rs ity ni ve U ap e of C To w n w n of C ap e To The copyright of this thesis vests in the author. No quotation from it or information derived from it is to be published without full acknowledgement of the source. The thesis is to be used for private study or noncommercial research purposes only. U ni ve rs ity Published by the University of Cape Town (UCT) in terms of the non-exclusive license granted to UCT by the author. rs ity ni ve U ap e of C To w n own umLidc::d It eX~lDlination at U ni ve rs ity of C ap e To w n dell!r:ree or I am SmCerelY ""U"~"""''''' to to to SUI)lec::t was To w n I C ap to "......_..,. gJra1J.tucle to en<linD4JUSJly to on .........6 ......""'" Chc;:clcs! U ni ve rs i ty numerous of am I e suprpm1ed me thr4)ugb measurements on maiKllltg sure Oloooswere w n To e ap C of ty rs i ni ve U 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 :SUUlDlary ............................................................................................. 1 ........ " .......... " 111> .......... II . . . . . . . . . . . . '" "' .... " ' " .... "' .... ". . . . . . . "' ...... " .. " .. II . . . . . . . . . . . . . . "' .. "' .... " .. '" "' . . . . . . . . . . . . " .. " ' " . . . . . " .... .: . . . . . . III" " ' ' ' "" .... .. II II .. " . . . . . . II . . . . . . . . . . . . . . " .. " ............ " .. '" . . . . . . . . " .. , , " " It" (I . . . . " "' .. " . . . . . . . . , , " It .. (I . . . . . . " . . . " " " .. ,, .. '" .. " .. of C ap e To 1\Ile:al;Ulnmu::t1·I:s .... "' . w n I:'atllenl:s ................................................................................... l:un<1ulgs ............................................................................... . KalllilOm ni ve rs i ty """uuu",.... gluc:ose ............................................................................ . ~ ........ " .. " . . . . . . . . . . . . . . . . . . . . '" . . . . . . " .. " ........ " . . . . . . . . '" " .... " . . . . . . . . . . II> .. (I .. " . . . . II> .. <II .. '" " ...... II . . . . . . " .. II . . . . . . . . . . . . . . . . " ............. " U .. .. to .. .. ....,........................................ .., ..., nA...............u ... "' ...................................................... " ........................ . svnc.tro:me ........................................................................... 31 nSC·ussllon .................................. . lylS.gl yl,;;CR:,llllit1 ............................................................................... . KanQI()m JO;U""",,,.,'" on QUJUll;:J"-"U'U . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . i lSllll'Uii:l.t:JUUi ............. '" n ...... _uv.JU... to .. 41 .. " . . . . . . . . . . . . . . . . . . . . . . . . . II <I> II . . . . . . . . . . . . . . . " • <I> • It . . . . (I . . . . . . . . . . . . . . . . '" • 41 .. to .............. " ., . . . . . . '" . . . . . '" '" SV1lOl"ODle ......................................................................... . Limitati,ons ......................................................................... . rec()mnlen(laU()ns .............................................. . To w n Rec4:>mnlendatiOJlS ......................................................................... . U ni ve rs i ty of C ap e AppelldlC:es ........................................................................................ . ii to as a cause cOllSi(lerc~ one To w n - is e more ni ve rs i ty of C ap esi1ulUIlies are U an acute cOl~narv SV]I1<.1rOD:le on a CfC)SS··sec::tiolnaJ OOISef1V'aU.ODlU. SUblSeQlUeIltly UU~UI~ Dn~eJnce were SmiUIle(l ac(~0~run:2 "'U'''"~'''''''' as ....,,,,,...,..... a dia:gtlolsed as ......." .... ". an co]~narv or abs:en(:e an event 1 no to were refltar(le<.t as aorlonnaJ men -C:::;l to C>3 :::; 1.3 was a common pn~SenUlLtlC'n to To w n C a uncommon rs ity of C ap e seems to "'UJLLU.'''''' COlIlpar:!SOn to I'Ip'-TPit'.n ni ve to U < ctOm.pllca110IlS " '....uu. ..... nl~!1tv was more common p= more co:mr.nolDl}i CII<l)!3"""JlaL~;U an mcreased a most common was a a 2 was more common = was more common more common 1- a of VVI'~L""""i:O C ap e I, To w n to seen ty same extent. a potlentiaJ are we ettlOemlC common sutliectq nres,entine .to U ni ve rs i uncommon COlllt:rm;t. nten-cmtion, or even Dn~VentaD1e ....i·......" ......t.r.... 3 1 ;ardlioV8SC1Ul81 Qlsc,ase is sec~ona -a - is COt1SlClen~ To w n common cause acute rs i ty of C to ap e outcome worse It is a cause it ni ve 2 starts to is set at not U is now as It is not not even more 4,5 . It is is even 4 contribl11tes to IS or more common normoglYlcaeJm1C patlen1ts. 6 It is now COltlUIlonJ~ 8(~Cet)ted anlce~g, is nn'i!PT"ilAll w rC~l!;taJlce To A.u.<......,.U Chl~nllir1'P.1M7.I'II1 n a COlrnplex .....,,'........... nroc:ess clusteJ'in~ of C a is IormalllY ap e U1GU"L''''' ty causes rs i to to ni ve IS to U as an as to 2 2 is is 7 8 to can 2 it is 5 is 2 UlQ.I~L\;;" is COIlSI(Jlerc:~ to a col'On:arv pre'lfent:ion. It theJ-etolre is not se IS recogJllZc;:(J as an mdlepcmdent are 2 ......".v...~.... mCludm2 a l11lCrease. moeeo an epllClenllc, is pre:<11cted n W"'dlffiiilll,; To w SvncIJrol1rle) 10 ruaD~jlty ap e to as U ni ve r si ty of C retj~rre:d a 2 ruallete:s: is seen 2 a is a 6 we can a most To w n are common inJ:an::tions. 17 is an 1mnnli'tl'llft{'P Cmlll()V8SC1.11ar ap e t(\IPr~nl'p AU............. women to of C IOOHo" ....." '... A ...AU.U"", a U aQCl1tlOn. ni ve r si ty is a recent or COlltu:1Ulllg tcmaen(:y mass a ".(\..'v""'.....,.,.... to Wi:liUCl'~. 20 a Ot)esl1~ 21 a slgIufic:ant conrela1tlon an two C1ec:aC1C~S was a 7 2 ...........,... ,....."'.23 to an l!e1ttmll! worse It n gec'gnJlPhllCal areas to m(hC~ln(mS U ni ve rs ity of C ap e are some To w to an is no reason to ........,,"""","" an mClreal!le not 31 so denllon.stralted to "1'I1"Ul~"'" an inc:rel'lSe over ..........."" ..,.. are an 8 is 2 dial)eti(~s. OC4:urred or is even to a ........."..,...t "'AV'..u~ SVI1nntom seen seen at "'-A"........J' a rs ity of C commonest acute cOI:unarv SVlllmnttles is ap e prc::aClllU:n8ltOO To w n it is It is U ni to cau:smg to h8]PPC;m ve W Q,lUlJLlil: ..........,....·......i to marna~~e an en,risa2ed increase a at to invlestiJ~ate 9 2 To w n 1. presen1ting to cross-~lectlonaJ olDserval1olnaJ, I1p~[I'"'ntnJP on COIlse<:Un U ni perton:ned a ve rs ity of C ap e I. to 4 was no CO]iD.pan!~on are measurement COlllec;tlOn was np1r1'nTTl"l were a stWtutardllsed To w n 1. ap e a. of no no ,..,...,.,,.11",,,,," bic,ml:lrk.ers or U ni ve r si ty - C 1. i. intiomled consent to 11 were not llllLjl<UAJ dla:gnolsed on auJ.jIU"~IAVU to 1. gIulCmle tc)ler'anc:e test To w n were too unStaDlle. ap e measures were Obt:am,ed: C 1 of 1.1 ity 1.2 ve U ni 2 rs 1.3 acute mv'oc~lrd.ial an n To w ap e 3 C 3.1 ity of em ve rs em 4 U ni em .lm-um".lUJ'''' "'Jl.la.u~"'i) were 1n'U'P1"C!tnn > 3 mm plpv9tlnn> on 5 syrldr1om,e was UUlgIlLOSOO, <II"',.,...1I"i" ....,." to Jns1tabJle aJlglIla was "'''I-n",'',,, as a ... UJ........,.... at .............. A ....... as: To w n acute COtnn:BrV """'11 ..·,........ .,." were ...A...u....._AJ is ap e or C or an or new,...,............... of . . . ",.,QT........ ity 6 U ni ve rs ona 6 case was or more onset MOlllUlt~2 on to ~"""'''''''''15'''' to sanlPU::S were obl:amle<1: 2 were ity of ~7 C ap e To w n ~rit~.rin g1uc:ose, IGT == imPlured U ni ve DM "" diabetes mellitus lmp~ured rs tolemnc:e, IFG == NGT= normal were ......."g..'i""'"' as aDIlonnru men cru)les~~ol was :5 1.3 ...... ,..., .... " women ~~~WlG"~ not ex(;eea = 8+ ] 15 DI()()(JIS ...V U _ I........ were were UU,AU':KU> was pertonnlOO C ap e .... ~..................'V.u as Dn~ente:<1 To w are as U ni ve rs ity of 10SPltlal n sum as were 3 1 1, were Iet1naie. were res:po:nsible To w n SVI1OO)m4e8 1 were are Dre:SeDltoo U DWleDI1.S e'vall1atc~ ni ve rs ity of C ap e 1, = 2 1. Total patieni\ ACS pmirnts 1I-11J1 , .\ge (lll~di'lIl. "al1!,~)(ye"n;) (I~ - 'JT) 62 e4 - 'J7) .~.--------+------- I£thnidty ~77 131 ('o[oui'ed 62<) 73 Rh,ck 623 0 Oll!~,. 2 951 h'JJI(lI~ j j )m 1m of C SO To w . Hale ap e I ------+--------, n White G~nder rs ity Figurt' I; I£thnk di,tdhutioll in p'llients st't'u ill 1£L1 and those with ACS ROO ,, -, iOO ni 'JIlIl ve I Ifllil U ! 44 n=l14 6()() • Total patients • ACS jlatknj, ~ •0 500 0 ..j()() 300 2(~ l()() 0 White C"lourrd lIJad, 3.2. Clinical Findings AI leasl one n sk 1,><:lor lilr ~ardiov;~,~u lar disea,e (on l1lslor),) was presenl in 20J palienl, (94,')'%) . HypenellSl(ln was Ihe mosl COmmOll risk I"clor, I"ll owed by known CAD and a 1;.Ll1llIy history 01' CAD, lyp" 2 diabct~s. ~lgmeU~ smoking (current), Iypc 2 dinbdcs, a fam ily histoJ), of high clx,kstCfOI, peripheral vns.culHr diseasc anc.l stroke (tnble 3), Two Of morc cardiovw;cular ri,k factors wen: preselll ill 4 or more in 50 palienls (23.4%). 5 OLmorc palienls ( I ,r·;.) had I) J!l 19 patients mor~ Hl 10] (g.9'~.;,) and 4 n (4S_1~__;,)_ pallellts OJ_x',,;;), 1 or nsk lactors. In tntaL 73 patients (:14. I '~.;,) were diHgnosed wilh low ri,k urlOlahle allgillH. 76 (.1';5~--o) To w pal lenls 1) ~ wilh high nsk unstable allgHla, .1 1 (14)~--;') wi th of C ap e NSTEMJ and 34 (1)_9%) wilh STEML In·hn'pLlal cmnplications OCClLITOO in 85 paticnls (3'),7"--0), Congcstive heal1 jllilure was the most common ~ompli~aljon_ A small subsd oj' paliellls were rd"elTed 10 a Ieltiary rn'''pitall;)r im'asive intcJ'>'CTitinn and Hn eVC11 sma ller ity gnlUp c.lied (table 4), ve rs Tablc 3: Risk faclol'S for CAD on hi,tor.,' "". l\'umhcl' paticnts Pcrccntllgc Hyp.,n~n,ion 143 66,~ Known CAD 113 52,g 1'-.l1ni Iy hi,toT) of CA I) 71 33,2 U ni Risk I:ar!<lr I Smoking hlSlory 64 Diabele, Mellitus 52 hunily hi,IO[',), ol D'vI 51 Hig h Crn,kstcrol .'14 Periph cra l vascular di sease .'12 Cerebwvascular disease 2'; I i I, 29,<) 24.1 2U 15.9 14.9 ! 11.7 19 I abk 4: In-ho~pit31 "omplic"tion~ -- ~- - --~ COIllpli\-,l1ion ~umbH 1'1Ijj~lIl~ PtH'cntage 129 6(),] , }S, I 6 H j} Ii. I 7 " ,'-,' \,jone: Congesliv~ hCaJt j,'ilurc RcelLn-cm ungmu ,,, ,, ,, R~krled De,,111 , ,, ,, ,, , w n I Oral glucosc tolerance To ~.3. ~, , admill~d e The glycUUlllc prome wul delnmincd Ul1<1 c-ollll'arcd in 1'14 of the 214 polk nt, \VQ' ''lOt d'l\le in 2(1 p"lien\< due lO unwillmgl1e_" (n- l(1), dealh (n-1) or ap wilh ."'(,S, [I A 1l1Odilied oral glueme loleranc e les l wu:< puJoml ed at disc-harl!c ty (;llIcosn'altgoric~ of C lran,rer to a leni ~'" in;;l ll ulC [()r rurther imer\'cnllo n (n- 7), rs i on a[1 pUliem s admilkd wilh un A(,S and nol nlrcndy known 10 have diabete,; (142)_ normal ni ve Taking thc known diabelics mlO alTounL palienL< Wer" Ihen divldcd imo gllLcos~ I()kmnc~ (6~. lllOS~ wilh n }S.I'%'\ and (ho,,, with dy,glycaemia (121i. 64_,)0/01 _ U SubjI'C(s who had a p,;or his(o,)' or diaOCle, W<'l'C dassllied as havmg P'evlOlLsly dia,,'lloscd diaheles_ Olher subje<:[s we,,, d,~"died ,,,,~ording 10 lhe modiiied 1997 ADA critcria. as having a n'Mmal glocose lo["rance, an lsolated impuired ensling glucose. nn isolawd impa ired g l u~o'e lOkl,mce. hoth impaired rasling- gl lll"'"'' und impail1cd gllLCOS~ l()kL'an.:~ (th~ lattcr thrc~ ca(cgo.-i es also ktlOWn ns prediabetes) or diaheles_ Palit'fll, w11h w~re ;; ubdl\'idcd ,nw those nlrcady known to havc diahete,; Qnd lho;; e wilh newly lilaOCleS llia,,'llostil cli abel."" C]a"dicalion oj' glucose abnonrw ljtics ncnll-ding to the ]<!97 lDod ified AIlA c,;(~ria are lab u[akd in luhl " 5_ Th e pL'e\ aknc~ or glu(os~ nbnonnaliti~s 2(1 w~re lh~ f~,lillg deknl1ined wlih ll", plasm,1 gluws~ prevalence of dysgJycocmia when adding lh~ (FT'Ci) lesl alone and lh~ll compmed lo 2 hr post-load glucose (PG) value (table 6). Table 5: Prevalence of glucose abnormalities according; to 19'n modified AHA criteria % ,VGT ~s iso/weeliFG IJ lso!wed J(iT :oJ -' 5.1 w l\"rmal n " I1 08 .1%) OM of New 22 11.3 52 26.~ ty i Iliab~t<" "I 16 C fFG ",,,I leil I 11.9 e t2~.il%) ap ! Prediabetes To (35.1%) "0m101 ::Iuc"," ",1""",,,._ TH, - imp'in:d j;"tlllg glue"",,, lCiT - impairt'J glue',,"e ni ve rs i ,,'(iT U Table 6: Nllmher 01' patients recruited with FPG, 2 br I'G and the t"tal "I' glutost' ahnonnali!ics -- FPG 2 hr PG Both NGT I(X) sa 68 IG, 2'! 39 52 Inl 13 18 '\'CiT - nonmLl ~lllC''''': lol' mnee, J(3 T - ._-- '''~.<\11' ...1"Iu",,,<, -- 22 (01.,-,"'000, 1)\1 - , ~ i ,hett, 21 Re~lUitll1g di aheLie ralle"Ls l>y ellh"r crite'rio" alo,,~ or lhl1r combi"aLio'L -'/0.1 % (9) ILlel bOLh, 18,2% (-'/) mel the fa,ling ~rileria alone onci 40'>""'0 ('I) met tllC 2 Ill' Xlst iO<ld eilh~r c1iknol1 alolle, SlIllil3Jly, n'cruiLing patknts wilh IInpaired glucose tolerance fly Cnlenol1 alollc {\]' Lheir cOlllb,nation, 30,8'~"i, (16) nre( b(){h, 25~";, (H) mct lhc fasling CI'ilCliJ only and 44,2% 123) met tlK" 2 hr post· lml(l criwrion alone. [)y~g iyca"mi" wa<; more commOll ill Co ioLll"eds (72.3°··;' 01' all dysgiycaellm buL lhese w h,~j To 1[>-0.071. The lllajority of macks (88.'l'!·") and ail Indians n Coloureds) than \Vh,Le, (58.8%). howe"er, this did not reach Slal1Slicai signific~ nce iJttcr two groups 'verc (ll" small to 1><: <;tati s1 iC'11i y sib'Tllllcall i (ligLire 2). h~' C '" I. ~G'T ni ve 00 ty 00 rs i ,, ",~ of 00 • '" Nhnidty e 2: Di,tribulion of rl~'sgly~:teUlia ap Figllr~ 00 ,. U '" '" " \\1,;," DysglycQcmia was comrrX)1l in both mules {·01011.. d (~2.9'!..~ Rb,"", 01' all lllak,) and females p-O.55 (!jgure 3), The mcdian age ofpaliellLs w1lh dysglycaerllla (65 ycars, rangc (67~";':1, J~-(17) was Slgrllficmltly highcr than tix)se with r-.CH (56 years_ T"Tlge 24-90) (I' - 0,(3). 22 . .. , .."I " i 1 • . . . . 0. .. " , ', ... 1< n " w '" prenou~ ,,~haeml~ e\enl wa, present in 46.2% 01' nnci 59.1%. "fne" diahctks. Pmients with l\GT 'vere more likdy to h..lVe C ~rcdiabelin e A hl,'tmy or a ap Clinit3i To " of low nsk LAP III wlllpans.on to both thelr prcdiaklic and diabcti~ COlLlltcJ'pmts (p < 0.0 j I I.hio In Will; diabetics (3, 4. j ".'f,). compared to pnxliabetics (1, 1,9%) Bild l\ GT (j. I .5%) hut nul ni ve highest rs i ty (table 7, figure 4) and leoo likely \0 develop wmplicatiOllo (I' - 0.04). Mortality wa, ,Iatisli~ally significant (p - O.5R)_ comnar~' e,'en!, and complicatiom In the U ruh!\> 7: A cm"parism, "f low risk diffl',-"nl glucme categoric'S L L",,· ~i~k , J";GT I rH'n( C<>mpiiealiom Prediabetes ._--- I 34 (5()'% ) 19 C 7.<fO(;,j 15 (2~,,)'_!-") '3 (44.~%) ! Viab....tes ! 20 (27'!-a) 35 (47.3%) 1 23 Fi~ur{' A rompal'is"" of 10'" .-is\.. "o,.""a,.y e'cnls and 4. differ{'n{ :::Incosf e()rnf'lic~lions III Ihe ca{p~ories 00% ;0)% -10% g ,,'.Il! .. Low mk .'" .. c, ","""'"'''''''' w n '~ -'Q"I. To 211"" ap e 10% 0"1. of C NGT gltlu",~ ,In (~l dis~haj'ge (){iTT U ni ve dCknnined w,th ",a, llcrcrmin.-:d ill paliel\t< ",hose rs i A ral\d"", ty 3.4. Ralldom glllcos(' nil admissioll 11,1 mmol . . l. diagnostil ofdiahete;, alrc-lriy known with d;ahet~, /\ nmdom glucose level ::. diabcl~s (59.6%,) random and j() ~ a",1 :l W'~ glyc~<ll11lc' proJilc , w~rc known «I' or known hislOry of diabete,). Ilw ",,,,lia,, ]ouud inn patiClllS of which 16 ra1ie!1ls T'~ti~'1HS wcn.; laicr dj,lgnosed w,th di~bet~s w~r~ by OGTT. (a ra!1(k,,,, cuI-of] vallLc for dysglycaelni,'1 W<lS found ill 5 rmiellt, w ith lle\vly diagnosed diabcks (47.6%), The ",,,,Iiall gh",,,,~ m pali~n(s with a low )i,k core'!U")' event Ihose wllh a high risk c:Dron<lry ~\'~Ill (5.~ w,,,, signilicilltly lower lhJll mmol ..'I am17.1 ",mol..'1 I\;SPCClivdy. p <. 0.011 24 C,llnilmly, the lllooian ntJl(]Olll gluGo,~ k"el,n paliellls who de\d0p"d ~Ompll~"liollS w:~, slglllflcanlly h ighcr th:m those who did nOI (7, 65 mmol/1 vs 5, ~ mmol/, r < I), I)] j, J.S.llbIAc An Hb I Ac was pert;mned 011 179 of lhe 194 delernllDed. A ~Olle(;lioll or labmltlory pall~nl' ~n-or ",~ts whose g-ly~"emi~ profile wer~ ",sponsib1e l')f misslllg- dala III :5 palicnts, The mcdian Ilb1Ac wa" k;;s in those with -"Gf than in the prcdiabetic. (I' < to diabetics (p < 0_01)_ The median HbA 1" was n ~ompared w 0.(1) as well as ill prediabetics To also "ig-mlicmllly highelln kno"n diabct,cs lhan in new diabetics (p < 0.1)1). Tllerc cvcnts and ill tbose who dc\'d0p"d ~ompllcalioll' C table~, alld lhose "ho ,lid 110l (p-O_5'f and U ni ve r si ty of r 0,05 l'Csj>cdi,cly) , See C"l"lIl:II')' ap e no diffet'GncG in the median j-]bAlc between patients with low "nct high risk \V~5 25 'r" hl~ 8; As'oci"tioll het" C,'" 'nedi,," H hA 1c a lid glyl,wlllic pmlil~, "lIrllllar." c, ('Ills alld c"'nplicalill'" \ledianllbAIC %, Ran~e ,v(jf' 5,2 4.4 - oJ) f',edi"hctics 5,4 4.5" 6.9 Diaberic,< 1i.1i 4.6 - 12.5 Old 7, I 4.9 - 12.) Nlw ~, <) 4.6 - 9.9 w n - (;Iy~a~mk I'rllftl~ ~.) l1igh risk ~,5 44 12.) 5.4 4.4 - 12.5 NSTE\1J 5,6 4.7 - 12.0 5,) 4 ,5-~,~ C ECG ChaIll'l" of STI"I,11 si ty Clllllplical i"n. y~-, 5,6 4.4-125 SA 4.4 - 12,) U ni ve r .\-'() -- 4.) - 12.5 ap e L"w risk To Cllmnar," c"CIII "'\ glyc<wmic tartd of Ilbl AC w~, 7 f01l!ld in W~rl' mol'~ 4~% alld rn()j'~ statistical ,ugg~'ted (\fpatienls known In have, ilkdy to have a low n,1.. cl~\ -clop Ulmpli~~tiom HblAC 7 (a, by th~ diahl·l~s. /ULkTicJIl Diabetes i\,.';c>eiali"nl Known rli<lbdlcS ",ith a Ilhl AC " ~nr",wry ~VL'fl1 (10. 41.7%) ~nd kS8 likdy to (R, :;3.3%) m comparison (0 their diabct'c u)Unte'l,mts wllh a 7. who "we Ie" likel:' to have a low risk coronary l,v~n( (6, 13.1%, p=O.lo) likdy to dndop complication, (14, 5-'.9%_ 1'-0,14) bllt this did not meet Slgmlicanc~, S~l' figur~ 5. 26 I'iglll'~ 5; . \,~odation bcn"rrn IlbA I C, low ri,].; ror'onary rwntl and rOlllplicalions oO"!. , ~ • L<I,," I;,k ~wnt 'j; In%. L11:1 Con",lic.tio", To w n " •• ap e lU% of C IlbAlC<7 rs ity 3.6. Anthropollletry and had an hody m"" index (8\11) "s a BM! :> 25). wilh a similar plnalGnc~ in th~ l1omwglyeaCtl1ic (47., 62.7%) dy'glyca~mic (S'i, 73.3%) gWlIp' (1' - 0.13) . There wa , 110 relationship to ;;ex, "ith (ddincd as a Dt>IJ :': 30) (p < 0.(1). See figure u. ulxle)l11mal dr~Ul11rcrelKe ')s.(,% (In) ()I'pali~nls 11l>nnog l ycaemi~ JCmotes iocr~a;;ed U ni t(kfin~'"(1 67 . 2'~--') ve Two [hLH/:; e)f the ,objcd, (135, (~4, c: ('~ntral gg em in females and ::: 102 hUI rlwrc COmllLOn in th~ oh-;,sity ~m (des~l;hoo in males) was as all p.-cs~nl in dysglycaemic (gO. 65.6%llh,,11 inlhe group 1-'2, 47 I";{" P - i).OJ) and llwre eommlm ly 7Q.3%J tho" mules (39, 37 5%, p ' 0.1)1). sc~ a;;s()cia[~d wilh iig.ure 7. 27 . ,. 741°,(. ..., .~ 500",• • r~ , ...... ~I! % l. •• )00,. To w n "'.k ~D~. ••• R~11 of C t ap e 10":-, ity of 1 111\11 and ce ll lui o ...."'i~, hy ~CDlI"r ve rs I'rf",.~n~,· U ni l'ij:urf 7; "" ! 50% t ~Q% • ~O% ... II:1M I 3.7. Lipid prolile The most common lipid abn0l1naiity seen in patients with ACS was thm or a low IlDL-L '('he I",,,-a lellce of di lien;llt lipid aiJnnnna Iil ies is detai Icd ill lable Q. The prevalence of a Inw HDL-C was less ~OmJllO[] mlhose with a nOntlal gl lJ(; os~ lolerdjl;;~ compm-~d lo th~ predwbelles as well as diahl.-'ties, A similm lrend was seen wilh increased lriglycerides, and the combinatioll or low lIDL-C and high triglycerides (the so-ca lle d ill5ulin re5istant -c, ~nmm(lll however. \Va., in all .l glucose ~a1~gnri~s, S"" 10 and ligure g. There was no ,ignifi~anl dift"renc~ groups or between rre,'"I~n~c and rcm~les profil~, I.h~ din~rem ~Ihni~ of within the same ethllic grou ps, See tab le 1 1, uf diff<Tenl lipid "bnurm"lities C Table <J, m~lcs 1:.:;lw""n the hpid ap e labl~ To w n dyslipidaemia). A hi gh Llli Prevalence of Lipid Ahn"rm"lit," rs ity --------1 HOI. InO ~2,9 127 6~.3 70 36,3 tin 34,2 ve r 1./)/ U ni r TG lHm&r TG Table I U: Pre\--alenc~ otlipid ahnormaliti~s in ,h~ diff~"cnl glucmc catcguric, (aucos~ ('lIt~g"'~' I NCiT i i 0;', " p - lJiaheles I',."diahere,' 44 (~(,.3%) 01 (91.0'%) 0.02 :, 1 n. " C,4"/) ' . " ,0 >R (2R.l%) 1~ (.15.3%) l2 (47.8%) ll.()6 I j IlJn & r 1(. 15 (23A%) 17 (33,3%) J2 (47,8%) lI, III 45 (72.6%) 34 (68,(1';;') 4U (63.5'~"') lI.50 1 HJ)L ~_[J)L T ~ble 11, Prenllellee 01' dill"erenl I i"id I , HJ Fellmlr, While i r {O{ (75.0"{') 1),67 8 (26,7%) 21) (34.5%) 1).4(, (3S"~~";') 0,35 , (26,7%) 1'1 (32,8%) 0,18 (75,4%) 0.71 (7 1.4%) 3! (56.4"..,,) I 0,59 25 (41A'~") 115 (41.7%) 2J 4' - . - 3O - - - 0.11 To ''-" ._- p 44 16 (44,4 %) --- j I (90,0%) 0.14 27 (75J)%) i While 27 (R-'.I%) 1 1lDL 1&r TG CoIOIlf<'d p 49 (Rii.I%) -'I ~nd ethnicit~· w n i gender l\1ule, ! C"lolired I . HDf ~bn"rrn al itie, b~' in the di lTerent glucose categories e ~bll"rrn ~l itk, C ap Hg;u rr 8; p'"r\'ulenl"e of Iipid of too'Yo, - rs i ty 90'1. 70% • "~ 60% - 0 :! « \HDL U < ni ve !lO"/o . jTG SO% .,HDL & ,TG o lLDl 40% 30% 20% 10% 0% '<GT I'rediaoctt"s Ili~beles 30 ':\.H. Metabolic Syndrome rwo thirds of patients .'ldnlltt~d wilh ACS (124, 63.6%) fullil l",1 Ifk diagno,;l.l, ,nteri<l tor Ill<el"boilc syndrome as ,;tipulill.en by the AT!' 111 30 The mediiln age oi"palients "lIh w", 60,5 jTM' (mnge 34"'J7), and 66 yeal'S respcctively. p < 0.01). The .\1,,1¢, w<ere felung<er than felllak~ (52 h ' gh~sl prevalen<:~ rcpr~,entali\'c. 88.9'/,) hUI 11m sample sue was IlK' small to be COIOUTCd patient> (45. 70,3"<.) met the /\TP jJj criteria for coloured kmaks wa< Illore e whil~ kmalcs (43, more at risk of developi ng I'r~v~lcIl<x 95~--(, C1 0.81 - 5.2<)). oj" thL' dm,t~ring rs i ddl'erencc in the metabolic syndwmc. as did ~ommon I~ble U ni ve eTh nic ,aTegone,; as outlined In In i"emul~s p < 0.01, and appeared to be nlore common in (n-26. R6.7°/,) than cOllnlcl'p""S (risk raTio 2.1, palients (g, \lore than two thirds of 70.5~--;,). ap i"~lllales 5m--ol, 11lelaholi~ syn drom~ C colour~'d than males (4S, syndrom~ of 7ti.S~--;.,) ty (76, th~ lh~ blu~k To 5S,7% (71) of\,·hites (p = 0.12). Th e metaholic Wll.' in w n mddboli~ ,ynJrolll~ 12 . 5e~ jiglL'" 9, Th= p~O.09, than pnlling lh~ ir white sc~med to be no Ih~ differ<ent of mctnbolic [isk f<letor, in Figllre 9: A"oriatioll het" een mr(:l bolk synrl rome, gentJer and ethnieil) lOU";.. 9U";'. HII% ~ •,,>. 700;. 60 % , 0 ~ 11! Male ~ .::, .." Female ~O% To E w n SU";.. 0 JO·/~ ~ ap e 211 ·/~ C 100;. Uo;. of Coloun.,tJ ty 'Vhile rs i Tahle 12: Pre\alenre of the rlustrring of mrtal.H>lic risk factnrs ill 111<' ni ve ratcgorifs .. U 1\0 risk factm, 1--- 0 _- m~in - e1fmk 1 Elhnjdl) Whites Colourrrl 0 (OJ) ,, (2.3) c' ( 12.) J 22 ( 17. j ) ,C J (2 6(1) J4 (2(,.4) ,, 25 (34.31 3:1 (25.('1 4 11 (15.!) 2J (17 .8) 5 9 (IV) 14 (10.9) 32 CHAPTER 4 DISCUSSION Chesl p~ln due lo ACS was a common pr~sel1tatjon to the LV, with a simliar pr~vaknc~ in thc' CniOllrL'tl (11,60".) U11d \Vhite (14,q.o/,,) populations. However, despite 1he I"rge proportion ofhlock p"tie nls asse,,,,d in the ED (623), ACS still '''ems to be lincommon in thi s pOP111mion (L4'!"o), It is commonly accepted Ihal /\CS afiCet;; male's mOre than (1',3'~--a vs ~,I%). This may indicate thm Iher~ w~s no bias in the study To similar extent w n fem"les: however, in our study population hO lh males "'k' females were affected to a or [I may bc an indicalor thai CAD has Jimlly caught up in Ii:'rllales, ap rcm~lcs), e sckclion (\vhich commonly occur, duc, to thc alypical prcsc'T1lmion of chest pam m lmp(lrtan~e of ioc'11li fyinl( not only people with asymplornatic diabcks but abo those of The C 4.1. Dysgl)'cacmia diseas~ IS a major ea llsc of deoth ill "II catego li es of g lucose ni ve llMI macl'Ovascular rs i ty with Ire; and I(iT (prediC1l:.etes) can not be emphasized enough. as it is well documcnled ablk'mnalitics, incllKl ing those hdow diabdic lcvd;; , t<ot only do patients willi incre~sed U c'slablished diabe,ks llavc' all mn\"lS~d ris~ fPG ,HId 2 Ill' blood glucose lor cardiovasC1llur disease. but also those witll th~se Me ~ J s o i n dep~ndent risk f"cl'~-,; fc~' nil· c~use and cardiovasc lliar mOlbidlly and mortality" , Incrc~ sj ng evidenc~ sllggests Ihat. for diagnnSlS, the lIS~ 01 lasling pl"smCl gl uco;;c' lcvds alone will miss pati,'nls "';lh ~ higll risk or diabcles relatcd morbidity and mOI1ality, " Furthemll~'e, the prevalcn£~ of undiagIJ{ls~d dwbdCS and IGT will be, lImkr eslimalcd 10 a largc' exknt. espcci~lly III lemale and elderly populutions, if li.o.'li ng l(hK:ose alon..:' IS usc,.],' Also, lasting glucose 33 l1l~aSUr~l1lellts alnne do t"~ "Ienti Cy 1mli "idual, ~T i ncre~'ed risl< of deJth J'soci med with hype'! glycaemia.' C~n'cntlytbel"<: i, nl' ~niqw biologi~Jl mJl'ker tbat ,an clistingui,h p":(~)k o r di alxtc;; from peop le with normJI glu\CO;;c metnbol i"n. thu;; th e ofJI with IrG_ IUT gl~~o,,' tokran-.;" k';! j, ]\yommerxkd JS tb~ gold standard in ide'1lti lymg tbe di lJC]'e'nt categorie, 01' gllLcose aLltlonnaliti~s_ imp~ired gl~co;;e with tolerance. who ba\ie tbe greate;;t ~nables deledi"n of" Jttrib~mbk risk of n indi\iid~al, It also provl(l"s additional prognoslic mlillmation ami To w d~alh' Sil fa"_ maS;; ,creening for asymptommic diab.:te;; Jnd IGT has not b.:en recommended in poplliation; howe'n".-. targeting of groups at high risk of diabetes e g~'n"ral cn~ld be ap th" C t>"ndici~1 as thes~ pali~nt;; collid bendit Ii-o", early int"rv~mi()n_)" Pati"nts wlth C\D by of ddinition Can be considered m high [i,1;: and ,hould tbll' he included in the subgroup of llndiagno;;~cl with undia;:nos~>J diabet~s (as up lO sm';, or patienls with ii' thq remain ""'tnptl1lnntic for many yeJr,) "" well "", ni ve diabcte's are pati~nts rs i identilying tho;;e ty poplLlation m whilm glycaemic tc,ting mlL>! be pe'rJiml1ed, [3mdits i\f ;;cre,'ning inclu,k th{lS~ >i! risk Ii" Jiabelcs (IfG and IGT). Early ide,ntiticiiticm of the IJtter group Ie",,, TO early U inte'!venTion -rrategic' TO f<'(luce or nelJY jll'()gr"" to di"beles·" as "ell as an lT1.;,;r~a",,1 s~rvei ll~txe ~nd Jysl!picla,mi~, TreJl l1l¢nt for olh~r obesITy JJ1d smoking ass<'ciakd nsk facl"" like, hypnle-Ilsion. Screening 111 CAD improw",,; pos>lhilllie" I'm l'r¢ventwn ,,1- ~,u,lj Ov,~,C~ 1"" compl ication'L We iilUnd ii high pre'valence of dy,glyc~emia (6~'!'Q) in pm;"n!;; admitlffi with an cnronmy ,yndrom,' tID.l it Can he a,sumcd Ihat Thi, condition is Jlso h(qllials ;;erving the swne pilpulmii)]l grolLpS, Thes~ re,~l!s are in rrev~lent ~gj'eement a~lLt~ al "ther with ;;everal 34 recml repli..t~·0 .42.43 or Ihe 12(, palients diagnos"d WI th dy,gly~aemia. 74 (5R. 7';'0) wcre ncwl y diagnosed wilh a gl ucose "b'lOmwlil y and 52 (41.3'~';'J werC prcviol1s1 y dl agno>cd wnh di .. heles. IT 'H.IY well bc Ihm Ihc tJue prevalence of dysglyc:'~lnia is higher in our P(}PUliltion he,mllg 111 nlll1d that all O(j'l I could not he pcrlimlled in a small suhset of palielllS due to serious canli(}Vils~ular relatcd complic,lIions {eg de,lIh Of" refelTaI j(} leniary ho'pi lals Ii)r reva", uiari/.:tti()nl. the prcvalcoce of dysglycaemia whcn adding md b()th, IS.2'~,;, palients hy 1 hr post-I(>ild gluC(}se valuc. By ~ither ~nl"rion alon~ lir their combinalion. e diilhdi~ th~ C of ai, >IlC or their ~ombinatil'n. 30. S% (n- I Ii) met hoth. 25% tolcran~e (n~ 13) by met Ih e ty ~riteri()n (n"'9) (n-4) met the lasting criteria alone al)(140.<;';'(, (n=9) mellhe 1 hr P(»t load criteri(>Il alone, SImilarly, r"cruiting patients willi imp,urnl glucose eitll"r 40.1~,'" ap rccmiting To w n In palicnts IlOt pre"io'.lsly diagnosed with diahetes. the prc\'aicllCe (}f gluC(}se rs i fasting crilel;a (}nly and 44.2% (n-23) met th" 2 hr p"st-Imwl crilerion alone. Thcse h~en llllSS",1 il a I-')'(i al()ne wa, lISed as thc sok U woul d have ni ve lindi ngs 'UggL'ht that a sigmfkant prop0l1ion of pallcnts wilh prediabetC8 or diahetes lI"ng the sugi!L'hkd 10" cr ~,,\-ojT "ahl~ s~rcemng pro",;dur,' (cven 01 5.6 rmm}I./1 li.>r diagnosis of Il-'G and 7 mmol"'-I for jhe diagno,is of dia bel,--s). Thcse findings also agree with previOll' findings lhal allhollgh a FPG and 2 hr PG k"c1 sometimes identify thc same llldividuals, lin~n lh"y may not ~oioci(k."' Tlli, ha, impod anl implications for llsual mediCal pnlctice. An 00'1'1 sh(}tlld he~om~ Paticms with a mor" wIdely dysglyca~mia t,,~d lo"lm 'YCrccning high-risk poPlllations. "ere (,Ider (mcdi,m ag~ li5 y~ilrs) lhan tho,,, with a nlinnal gluco,e lOlcraoce (median agc 56 years) in (}\Jr st 'Kly coh(}!t. This IS ll(l l slll}1rising '" Ihe ~ge: 'I'ccitlc I'r~vak'IKe o('l'alie:ms ",ilh d",l:>eles and Impaired gIUt:o.,., I()l erallec IIInease.' llllearly with agc ui' to HI<: sev~nth to cigln d0lO00CS in both me:n and worn~n," A iligk' prcv~lGncc Clf dysglyc"e:m',a ;)1 kmaics th.m male:s was sugg~sled.4< h"wewr. "e foul1d dy>glye""m", to I:>e "" wmlllon ill males (hY,";,) ,e, I';;male s (67%) ill our study grollP, High diabetes rate., havc preYEolisly bcenl\;porkd in Colourcds comp~red to Whites .md !3lxks:14 Then: was a trend 10 all inneased rreyaleoc~ oj'd:>'sglyeaemia m C()loureds (72,3~,'(.) n mmparcd to Willtes (5S.S%). I:>ut litis did not n:.lCh ,tmistic,,1 ,ignitleal1ce st~tllS. ~lu~h e '11\; lInawarc ot th"'r high 11,k and those at hEgh risk of be~n allel1tion ha.' ap diabel~s To di"l:>el~s TYP ically. pcrsons with rUT .md asymplOI11alic devel()ping w (p=(L(l7). slll:>s~'quellt C dircckxi "t delc:cting undiagnosed diabetes as its ",creased risk for of ~omphcations ~nd nWJ1ality i, well acknowledged". Only r""eml:>'. alt~ntion Iws tumcd new (habeti~s those: with type 2 diab"'~s. We l(lUnd rs i fadon;~, in our study I'Cll'ul"tiol1 "irc:aQy ni ve risk ty to those ",ilh IeS.,er degree., oj' gluLOmelab"hc abnormalitics. who tend to sharl: the same: One would hke t() pre sullIe that tim, was " at hl~l U pali~ms risk I(\r dcvd oping lhal46~,';, e:xpe[l~n~ed v~ lu"bk c~rdiova.,.,ular ofpredi"bctic, .lIld a previous 5\1'~,', i.,~hocmi~ of cvcnt. ()ppoitlll1ily mis",d lo idemilY disease and ils ~()TlIplicaliom" Earlicr ddeelioll of lm p"ircd gluco&.' toicrance and ,e,:>'mplomallc d,abelcs cou ld Ll(l to mili alion of secondary pr\;ycl1live me"-surc:' al an earher .'lag~. 1l has been report~d that p'llicnts with imp~irl"d of inerc:ased cardIOvascular modlidity .lIld norIllal ~llIcose toler~l1~e; lhis ~x~ess gluco.,e loienmee run an ""~1"lity addition~1 risk nlll1jlared with palienls wilh a eardi()vascular nsk is prGscnt evcl1 '11 lower bl(l(,d glucosc concentr~tion-s th~11 those Ihal cau"e: ll1ienlvasc,,]ar cOlllplications.";'In our study_ 36 dysglycacmi~ p"t'GnlS "·'tb ,,"crG mor" likely ;0 pl'csGnt with a high risk (7 3%,'1 and more likdy 10 (kveiop cal'diov<J>clJar ~omplica!ioI1S !hen-wunkrparts ". ilh a nonn"l gluc()se (27'};, and 25'}'~ coron~['y "VCllt (75%) in comparison to ],CS1X-'(;ti,'dy), 4.2. HhAlc fily~akd hac-'lll()gIOOiTl (HbAlc) has ne,'"r occn ],Gcommcnd~d as a diahel~s kst fo], ha., b""n n dmocks, altho"gh its usefulllt'Ss in the screening and diagrK"'s ())' di~gnos1ic To w w](I~I\' ddmtcd.-" It is msensitiv~ in the low mnge, thus a normal HbAIe can not excl\lde the pre",,,,,e () I" diab,,!es or KiT-",' ATl()lhcr dmHl !all is Ihat j I dlX'S not reveal lllfonn~tioJl ap e about p(\st-prandial glucose levels: Ihis ini')I1natiol1 i, tLsel"u1 in order!() f1I'"dlct incrcas crl ~Jl(1 impaired glu~os e tokraoce_ C cardinva'ndar ri,k in paticnts with both normal of A lllwllgh there \Va, a statistically significant differen.;e in Ih~ llltdJim HilA Ie m O\lf Sllldy thos~ b~ imerpret<xl '" wilhin nOfl11allimils. Th" suggests that OIl II, OWn is insCTlSitivc to di"gl1o,,,d diahel~s I\'oold still dy ,g1y~ueI111~. I\'a" a., cX!"-'(;tcd, per~eived dGtermin~ those subset of palienl, ",ilh ntlWly ThG mcdian HbAlc in patients wi1h prevjou,ly diugn,,,ed U HbAI~ e~ch val~~ ni ve r dinoctcs, wnh IGT and those with Tlewjy diagnos(.'(l si ty group hetween tho,e with \lfi'!', ,ignijjc~ntlv high~r 'mlnnal' hmit. In viGI\' 01" this, we than all wo~ld oth~r groups and above IhG like to s~ggesl Ihal HbAI~ d"lennination is n()t esscnlial in the ilCutC managel11en1 of ACS in palients TlOl known wilh dial"'t~, HbA I~ i, tho\~ wid i, thus ol"mmimal howev~r a lLset",,1 v~lue m~a"Ll-~ in the ED_ ())' the dlicacy or gi1lcosc jowering trealmen! in known with diabetes_ as it gives an integrated suulJnary or blood glucose kvds <il.!ling thG prcrcciitlg 6-8wceks. There is ~ol1\·indng eviden~" Ihm diabetic :\7 micmangiopal.hy can be reuuc~ll hy lighl glyca~ll1lC ~()JJlnJL /\ r~~ent ranUOll1l/l'U I"" llcrnonmnktl thnt mncrovn"cuiar morbidity mid mOl1nlity in typ;; I dinhct~s ~tlLlly enn al~o be dfectivdy reduced with light glyc:I~ll1i~ ~onlmL'" Whether lhis can be ~xlrap<llal~d tn type 2 uiabele,; is yet to th~ imponant factor behind in lIbA Ie be det~nllin;.;d, Thc redllction ofHbAlc was by rar thc most reduction pf CAD with :1 21 '>'0 reducripn in each 1';'0 ue~rea,e Similarly. the Hnlled Kingllom Pmsj",clive Diabeles Stully (lfKPDS) ha~ n deady ,hown Ihal exh p"rcent dcdme m Hb/\Ic cau8ed a 14':..;, lowcr rate of myoc:lrdi,11 have advocmed tlhAl~ largels <7%, I,~% To w miarclion and l"cwer dcaLhs ti'om diabetes PI' any c:lUse,-" V,lr;olLS diabetf!.-' ,lsso~latiOlls ll,an 5(f";' of known diabctic~ m our ,tlLdy high risk group, All.lHlugh th~re was a tenocncy ror known diaoctics with a IIbAlc C thi~ ap e gmlLr rcachcd this proposed glYC:lemic largeL indiC:lling the ,;uhnpllmal management in ~nmplicall()n_ of 7 tn have a low risk coronal}' event :lIld they were less likely lo .revelop <' Oil admis~iol1 rs i 4.3. Random glutusc ty thIS dill nOl reach 'latistical >lgmlicance. as a 'fLith' vital sign on admission or patients with .ACS, Ollainly ,IS :1 ,creening U gillcos~ ni ve ClInTnt practice in most smaller hospiials in the \Vestem Cape is to deknnine a ranuom te>.t to LdentilY thosc with dJaoctes, disreg:ll'ding those ,lIhsel ~"l~gory nfp'llj~nls or Lmpair;.;ll gillcose loicrance, I\·pt pnly is ,,1\1<10111 ialling mto (he glll~o,e inS"'1';l(lV~ llia1o'J1(),ing lliabet", and thtls umtlitabic In thi8 high risk pr>pUlmion, but it is ,,,erul in lli:lgnn,tllg tillse neg:l(i\'e lhos~ r~Sl.Ilh_ In eY~n I~S'; wilh predLaoctes, It abo has a high risk of false Ix"ilive anll 11 ha, rn,~n sllg~cslcd howevel' to have a significant increasf!(l sensiti\"ty in diagnpsing diabele, if the ~lLl-n If poin l is marhllly r~dllced to 7.2nllnolil'f. but this still need 10 be v,ilid:lted_ Hy loweling (h~ cllt-ol1' point or randpm glucose to ~mm(\L,'1 in ('11 r stndy. wc idcntifkd only 4 1 patl~nts (~9. 1%) of p" ticllts latcr di~gn(\s~d with di"hele., onll 12 palienls (2.'.5%) wilh ](iT gllLLOS~ Alth"ugh delemnnmg random abll(mmllilie< is !Wl nsduL lhere "strung. th~ indqX'ndclll c)n on admis.,i(lIl lO diagn"se lhos<' wilh gluc"se subs~quenlmorbidity state of evid~nce pr~morbid glueos~ and m(,rlality "fter an acute gln~c).'~ at that high hloo..i pr~dieh wkranec. admission, in-hospital arK! myo~anliall!llurdionl!l bOlh diaheli~., be ~xtrapc)lated to the whole sp'-'eulI m c)1 ACS is unsurc. It was clcar from (,ur w ~an pali~nls pr~senling findings though lhal lho.,e To llllS n and non-diabelic~, th~ mechanism or whid, "Il<.'l fulh' underst,,,xl a., yd,H." Whelher with a high risk ~vent had a ~ignili~alllh' high~L' odtnissic)n p"ti~IllS that dcvdc')Jcd in-hospItal gl ucos~ k\ds (7.7mmol/l) ty ~igllLficantly thosc of Simil~rly, lhe twc) groups , ,,1' similar prn lOuS gluwmctabolic SWtus in C i!l(li~alive desp Ile a .,i11111 ar HbA k (5.5 % J, ap e highcr admissic)n gluCl'se (7,lmmol./l) than tho.'e with a low risk evenl (5.8 mnll'I./I), dit1;;'rene~ two groups . Recenl sllLdl~s "I", suggest thal rner.,al ni ve thes~ rs i "c1mplicalions (5.Snm.ol/l), but again lhere "as link in or~tres~ compli~Ulion~ had than l!,,,.,e "" thc)ul th~ IlllA Ie hctwc~n hVp'-'rg.lycaemia at the that thc us~ U timl' oj' lJ.yocardi~1 infareti,)n ~an imp.\)v~ thc clini~al oUlcome in th~se pat,ent.'~' and of a glucose. msulin amI pota.'Slum l!lrU~HJn I1W,' reduce sholt an d long t~l'1n cardiovascular morbidily and monality in both diahetic and non-diabetic pmients with acute myocardial in(~rcti(,ns olll1l'ugh de~nll;ve proor ,,(' the latter i., lac king and the practice hils not g"imxi univcrsol npprovol."'-" Agai n, we do not knuw ,('llns data extrupolatN to all categorks c)l ACS, Jr S c), eli nici"n., these patienl~ r~.'pon si ble Clin b~ h'r lhe n"\Ila!lL>JHenl () (' may nut c)nly have a res]X,nsihiEty to perfonn an OUI'!' (In patienls with ACS lX'n,re <lisdmrge, but al", need to d(;t~nnill~ the admis~ion gluCl's~ and managc it 39 "Pllrl'l"i"ldy '" thi, will hav~ dCJr bend,t, in dL,:rea,ing morbidity aJl(1 m",1ality_ lL i, imlxmanlto 'lre", that a 'ingle glu..-l"C mca,urcmCllt OJ] "drllission Jilme '" ~,cn lh",~ p,-~)pk do~, not s"ffk~ wilh()Ul diahde, mighl rn.nefit I'rom light glocow COlltrl' ] ,mel ')ll'uld lil"", be prcfo1111Lxl routinely thn ,ughoul their iK"pital ,lay_ lL !-la, n".,n ,ugge,led lhal palienl, wh() deve k,p sIre" hypcrglycaemi" arc likdv 10 be dysgIYl'aemi~ when not str~%ed.'" OlLr I'mdmg s slLggat a similw- j'~sult a, 53 oj' the 5S di,~harge, and 22 diagno,ed with (lj' which 3 I palienl, wer" pr"vi()u, 10' d iagW',ed wilh di abetes dy,gly~acmia To dy,gIYC-:'emia on w n p"ticnts (91.4%) with" randl'l1l gluco'c of8 e,r morc werc ,ubscqocnt ly diagnoscd ,,·ith on the OGTT. ~llJSlered wHh mher c(lmp()n"nls syndromc (incilKling visccl,,1 obe'ity. hypcrtrigly~cridemia. ()j' lh" mctahl,lic low HDL hypcrin,ulincmia C ap e AI1(l()nmLI gluco,,, 1()lenLJK'e i, onen Farly in idenliti~mi('n rs i nOf1ll('glyca"mic' palienl" ~mllmon ty foct(lrs th"t tend tp Ix' higher OJ' Illore' of and hyp"rlen,ion), each (,I- ",hK'h mdeT",ndelllly promOle mheJl)lhmmllo."i, /\11 arc ni ve cnab lc initiaTion 01' potenti"lly bCJldki,,1 hypcrgly~a~mic oj' lh~,e tr~atmcnt pmicnts compared wllh l1lelar.,lLc' allll()mlaliti", w()lLld contribut in g to an impro\'cd U I'rogno,is_" We can tIlU' J%UmC th.11 intc"..-cntion, lh,1\ 1'C{luce the r;,k ofprogrc»ion 10 dial>eks arc abo p01cmi,,1 li~e ly t() r",luce CIlI) mOltalily in thi, group 'll1d ~otlld he 01' )ir~at ~ncf,l..<r, 4.4. Anthnlpumetry It i, gcnerally "cceptC'd that obc,il}" whelhcr it b mC"'UI'cd '" CCll1rrn obesity. ~aJTks an incr"a,C{l f-l~'11 or a health ri,k lx.---cause of it, a,'>OCimion Wilh numcrou' mctalx,lic ~omplication, ,ud as ~ardi()vasl'l,lar cli,ease. lyp~ 2 diabetes and dy,lipidacmia," Bcing (w"rv-;"iglll and (,rn.,~ i, a""clated ,vilh insulin re,i'lafl(;~ and the 'yJl(lrol11~'s duster ()f 40 metabolic di,ord~rs compon~nts "nei sub,cqllCntly all th~ melaholi~ oj' syndromc ar~ positively ancct~d by ,,,eight loss." In,ulin rcsistance is consiJcr~d to rn, the link prcsGn~c between obeSlty "ml dysglycilcmia. It is paJ1icuiarly the ,,"hi~h orn,sity th~ is one oj' hallmarks of the disca,~. oj" vlSc~ral or It has long ocen noted that ,,"hcr~ th~ complications commonly IOllnJ in oocse palients are more dosely relatcd to ~xccss fal is ralh~rthan to cxc~ss fat pel pr~v"l~nce measured as all increascd higher t~mkncy OJ"0\'C1Vicight and obe,ity in our study population. whcthcr BMI167~";'J w n I"und a high 'c.'" or cenlral obesily (59"'-0). Females had a significant obcs~. than llde, to be To w~ ~entral regardless of whether incrcased B\H Or ap e abdominal circumferencc \vas dctermiIled .. Our slud" agrces with the lindings or lhe C lnlerhean -\Iil~a ,wdy'" that ov~"'v~ight and ob~sity ar~ ,I, common in ColoulX'd, ,I, in rrcvaknc~ of abdomin,11 oiX'sity has b~~n showll to be morc highly cOlTdatcd with ty I'hc of Whites. Slgl1iti~anl ~ould hie demonslraled ill tlOrtl1oglycacmi ~ ill the prevakncc of ccntrill obesity (47%) und dy'gIYC<lemic (61\%) gI'OUP, (p-().()I), but no U l1()rtl1oglyca~mic diff~r~ncc ni ve ]'IIl<liIlgS 01' ,I rs i metaboilc ri,k factors than is an elevaled B'vIL<'l Thes~ data ~aIl rn, extrapolaled 10 our (('~'/,) and lhe prevalenc~ dysgly~acmic of an i73'h,) inaeased "Hr.,11 ~'fOlLpS difTcrcn~e I.,.,tw~~n (p=(), I 3). Further. oocsity was as,<xiatoo with more metabolic ri,k f;'lCtor, than an incr~a,~d b~tween lhe c~ntral 13.\11 (3 and 2 ri,k 1;1ctor, re'pectivdy). 4.5. I>plipidat'lllia DysiLp](iaemia is a maioT risk faclor I,)r diabct~s and melaboli~ ~ardiova.'~lLlar diseas~, syndrome typic,llly dcmolls1r,lle a 'vIany patients wuh Iyp~ characlcrisli~ ~ dyslipidacmia 41 (als{\ kll""" as dd,dic dyshpida"mia or mherogcnic d J sllpidacmiaL which consists of jfl(xlcrale c1evalH~] ~ hol ~,krol in l11 ,:lycende kvch, 1m,· HDL LDL panicll". Thi.' lipoprolein paUL"" 1., v"luc>. and "nail d~nse a"ociall'<] wilh inollim re,islmlec' and. IInponantl y, i.s pr~.sCllt long bL'lore 1hc nnsl1 "fdiahetes. ,.1 l! was predicl"d tong: '!gO lh"l 11", hp]d ahnorma[itlC' of trw insulin rc, i,tnrx:" .<yndl'Omc arc lil.d}, 10 be the COmm01]e,li'onH of dy.,hl'idocmia ,eenlll Soulh A[iiea., Il! i, lhus n0l i n~reas",1 LDL (()S%,J. Dc'pile the pr",!i~led hlgh w ", llum an pre\'a[en~e 01' To (,~3'y,), mor~ n ,"rpri.sing th<lt we f"und thm " [ow I [Dt ·C was thc most common lipid ahnmlll J [ity in,ullll reSlsla"t tly.,lipidaemia (I"" HDL -C and/ or elevalcd higlyccritle,) in prcdiabdics \w al,{\ found a hl g:h pr~""l enee ,'f lh], l"nn pI' dJ sli pidaemla e and d ",h<.:li~s ('-J I ~.,(,) th~ insulm v.'" arc templed to assume that th".se r~SlSlaocc palh and lhal many m{\r~ p"li~m, are of pmicnts are alrc,.-jy on (7W~'-i,), C in patiC1l1S wilh a nNmol gjuco.<c t.,icrance ap (~~%,) ~Olllrasl I., lh ~ lIln~a'lIlg pre\'alenc~ rs i In ty destincd to dcvelop dy,gl ycacmia in thc ncar fum rc. or lilL' in,"lm rc,islant dyslipi dacmia in the j, in agr~~m~nt wilh pr<;ViOllS r~ports.03 Ho'Wcvcr. in lhc UKPD study. U cakgoric.S, Thi, ni ve di fidCll! gluco.sc catcgorics, thc prcvalencc of a low I .1 )1 , r"mainoo .I imi la, in "I I g 1lJ(;{\se LDL "la' thc 'trongcst inocpcndent predicl{\[' pI' CA l) loll"w~d by HDI. dwl eslemL suppolting current guiddi]ws in which 1.-1)1 , lowe]ing remain, lh~ p,-im af)-' ilpid largd ." Thc C"louroo population ofthc Vic,tcm Cape has hcen sh '."'"lo have a high p r~""l"nc~ or card,o,a>Clllar lisk factors. particularly dy,l lpidacm ia,"'" Our smdy contlrmed lhis lindin g and also IH"",llhal dy'llpidacmia di,rcgartl, oolh gClldcl' and racc with similar high pI~val~oces in ",-hiles and C.,loured., a, wdl a, lm,k, and J'cmaic,. 42 4.6. Metabolic syndrome The dinital impOltante of the mdab..,lic syndrome i, rdatcd to its puta1i\'~ impact on c,u'diovascuiar morbidity arid mortality. People with the mCI.'lbolic syndnJme have been sl)own lo be at ijl<;r,,,,,~d nsk j()r canliovasculw' dise,,,~ and diabde,. as we II as ror u~ath ji"l.'lll cardiovascular dis~as~ and Ji\'m all taUsL"S."H', Once idclltified. carly preventative meaSlLres are needed m ll..."e high lisk people wi lh the mam j()CUS on hk ,tyle chang.~ n anu tr~atmCllt of thc individu,li componellts if thc f01mcr fails.'" To w "I'h" prevaknte oj" the mdabolic synd",m~ " dql~ndent Oll th~ ddlnitioll u;;ed to diagJlosc it, Sc\'eral definitions of th" melaix,llc syndrome ex"i, on~ consensu, group redcfincd thc metabolic syrldrome in pntdicai dclinilion lha( w,uld 1:x; used in ally country to ioclltitY C order 1.0 provl{k lh~ ap e Inl~rn:Llional Diab~\(;, r~dnation R~cently, of people at high ri,k 01' cardio",,,clLlar dise,,,~ and dJabdes, " Thq u;..;u lh~ ATP III C.irc.wllkrCIlc~. syndrome, and ethnic-spetllic waiS[ ddinili(~l. ~) clrc,umfcrcnc~ cut-on~ hav~ FPO only, and not an U thc l) cenlral oocsily. a, a,,~ss~d by is now a compul,ory compOllCllt to m,lk" the d"lgnosis of metabolic ni ve r waisl chan~e" si ty comp,"lCnts ,IS background with lwo main abnOlmalilies but it I, llOw rcrogIliL~d hr I'Ci" also accep(abk in clinical FPG "' 5.6. (ClmicillilS and oon. becn incorporated into 's ,till rrquil\;U to diag.nose glucose that impaircd glucose to\craocc delClll1ined by a 2 practit~ res~arth~l-'; and lbey strongly rccommend an OUI'"!' if al\; CIlcouraged though to 1',ltller add the 2 hr PO as supplementary finding m order 10 rdam th.;; ,impliel1) ol-lhc ddlnitioll), Atti1c ti me of pmccssing daw lor our sludy. we slill ,,,,,d diagno,i, of mctaholic syndromc, lh~ ATP 1!1 aitnia ror th~ Th~ ~t~npon~nb () (' lh~ mdaholil' syrlllroml' w~rc I'n;(I"~nlly pr~sel1l Wilh ACS at Karl13remer Ilospit'l!. We found a large p]'(}p(lltion of 'yndmm~ delin~ gluco,~ ha\'~ h~en to hav e mdaboli~ _'yndrom~ (64~,';'), liiagnoscd had we adde.J m~labok synlirom~. ]( L' thos~ tolerallc~ only uSlXllh~ FPG thererore not with K;T di,lgno_'ed with the OGTT_ A,; is often d u_,t~red surprisin~ (61_5~--o) wilh olher ~ompnn~l1ls or the that we f01ll1d a high er prev,l!ence of and diaheles (S2.4o,i,) lhan Ihos~ wilh To mClabolic ,YlKlrome in patie11l'; wilh (;T (.173~--':'J_ w~ wllh aooormalilics, wc can >afcly a_"lLmc. thal cvcn more patients would mentioned. abnol1nal glucose '\IGT A,; n LO corollary p,lti~llts ,Idmitt~d w acut~ III pali en!> admilled An locn;ascd d lLsterin g 0(' mctabolic risk Llct(}J'~ \\',1'; al,o noted as the pre""l~nl'e 0(' m~1ab()lil" synlirolllc in males and female, ha,; been not~d C A SIIllLlar ap e glycaemic profIle deteriorated fl\)m NCiT to IGT lO diab"le,;_ of before.'" Howcver. we fOl1l1d a _'ign ificanlly higher pr~valen~~ in I~lllale_, (77',,;,) Ihan w~ could not den")flslrate a _'ignilic anl differencc in the prevalence of rs i for age. Although ty males (50",,',,)_ 1'<0.0 I. ]( is po>sibk lhat the gender (Jl'ev,l!enc e may change when adj ust~d syndmn~ col()lIr~d r~male_, W~T~ U app"ar; lhat ni ve metaholic syndrolllc belween the hvo main (risk ratio 2. L 95~--;, vanahl~s_ ar~ groups (Coloured and White). it al hlghn risk than white l;;"na!c, tt' have melaholic ('] O,SI - 5,29). The lllctalx,hc syndrome 1S variously dellnllions ethni~ d etln~d by ditf~rent 10 some exknl aroitrarv Qiven the mllural Clinicians rcco~nising orgaTll,;atiuns and all ~ol1linllllln u(' biological this will pay attention lo w[r""l.ing abnonnalilic, or each of lh~ comjx,,,,,nts of lk _,yndronl<;_ 44 CHAPTERS LlJ\'1ITATlO\"S Our sllLdy has hospilal slay th~ l\:~lllt~. s~\ ~ral Imlilations. Fir,ll y. wh~rc lh~ clkCI or so-c~llc,i lh~ diaglhlsis or dysgl yca~m ia was mll<le during Slrc~s- induc~d 'I his iong"sl,l1lding concern ,1110 objection , "orh:'llnmer eI ai . who demon~Lraled a ~Lrong bypcrgiyc;;;:mi:l h~s lx:en answercd by blood glu~o>c lcvds :lrc n rai~ed To w indu~ed con~lusively wlTeiallon 1.,.,1 We~n Lhe 2 ilr blood gi uco", ,<,Iucs al discharge and al 3 mootic, 1<lllow-lOP, indicaling nol only relaled 10 sLress ~ouid influ~nce by lhe ischaemic evenl and Lhis was "onlinned in a Ihe early pha.,e ,,(' illl aCUle ~oronm)' during thdr bospil:ll preveillive m~a."Ll"S syndrome and ~1<IY. lil~reror~ high risk indivi<llLab can be Ihereby pel'lnitling e,llly iniri,ihon of "Ppropri,l1e fOl ceti,lin sl1ldy ity S~condly, l~bor!'loJ)' d,lt~ of C i<lcnti1i~tl ap e latcr study" supf>OI1ing ~vidence thm :lbnorm,11 glu~os.e met~bol i sm ~'Ul be identified Ul me~sures were nol obLained III a small sub"'l s~mples, ve rs or paliellls tllle to inaoc..lualc colkClion <11' inabilily of the lalxl1;110ry 10 process sm all. U ni I'his could possibly klve inl1uenced the ,-esulls; alLbough lhe numbcn; inVl11ved were Ih~ m~gnitude of this effecI is unknown, Thin!l)', the ovedl mmialily recorded was low al 3.3%" 'I'his may rdke! including" in~omplele follow-up, as Lhe oul~{)[n~ oJ' lhos~ s~wnll fac\Or:<; patienls IransiC:rrc<l for hll'lhcr in(er..-enlion is unknown rin:llly, lbere W:IS no subS~'luenl rollow-up of patiellls adnnlle<l with ACS WC C,ll lWI comment on the ,hOlt or iOllg term gl oco,~ cat~gories, Thi~ OU1~Oll1e an<llh~rdore or p,lliellls in 1.1", dill"erenl is an alea of C<lJlC~l1ls wb ,c h ro.luirc~ limber study. 45 CHAPTER 6 COl\CLUSIO:"l" ANI) RECOI\nlE~I)ATIO~S 6.1. CO:,\/CLUSION Che,l pmn due 10 an ocu(e CO'lmaf), symlwlllc ~ollstil"lcs" large proportion oJ'p"licnls sccn in Ule ED and afkclS bOll> Coloureds ,md \Vhiks \() the Ih"t CAD i., not only" discasc of tile highcl' in~omc '~Il1C cAkn!. This ,"gg",ts \\,'hitcs, In ~ontrast un~omlllon in w n rrcvab,cc uJ' AC S In both \Vlnte, ami Colowuh, we (,Juncl ACS lo be 'lill 10 the high of p,~ients ho,pi l~l, with ,'>Cutc In Ule Wc,km C'l't, 1Khmssion ~nd m~nag:emcnt lo ap e In many snwlk,. To Bk..;k" dc"pilc prcdi clion' of " potcnti" I cpidcmic in this lX'pul at Lon gWlI p, ~oronary "yndromc is the rC'IXlJ~,ibility of th~ uischargc Emcrgcncy C Dep,,,tmenl '" the chest pain 1LIlll I,mn, an ,ntegrul 1',,,1 ol'the ,,,,,,te "Jmi"",,'1..' w;·lru. Il "c~ur' of h"s been ,hown repe"tedly th"l dy'g lyc,,,,mi,, ~swciatcd e.~dlLdcd us mJic.ated In OUr ,11LJy, ll,e high prevalence ill' JysglyC.";:LlH~ m ni ve r Cupc" nilt with sevcral Nhc]' mctabolic risk factNS: the poPlllation of thc \Vcstcrn si ty is commonly in paticnlS with ACS anu patient' with ACS and thc poor managcmcnt of thosc palicnts alre,,,ly diagno'''d wilh U diabetcs implicatc Ihal urgcnt 'tmtcgies ,hould be dcviscd 10 m"n"l!c dysglycaemi" 'lIId to pi'cvcnt the con..'C'lucnccs of thc syndromc. Surely, few dink,,1 'cUings cxi,t whcre the p"tien[, can he aculc coron~ry cx~""ueu, iuentifi~"lion of lhi, munher ,mJ nol lo perfonl1 "n (KilT dming Ihe Jysglyc"emi~ conv~lescen~" oj' un syndromc is" val""t>lc OPIXlrtunity nlisscd 6.2. RECO\'I\'IEl\DATIONS 1, All p.'llic'* admittcd with an ACS ,hould hmfC "recning f,~' di"hc[es. 46 }, This scre~ning is be,! done with an OOT'I prior to discharge . .1_ Asso<,iuku mC!uh"li~ ri,k bdors should xlivdy uccordingly: mo,t of these can h~ h~ searched ti,,- ~nd managed meosufcd wilh simp le clinical parameters l-.btained U ni ve r si ty of C ap e To w n ill the ED, 47 REFERE:\"CES I, Bradshllw D, GwclIcwald P. i(~' So~lh La~t.;chcr R. cl al. Initll11 burden 01 diseas.c e,timllIC" AJrica. 200(!. SAt;. Med.l 21XJ3; 93 :6S2-IiRS 2. Gray RP. Yudkill JS, Cardi0"asclII~r disca>e in diabetcs mcllitm" In: PickllP Jc. V,.-iliiams G, ediwrs. i'cxtbook oi" diaoctcs, OxionL l. Kannel Kbdwdl~ I L)~7 p. l-:i 7 WB. Liplds. diabetes and comnary hearl d,sease: in,i ghls 1;-0111 the 'l~dy gm~p. GI ~cose loleranc e and morlaluy: Compan'i-On 01' WHO an w I 'he I ) b.(01)1': To 4. n Framillgham Study, Am lIearl J 1995: 110(5): 1100-1107 A Illeri~all Di aocti~ A ,,,o~i alil)ll di agno, lic "rileri u. Tlw Taned i ~')9; 354: Ii 17-21 ap e 5. Shcr"'''l RS, Allder>Oll RlvL Dusc 18 eI al. Thc Prcvclllilln lW Deby l)i" Type 2 Co~tinhl).\1, (,cr,tcill It. \Vang: Y. Y~sul·S. TI-.e Reblionship between GlliCOSC and of 6. C Diabeles: Dia"etes em'!' 2003; 26, supplemcnt I :S62 -S69 Hamler S'\-1. Lehto S. h~an disease ROnll("11~~ T. Pyorab K. LauLo \1 \1ortalily Ii-om cClronary ni ve r ., si ty Illcident CardilwasC lIiur lOvell\:;. Diabercs Cay" I ~99: 22: 233-40 In sllbiects \\luh type 2 diahctes an in lll'n-diabeti~ subje<:ts ,,';lh alld U wllholll prim myo.:anliallIlbrction. N En,," .IMed 1998; 339: 229-234 S. Muuhews DR. Thc natmal h"te>ry of experien~e. 1999~ diobctcs-I'cl~ted Lmled KiTlgdom Prospectivc Di~be(cs wmpiica(ions the UKT'IlS Study. Diabeles Ohes .\,fer"" 1 (SuppI2) : S7-13 Y. Kdl IlS H, Ovalle F. Diabetes Sprillg 21)()(): p. R~-92 ~" a ri,k factor lor lschocrnic hcart diseuse , ("{ill /I"v II), \01 Uf'-~Y CJ. Lopez All. 1h~ Glohul B LLnkn oj" \olorlalily anJ O,suhilily From p",j~"ted .,f Disease: A (" ornpreh~nSl ve A.,.,es.,mcnt Ois~ilSe. Injuries :mo Risk Factors in 1991) anJ to 2U21). 21Xl(), Patnphk( II /.;mmd I'. Alber1; KCi. Sh",,; J (;IO[>ill and ",-..;iewl Illlplicatil>IlS of liw dial",;(cs ~'pidelll ie, .'Jmurc 21l(1 I : 414: 7S2- n 7 12. Am(1.' AF. 'vkCarty DJ, Zilllmel p, el ill. The lising global burden of dial",;\cs and its LktUlet I'll. w rpid~llliology Mdilis. Rllkin J! Pon~ D Jr of diabet~s 1~'tlS). To )3, S5 tTlcllitu,. In: L lcnberg Jnd Rilkin's Diabetes Elsc,icr. Ncw YOjl< 1991: 363 e 14(sul'pI5):SI 'lllrl projections to llw yCJr 2010, Diabclic Mooicinc 1997: n ~.,tiL11at~s ~I aL locreaslllg prevalence .,f lype 2 0\-1 111 C 14. C"llins YR. [XlWSC GK. Todlq"" PM. ap colllplicilti.M1S: 13 yeo'- period . I H(lb"",!; ('(11"1' ns ty 1'1')4: 17: ~ of the PacifIC island popul il11 011 of W ~Slcrn SOIll oa over rs i 15. \1otala AA. Diabclcs lrcnds in Altica, DiuM!e.I' Melah Res Rer 2002; H! (Stlppl 3): diil~'tcs AA, Pirie F.I, Ciouws E, AL11(xi A, Omar "·Il\. High inciden~~ oj" TYI"" 2 U I~. ~1(llala ni ve SI4-S20. llIellilus ill Soulh Ali-iciln Indians: a lO-ycar follow-LLp S\udy, Diahel M",I 2003; 20: 23-30 17. Hullnd Sl\1. Stcrn Mr, HaLLLdu HI', Mitchdl BD, )'allcrson JK. Cardio,ascular risk faclors in ~oniinned pr",liuklic mdividuak IXJes the clvd I(n' diseilse slilr1 tic--king l""f."" the .ms~t ~orom'T)'- ar(~ry of clinica] diabetes1 J4MA 1990: 263 2R93- 49 IS. Sewdarsen 11,1_ abnOllllaliti~ .Ii~bl L Vylhilillgum S. Aht)ormal lllyOCMdi~1 in Indian glu~ose 1()ler~Il~~ infarct survi vor" S Afj· }ded J 19B3; 63: and hp"l 13~-140. I'), Se,vd,m,en .\ 1. Vythilinguill S. Ji,II,11 l. Abnol"lll,11 glucose loier,l1lce is the domin,1111 risk f,lctor in South Afric,1t) Indian womeil wilh my<.;.: ardi'll 'nl" lrdion. Cardiology 20, I\-jotal,1 .11..'1., Om,lr .\1A•. Gouws E. High ri,k of imp~lred 10 r--,II)D~1 in S(\lltb- gluwse l()lenmce, Di"helcs I 993; 42: 556-563. n A ii',~'m 111di al1S wilh progr~ssion (\1" 'Iype 2 To w 21, \1otala .11..'1.. Pirie FJ. GOlLW, E, Am<.xl A, Om,I' '1-1.'1.. Higll incidellce diabetes mellitus ill SOlllh Afi-ican in<li<\t)S: a IO-year follow-up study, Di"hel ,}fed Sewd,lrsen \1. Vylhihllgum S, Jiahtl L 8e~ker p, Ilpid al1d lipopwlcil1 ubnonnaiitics C ~~ ap e 2003; 241: 23-30. of in SOlLth Aliican indi,11l Olen witll Olyoc,mli,11 inliu"Ction. Cardiology 1~() I: 711: 34S- si ty 3SI, be~rr dise~se ni ve r 23, Scedat YK. Mayel FG, Khan S. Somers SIC J(\ul>erl G. Risk 25 R~l1iilh M(~)diey U m~les T. M1Llw AS, Ri,k 1&'10'" in young wilh myocardwl ini"arclion, S ,1/;- M",J j 1')~7: 71: 261-261 "l. Verho "lK Verh() M, WlIlkclOlann GR. Acute mYllC,lnlial young Soulh for Wl\)JlM)' III tIle Indians (\I'D",ban, S Afi' '}fed J 1990: 7!l: 447-454, 24, Sewd,il'>e n '1-1. Vyt bilingllTn S, Jialal L Indiall f~do", Ai"Ll~"n Indi~n-bascd ,lIld gender-specific risk pO]llLlmioll: patient ra~lor pre\-'alen~e, ch,lr,lct~riSlics inf~rclion 011 III ~ ~dnlLSSk\ll Oil'! }ded Res Opill 2002: 18: 242·248, 26. Steyn K. Joostc PL. Lallgenhove n \·11., N aL Comnary l;sk loctor, in the coiolH'e(i pOPlLlation of the Cape Penins\Jl~, S Ai;- . IIcJ.! 19S~; 67: 619-~25 ~7. Sley" K, R(\swuw JE, Joubcr1 G, The co~xlSlCnce (\1' 1J"~or ~on)l1ary h~art di,e.l,e r;,1< hetor, III (I", coloured popllialion of the Car'" Pcnin,ula (CR1SIC ,tlldy). S Ali- M",/J 1'190; 711: 61-63. 2~. Steyn K. Swyn M. Langcnil(>l'Cn \lL, ROSSOlLW IE, FOl1rie 1 llc<lllh actions and disease p,lltem, rclaled to c(\ronal)' hcalt d':lCa,e III ttK: coloured populalion 01' lhe Care Penill'U h SA/i' """cd.1 19911; 7,11 73-77. ~el1lr~. Cape Town comJllunLty. hcallh 30 Stc".n K, Levitt N, Fouric J. patient> at a large health cI ~ell1er ~ar~ K. U>1nhard CJ, Fehr,en (is. HyperlenSlOn al " To w n St~yJl S Afi' .-'.-1I:-d J 19')g; IIR: 544- 54~, . "I, Treatment ,tatlls and expelien(;es 01' hypenens]{)n III elpe Town, FiliI! I);; 19')'); 9: 441-450, ap e 2'J. LlLnl i)W , r;dw,lr(i, PI<, of C 31. Skyn K. Kazcl1clknbogcn J/...l, Lomhard CJ, !3oume LT. CrballizatioJl and the risl< li)[ chronic d i,ea:le, ol'li iC:llyle III tfle h lad poplLl <Ilion 01' the ( "PC l'e l1illSU la, SOllth rs ity Afri~a . .I C,,,.diova'i(' Ri'ik 1')'J7: 4. 135- 142, 32, Stcyn K, Fouric J, Lombard C e/ ai, Hyperlen,ion ill tl", Katzcn~llcnbogcn U ]], I ,~vitt ,",S, pre\'al ~ n~e and of l~ S(\uth A r,;c". 1;"<1 Aji' Met! j 1<)96: 73: 75S-763 ni ve Cl)X P~l1 illSl1I<1_ hla~1< ~on1ll1l1nity id~ntill~atinn 1M, Bradsfl:Lw D, HolTman 1...1\1. I:lonni~j F, The of risk f,lctors for NlDDM in laban Ali'icans in Capc Town, Soulh A fri~,l. I Hahn,''i Cal'<' I'N ]; 16: GO 1-607. 34. Levitt r-,S, / ,warells1ein MI', Doepfmcr S er al. Public scctor primlll)' care of di,lf>ctic~--,1 rccord rcvi~w of qu"lity (.1' care Ln Cape Town. SA/i' MalJ 1996: 116: 10 13-1017, 35. Ln'itt NS. Bmd,haw D, sedor primary Zwarcnst~in diah-et~s ~ar~ Mr, [lawa AA. Maphumolo S. AlLdit ill Cape Town, South Ahic,,: hi gh ofplLbli~ prc\'"ICl1c~ of 51 complkat iOilS, 1lllCflntr(llkd hYTX'['glyca~mia. and hyperknw"l. f)illiwi Med I 997: 14: 107.1-1077. 36.1',('(;utivc Sumnwry of f'rflgr"mm~ Th~ hlu~atifln Third Rcpml (ll' The Nat""",l Cholesterol (NCLl') ['pClt Panel on Deketion, Evaluation, And Tmttmellt oj Kl[l(ld Cholestcrol Hl~h Adults (Adull t,.cmmenT I'and Till . JAMA 2001: 2S5: 2486 - !Il 2497 ~'orc~ fln Diafx,t c;s '''ld ('.,,(1 iOvasc LLI"r D isea~~s of the Europ~an Soci dy oj To w n '\7. I h~ Task Cu,l!nlogv (ESC) and 01' the European Association i"r the Study or Dia)",res (E.ASD). Guidelincs ell] di"bdcs, prediahd~s and cardiovascu\al di,~asc: ncculivc th~ risk (lftype 2 diabdcs 2001, IN slLpplemel\t1: SI-, Care ~vl'v1, 2(;(~1: l\arayan KM, covcring an ba'~s. PmCi [lian inl SIS . H~nmm WHo Screening rs ity .l9. Engdgau of C JS. Davies /vlJ. RedllC ing ap e sum mury. r.u""pcan H"art '/",,,.,Ull 2(;07; 211: SS- I 36 j'(~' type ~ diabetes. Oiahere", 23: IS(,3 - I ~S(; T~ner/ A Ni\s"m (i, el al. ni ve 40. l\orhammar A, (jlucos~ me!ubnlism inpatients wilh aClLte U myoca,.dial inbrction "mlno prcv;ou;; diagno,;< fl f diilbctc<. "I1,e /.allcer2002: 15'): 2140-2144 41. Bartnik \1, \lallllhcr~ K. Hamslen A ,,1 al. Abnclmlal gllLcose tolerance risk fador m pmient, wilh anLte myocardJal mEudion in ~ collUlwn ~olllpaj'is(ln with popul atiml- hased contmL<. JOlin",! "f'{lIIema! Medicine 2004: 256: ng-297 4~. \1cic,..1 .I. Ilc if]uss S. (iallwi17 fl. rI ai, Influencc flf impaircd Ion£! krm survival alie::.- OCUl~ myocBrdi~1 ~Iucos~ toleran~e iniftl'difln. Thc LAngcndrcer Oil MYOCilrdi~1 ,--, Infarction andlllOO<! gluw,c in Diaoctlc palLent, A"e,sm~nl (L'>\1BDA1. TJrs,:h Met! W"c;hL'IJ.w;l". 2((l2; 117: I I 2.l-~ 43, The DECODE ,twly group. AS~ and ,~x "p"~ili~ prevaienc~, of diabetes and impaired gluCD,e I\'guknion In I3 Euro))Qn cohorts, TJi(lneles C(lre 2003: 26: 61-69 44. Stcjn K. Siiw" K. llilwkcn S. e/ "I. Risk Factors As>cxiatGd With Myocanlial inl"rdion in ,'>Inca Th" TNTERHEART Afn~" Study, CirCiliari(m 2()O'): 112: 3')')4- 4'). Laabo VI H)-1>Crsiy~a~m'" ~ardiovascular dis~,~,~ ltl ami 1',99:48 :937-942 Fll1~berg '-.i. M~niil Th~ Level, of Fa,l.ing Plasma Diabde" Control lnten!~ntions and and C"mpli~ali()ns di,e ~be HbAl~ 'vI~a,"rem~"l Hogh-Risk IndividuaL; \\'ith IJiahc/cs ('arc 200 1;: 465-471 (rX:(TiEDlC) Study diaoctc, trcatn,cnt and cardiovascular ni ve gll1COS~. HI C(lmpiications Trial' rs ity 47. of C Improve s the lktectie)n of Type 2 Diabetes No"diagn,-,sti~ type 2 diabetes. IJiaheles I. f-j,lwn AD. ap e 46. Perry Re . Shankar RI< . To w n :;561 Epidcmiology R~sear~h e)1 Dial:>ctcs (jroup. Inkn",,'e ill patient, wllh tjpc I diabetes.}-i Elig/ U .I '"led 2005,353: 2643-2653 4S. Qlau Q. Tuncn LH. ""cn-KiLLl.:aanniemL SK. el ,,/, Rm'Jde)m capillary whelie hh.)(xl gilocose test as a sc,Iwning teSI fe).- diabetes mellit,,> in an elderly I}()pubtio". Europmn Journal o{Public jjea/lh 1995: 5(4): 277 -1~(J 4'). o.,wald ri. Smith C'. BCllel;dge.1. Yudk,,' J. Dctcmnmml" and impe)ftance of stress hypergiy~a~mia m tlo,,-diabeli~ pati~ms with myoc,mlialml',rdwn. RUT 1936: 29J' 9 I 7·922 53 50, O'SlIUivJn J, Conroy R. Rol"'''()/l K, pali~llts Hid~y N, l\,{lllcahy k.. In-hospiwl progllo,i, of' with f;willg hypcrgiycJCllllJJfler lirst myocardial lllf;"dioll TJ;al>eles ewe 14:75S-760 11)')1; 51, 13dlodi G. Manicmch V, Malvao' V. et ai, II YPL'Tglycactnia Inyu(;Jr~iJI Jn~ progrw,i, of Jeutc inti,rClion in pallGllls wnholLt diahetes melhllld_ ,1111 J C"rdiol. I')~<); 64: S85-SSS 11,. S E. Hum D, ;vlalmlX-'Tg K, GeT';lein H C. Slrcss h::.--pergIJ'Catmia and incrcased n C~pcs of death nfier lllJLXardial infarctioll in pJtlcnts wilh and ",ilholll diabelL"" a s},slemHtic o"<'rview_ n", raileet 2(jf)(); 3:5:5:773- 77~ I'ath .() r(~'llbndi I', lkJ11 K, GllIco,c-Imlllin-Potassiulll Therapy j"r Trealmenl oj' ap e 5}, To w 52, C Al'lLte Myocardial In (;lrdioll tiJ'('ulmiol/ I 997, '!fi: I I 52 -I I 5b of 54. Diaz R, Paola",o L A, Picgas L S, c/ ,,/. McWhohc ro..loduiatioll "j-Acute ro..lyocardial ty Infarction, '1 he LelA Gllicose-lnsuIHl-POWSSjurn PilOI Tnnl. Circuiul;on 19%: 98 ni ve rs i 2227-22.14 55, Malmberg K, Norhatnmar A, Wedel H. Ryden L (Jly<:omcwholic State at Admi'SloTl: U important Ri>k MaThcr in ConVCntiollal! y 'i"realed Pali ents with l)iabeleo M ell itus and Anl1e Myocardia I Inbrction. O,-"uiul;o" 1999: 99: 2626-2632 56, Davi"", M.I, Gray IP, Impaircd glu~m,e tolcJ'Jllc e, BMJ 1996: 312:264-265 57, De,pres, JP, LClllkux 1. Prlld'homrnc D, Trcatmcnt orobcsi1y: necd to fOCIIS on hi.,h risk alxlomirlJUy OOC>c paticnts, BMJ 2()()1: .122: 7 I 6-720 5S, Goldstcin OJ, BcncJicwl health elTecl, of'a modest weightlos,_ fill.! 01"", 1')<)2: 16: -'97 415 54 59 Vaguc J. La dilTercnliation se\udk fadcur determlllant des formcs dc l'ob6,itc. l'r('sS<' Med 1947; 30: 339-411 60. Ll~,e All, \1eycr-Da\ls EJ, Tymicr HA. ,,/ ul. Dcve](:>pment c)f the Multiple \1ctaboltc Sync1rome in lhc' AR1C cohorl: Joint Co ntrihutiClII Clf In sulin. HMl, al1d W HR .. -11111 Lpirleillio 1<)<)7: 1: 41)7-4 I (,) iii . rum.,,- I<C, II.fili us 11, Nd HAW. etall"r the Unilnl Kingdom PrO\r~cti\'eDiahetes To w n Sllldy (,roup. Risk faclc))'s fc)f comnary artery d i,easc in non-in'lliin depetxlant diabeks mellitus: UnlleJ Km/Cdom pwsI",c.tive dtabetc, ,tuc1y (UKPDS 23), BAfJ ~1arj\Z f-J Ilyslipidaemia in Sooll th Africa. Chnm;G D;"nll'« .I' oj'lifestyle iii Suu,h ~hapter 'l. 97 - 1n~. of C Afrim ,i'l<:c 1995- ~O\l5. ap e 62. 63. Wilson I' W F, Iliaheles MelhllLs and Cnronaf)' Heart DiseaSe. L'"docrinu/ MClab ~~7-~1 rs ity CiiIl2(11)1: 30: 64. lsomaa B, Almgren P. Tuomi T. e/ al. C"rdiovas~ular lI.\orhldilY and Mc)rtalily ni ve Associated Wilh the Me1ai:>.lh~ Syndromc. Diul><:/e.l' Cure ~OOI ; 24: 6~3-6~~ U 65. Lakka HYI ct 01. Th~ mcta!>"lic. <yndmme and ~ltal anu cardiovas.c,uiar disease mortality in nlid<lle-age<1 m~n, JA .VA 211m: 2R8: 2709-2716 6(" Juutilainc[l A. Le·hlo S. ROl1Il~maa T, Pyiir;;i;; K. Laaho YI, Pwtcillu ria "nd metabolic <yndm nw as p redidors oj' cardiovascular dcath in no n_d i"hetic omllype 2 diabetic men at,,1 ",'linen, TJiahetologiu 2(~)6: 49: 56--65 67. Gc'\xge K. Aicrti M, /.in1n1"\ 1'. Soh"w J, I'he n1dahok syndrc)me a nc\v\vorld wide deti 1l11ic)n. The L"neel J005: 366: I 05~-ll)ii I 5', 6R Ok",o C, Zhong Y. Ford E, e/ al_ Ass"",ialion be("ecn the ill' c()mrO I1~l1t< 'md gilit <pe~d melal>oh~ syndron-..e and among U,S. adults aged 50 years _,"d o](kr: a c['()ss - U ni ve rs ity of C ap e To w n sedional analy,i,_ HAle f'uhlic Healrh 20(l6; 6: 2R2-2R9 56 l"'I'ORl\IEJ) COl\SENT \V e inviw you to partici[laW in a SllrV~y to ~stabli sh whm r",rC~lltage or p~liel1t' adm i!led sun~r.s with the InslLlin ReSlslmlce SYlldwme. Thi, JcnlTlgem~nt 01 tlw sugar lUld cholesterol metabolism, to Karl Bremer Hospital with angma. wndition IS chamcklized by al'llol'mal blO<X1 lJ1~reased to the actiol1 of il1sulin in your f><xly, leadin g lo risk oj heart disease. II it appears dlLring this survey lhat a high percentage w n an pressur~ ~nct resi,tanc~ stmt~gies can he devi>cd to nctctn:;ss this probkm and reduc~ the ri,k or C you aped dlLnng this survey? Yo", doctor wii I perIorm a and lUl ECG wi lllx dOll~ routil1~ ex~minati 011 ns u,unl. YOll will be weighed alld we wlll meaSlL]'e yoU!' kllgth of \V hal ~~n ap e in our populat ion, To of pati~nts actillitled with all gil1a sulfers flnm this wlldil iOll. which seem, to he mcreasLTlg cil'cumfel'~I1Le. rs i ty as well as .VOlL]' hip and aNominal ni ve ;, kllliry if any undcrlyillg myocardial damagc is a<kJitionai blood will nl so he ~ollcded Blc,od wi ll rom;l1ely. be lakell lo pr~sent. During thi> vcnepullclure. to check your blo",icOllJl\. hpid pmtilc. YO!lI U glucose control ovel th e Inst I:;'w mOl1ths, illsul il1 leve l, and inil ammmory markers. 1\0 extra vellepulKtures wi l oc pcr l(lrm ect Oil admission. A urine sample will abo "" co llede d to W~ if there ar~ nll y [>fOldns pl'e,el1t ill YOllr urillc. ROlLtlJlC care will be takell of you during your hospiwl st"y. OIl your day or discharge additional blc'l'>d smnpk to Lheck your fnsting glu~ose w~ wJ!1 ask you for nn alld d",l e,temi. This mean, that you will be a.,ked 1l0t 10 Cal or drink anything fl'l!m 22hllll th~ previou, night, alld hhxxi will n., tnkell early m the morning so thm YOlL can , till havc your breakfa,L We wi ll abl provide you wilh "' wsm drink (iI you are nol already diagllO,ed with ctiaocte>:1 nllct 57 repeat the b\,xl<1 sample ill 2 hl'S. Th is ~nable, already dlagnosed, or atl;sk li)T devdoping us 10 s"c if you hove di abetes, if not tliabcte~. !r~o , we w lll alh i s~ you regarding your flLtlLrt management. If at any point during this surve::.. YO)I w()\l ld like to discontinue your panicil'alion. you are free to do so and }our car" lh"rean"rw,\lnol rn, al re~led_ I hove read ami understand th" ab()v~ miimll ation and woul d ljk~ to participak.-i would ap e To w n not like 10 pJ1ticipatc in thc survcy. ty of C Paticnt: Signaturt Daw U \Vitncss: ni ve rs i Prinl",lname 5R APPESDIX B ,\nj\'IISSION SIIEET FOR /.. 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