BenchandBedImmunology2015 Thursday,15‐Jan‐2015 9:00 9:40–10:00 10:00–10:40 10:40–11:20 11:20–12:00 12:00–12:40 12:40–14:00 14:00‐15:00 15:40–16:40 RegistrationandWelcome Presentationoftheseminar ReinhardVoll,Freiburg Primary(PID)andsecondaryimmunodeficiency(SID): clinicalproblemanddiagnosticapproach JeanLouisPasquali,Strasbourg PredominantBcelldeficiencies Blymphocytedevelopment PaulineSoulas‐Sprauel,Strasbourg Agammaglobulinemia MartaRizzi,Freiburg Hypogammaglobulinemia,CVID KlausWarnatz,Freiburg Lunch Secondaryimmunodeficienciesduetodrugs BlockingofTNF,IL1,IL6,..‐AndreasSchwarting,Mainz Steroids,HCQ,MTX,AZA,MMF..‐JensThiel,Freiburg Workshop:Bcellsimmunodeficiencies Chair:ThierryMartin,Strasbourg  ImmunosuppressiveroleofTrib1,L.Simoni,Strasbourg  Towardssingle‐locusproteomicstorevalthemechanismsof genomestabilityandDNArecombinationinBcells,L.Gaudot, Strasbourg  SearchingfornewgeneticmutationsinCVID,J.Kemmig, Freiburg Thursday,15‐Jan‐2015 16:40–17:40 Workshop:Secondaryimmunodeficiencies Chair:AndreasSchwarting,Mainz,NilsVenhoff,Freiburg SecondaryimmunodeficiencybyRituximab,N.Venhoff,Freiburg  BcellsimmunodeficienciesduringHIVinfection,J.Tricallotis, Strasbourg  CTLA‐4‐Igtreatment,J.Tkocz,Freiburg  17:40‐19:00 Postersessionwithcoffee,reactivenetworking Chair:MartaRizzi,AlesJandaFreiburg,Anne‐SophieKorganow, Strasbourg  PI3Kdeficiencies,M.Martin,Strasbourg  ImmunereconstitutionafterHST,K.Piszcelskka,Strasbourg     20:00  SIDbymyeloma,J.Udi,Freiburg SCID,R.Rothenberger,Heidelberg/Lausanne TACIandCVID,Z.Escandaryan TheAirWayInfectionSusceptibility(AWIS)study:an epidemiologicalstudytocharacterizeinfectionprone individualsatpopulationlevel,L.Maccioni,Freiburg TheAWIS‐Score:AnApproachtoDetermineSusceptibilityto InfectionsintheGeneralPopulationM.Bäurle,Freiburg Immunoglobulinglycosylation,S.Schaffer,Freiburg Diner Friday,16‐Jan‐2015 8:30–9:10 9:10–9:50 9:50–10:30 10:30–11:00 11:00‐11:40 11:40–12:20 12:20‐13:00 13:00–14:20 14:30‐15:40 PredominantTcelldeficiencies Tcellactivationandsignalling WolfangSchamel,Freiburg SCID‐Tcellimmunodeficiency SebastianFuchs,Freiburg Cytotoxicitydeficiencies(HLH,MAS) StefanEhl,Freiburg Coffeebreak OthercausesandmanifestationsofPID Cytokinespathwaydefects AnneSophieKorganow,Strasbourg AutoimmunemanifestationsinPID BodoGrimbacher,Freiburg TLRsdefects FrédéricGros,Strasbourg Lunch Workshop:Tcellsdefects Chair:AlesJanda,Freiburg  RoleofmacroautophagyinTcellfunction,D.Murera, Strasbourg  HBVspecificCD4+Tcell:CharacterizationandroleofOX40, F.Jacobi,Freiburg  TcellexhaustioninchronicHepatitisBandC,P.Müller, Freiburg  IdentifyingmodifiersinCTLA4deficiency,C.Schwab,Freiburg Friday,16‐Jan‐2015 15:40‐16:40 16:40‐17:00 17:00‐18:00 18:00‐19:30 20:00 Workshop:PIDImmunityatbarriers Chair:PaulineSoulas‐Sprauel,Strasbourg,BodoGrimbacher, Freiburg Introduction:MucosalImmunity,BodoGrimbacher  Inflammatoryboweldisesase‐microbiomeandgenetics, S.Jendrossek,Freiburg  LunginvolvementinCVID,I.Tröster,Freiburg Coffeebreak Workshop:Innateimmunitydefects Chair:FrédéricGros,Strasbourg  NKcellsimmunodeficiency,M.Sawaf,Strasbourg  CARD9deficiency,F.Danion,Strasbourg  Autophagyimmunodeficiency,J.Arnold,Strasbourg  InnateimmunityinLupus,T.Aschman,Freiburg Discussion Diner Saturday,17‐Dec‐15 8:30‐9:00 9:10–9:50 9:50‐10:30 10:30‐11:00 11:00–12:00 12:00‐13:00 13:00 13:15 ImmunereplacementandimmunomodulationbyIVIg/SCIg Hans‐HartmutPeter,Freiburg Hematopoieticstemcelltransplantation(HSCT) BrigitteStrahm,Freiburg ImmunereconstitutionafterHSCT ThierryMartin,Strasbourg Coffeebreak Workshop:Immunedeficienciesandautoimmunity Hanns‐MartinLorenz,SophieJung,Strasbourg  Thrombopeniaandimmunodeficiencies,A.Guffroy, Strasbourg  Stromacellsimmunodeficiencies,A.Farouk,Strasbourg  NewgeneticdefectsinPIDandimmunedysregulation, J.Raabe,Freiburg  Complementactivatedcell‐boundproductsinSLE, J.Beckmann,Freiburg Workshop:PIDandtherapies ChristophFiehn,Baden‐Baden  IVIgandkidneytransplantrecipient,M.Joly,Strasbourg  Genetherapyandimmunodeficiencies,D.Bouis,Strasbourg  Modulationofderegulatedchaperone‐mediatedautophagyby P140peptideinLupus,F.Wang,Strasbourg  Endothelialcellsplayanactivetoleinthymicregenerationvia BMP4signaling,T.Wertheimer,Freiburg Closing AnneSophieKorganow,Strasbourg,ReinhardVoll,Freiburg Lunch SPEAKER: KORGANOW,Anne‐Sophie VOLL,Reinhard EHL,Stefan FIEHN,Christoph FUCHS,Sebastian GRIMBACHER,Bodo GROS,F JANDA,Ales JUNG,S LORENZ,Hanns‐Martin MARTIN,Thierry PETER,HansHartmut PASQUALI,JeanLous RIZZI,Marta SCHAMEL,Wolfgang SCHWARTING,Andreas SOULAS‐SPRAUEL,Pauline STRAHM,Brigitte THIEL,Jens VENHOFF,Nils WARNATZ,Klaus ADMINISTRATION: AGENAIS,Silvie WÜNSCHE,Inge