Institute for Surgical Technology and Biomechanics, University of
Bern, Bern, Switzerland
Oct 2003 – Oct 2006
BSc Business Information Technology
Institute for Information Systems, University of Applied Sciences
Northwestern Switzerland, Olten, Switzerland
Postgraduate Education
Apr 2011
The Art of Presenting Science, Eindhoven University of Technology
Jul 2010
Bone Cell and Tissue Mechanics, International Centre for
Mechanical Sciences, Coordinated by Stephen C. Cowin, The City
University of New York
Apr 2010
Fundamentals of Biostatistics, Eindhoven University of Technology
Jan 2010
Supervising Master Students, Eindhoven University of Technology
Supervising Responsibilities
Dec 2014 – Feb 2015
Joost de Jong, ETH Visiting PhD Student Biomedical Engineering,
Maastricht University Medical Center, The Netherlands
Development of a registration method for highly dynamic high
resolution CT images
Sep 2012 – Feb 2013
Michiel Peters, MSc Student Medical Engineering, Eindhoven
University of Technology, The Netherlands
Subchondral bone structure analysis of excised tibial plateaus
Jan 2012 – Apr 2012
Yorick C. F. van Leuven, MSc Student Biomedical Engineering,
Eindhoven University of Technology, The Netherlands
Allometric trabecular bone scaling and bone adaptation
Mar 2011 – Jun 2011
Andreia A. dos Santos, MSc Student Biomedical Engineering,
Eindhoven University of Technology, The Netherlands
Validation of a bone loading estimation method
Teaching Responsibilities
Feb 2015 – May 2015
Lecturer
Undergraduate course Orthopaedic Biomechanics
ETH Zurich, Switzerland
Apr 2012 – Jun 2012
Tutor
Undergraduate course Casus Pericardial Patch (Tissue Modelling)
Eindhoven University of Technology, The Netherlands
Programming/Software Skills
C/C++, Image Processing Language (IPL), Scanco FE (IPLFE), ParFE, ParOSol,
Abaqus, Matlab, Amira
Professional Societies
Dec 2014 – current
Member in Training, International Bone & Mineral Society (IBMS)
Oct 2010 – Dec 2013
Student Member, European Society of Biomechanics (ESB)
Reviewing Activities
Journals
Proceeding of The Royal Society B
PLOS ONE
Bone
Biomechanics and Modeling in Mechanobiology
Journal of Biomechanics
Journal of Biomechanical Engineering
Journal of Experimental Biology
The Anatomical Record
Computers in Biology and Medicine
Grants
Israel Science Foundation
Media Appearances
Lineair verband tussen botbelasting en botaanbouw aangetoond. TU/e online news, 11 Sep 2014.
IBDW 2014 Young Investigator Travel Award. Institute for Biomechanics ETH Zurich online news,
8 Aug 2014.
De geschiedenis en toekomst van botten. Cursor, Magazine of the Eindhoven University of
Technology, p. 9, 24 Jan 2013.
Biomechanica: Bottenformule gekraakt. De Volkskrant, Dutch newspaper, 1 Feb 2013.
Internal structure of bones reveals loading and walking. TU/e online news, 31 Jan 2013.
Awards
Oct 2014
Young Investigator Travel Award
20th International Bone Densitometry Workshop, Hong Kong, China
Mar 2010
Best Overall Presentation Award
18th Annual Symposium on Computational Methods in Orthopaedic
Biomechanics, New Orleans, Louisiana, USA
Invited Talks
P. Christen. In silico multiscale simulations of bone remodelling in health, disease and treatment.
Invited Speaker, 5th Symposium on Academic Exchange and Collaborative Research (AECoR-5
2014), Zurich, Switzerland, 27/28 November, 2014.
P. Christen. In silico multiscale simulations of bone remodelling in health, disease and treatment.
Invited Speaker, 20th International Bone Densitometry Workshop (IBDW 2014), Hong Kong, China,
13-17 October, 2014.
Monographs
P. Christen. Deciphering the secret message within bone microstructure. PhD Thesis, Eindhoven
University of Technology, ISBN 978-90-386-3323-7, 2013.
P. Christen. Contact mechanics of a discrete fiber-reinforced cartilage model. MSc Thesis,
University of Bern, 2009.
Journal Articles
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P. Christen, B. van Rietbergen, F. M. Lambers, R. Müller, and K. Ito. Bone morphology allows
estimation of loading history in a murine model of bone adaptation. Biomechanics and
Modeling in Mechanobiology, 11(3-4):483-492, 2012.
P. Christen, K. Ito, R. Müller, M. R. Rubin, D. W. Dempster, J. P. Bilezikian, and B. van
Rietbergen. Patient-specific bone modelling and remodelling simulation of hypoparathyroidism
based on human iliac crest biopsies. Journal of Biomechanics, 45(14):2411-2416, 2012.
P. Christen, K. Ito, I. Knippels, R. Müller, G. H. van Lenthe, and B. van Rietbergen. Subjectspecific bone loading estimation in the human distal radius. Journal of Biomechanics,
46(4):759-766, 2013.
P. Christen, K. Ito, A. A. Dos Santos, R. Müller, and B. van Rietbergen. Validation of a bone
loading estimation algorithm for patient-specific bone remodelling simulations. Journal of
Biomechanics, 46(5):941-948, 2013.
R. Ellouz, R. Chapurlat, B. van Rietbergen, P. Christen, J. B. Pialat, and S. Boutroy.
Challenges in longitudinal measurements with HR-pQCT: Evaluation of 3D registration
method to improve bone microarchitecture and strength reproducibility. Bone, 63:147-157,
2014.
P. Christen, K. Ito, F. Galis, and B. van Rietbergen. Determination of hip-joint loading patterns
of living and extinct mammals using an inverse Wolff’s law approach. Biomechanics and
Modeling in Mechanobiology, doi:10.1007/s10237-014-0602-8, 2014.
P. Christen, K. Ito, R. Ellouz, S. Boutroy, E. Sornay-Rendu, R. Chapurlat, and B. van
Rietbergen. Bone remodelling in humans is load-driven but not lazy. Nature Communications,
5:4855, doi:10.1038/ncomms5855, 2014.
P. Christen, K. Ito, and B. van Rietbergen. A potential mechanism for allometric trabecular
bone scaling in terrestrial mammals. Journal of Anatomy. Accepted.
Journal Articles in Preparation
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S. D. Badilatti, P. Christen, A. Levchuk, and R. Müller. Towards simulation of whole bone
microstructure adaptation. Invited for Publication in Biomechanics and Modeling in
Mechanobiology.
P. Christen, F. A. Schulte, A. Zwahlen, B. van Rietbergen, L. J. Melton, S. Amin, S. Khosla, J.
Goldhahn, and R. Müller. Voxel resolution dependency, reproducibility, and sensitivity of an in
vivo bone loading estimation algorithm. In preparation for Bone.
P. Christen, S. M. Walker, and G. K. Taylor. Microtomographic reconstruction of the haltere
kinematics in blowflies reveals out-of-plane motions hampering Coriolis force sensing. In
preparation for Scientific Reports.
Conference Proceedings
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P. Christen, S. J. Ferguson, and S. Chegini. Contact mechanics of a discrete fiber-reinforced
cartilage model. IV International Conference on Computational Bioengineering (ICCB),
Bertinoro (Forli), Italy, 16-18 September, ISSN 2036-9247, p. 58, 2009.
P. Christen, B. van Rietbergen, F. M. Lambers, R. Müller, and K. Ito. Determination of
physiological external loading conditions based on bone morphology. 18th Annual
Symposium on Computational Methods in Orthopaedic Biomechanics, New Orleans,
Louisiana, USA, 5 March, 2010.
P. Christen, B. van Rietbergen, F. M. Lambers, R. Müller, and K. Ito. Determination of
physiological external loading conditions based on bone morphology. 56th Annual Meeting of
the Orthopaedic Research Society (ORS), New Orleans, Louisiana, USA, 6-9 March, 35:659,
2010.
P. Christen, B. van Rietbergen, F. M. Lambers, R. Müller, and K. Ito. Determination of
physiological external loading conditions based on bone morphology. 17th Congress of the
European Society of Biomechanics (ESB), Edinburgh, UK, 5-8 July, 509, 2010.
P. Christen, B. van Rietbergen, F. M. Lambers, R. Müller, and K. Ito. Morphology-based bone
loading estimation. 20th Annual Meeting of the Dutch Society for Calcium and Bone
Metabolism (NVCB), Zeist, The Netherlands, 11-12 November, 2010.
P. Christen, G. Armbrecht, G. Beller, D. Felsenberg, K. Ito, and B. van Rietbergen. Bone
strength loss during long-term bed rest is related to bone loading history. 57th Annual Meeting
of the Orthopaedic Research Society (ORS), Long Beach, California, USA, 13-16 January,
36:2257, 2011.
P. Christen, B. van Rietbergen, F. M. Lambers, R. Müller, and K. Ito. Morphology-based bone
loading estimation. 3rd Dutch Conference on Bio-Medical Engineering, Egmond aan Zee, The
Netherlands, 20-21 January, 232, 2011.
P. Christen, B. van Rietbergen, R. Müller, M. R. Rubin, D. W. Dempster, J. P. Bilezikian, and
K. Ito. Altered mechanosensitivity can explain the substantially increased bone mass in
hypoparathyroidism. ASME 2011 Summer Bioengineering Conference, Farmington,
Pennsylvania, USA, 22-25 June, SBC2011-53485, 2011.
P. Christen, I. Knippels, R. Müller, G. H. Lenthe, K. Ito, and B. van Rietbergen. Bone loading
estimation in the human distal radius. 58th Annual Meeting of the Orthopaedic Research
Society (ORS), San Francisco, California, USA, 4-7 February, 37:374, 2012.
P. Christen, B. van Rietbergen, R. Müller, M. R. Rubin, D. W. Dempster, J. P. Bilezikian, and
K. Ito. Altered mechanosensitivity can explain the substantially increased bone mass in
hypoparathyroidism. 58th Annual Meeting of the Orthopaedic Research Society (ORS), San
Francisco, California, USA, 4-7 February, 37:1535, 2012.
P. Christen, A. A. dos Santos, B. van Rietbergen, R. Müller, and K. Ito. Validation of a bone
loading estimation algorithm for patient-specific bone remodeling simulations. 18th Congress
of the European Society of Biomechanics (ESB), Lisbon, Portugal, 1-4 July, 1313, 2012.
P. Christen, B. van Rietbergen, I. Knippels, R. Müller, G. H. van Lenthe, and K.
Ito. Determination of physiological loading conditions at the human distal radius. 18th
Congress of the European Society of Biomechanics (ESB), Lisbon, Portugal, 1-4 July, 1311,
2012.
B. van Rietbergen, P. Christen, M. Colloca, and K. Ito. Toward a patient-specific simulation of
bone remodeling. 6th European Congress on Computational Methods in Applied Sciences
and Engineering (ECCOMAS), Vienna, Austria, 10-14 September, 2745, 2012.
P. Christen, R. Ellouz, S. Boutroy, R. Chapurlat, K. Ito, and B. van Rietbergen. Local changes
due to bone remodelling are triggered by mechanical loading. Annual Meeting of the
American Society for Bone and Mineral Research (ASBMR), Minneapolis, Minnesota, USA,
12-15 October, SA0071, 2012.
M. Colloca, R. Blanchard, P. Christen, C. Hellmich, K. Ito, and B. van Rietbergen. A multiscale
approach to describe changes in bone volume fraction due to bone remodeling at the cell
level. 59th Annual Meeting of the Orthopaedic Research Society (ORS), San Antonio, Texas,
USA, 26-29 January, 38:1489, 2013.
P. Christen, K. Ito, R. Ellouz, S. Boutroy, R. Chapurlat, and B. van Rietbergen. Revealing
load-adaptive remodelling in human bone. 59th Annual Meeting of the Orthopaedic Research
Society (ORS), San Antonio, Texas, USA, 26-29 January, 38:0345, 2013.
17. P. Christen, K. Ito, R. Ellouz, S. Boutroy, E. Sornay-Rendu, R. Chapurlat, and B. van
Rietbergen. On Wolff's Law in human bone. V International Conference on Computational
Bioengineering (ICCB), Leuven, Belgium, 11-13 September, C0012, 2013.
18. R. Ellouz, R. Chapurlat, B. van Rietbergen, P. Christen, P. Szulc, E. Sornay-Rendu, and S.
Boutroy. In vivo local bone remodeling assessed by High Resolution pQCT. 22nd Annual
Meeting of the European Orthopaedic Research Society (EORS), Nantes, France, 2-4 July,
O19.10, 2014.
19. P. Christen, S. M. Walker, and G. K. Taylor. Microtomographic reconstruction of the haltere
kinematics of the blowfly. 7th World Congress of Biomechanics (WCB), Boston,
Massachusetts, USA, 6-11 July, R29, 2014.
20. S. D. Badilatti, P. Christen, A. Levchuk, I. Parkinson, and R. Müller. Towards simulation of
whole bone microstructure adaptation. 7th World Congress of Biomechanics (WCB), Boston,
Massachusetts, USA, 6-11 July, M120, 2014.
21. P. Christen, F. A. Schulte, A. Zwahlen, B. van Rietbergen, L. J. Melton III, S. Amin, S. Khosla,
J. Goldhahn, and R. Müller. Reverse engineering estimation of in vivo bone loading history.
20th International Bone Densitometry Workshop (IBDW), Hong Kong, China, 13-17 October,
Journal of Orthopaedic Translation, 2:230, 2014.
22. P. Christen. In silico multiscale simulations of bone remodelling in health, disease and
treatment. 5th Symposium on Academic Exchange and Collaborative Research (AECoR-5),
Zurich, Switzerland, 27/28 November, p. 14, 2014.
23. P. Christen. Unravelling the mechanoregulation of bone remodelling in humans.
AIMM/ASBMR Young Investigators’ Meeting, Snowmass, Colorado, USA, 6-10 April, 2015.
Submitted.
24. D. Ruffoni, P. Christen, H. Scherf, R. Weinkamer. Wolff’s law and the interplay between bone
structure and external loading. 4th Joint Meeting of the European Calcified Tissue Society
(ECTS) and the International Bone and Mineral Society (IBMS), Rotterdam, The Netherlands,
25-28 April, 2015. Submitted.
25. P. Christen, Y. W. W. Lee, B. van Rietbergen, C. Y. J. Cheng, and R. Müller. Time-lapse in
vivo image analysis to determine local disease and treatment effects on bone remodelling in
patients. 4th Joint Meeting of the European Calcified Tissue Society (ECTS) and the
International Bone and Mineral Society (IBMS), Rotterdam, The Netherlands, 25-28 April,
2015. Submitted.