1. No category

TOBACCO RESEARCH COUNCI L ~
Librar
~
v
Check List
Volume 34 No .3
~ September 1976
COkTF:NTS
Smoking and health (general)
Items 301-309
Smoking habits . Health education
310-318
Smoking and lung cancer
319-320
Lung cancer not associated aith smoking
321-325
Smoking and the cardiovascular system
326-337
Smoking and diseases other than lung cancer
and diseases of the cardiovascular system
338-339
Diseases other than lung cancer . Papers not
implicating smoking
340-356
Atmospheric pollution
357-365
Chemical research
366-377
Biological research
Research into ce11s and tissues
378-396
Theories and mechanisms of carcinogenesis
417-419
397-416
Physiological research . Pharmacology
420-436
Psychological research
437-439
Stat-istics (general)
Cancer statistics
440-442
443-447
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BLUI~Q:NSON, L .E . When is screening effective in reducing
the death rate?
Mathemat .Biosci ., 1976, 30(3-4), 273-303 .
300
HECKF.R, E .
Definitions and terminology in cancer (tumor)
etiology .
An analysis aiming at proposals for a current
internationally standardized terminology . (Editorial)
Z . Krebsforsch ., 1976, 86(3), 219-30 .
SmAing and health (general)
O1* HORN, D . A model for the study of personal choice health
.-behavior .
Int .J .Hlth Educ ., 1976,- 19(2), 89-98 .
02* HUNTER, R .B . Smoking and health . The philosophy of the
• Committee . Paper presented to the Royal College of
Physicians, Edinburgh, 21st_April, 1976 . 12 pages .
Available from : Publications Officer, University of
Birmingham, P0 Box 363, Birmingham B15 2TT . £1 per copy .
303* JARRETT, C .G . Nicotine, tobacco substitutes, and smoking
habits .
(letter)
•
Brit .med .J ., 18 September 1976, 2, 695-6 .
Sir Clifford Jarrett, Chairman of the Tobacco Research
Council, replies to the letter by Mr . Gaylarde (Check List
34/140) . He refutes the suggestion that no research work
has been ~dertaken to provide a safer cigarette and
correct Mr . Gaylarde's assumption that oxidants are
inclu d in the manufacture of British cigarettes . Oxidants,
like ther additives, are not permitted in cigarettes sold
in he U .K .
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304 ,,iCULLBACK, S . and CORNFIELD, J . An information theoretic
contingency table analysis of the Dorn study of smoking
and rtality .
Com ters & Biomed .Res ., October 1976, 9(5), 409-37 .
305 1 Jf6ILWN, P ., et al . Smoking and the subjective health
d 0 - con tion among Finnish military conscripts .
~~~ • ` Sca d .J .soc .Med ., 1976, 4(1), 21-3 .
346i I . NAN, G . Passive smoking in enclosed public places .
Hed .J .Austral ., 10 July 1976, 2, 68-70 .
307*
PIPER, A . Off the tobacco road . U .K . cigarette
manufacturers have reached a crucial stage in the
development of substitute tobacco .
Nature, 2 September 1976, 263, 2 .
308* SIEGEL, R .K . Herbal intoxication . Psychoactive effects
from herbal cigarettes, tea, and capsules .
J .Amer .med .Ass ., 2 August 1976, 236(5), 473-6 .
Author's abstract :
Herbal preparations, designed to be smoked or ingested for
"health and happiness", are promoted as legal hallucinogens,
euphoriants, and marihuana substitutes . A total of 25
psychoactive substances have been identified in these
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- 2 Smoking and health (general) continued
308* continued
products, and a number of intoxications have resulted from
their short- or long-term use . Physicians should be alerted
to the nature of these effects when taking drug histories,
and their possible role in the causation of medical complaints
should be considered .
309 {YEBER-TSCHOPP, A ., FISCHER, T . and GRANDJEAN, E . Physiolo,gical
and ps 'Eiological effects of passive smoking . (In German)
Int . ch .Occup .Environ .Hlth, 1976, 37(4), 277-88 .
Smoki .n abits . Health education
310* ~RIC,,L ., MacARTHUR, C . and SHERWOOD, Ii . A study of health
,~ ~ educ ion aspects of smoking in pregnancy .
~1~~~5 Int J .Hlth Educ ., April-June 1976, 19(2) Supplement, l7pp .
311 RNARD, J .G . and BOYER, G . Epidemiological study of
tobacco smoking among young men in France . (In French)
Bu12,Nld Hlth Org ., 1976, 53(1), 75-81 .
312* (esdA$~VEIT, K . Tobacco law in Norway : experience from its
re~nforcement . (In Norwegian)
N~ disk Medicin, 1976, 91(8-9), 224-6 .
nglish translation in library
313J CZYZYK, A . and KROLEWSKI, A .S . Is cigarette smoking more
I~ frdquent among insulin-treated diabetics?
y~ Diabetes, August 1976, 25(8), 717-8 .
Authors' summary :
During epidemiologic investigations of vascular complications
of diabetes in Warsaw the habit of cigarette smoking was
analysed in the subjects studied (4,530 diabetics) . It was
found that in the group of diabetics the number of ex-smokers
was much greater (P<0 .01) and that of present smokers
lower (P--- 0 .01) than in a representative sample of the
Warsaw population . Furthermore, it was observed that in
the subgroup of insulin-treated diabetics the number of
smokers was highest and the number of ex-smokers and nonsmokers was lowest in relation to other treatment sub-groups .
314* GUILLERM, R . and RADZISZEWSKI, E . A new method of
analyzing the act of smoking . (In French)
Ann .tabac ., Section 1, 1975, 13, 101-10 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Authors' English summary :
The new method for analyzing the act of smoking which is
presented comprises a combination of three methods of
investigation : measurement of the frequency, volume and e+
duration of puffs using two complementary techniques °
(metric-flow technique and pyrometric technique), ~
simultaneous analysis of the ventilatory behavior of the ~
smoker, and an evaluation of the amount of smoke inhaled . v,
The methodology was adapted to study the behavior of a
smokers when a low-irritant cigarette was substituted for
their usual cigarette . Owing to the changes in the way of
smoking which are observed in smokers, the method for
analyzing the act of smoking may be said to be indispensable
in order to evaluate the potential biological effects of a
new cigr.rette .
- 3 .
Smoking h its . Health education continued
315* ALTH AND WELFARE CANADA . Smoking habits of Canadians,
1965-1974 . Technical Report Series No .1, January 1976 .
Research Bureau, Non-Diedical Use of Drugs Directorate,
Healto Protection Branch, Health and Welfare Canada .
Otts.dia, 1976 . 24pp
316, /SACSSON, S .O ., et al . Results of a quit-smoking research
~_y-_
4~- }~a-vJcv~ au a auuuumay e,vaea ;Leu POyuiu~ivi1 .
I~~j~~~~ Scand .J .soc .rlod ., 1976, 4(1), 25-9 .
317* JOHNSTON, L . Nicotine chewing gum . (letter)
Brit .med .J ., 4 September 1976, 2, 585 .
Comments on the paper by Dr . M .A .H . Russell, et al .
(Check List 34/151)
Cil,8* TURNER, J .A .McM . Confirmation of abstinence from smoking .
(letter)
Brit .med .J ., 25 September 1976, 2, 755-6 .
Dr .'Turner comments on the paper by Dr . M .A .H . Russell and
his colleagues (Check List 34/151) . Dr . Russell and
Dr . Cole reply to the points raised .
Smoking and lung cancer
319* BURCH, P .R .J . Lung cancer and smoking : is there proof?
(letter)
Brit .med .J ., 11 September 1976, 2, 640 .
Comments on the leading article (Check List 34/153)
.,009•: :
320 DeWYS, W . Changing attitudes towards cancer . (Editorial)
J .chron .Dis ., September 1976, 29(9), 545-8 .
"There is increasing evidence that many forms of cancer may
be preventable . An example is the association between
smoking and lung cancer . Subsequent to the publicity
surrounding the Surgeon General's Report there has been a
striking reduction in smoking among physicians illustrating
the use of scientific information to change the attitudes
of a population group toward cancer . However, in contrast
to the/physicians' change in smoking habits, the smoking
habits/_of the general public have changed little . We
.appar~ntly need a better flow of information to the general
publ~;c . Since many patients look to their physician as
their major source of health information, we should
enc urage physicians to increasingly inform their patients
abq~t health hazards such as the hazards of smoking ."
Lung cari/cer not associated with smoking
,321~ DROBSE, M . and BAYER, E . Cytological classification of
~/ bronchial carcinoma . (In German)
Deut .med .Wschr ., 24 September 1976, 101(39), 1417-20 .
322* MULVIHILL, J .J . Host factors in human lung tumors : an
- example of ecogenetics in oncology . (Editorial)
J .nat .Cancer Inst ., July 1976, 57(1), 3-7 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
- 4 Lung cancer not associated with smoking continued
323* NEWHOUSE, M .L . and BERRY, G . Predictions of mortality
from mesothelial tumours in asbestos factory workers .
Brit .J .industr .Med ., August 1976, 33(3), 147-51 .
Authors' abstract :
Using the accumulated data on deaths from mesothelial
tumours among cohorts of male and female factory workers
at a London asbestos textile factory, the mortality from
this cause up to the year 2000 AD has been predicted .
The limitations of the methods used are pointed out, but
it is estimated that for men the mortality due to mesothelial
tumours will be between 7% and 11% of the total mortality
and so 'what higher for women . The highest number of deaths
from sothelial tumours will occur during the 1980s,
the after the numbers will decline because of the decreasing
si of:the cohort resulting from general mortality .
3?.'4 XOGW, V ., et al . Cytologic differential diagnosis of
chiolo-alveolar carcinoma and bronchogenic adenocarcinoma .
A a C tol ., July-August 1976, 20(4), 303-7 .
325 ALHADIN, A ._, et al : The unique cytological picture of
oat cell c}~ rcinoma in effusions .
Acta Cytp1 ., July-August 1976, 20(4), 298-302 .
Smokin an the cardiovascular s stem
326 1A RTINI, D ., et al . Epidemiological study of coronary
isk factors in seTe-cted bank clerks of Parma . Investigative
- model and preliminary results . (In Italian)
L'Ateneo Parmense Acta Bio-Medica, 1976, 47(3), 201-48 .
327* CLARKE, J .M ., et al . The rhythm of the normal human heart .
Lancet, 4 September 1976, 2, 508-12 .
In this study of 86 subjects, heart-rate but not the number
of arrhythmias was significantly higher in smokers .
328* CRYER, P .E ., et al . Norepinephrine and epinephrine release U
and adrenergic mediation of smoking-associated hemodynamic W
and metabolic events .
~
New Engl .J .Med ., 9 September 1976, 295(il), 573-7 .
''
m
Authors' abstract :
0
We studied the effects of cigarette smoking, sham smoking m
and smoking during adrenergic blockade in 10 subjects to
determine whether smoking released the sympathetic
neurotransmitter norepinephrine, as well as the adrenomedullary hormone epinephrine, and whether smoking-associated
hemodynamic and metabolic changes were mediated through
adrenergic mechanisms . Smoking-associated increments in
mean (+ S .E .M .) plasma norepinephrine (227+23 to 324+39 pg
per milliliter, P<0 .01) and epinephrine (44+4 to 1115+27 pg
per milliliter, P< 0 .05) were demonstrated . Smoking-associated
increments in pulse rate, blood pressure, blood glycerol,
and blood lactate/pyruvate ratio were prevented by
adrenergic blockade ; increments in plasma growth hormone
and cortisol were not . Since significant smoking-associated
increments, in .pulse rate, blood pressure and blood lactate/
pyruvate ratio, preceded measurable increments in plasma
catecholamine concentrations, but were adrenergically mediated,
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
- 5 Smoking and the cardiovascular system continued
328* continupd
thes changes should be attributed to morepinephrine
rel as©d locally from adrenergic axon terminals wii :hin the
t sues rather than to increments in circulating catecholamines .
329 NAHER, B .G ., LICHTENSTEIN, E . and SULLIVAN, J .M .
Comparative effects of rapid and normal . smoking on heart
rate and carboxyhaemoglobin .
J .consult .clin .Psychol ., August 1976, 44(4), 556-63 .
q0 ;
Authors' summary :
A rapid smoking procedure closely approximating that found
in clinical and research practice was compared to normal
smoking and a rapid breathing/sham-smoking control .
Nicotine concentration of cigarettes was systematically
~
varied . lialor dependent variables included heart rate and
• estimates of blood carboxyhaemoglobin (COHb) based on
expired respiratory air carbon monoxide . The results
showed rapid smoking produced significantly greater rise
in heart rate than normal smoking . No carbon monoxide
differe nces obtained across the smoking conditions .
Individual subject data incidated that no subject exceeded
estimated danger levels of COHb or heart rate increases .
Although replication and extension of these findings are
necessary, the results indicate that rapid smoking is not
undyly hazardous to nonsymptomatic young adults . A suggested
sc~ening procedure for rapid smoking is presented .
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330\ ;`"ARD'Y, P .S ., et al . An assessment of the influence of habitual
uphysical activ~ty, prior sport participation, smoking habits,
,~ and aging upon indices of cardiovascular fitness : pre .liminary
"~ report of a cross-sectional and retrospective study .
J .sports lfed ., June 1976, 16(2), 77-90 .
331* HAWKINS, L .H ., COLE, P .V . and HARRIS, J_R .W . Smoking habits
and blood carbon monoxide levels .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Environ .Res ., June 1976, 11(3), 310-18 .
Authors' abstract :
The carboxyhaemoglobin concentrations (COHb) of 97 meat
porters, 77 office workers, and 200 pregnant women have
been determined . Individuals were questioned on smoking
habits including numbers normally smoked per day, numbers
already smoked on day of sampling, and time since last
cigarette . The number of cigarettes smoked per day appears
to allow the best prediction of COHb concentration .
Individuals whose occupation involved them in physical
exertion (meat porters) accumulated less carbon monoxide
(CO) for numbers of cigarettes smoked per day than individuals
smoking whilst sedentary . Pregnant women were seen to
accumulate CO in a similar way to the active meat porters .
In all groups, smokers had significantly higher COHb
concentrations than nonsmokers . The effects of activity
on CO uptake and elimination are discussed in relation to
cigarette smoking, and it is suggested that the effect of o
act,tvity on COHb is related more to elimination in the W
nonsmoking periods rather than uptake in the smoking periods ~
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- 6 Smokin a the cardiovascular system continued
33?,* } S, b1 .J ., r1ORRIS, G .K . and HAatPTON, J .R . Lack of effect
f bed rest and ci arette smokin on develo ment of dee
`~ vein thrombosis after myocardial infarction .
Brit .Heart J ., September 1976, 38(9), 981-3 .
Authors' abstract :
In a prospective study of patients admitted to a coronary
care unit, the incidence of isotopically diagnosed deep
venous thrombosis was found to be related to the severity
of the illness rather than to the duration of bed rest .
In addition, no negative correlation was found between
cigarette smoking and deep vein thrombosis .
333 JULIAN, D .G . Toward preventing coronary death from
ventricular fibrillation .
Circulation, September 1976, 54(3), 360-4 .
'
. Author's summary :
Sudden coronary death from ventricular fibrillation is the
biggest and probably the most remediable of the major public
health problems at the moment . Most of those liable to
sudden death can be identified and it is possible that by
the use of beta-adrenergic blocking or antiarrhythmic drugs,
by reducing the consumption of cigarettes and perhaps, by
different therapies for hypertension, a substantial
proportion of coronary deaths might be prevented or, at
least, postponed .
334 KOZAREVIC, D ., PIRC, B ., RACIC, Z ., DAWBER, T .R ., GORDON, T .
and ZUKEL, W .J . The Yugoslavia Cardiovascular Disease Study .
II . Factors in the incidence of coronary heart disease .
Amer .J .Epid ., August 1976, 104(2), 133-40 .
Authors' abstract :
In a 7-year follow-up of 11,121 Yugoslav men first examined
in 1964-1965 when they were 35-62 years old, it was found
that the incidence of coronary heart disease (CHD) was
one-fourth that of a comparable Framingham (USA) group .
Incidence in rural men was only 59% of urban men . In both
urban and rural groups, men with higher blood pressures had
greater CHD incidence, and cigarette smoking was also
associated with greater incidence . In the urban but not
the rural groups serum cholesterol and weight were lower in
urban Yugoslavia than Framingham and lowest in rural
Yugoslavia . At the same levels of these characteristics
Framingham incidence was 3 times that in Yugoslavia . At the
very~low rural levels of weight and blood pressure CHD
inc#~dence was the same in urban and rural Yugoslav groups .
335* LFytCKOWITZ, R .J . Smoking,_catecholamines, and the heart .
ditorial)
[few Eng1 .J .bied ., 9 September 1976, 295(11), 615-6 .
336 /THELLE, D .S ., et al . The Troms$ heart study . Methods and
main results of the cross-sectional study .
Acta med .scand ., 1976, 200(1-2), 107-18 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Authors' abstract :
The mortality from coronary heart disease (CHD) in Norway
increased rapidly during 1951-70, the highest mortality
rates as well as the most rapid increases being found in
- 7 Smoking_and the cardiovascular system continued
336 continued
Northern Norway . Several surveys of CFID worc thev rlannedt one of them is reported here
. All mon, 20-49 year . _-f age,
living in the municipality of Tromsd, Troms county, • .,ere
called up for examination . In total, 6,595 men, 74 .4% of
those invited, were examined . Cholesterol, triglyceride
and Hb values, BP, body weight and height, the percentage
of smokers, and cigarette consumption have been tabulated
according to area, age, work schedule, health condition,
physical activity and ethnic background . The results suggest
that the relatively high mortality from CHD in Northern
Norway is, .associated with high serum cholesterol concentration
as well s a relatively high prevalence of smoking . During
the s eening there were indications of changes in dietary
habi s in the municipality, presumably as a result of
' , ac mpanying publicity .
337 AALCZAK, Z . Effect of tobacco smoking on acid-base
equilibrium in arterialized capillary blood . (In Polish)
Pol .Tyg .Lek ., 1976, 31(16), 653-4 .
Smoking and diseases other than lung cancer and diseases of the
cardiovascular system
338* Heavy drinking, smoking linked with oral cancer .
J .Amer .mead .Ass ., 2 August 1976, 236(5), 435 .
An accont of the work of I .D .J . Bross and J . Coombs of
partment of Biostatistics, Roswell Park rfemorial
itute, given at the Toronto meeting of the American
ociation for Cancer Research .
339*/REID, L . Incipient emphysema .
Progr .Resp .Dis ., 1976, 10, 3-13 .
Diseases other than lun cancer . Papers not implicating smoking
see a so item 4
340* Regression of atherosclerosis? (Leading article)
Lancet, 18 September 1976, 2, 614 .
341* ALLEGRA, J ., et al . Decreased prevalence of immediate
hypersensitivity atopy) in a cancer population .
Cancer Research, September 1976, 36(9), 3225-6 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Authors' summary :
It has been suggested that the atopic population has
decreased risk of cancer . This investigation examined the
cumulated prevalence of atopy in a population with neoplastic
disease and compared this with the prevalence of atopy in
an age-matched control group and with published estimates
of atopy in the general population . Seventy-four patients
with neoplastic disease and 86 patients without cancer were
evaluated . The subjects were given a standard allergic
questionnaire which evaluated them with regard to a history
of allergic symptoms, hives, eczema, frequent colds,
frequent unexplained rashes,-hay fever, and asthma . All
were skin tested with a representative group of regional
allergens . There was a 15-fold decrease in prevalence of
atopy in the cancer population, compared with the control
group and compared with published estimates of atopy in the
general population .
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- 8 Diselses other than lung cancer . Papers not implicating rmcking
conti nued
342*
. ARIt§WONG, B ., LEA, A .J ., ADELSTF.IN, A .s1 ., DONOVAN, J .W .,
E, G .C . and RU'M'IE, S . Cancer mortality and saccharin
onsumption in diabetics . .
Brit .J .Qrev .soc .ried ., September 1976, 30(3), 151-7 .
It was concluded that the relatively high levels of
saccharin intake among the 5971 members of the British
Diabetic Association included in this study had not
increased the risk of cancer in general among BDA members .
343* ARObIAA, A ., et al . Rauwolfia and breast cancer . (letter)
Lancet, 4 Septeiaber 1976, 2, 518 .
Dr . Aromaa and his colleagues present data from a
nationwide Finnish study from which is was concluded that
~ it is unlAicely that use of rauwolfia increases the risk
• of breaat cancer .
344* BERR , R .E . Estimating the economic costs of alcohol
ab e .
N En 1 .J .bied ., 9 September 1976, 295(11), 620-1 .
345* IGNON, J . Methods for quantitative pathology with
special reference to emphysema and chronic bronchitis .
Bull .europ .Physiopath .resp ., September-October 1976, 12(5),
675-92 .
346* BRINTON, L .A ., et al . Nasa1 cancer in U .S . furniture
industry counties . (lette )r
Lancet, 18 September 1976, 2, 628 .
347 CORONARY I7ItUG PROJECT RESEARCH GROUP . Serum uric acid :
its association with other risk factors and with mortality
in coronary heart disease .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
J .chron .Dis ., September 1976, 29(9), 557-69 .
Authors' abstract :
Serum Uric Acid (SUA) was measured at baseline in the
placebo group of 2789 men with previously diagnosed
myocardial infarction in the Coronary Drug Project (CDP) .
(1) In the CDP group, several cardiovascular risk factors
measured concurrently showed a statistically significant
low-order correlation with SUA . (2) Follow-up experience
-for 3 yr was used to evaluate SUA level as a prognosticator
of subsequent total mortality and of definite nonfatal
myocardial infarction in this group of patients . Univariate
analysis suggested that the total mortality rate was
higher in patients with higher SUA than with lower . However,
when prescription of diuretic drugs was controlled in this
analysis, SUA had little independent predictive power for
total mortality . Rate of occurrence of definite nonfatal
myocardial infarction was unrelated to level of SUA in
either univariato or multivariate analysis . (3) In both
diuretic users and nonusers, rate of occurrence of attacks
of gout was low in persons with no history of gout prior
to_baseline with SUA levels -<9 .0 mg/dl ; moderate in men
with no history of gout prior to baseline but with SUA o
levels G 9 .0 mg/dl ; and high in•men with a history of ~
gout prior to baseline .
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Diseases othe'S than lung cancer . Papers not implicating smoking
continued
3481
CUCCHIARA, A .J . and ASAL, N .R . Laryngeal neoplasm
ortalit -in Oklahoma : 1950-1970 .
Soath . d .J ., July 1976, 69(7), 908-10 .
349
D STL, F ., et al . Incidence and presentation of myocardial
n farction in y ol, Austria (WHO Ischaemic Heart Disease
Register, Innsbruck 1973/72) . (In German)
Wien .klin .Wschr ., 3 September 1976, 88(16), 517-26 .
The results from this study confirm indications from the
national mortality statistics that Innsbruck belongs to
the group of areas in Eur.ope with a relativel.y-low incidenceof AbII
350*
FINE, L .J ., PETERS, J .M ., BURGESS, W .A . and Di BERARDINIS, L .J .
Studies of respiratory morbidity in rubber workers . Part IV .
Respiratory morbidity in talc workers .
Arch .environm .Hlth, July-August 1976, 31(4), 195-200 .
Authors' abstract :
Pulmonary function tests, chest x-rays, and respiratory
questionnaires were administered to eighty talc workers
and 189 non-exposed rubber worker8 from three rubber tire
manufacturing plants . The talc workers, who were exposed
to talc at levels below the current threshold limit value
(TLV) of 20 mp pcf for nonfibrous talc, had a statistically
significantly greater prevalence of productive cough and
positive criteria for chronic obstructive lung disease
(COLD) than did the control workers . The talc workers with
more than 10 years of exposure had significantly decreased
residual FEV 1 .0 . Multiple regression analysis of FEV .1 .0 in
the talc workers estimated that each year of exposure to
talc dust reduced the FEV 1 .0 by 26 ml . Talc workers had
a clear increase in respiratory morbidity, despite the
absence of chest roentgenographic changes . Based on this
study, a safe exposure level for talc appears to be
25 mg/0 as a time-weighted average .
351*
IO[OGALI, M . Byssinosis : a follow-up study of cotton
ginnery workers in the Sudan .
Brit .J .industr .bied ., August 1976, 33(3), 166-74 .
Smoking habits are recorded .
352
LILIENFELD, A .M ., et al ., Rauwolfia derivatives and
breast cancer .
Johns Hopkins Med .J ., August 1976, 139(2), 41-50 .
353*
POWLEDGE, T . Can genetic screening prevent occupational
di s e ase?
New Scientist, 2 September 1976, 71, 486-8 .
354*
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Clinical potential for
PRITCHARD, J .A .V . The MEM test .
the early detection of cancer . (Abstract)
Brit .J .Cancer, September 1976, 34(3), 317 .
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- 10 Diseases other than lung cancer .
continued
355*
Papers not implicating smoking
SAINANI, G .S ., et al .
Onion, garlic, and atherosclerosis .
(letter)
Lancet, 11 September 1976, 2, 575-6 .
Dr . Sainani and his colleagues report a study carried out
in Poona on three groups of healthy volunteers . They
conclude from their findings that regular consumption of
onion and garlic in diet has a protective effect on some
important factors which influence atherosclerosis .
356* TURNER, R .W .D . Breast is best for coronary protection .
(letter)
Lancot,,,25 September 1976, 2, 693-4 .
Atmospherpollution
3e7*, /6OR, N .A ., MERIGAN, W .H . and McINTIRE, R .W . The effects of
brief exposures to carbon monoxide on temporally
, ~ 391 qti diff eren tia ted re spon di ng .
'( Environ .Res ., August 1976, 12(1), 81-91 .
~ . ._
358*
BIERSTEKER, K . Sulfur dioxide and suspended particulate
matte . : Where do we stand?
Env on .Res ., June 1976, 11(3), 287-304 .
359'}
OWN, A .,L . Evaluation of environmental carcinogens for
cancer n man .
Onc o, 1976, 33(2), 58-60 .
ISHBEIN, L . Atmospheric mutagens : 1 . Sulfur oxides
360
and nitrogen oxides .
Mutation Res ., 1976, 32(3-4), 309-30 .
361
MONTESANO, R . and BARTSCH, H . Mutagenic and carcinogenic
N-nitroso compounds : possible environmental hazards .
Mutation Res ., 1976, 32(3-4), .179-228 .
362*
PISCATOR ; M ., et al . Contamination of cigarette and pipe
tobac by cadmium-oxide dust . (letter)
Lan t, 11 September 1976, 2, 587 .
363
USS!1fANN, R . Chemical carcinogens in the human
enviro ment . Problems and quantitative aspects .
Onco , 1976, 33(2), 51-7 .
364,~
N, P .B ., GLINER, J .A . and SUTTON, J .C . Dynamic lung
functio~'changes following long-term work in polluted
atmosvheres .
0
E_nvilfon .Res ., August 1976, 12(1), 18-25 .
~
J
365* ~bBKIN, M .A ., BEACHLER, D .W . and SHEPARD, T .H . The effect a
/
oi
carDOn
monoxlae
on
earty
raL
emoryo
Deart
raLes .
r~3z~ly` Environ .Res ., August 1976, 12(1), 32-7 .
o
°
'~ Authors' abstract :
Rat- embryos cultured in vitro at days 101, 11, and 12 of
gestation were challenged by carbon monoxide mixed into their
perfusing gas as concentrations of 0 .04, 5, and 10% by
volume . Their heart rates were determined visually and
compared to controls cultured in vitro without administration
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
- ~t Atmospheric pollution continued
365* continued
of CO . No significant differences were observed at all of
these concentrations between the experimental animals and
their controls for observation periods up to 2 hours .
No explanation was found for this apparent embryonic
insensitivity to hyperlethal concentrations of CO .
Chemical research
366 CAVALIERI, E . and ROTH, R . Reaction of methylbenzanthracene
and pyridine by one-electron oxidation . A model for
metabolic activation and binding of carcinogenic aromatic
hydrocarbons .
J .org .Chem ., 6 August 1976, 41(16), 2679-84 .
,367* DAVIS, R .E . A combined automated procedure for the
' determination of reducing sugars and nicotine alkaloids
in tobacco products using a new reducing sugar method .
Tobacco Science, 17 September 1976, 20, 146-51 .
368* DEVREUX, M . and BOURCIER, F . Method for weight determination
of tobacco hydrocarbons . (In French)
Ann .tabac ., Section 1, 1975, 13, 111-5 .
369* DEVREUX, M ., et al . The essential oil of tobacco . Study
of a new nor-thunberganoid : prenylnorsolanedione .
(In French)
Ann .tabac ., Section 1, 1975, 13, 49-53 .
370* DUMAS, C ., BADRE, R . and GUILLERM, R . 3tethodology for
determining nicotiue .and cotinine in biological media .•
(In French)
Ann .tabac ., Section 1, 1975, 13, 5-14 .
Authors' English summary :
When the principle of the methods which may be used to
determine nicotine are recalled, it is seen that the very
low concentrations in which it is found in biological media,
and notably in the blood, necessitate the use of a very
sensitive technique . The thermionic detector specific
to nitrogen molecules provides an advantageous solution .
The authors define the conditions for extracting nicotine
and cotinine, its principal metabolite, from urine and
•blood, and describe in detail the techniques of gas phase
chromatography . Two applications are given : the kinetics
of the plasmic levels of five subjects after smoking one
cigarette and the measurement of the nicotine impregnation
of active and "passive" smokers confined in the same
enclosed space .
371* HARVEY, W .R ., BAKER, P .G . and HANDY, B .11 . The automated
determination of total volatile bases and total alkaloids
in tobacco using a technicon distillation head unit .
Tobacco Science, 17 September 1976, 20, 143-5 .
372* KELKAR, S .S . and GANGAWANE, L .V . Effects of HBAg-containing
sera on tobacco plants . (letter)
Lancet, 4 September 1976, 2, 519 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
- 12 i
Chemical research c9litinued
373 KLIMISCII,
.J . and AMBROSIUS, D . Quantitative determination
of bonz a)pyrene in cigarette smoke condensates by high
press e liquid chromatography . (In German)
Frn nius' Z .Ana1 t .Chem ., 1976, 280(5), 377-80 .
374 `~NGER, E .M ., et al . Free radicals derived from benzo(a)pyrene .
----/ Biochem .Biophys .Res .Comm ., 26 July 1976, 71(2), 610-16 .
375*
IAOREE-TESTA, P . and Do SALLES de HYS, L .
fraction of cigarette smoke and tobacco .
the principal components . Application to
of 2-hydroxy 3-methyl 2-cyclopenten 1-one
Ann .tabac ., Section 1, 1975, 13, 73-9 .
The carbonyl-acid
Identification of
the determination
. (In French)
376*
NEIDLE, S . Polycyclic aromatic carcinogenesis .
Nature, 9 September 1976, 263, 92-4 .
~ ,
377*
VIART, P . and PENVEN-GUILLEAU, R . Phenolic index of tobacco .
(In French)
_A_nn,tab_a_e_:,f Ser_eti_o_n_ lf ]_975~ 7_3y 2_]_-32 .
Biological research
378* Vivisection
. (LQading article) Lancet, 25 September 1976, 2, 667-8 .
379* Transplacental carcinogenesis . (Leading article)
Lancet, 4 September 1976, 2, 506 .
.iD
380* AKIN, F .J ., SNOOK, M .E ., SEVERSON, R .E ., CHAMBERLAIN, W .J .
and WALTERS, D .B . Identification of polynuclear aromatic
hydrocarbons in cigarette smoke and their importance a9
tumorigens .
J .nat .Cancer Inst ., July 1976, 57(1), 191-5 .
Authors' abstract :
Fraction F20, which in other studies was the most tumorigenic
neutral fraction of cigarette smoke condensate (CSC), was
separated by gel filtration chromatography into refined
subfractions for identification of the polynuclear aromatic
hydrocarbons (PAH) and for bioassay on mouse skin . Several
hundred PAH were identified . Subfraction F55, containing
most of the carcinogenic PAH as well as numerous unidentified
.components, was almost as tumorigenic to 7,12-dimethylbenz(a)anthracene (DJtBA)-pretreated female outbred CD~ -mice
as was F20 . When F55 was separated into two parts, the first
containing unidentified material (F55a) and the second
containing the PAH (F55b), neither was significantly
tumorigenic . F55b, combined with two other active fractions
fr9m the neutral and acidic portions of CSC, exhibited a
s nergistic tumorigenic effect on DMBA-pretreated mice .
e results supported the concept that the PAH in cigarette
moke must interact with other components in order to exert ,
a tumorigenic effect .
38 1 BROWN, C .C . Mathematical aspects of dose-response studies
in carcinogenesis - the concept of threshold .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Oncology, 1976, 33(2), 62-5 .
-13 Biological research continued
382* CRUb1P, K .S ., HOEL, D .G ., LANGLEY, C .H : and PETO, R .
Fundamental carcinogenic processes and their implications
for low dose risk assessment .
Cancer Research, September 1976, 36(9), 2973-9 .
1
Authors' summary :
Various possible models of carcinogenesis are analyzed with
respect to low dose kinetics . The importance of background
carcinogenesis upon the shape of the dose-response curve
at low dose is emphasized . It is shown that, if
carcinogenesis by an external agent acts additively with
any already ongoing process, then under almost any model
the response will be linear at low dose . Measures of the
degree of linearity are obtained for multistage models of
carcinogenesis, where it is shown that throughout the dose
range where the extra risk is less than the spontaneous
.0 risk linear extrapolation must be quite accurate .
383* FLESHER, J .W ., HARVEY, R .G . and SYDNOR, K .L . Oncogenicity
of K-region epoxides of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene .
Int .J .Cancer, 15 September 1976, 18(3), 351-3 .
384* GORI, G .B .,,ed . National Cancer Institute . Smoking and
Health Pr ram . Report no .l . Toward less hazardous
ci aret s . The first set of experimental cigarettes .
ation Institutes of Health, DHEW Publication No . (NIH)
76-9
. 148 pages .
385 %, RIS, C . Chemical carcinogenesis and experimental
models using human tissues .
Beitr .Path ., September 1976, 158(4), 389-404 .
386 KALLISTRATOS, G . and FASSKE, E . Prevention of 3,4-benzopyrene carcinogenesis in presence of Putrescine .
Z .Krebsforsch ., 1976, 87(l.), 81-92 .
387 KAUFFMAN, S .L . Autoradiographic study of type II-cell
hyperplasia in lungs of mice chronically exposed to urethane .
Cell Tissue Kinet ., September 1976, 9(5), 489-97 .
388 KENDRICK, J ., et al . Tobacco smoke inhalation studies in
rats .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
.Tox .appl .Pharmacol ., September 1976, 37(3), 557-69 .
Authors' abstract :
The feasibility of using rats in a bioassay for the effects
of fresh tobacco smoke was investigated by a series of acute
and long-term inhalation studies . Female SPF rats were
exposed to 10% smoke from standard test cigarettes on an
intermittent smoke machine . C14C] dotriacontane was used as
label for the smoke particles, and it was calculated that
under the described exposure conditions 0 .3-0 .4 mg of total
particulate matter was retained in the rats from exposure to
the smoke of one cigarette . This is similar to the dose
sustained by hamsters under identical conditions . It was ,~
found that respiratory minute volume is decreased to 25%
W
of normal during smoke exposure . The great sensitivity of ~j
rats to smoke toxicity could be overcome by gradual
adaptation . This made it possible to chronically expose
;
0
~
- 14 T3iological research continued
388 continued
rats to 7 and 10 cigarettes per day with a death rate of
10 and 20%, respectively, at 12 months, and of 18 and 5311,
respectively, at 18 months of exposure . This represents a
far better survival rate at high smoke exposure levels for
rats (or hamsters) than has ever been reported in the
literature . Smoke-induced pathological changes were observed
in the respiratory tract only . These fiicluded mild focal
hyperplasia of the upper airways, bronchiolitis of the
terminal bronchioles, and severe focal alveolitis .
389* LASNITZKI, I . Reversal of methylcholanthrene-induced
changes in mouse prostates in vitro by retinoic acid and
its analogues .
Brit .J .Cancer, September 1976, 34(3), 239-48 .
,
' The influence of vitamin A-related compounds on hyperp]asia
and metapl"ta induced by methylcholanthrene was studied in
mouse progtate glands in organ culture . It is tentatively
sugges~eia that vitamin A and its analogues may act as
horm040s .
390( JfACKENZIE, J .S . The effect of cigarette smoke on influenza
virus infection• a murine model s yste m .
~514t Life Sci ., 1 August 1976, 19(3), 409-12 .
391*
NAGEL, D .L ., STENBACK, F ., CLAYSON, D .B . and WALLCAVE, L .
Intratracheal instillation studies with 7H-dibenzo(c,g)carbazole in the Syrian hamster .
J .nat .Cancer Inst ., July 1976, 57(1), 119-23 .
392*
NAGEL, D ., ;'TOTH, B ., KUPpER, R . and ERICKSON, J .
Trimethylhydrazine hydrochloride as a tumor inducer in
swiss wice .
J .n
.Cancer Inst ., July 1976, 57(1), 187-9 .
393
~,1+cmT, R ., SCHMAHL, D . and WAHRENDORF, J . Some examples
of dose-r~sponse studies in chemical carcinogenesis .
Onc_ _ . ology,/ 1976, 33(2), 66-71 .
394
S~CHMI~IYT~ K .G ., SCHMAHL, D ., MISFELD, J . and TIMM, J .
Exper~4nental studies in syncarcinogenesis . 7 . Syncarc ogenic effects of polycyclic aromatic hydrocarbons
(PAI in epicutaneous tests in mice .
Z .K ebsforsch ., 1976, 87(1), 93-100 .
(In German)
395 ~ NBACK, F . and ROWLAND, J . Carcinogenicity of benzo(a)yrene and dusts in the hamster lung (instilled intratracheally
with titanium oxide, aluminium oxide, carbon and ferric
oxide) .
Oncology, 1976, 33(1), 29-34 .
396*
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WORLD HEALTH ORGANIZATION . INTERNATIONAL AGENCY FOR
RESEARCH ON CANCER . IARC btono a hs on the Evaluation of
Carcinogenic Risk of hem cals to Atan . olume 11 .
Cadmium, nickel, some epoxides, miscellaneous industrial
chemicals, and .general considerations on volatile
anaesthetics .
Lyon, International Agency for Research on Cancer, 1976 .
£8-50 .
15 -
397
•R, B ., t al . Repair-defective mutants of Proteus
irabilis as a prescreening system for the detection of
potent carcinogens .
Biol . 1, July-August 1976, 95(4), 463-9 .
398 `CJ~RK,/A M . Naturally occurring mutagens .
Tiutat on Res ., 1976, 32(3-4), 361-74 .
399 J STON, W .W . and FRABLE, W .J . The cytopathology of the
~. .espir tory tract .
Amer
.Path ., August 1976, 84(2), 372-424 .
400 ~ LIERMAN, G ., et al . Elimination of antipyrine and
benzo(a)pyrene metabolism in cultured human lymphocytes .
Clin .Pharm .Ther ., July 1976, 20(1), 72-80 .
401* KING, H .W .S ., THOMPSON, M .H . and BROOKES, P . The role
of 9-hydroxybenzo(a)pyrene in the microsomal mediated
binding of benzo(a)pyrene to DNA .
Int' .J .Cancer, 15 September 1976, 18(3), 339-44 .
402 LEUCHTENBERGER, C . and LEUCHTENBERGER, R . Cytological
and cytochemical studies of effects of fresh marihuana
cigarett smoke on growth and DNA metabolism of aniinal
and hu n lung cultures .
In P rmacolo of )4arihuana, edited by M .C . Braude and
S . zara . New York, Raven Press, 1976, pp .595-616 .
cDOWELL, E .M ., et al . Abnormal cilia in human bronchial
epithelium . '
Arch .Path ., August 1976, 100(8), 429-36 .
Authors' abstract :
Abnormal cilia are a common occurrence in human bronchial
epithelium . Bronchial specimens were obtained at surgery
or at "immediate autopsy", from patients with neoplastic
and nonneoplastic diseases ; these patients-included
smokers at}d one known nonsmoker . Areas of bronchial
epit/hhell m far removed from the tumor aasses were studied .
Ciliary bnormalities fell into four major categories :
(1) ci a with a single axoneme and exoess cytoplasmic
matri ; (2) compound cilia ; . . (3) intracytoplasmic
micr ubular doublets ; and (4) cilia within periciliary
•she hs .
404* WLT~j , M .L . DNA repair in baboon alveolar macrophages :
~ a s qfitem for assessing biohazardous materials .
En iron .Res ., June 1976, 11(3), 359-66 .
405* NOTTI, A . and PUDDU, V . Death rates among Italian
L railroad employees, with special reference to coronary
I/I( heart disease and physical activity at work .
Environ .Res ., June 1976, 11(3), 331-42 .
NB The above item should have appeared under the heading
Diseases other than lun cancer . Pa rs not im licatin
- smo ing . Sorry :
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Research int cells and tissues continued
409
11 t T i AIJEC de BYANS, B ., et al . Variations in carcinoembryonic
an gen 1ev1
e s
l co
ted
rre ith
a
tobacco
w
consum
p
tion in
normal subjects . (letter)
~~ Biomedicine Express, July 1976, 25(6), 197-8 .
Authors' summary :
The effect of tobacco consumption on CEA levels was studied
in 646 subjects assumed to be normal . It was shown that
the use of tobacco caused an increase in CEA levels in the
hours following tobacco smoking ; this phenomenon was more
marked in subjects who inhaled the smoke . This parameter
must be taken into account when collecting samples for
the assay of CEA .
407* OSBORNE „M .R ., BELAND, F .A ., HARVEY, R .G . and BROOKES, P .
The re~tion of (+)-7 alpha, 8 beta-dihydroxy-9 beta,
10 be -enoxv-7 .8 9 .10-tetrahvdrobenzo(a)pyrene with DNA
• Intrd .Cancer, 15 September 1976, 18(3), 362-8 .
408, PECPADOPULU, G . and SCHMIDT-RUPPIN, K .H . Methodological
study on examination of primary tumors of the respiratory
tract "in toto" and histologically .
Oncology, 1976, 33(1), 40-3 .
409* RAHA, C .R ., GALLAGHER, C .H ., SHUBIK, P . and PERATT, S .
Covalent binding to protein of the K-region oxide of
benzo(a)pyrene formed by microsome incubation .
J .nat .Can F Inst ., July 1976, 57(1), 33-8 .
410*
RJC
RT, W .S . and FORBES, W .F . Changes in collagen with
age - VI . Age and smoking related changes in human lung
connective tissue .
Exp .Gerontol ., 1976, 11, 89-101 .
Authors' abstract :
Samples of human lung connective tissue obtained at autopsy
from 44 individuals (21 smokers with smoking histories and
23 non-smokers) w-ere extracted to obtain the acid-soluble
and guanidine-soluble fractions . A collagen ratio
(acid-insoluble over acid-soluble) and a stability ratio
(guanidine-insoluble over acid-soluble) were obtained and
these ratios showed changes that could be associated with
both aging and tobacco smoke exposure . Moreover, a paired
comparison of the collagen contents of smokers' and
-nonsmokers' lungs indicated that smokers' lungs contained
sign ficantly more collagen ;
411* , RTS, G .P . The role of disulfide bonds in maintaining
the gel structure of bronchial mucus .
Arch .Biochem .Biophys ., 1976, 173, 528-37 .
The author acknowledges the support of T .R .C .
412 SHAPIRO, B .J ., et al . Sputum cytology following subacute
.marihuana smoking in healthy males .
In Pharmacology of Marihuana, edited by M .C . Braude and
S . Szara . New York, Raven Press, 1976, pp .685-8 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Research 1 o cells and tissues continued
413 T IKATA, C ., et al . Abnormal cilia in the bronchial mucosa .
~ ~U~ ase reports of non-smo k ing women with bronchogenic
„~' carcinomas and an experimental model in guinea-pigs .
~~ Virchow rch .A . Path .Anat .Histol ., 1976, 371(2), 121-9 .
414 , V L, E . and SOBELS, F .H . Mutagenicity testing with
rosophila as system for the detection of potential
carcinogens . (In German)
Biol .Zbl ., July-August 1976, 95(4), 405-13 .
415* WISLOCKI, P .G ., et al . Mutagenicity and cytotoxicity of
benzo(a)pyrene, arene oxides, phenols, quinones, and
dihydrodiols in bacterial and mammalian cells .
Cancer Research, September 1976, 36(9), 3350-7 .
,416* WOOD, A .W . Mutagenicity and cytotoxicity of benzo(a)pyrene
' benzo-ring epoxides .
Cancer Research, September 1976, 36(9), 3358-66 .
417, xFALK, H .L .i Possible mechanism of combination effects in
`- ch emica l
rc i nogenes i s .
Oncolo , 1976, 33(2), 77-85 .
418 O YE, A .C . Cancer in humans : exposures and responses
in a real world .
Oncology, 1976, 33(2), 90-100 .
419, "1AHL, D . Combination effects 1n chemical carcinogenesis .
(Experimental results) .
Oncology, 1976, 33(2), 73-6 .
Physiological research . Pharmacology
see also item 370
420 ASHTON, H ., MILLMAN, J .E ., TELFORD, R . and THOMPSON, J .W .
A comparison of some physiological and psychological effects
of proprapolol and diazepam in normal subjects .
Brit .J .clin,4'harmacol ., August 1976, 3(4), 551-9 .
EVANS, J-N . and JAEGER, lt . J . Uneven
tion in smokers .
Res
.Ph siol ., September 1976, 27(3), 277-91 .
422 ODE,
.R ., et al . Age and sex differences in lung
city, and in closing capacity in nonsmokers .
J .a 1 .Physiol ., August 1976, 41(2), 129-35 .
423*,OLLEY, J .R .T ., HOLLAND, W .W ., LEEDER, S .R . and CORKHILL, R .T .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Respiratory function of infants in relation to subsequent
respiratory disease : an epidemiological study .
Bull .euro .Ph sio ath .res ., September-October 1976, 12(5),
651-7 .
Ln
0
W
r
v
m
O.
r
r
Physiological research . Pharmacology continued
424* DOSMAN, J ., et al . The relationship between symptoms and
functional abnormalities in clinically healthy cigarette
smokers .
Amer .Rev .resp .Dis ., August 1976, 114(2), 297-304 .
Authors' summary :
Because a number of "early tests" may now be used to measure
abnormalities of lung function in cigarette smokers with
normal airflow rates, we evaluated the symptoms of cough,
sputum, wheezing, and shortness of breath in 60 nonsmokers
and 49 smokers to determine whether these symptoms correlated
with measurements of lung function that are believed to be
altered by mild obstruction . One or more symptoms were
present in 5 per cent of the nonsmokers and 90 per cent of
the smokers . Individual symptoms, sums of symptoms (symptoms
score), and various combinations of symptoms correlated
I . poorly or not at all to measured values for dynamic lung
compliance, closing volume, closing capacity, slope of
Phse III, and helium flow-volume curves .' The symptoms score
correlated negatively (PC •0 .05) with forced maximal
expiratory flow at 50 per cent of vital capacity . Inasmuch
as the serious consequences of chronic airway obstruction
are related to abnormalities of lung function, it is likely
that func ,ion tests will prove more useful than symptoms
to reve smokers at risk to develop chronic obstructive
pulmon y disease . Symptoms cannot be used to detect
smok s who are liable to have functional abnormalities
sug stive of mild peripheral airway obstruction .
4251~, RGUSON, B .B ., WILSON, D .J . and SCHAFFNER, W . Determination
of nicotine concentrations in human .milk .
Amer .J .dis .Childr ., August 1976, 130(8), 837-9 .
Authors' abstract :
A total of 34 samples of human milk from 15 donors were
analyzed for nicotine content, using a new method of sample
preparation and subsequent quantification by gas chromatography . Nicotine was not found in the six samples of
milk from non-smokers . The 28 samples from smokers contained
an average of 91 parts per billion (ppb) nicotine (ranging
from e20 ppb to 512 ppb) . While no adverse effects to
the infant due to nicotine in human milk have been
documented, this method of analysis will allow systematic
monitorin$ .•of nicotine concentrations in the milk of
lactatii)g women . These results should not be used to deter
breast+,feeding ; rather, they offer another reason for
moth ~s ~to reduce or cease smoking .
426
, F ST, A . and WILCOX, K . Comparison of two anesthetics
i or heir effects on the'clearance rate of benzo(a)pyrene
mouse lungs .
Voc .West .Pharmacol .Soc ., 1976,
19, 32-5 .
427 / GIBSON, G .F ., PRIDE, N .B ., O'CAIN, C . and QUAGLIATO, R .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Sex and age differences in pulmonary mechanics in normal
nonsmoking subjects .
J :appl .Physiol ., July 1976, 41(1), 20-5 .
- 19 Physiol (gical research . Pharmacology continued
428 9OK, E .B . Changes in tobacco smoking and ingestion of
lcohol and caffeinated beverages during early pregnancy arv these consequences, in part, of feto-protective
mechanisms diminishing maternal exposure to embryotoxins .
In Birth defects : risks and consequences, edited by
S . Kelly, et al . New York, Academic Press, 1976, pages 173-84 .
429* NEWCOMBE, R .G . Cigarette smoking in pregnancy . (letter)
Brit .med .J ., 25 September 1976, 2, 755 .
lir . Newcombe says that the leading article on 28 August,
draws attention again to the hazards of smoking in pregnancy,
but one aspect which has not hitherto been evaluated is
the changing composition of cigarettes in time . He goes on
to quote figures from the Cardiff Births Survey concerning
the smoking habits of patients between 1965 and 1974 .
', Data giving average weight of tobacco smoked and average
tar and nicotine yields for cigarettes sold in Britain for
each of the 10 years 1965-74 were made available by
1dr . .G .F . Todd . A table has been derived from the two•sets
of data . Mr . Newcombe concludes : "Among women who smoked
throughout'pregnancy, the mean number of cigarettes smoked
daily has%increased, weight of tobacco consumed has risen
slightly but tar and nicotine intakes have fallen .
However, over the same period the excess risk of perinatal
loss
r smokers has increased and the birth-weight deficit
has
sta
creased, but neither of these trends reaches
stical,significance . Perhaps outcome is more closely
re ted to :carbon monoxide or cyanide intake, for which
n i nfor 'tion was available ."
~
430 1~CKHA~4, C . and PEARSON, R . Preliminary findings at ' the
age o
16 years on children in the National Child Development
Stu
(1958 cohort) .
Pu
.Hlth (Lond .), September 1976, 90(6), 271-80 .
431 1 SH, D . Cigarette smoking during pregnancy ; -relationship
with depressed weight gain and birthweight . Updated report .
In Birth defects : risks and conse uences, edited by
S . elly, et al . New York, Academic Press, 1976, pp .161-72 .
432 TASHKIN, D .P ., et al . Chronic effects of heavy marihuana
smoking on pulmonary function in healthy young males .
•In Pharmacology of Marihuana, edited by M .C . Braude and
S . Szara . New York, Raven Press, 1976, pp .291-8 .
433 TESTA, B ., JENNER, P ., BECKETT, A .H . and GORROD, J .W .
A reappraisal of the stereoselective metabolism of nicotine
to nicotine-1'-N-oxide .
Renobiotica, September 1976,
6(9), 553-6 .
434
TROJNAR, R . Effect of tobacco smoking on the adrenergic
system and serotonin metabolism . (In Polish)
Pol .Tyg .Lek ., 1976, 31(11), 459-61 .
435
TROJNAR, R . Adrenergic system and serotonin metabolism 0
w
~
in cigarette smokers . (In Polish)
Pol .Tyg .Lek ., 1976, 31(12), 473-6 .
J
a
P
436
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
TRUITT, E .B ., et al .
Behavioral activity in various
fractions of marihuana smoke con-lensate irn rat .
In Pf~armacology of Marihuana, edited by M .C . Braude and
S . Szara . New York, Raven Press . 1976, pp .463-74 .
w
Psychologi al and psychosomatic research
43?, AVRS, J ., RUFF, C .F . aneTEMPLER, D .I . Alcoholism,
igarette smoking, coffee drinking and extraversion .
J .Stud .Alcohol, July 1976, 37(7), 983-5 .
Authors' summary :
Alcoholic patients smoked significantly more cigarettes
and drank more cups of coffee than nonalcoholic psychiatric
patients even when the higher extraversion scores of the
alcoh9lics, as measured by the Eysenck Personality Inventory,
werg/statistically controlled .
438 KQi`LLOWSKI, L .T . and HARFORD, rf .R . On the significance of
u~/ ~~/:fever using a drug : an example from cigarette smoking .
-1
J .abnorm .Psychol ., August 1976, 85(4), 433-4 .
Authors' abstract :
,
Nonusers of a drug who have never once tried the dru g are
' usually treated by researchers in the same way as nonusers
who have had some experience with the drug . The nonuser
groups are, however, significantly different . The former
group has not had the chance to have the effects of taking
the drug act as a motivation for or against the drug use,
whereas the latter has had this opportunity . The discussion
of this problem uses examples from research on cigarette
smoking .
439 RIME,
. and BONAIII, M . Goal-setting behaviour and
coro ry heart disease .
Bri .J .soc .clin .Ps chol ., September 1976, 15(3), 287-93 .
Statist s (general)
440, AOWN, K .S . and FORBES, W .F . Concerning the estimation of
biological age .
Gerontology, 1976, 22(6), 428-37 .
441 DUBOIS, G . Comparison of relative risks computed from
prevalence and incidence studies . (letter)
Amer .J .Epid ., August 1976, 104(2), 222-3 .
Comments on the paper by Beaglehole (Check List 32/209)
442* VETTA, A . Correction to Fisher's correlations between
relatives and environmental effects .
Nature, 23 September 1976, 263, 316-7 .
Cancer statistics
443
CHAMBERS, L .W ., et al . Underreporting of cancer in medical
surveys : a source of systematic error in cancer research .
Amer .J .Epid ., August 1976, 104(2), 141-5 .
o
444*
METROPOLITAN LIFE . Recent trends in mortality from cancer .
w
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Stat .Bull ., June 1976, 57, 6-8 .
~
m
'!Recent mortality figures show some changes in death rates ~
from cancer of various sites . Between 1963-64 and 1973-74, ~
mortality from cancer of the respiratory system among
white males in the general population increased by more than
a third while that among insured males increased by 10 per cent .
There has been a substantial rise, however, in the mortality
1
-
21
-
Cancer statistics continued
444* continued
froip respiratory cancer among women . Death rates from
cancer of this site doubled during the period under review,
rising from 6 .2 to 12 .4 among white women in the general
population and from 6 .1 to 13 .0 per 100,000 among insured
women . As a consequence, the differential between the
sexes has diminished significantly . Ten years ago the
male-female ratio was about six to one for both the general
population and the insured population ; in the later period
the ratio narrowed to four to one in the general population
and to three to one among the insured group ."
445 SCHMAZjZ/R . and HOLM-HADULL4, M . Cancer mortality in
WUrt bmberg, 1910 and 1970 . (In German)
Z . ebsforsch ., 1976, 87(1), 101-13 .
,
446*)/WEST, R .R . Accuracy of cancer registration .
Brit .J .prev .soc .Med ., September 1976, 30(3), 187-92 .
447 ZAJICEK, G . On the age specific incidence and death rates
of carcinomata .
J .chron .Dis ., September 1976, 29(p), 549-55 .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
Author's abstract :
Cancer age specific incidence and death rates of the U .S .
population between 30-55 yr of age were approximated log
linearly . This approximation is excellent in all
carcinoma rates and only partially adequate in nonepithelial
cancer rates . The present study focuses upon the rate of
change of both rates with respect to age, known as Gompertz
coefficient k . In male carcinoma death rate curves
k(mortality)-0 .158+0 .009(S .E .) . In male carcinoma incidence
rate curves k(incidence)-0 .142+0 .01 . k's narrow variation
implies that 95 .5% of all carcinomata exhibits a k(mortality)
in the range of 0 .140-0 .174 . In view of such a narrow
variation it is postulated that at the age of 30 yr age
specific death rate curves of all carcinomata share the
same Gompertz coefficient . The same holds for age specific
incidenee rate curves . Both coefficients differ slightly .
U
0
W
r
v
O
~
.r
V
- 22 -
I
Author index
342
Danaher, B .G .
329
Davis, R .E .
367
Ashton, H .
Ator, N .A .
Ayers, J .
397
380
326
341
373
342
343
348
420
357
437
Badre, R .
370
Baker, P .G .
371
, Banerjee, M .
Bdric, L .
421
Erickson, J .
392
Evans, J .N .
421
Bartsch, H .
310
361
Bayer, E .
Beachler, D .W .
Beckett, A .H .
321
365
433
Falk, H .L .
417
Fardy, P .S .
330
Fasske, E .
386
Beland, F .A .
Bernard, J .G .
407
311
Ferguson, B .B .
Fine, L .J .
425
350
Berry, G .
323
Fischer, T .
309
Berry, R .E .
Biersteker, K .
Bignon, J .
Bjartveit, K .
344
358
345
312
Fishbein, L .
360
Flesher, J .W .
Forbes, W .F .
383
410
Blumenson, L .E .
299
Frable, W .J .
399
Bode, F .R .
Bonami, M .
422
439
Furst, A .
426
Bourcier, F .
368
Boyer, G .
Brinton, L .A .
Brookes, P .
311
346
401
407
Gallagher, C .H .
Gangawane, L .V .
Gibson, G .F .
Gliner, J .A .
Gordon, T .
409
372
427
364
334
Brown, A .L .
359
Gori, G .B .
384
Brown, C .C .
Brown, K .S .
Burch, P .R .J .
Burgess, W .A .
381
440
319
350
Gorrod, J .W .
Grandjean, E .
Guillerm, R .
433
309
314
Cavalieri, E .
Chamberlain, W .J .
Chambers, L .W .
Clark, A .ld .
Clarke, J .M .
366
380
443
398
327
Hampton, J .R .
332
Handy, B .M .
371
Harford, M .R .
Harris, C .
438
385
Harris, J .R .W .
331
Clayson, D .B .
391
Harvey, R .G .
383
Cole, P .V .
Colley, J .R .T .
Corkhill, R .T .
331
423
423
Harvey, W .R .
Hawkins, L .H .
371
331
Hayes, M .J .
332
Health & Welfare
Canada
Hecker, E .
315
300
382
423
Adelstein, A .M .
Adler, B .
Akin, F .J .
Albertii,i, D .
Allegra, J .
Ambrosius, D .
Armstrong, B .
Aromaa, A .
Asal, N .R .
Cornfield, J .
304
Coronary Drug Project
Research Group
347
334
Dawbor, T .R .
De Salles de Hys,L . 375
368
Devreux, M .
369
320
DeWys, W .
Di Berardinis, L .J . 350
349
Dienstl, F .
•
Donovan, J .W .
342
Dosman, J .
Droese, M .
Dubois, G .
Dumas, C .
424
321
441
370
440
370
407
Crump, K .S .
-Cryer, P :E .
382
328
Cucchiara, A .J .
348
Hoel, D .G .
Holland, W .W .
Czyzyk, A .
313
Holm-Hadulla, M .
445
Hook, E .B .
Horn, D .
Hunter, R .B .
428
301
302
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
- 23 316
Papadopulu, G .
Jaeger, M .J .
421
Jarrett, C .G .
303
433
317
Pearson, R .
430
Peckham, C .
430
Penvon-Guilleau, R . 377
Isacsson, S .O .
Jennor, P .
Johnstor., L .
Johnston, W .W .
Julian, J .G .
Peratt, S .
Pirc, B .
386
Kauffman, S .L .
Kelkar, S .S .
Kendrick, J .
Khogali, M .
King, H .W .S .
Klimisch, H .J .
387
Kolbye, A .C .
418
334
438
313
304
392
I Kozarevic , D .
Kozlowski, L .T .
Krolewski, A .S .
Kullback, S .
Kupper, R .
409
350
Peters, J .M .
382
Peto, R .
Piper, A .
307
399
333
Kallistratos, G .
334
362
Piscator, M .
393
Port, R .
372
388
351
Powledge, T .
353
401
373
Pritchard, J .A .V . 354
Puddu, V .
405
Preussmann, R .
Pride, N .B .
Lasnitzki, I .
Lea, A .J .
Quagliato, R .
Racic, Z .
. .
. -':: 1 .
.
. .
._
.
. . .
.
.
. . . .
.
427
334
Radziszewski, E .
Raha, C .R .
•
314
409
364
Reid, L .
339
Rickert, W .S . 410
Rime, B .
439
Roberts, G .P .
411
335
Robkin, M .A .
365
Leuchtenberger, R .
402
402
Roger, V .
Roth, R .
Lilienfeld, A .M .
352
Rowland, J .
Lichtenstein, E .
329
MacArthur, C .
McDowell, E .M .
310
403
437
Ruff, C .F .
431
Rush, D .
Ruttle, S .
342
McIntire, R .W .
Mackenzie, J .S .
Meltz, M .L .
Menger, E .M .
Menotti, A .
Meriadec de Byans,B .
Merigan, W .H .
Metropolitan Life
Millman, J .E .
Misfeld, J .
Moilanen, P .
Montesano, R .
Moree-Testa, P .
Morris, G .K .
Mulvihill, J .J .
357
390
404
374
405
406
357
444
420
394
305
361
375
332
322
Nagel, D .L .
391
392
Neidle, S .
Newcombe, R .G .
Newhouse , M . L .
Noonan, G .
376
429
323
O'Cain, C .
Osborne, M .R .
427
407
Leeder, S .R .
Lekkowitz, R .J .
Leuchtenberger, C .
. .-., . . . . . . . . . . :~;:
382
389
342
423
363
427
Raven, P .B .
Langley, C .H .
408
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
306
324
366
395
Sainini, G .S . 355
Salhadin, A .
325
Schaffner, W . 425
Schmahl, D .
393
394
419
Schmauz, R .
445
Schmidt, K .G . 394
Schmidt-Ruppin, K .H .408
Severson, R .E . 380
Shapiro, B .J . 412
Shepard, T .H . 365
310
Sherwood, M .
409
Shubik, P .
308
Siegel, R .K .
380
Snook, M .E .
Sobels, F .H .
414
Stenback, F .
391
Sullivan, J .M . 320
Sutton, J .C . 364
Sydnor, K .L .
383
- 24 -
.01
I
Tashkin, D .P .
Telford, R .
Templer, D .I .
432
420
437
Testa, B .
Thelle, D .S .
433
336
Thompson, J .W .
Thompson, 11 . 11 .
420
401
Timm, J .
394
Torikata, C .
Toth, B .
Trojnar, R .
413
392
434
435
Truitt, E .B .
Turner, J .A .bicM .
Turner, R .W .D .
436
318
356
Vetta, A .
Viart, P .
442
377
Wdgel, E .
414
Wahrendorf, J .
Walczak, Z .
393
337
Wallcave, L .
Walters, D .B .
391
380
Weber-Tschopp, A .
West, R .R .
309
446
White, G .C .
342
Wilcox, K .
426
Wilson, D .J .
425
Wislocki, P .G .
415
Wood, A .W .
416
World Health Organization
International Agency
for Research on
Cancer
Zajicek, G .
Zukel, W .J .
http://legacy.library.ucsf.edu/tid/hnf68d00/pdf
396
447
334