Q\[F KMZEC OKPGFKH \GZDGCP OK[R NXB QGMKSF KPZGD \B GRPMKS FC[ FEGCT GRTXKC :GPM \GKNJKRDGZGB \GTZVF[ ,GRBXP GR\EGCTC .["EHP \GNCGSF ,Q\[ \GKZB[G OKPEGY OKKDGNGYRKD OKIG\KR ,FJKN[=KB ,FNXGJSKX EKYV\ YI[P QDGZJSB ZETKF ,USGRC .(5) ["EH \TVGF \B \GZKCDP .(6) ["EH N[ FKDGNGKHKVG\VC CG[I OKNKXCGJYN OKYEKKIF \GCZ\F \B EEGTP QDGZJSBF QGPZGF =F \B OKXKPIPF .OKKTP KYEKKI N[ \GC[KK\F OKTRGPG YK\ZRC =F ,OKNKXCGJYN QKB QDGZJSB ZETKFC Z[VBPG FNGT YK\ZRC .(1 OK[Z\) \KNJKRDGZGBF \KZKZC OKRDG\VGZGB \GIMGR pH p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coli ZYKTC \GZKTX OK[R QGMKS KPZGD .["EH \TVGFN QKP KSIK OGKY QKC Z[Y GIKMGF \GCZ \GEGCT KSIK \GPKKYP QRKB[ OK[RC ["EH \GIKM[[ GBZF (6) GKZCIG QKP KSIK \GPKKYP[ FNBC FR[N 52/100 \PGTN ,FR[N 7/100 BKF QKP .(4) Z\K \GIKM[N BGF OD ZG[Y FTKRP KTXPBM FPDZVBKEC [GPK[F ,9 NGRKSYGRGP GPM OKKEKXKJPZVS OKZPGIC [GPK[ UBG ,["EHC KNNGIP N[ \GC[KK\F Z[VBPG YK\ZRF N[ FZGNVF \B FR[P .Q\[F KMZEC OKPGFKH Dennis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coli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coli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atton JP, Nash DB, Abrutyn E. Urinary tract infection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economic consideration. Med Clin North Am 1991;75:495513. 2. Schaeffer AJ, Urinary tract infection in men - State of the art. 3. Romano JM, Kaye D. UTI in the elderly: common yet Infection 1994;22 (Suppl. 1):19-21. atypical. Geriatrics 1981;36:113-5. (.\MZTPC OKZGP[ \GZGYPF ZB[) \GKPGFKH \GNIP FKRKEJSGZV GB OKKRGZM OKCBM OKNCGS ,FR[ 40 =30 KRC ,OKZKTXF OK[RBFP 40 %=20 % O NX B Q KB LB , FR G \I \ QJ CC O K CBMP G Q \[ Q \P C \ GT ZVF P Q \[ F \G KC Z\G FK ZG K V Q KB ZPG N M ,K \Y NE LK N F\ N G B O G F KH N \G ET . \GZY T TZHFG 26
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