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JAMA
The Journal of the American Medical Association
105 Years of Continuous Publication
George D. Lundberg, MD
Deputy Editor (West): Drummond Renme, MD
Senior Edltors: Helene M. Cole, MD, Don Riesenberg, MD
Senior Contributing Editors: Bruce B. Dan, MD, M. Thérèse
Southgate, MD
Contributing Editors: Charles B. dayman, MD, David S.
Cooper, MD, Lester S. King, MD, Harriet S. Meyer, MD, Jody W.
Zylke, MD
Consulting Editors: Roger C. Bone, MD, Richard M. Glass, MD
Editor:
Statistical Editor: Naomi Vaisrub, PhD
Morris Fishbein Fellow: Carin M. Olson, MD
Assistant to the Editor: Annette Flanagin
Medical News— Editor: Phil Gunby; Associate Editors: Marsha
F. Goldsmith, Charles Marwick (Washington, DC). Beverly Merz
Associate Editors: Charlene Breedlove, Roxanne K. Young
Editorial Services Manager: Elaine Williams
Production Manager: Marlene M. Hinsch
Assistant Production Managers: John R. Sayban, Mary C.
Steermann
Editorial Processing Manager: Cheryl Iverson
Assistant Editorial Processing Manager: Paula Glitman
Permissions and
Graphic Design Manager: Dennis J. Shipley
Staff Assistants: Diane Darnell, Bonnie Van eleven
Production Supervisors: Lori A. Barba (Copy Editing), Thomas
Handrigan (Illustrations), John R. Sayban (Advertising), JoAnne
Weiskopf (Layout)
Copy Editing: Vickey Golden (Free-lance Coordinator), Paul
Frank (Senior Copy Editor), Lisa Cluver, Daniel Halibey, Jerri
Schwartz, Jennifer Sperry, Melissa Ulloa
Proofreading: Teresa H. Omiotek, Richard T Porter, Jennifer
Reiling, Barbara Wojtowicz
Original Contributions
Allelic Loss in Colorectal Carcinoma .3099
S. E, Kern, E. R. Fearon, K. W. F Tersmette, J. P. Enterline, Baltimore, Md;
M. Leppert, Y. Nakamura, R. White, Salt Lake City, Utah;
B. Vogelstein, S. R. Hamilton, Baltimore, Md
Serum Immunoreactive Erythropoietin
in HIV-lnfected Patients.3104
J. L.
Spivak, D. C. Barnes, E. Fuchs, T. C. Quinn, Baltimore, Md
Presymptomatic Diagnosis of Delayed-Onset Disease
With Linked DNA Markers.3108
J. Brandt, K. A. Quaid, S. E. Folstein, P. Garber, N. E. Maestri, M. H. Abbott,
P. R. Slavney, M. L. Franz, L. Kasch, H. H. Kazazian, Jr, Baltimore, Md
Knowledge, Attitudes, and Reported Practices of
Medical Students and House Staff Regarding the
Diagnosis and Treatment of Alcoholism.3115
G. Geller, D. M. Levine, J. A. Mamon, R. D. Moore, L. R, Bone, E. J. Stokes, Baltimore, Md
Unique Aspects of Heart and Lung Transplantation
Exhibited in the 'Domino-Donor' Operation .3121
Baumgartner, T. A. Traill, D. E. Cameron, J. D.
I. B. Birenbaum, B. A. Reitz, Baltimore, Md
W. A.
Fonger,
J.
Production Associate: Susan Price
Senior Production Assistants: Melinda Arcabos, Laura Blei 1er,
Karen Branham, Cynthia Gelper, Jerri Hall-Gortowski. Anita
Henderson, Debra Lucas, Dorothy Patterson, E. Ruth White, Ellen
Yoshihara
Production Assistant: Darlene E. Filips
Illustrations and Layout: Can Biamonte, Juliana K. Mills
Cover Editor: M. Thérèse Southgate, MD
Editorial Coordinator: Lenette Williams
Editorial Supervisors: Cassandra Johnson, Steve Sarang, Gale
State of the Art/Review
Drug and Neurotransmitter Receptors.3126
S. H.
The Molecular Biology of Medullary Thyroid Carcinoma.3130
B. D. Nelkin, A. C. de Bustros, M. Mabry, S. B.
White, Helga Wutz
Electronic Input Specialist: Vee Bailey
Scientific and Socioeconomlc Indexing Department: Norman
Frankel (Director), George Kruto, Susan McClelland, Mary Kay
Tinerella
Baylin, Baltimore, Md
Special Communication
A Model of Its Kind.3136
Harvey, G. H. Brieger, S. L Abrams, V. A. McKusick, Baltimore, Md
A. M.
Saulsberry
Administrative Assistant: Michèle Bacuros
Editorial Assistants: Mary Cannon, Kemberly Evans, Shirley
Goines, Sharon Iverson, Mary Ann Lilly, Ethel Pinkston, Dorothy
Snyder, Baltimore, Md
Concepts in Emergency and Critical Care
Current Concepts in Brain Resuscitation .3143
M. C.
Rogers, J. R. Kirsch, Baltimore, Md
Topics in Radiology/Diagnostic Radiology
published, including editorials, letters, and book
reviews, represent the opinions of the authors and do not reflect
the official policy of the American Medical Association or the
institution with which the author is affiliated, unless this is clearly
specified.
Evaluation and Percutaneous Management of
Atherosclerotic Peripheral Vascular Disease.3148
JAMA, The Journal of the American Medical Association
In
All articles
D. M. Widlus, F. A. Osterman, Jr, Baltimore, Md
(ISSN 0098-7484). is published four issues per month by the
American Medical Association, 535 N Dearborn St, Chicago, IL
60610. Phone (312) 645-5000. Cable address "Medic" Chicago.
SUBSCRIPTION RATES—The subscription rate per year for
members of the AMA is $2 included in the annual membership
dues. The subscription rate per year for nonmembers is $66 for
1 year, $117 for 2 years in the United States and US possessions;
in all other countries, 1 year, $83; 2 years, $151 (add $35
surcharge to each 1 -year subscription and $70 surcharge to each
2-year subscription for air delivery available to most countries).
Rates to US medical students and residents, $33 for 1 year,
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Rates for subscriptions for delivery to Japan or South Korea are
available through respective exclusive agents. Address all sub¬
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60610. Phone: (312) 280-7168.
CHANGE OF ADDRESS-POSTMASTER, send all address
changes to JAMA, The Journal of the American Medical Associ¬
ation, attention: Subscription Department, 535 N Dearborn St,
Chicago, IL 60610. Notification of address change must be made
at least 6 weeks in advance; include both old and new addresses,
a recent mailing label, and your new zip code.
Second-class postage paid at Chicago and additional mailing
office.
JAMA® Registered in the US Patent and Trademark Office.
Copyright © 1989 by the
Wrda
»• "
American Medical Association
Retrospect
Forty Years of Medical Genetics.3155
V. A. McKusick,
Baltimore, Md
Grand Rounds at The Johns Hopkins Hospital
Blastomycosis.3159
P. A.
Murphy, Baltimore, Md
Editorials
.
The Synergistic Triangle.3163
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R. S. Ross, Baltimore, Md
Medical Grand Rounds at Hopkins.3164
The Cover.3060
John Singer Sargent, The Four Doctors
M. T.
Southgate, Chicago, III
JAMA
The Journal of the American Medical Association
Medical News & Perspectives
.
.3067
Hopkins Celebration This Month Prefaced by Science Writer Seminar... Evidence of New Physical,
Genetic, Links In Autism
Seeking Scientific
Paleontologist Offers Lessons From Other Eons
Acceptance of In Vitro Tests
Exploring
Promising Drug Combination For Sickle Cell Anemia
Pieces
Insulin
Puzzle
Causes of Paralysis In Spina BlfIda
Add
to
Investigators
Studying
...
...
...
...
...
Color Blindness and Other Visions
...
...
Information Accumulating on How Brain 'Hears'
Questions and Answers.3081
Diarrhea Associated With Nonsteroldal Anti-Inflammatory Drugs MC
Hochberg
Cholesterol Elevation in the Elderly S Margolis
Potency of Expired Ophthalmologic Preparations IM. Leopold
Abstracts.3086
...
.
.3166
By William Osier, MD
.3169
Organizations of Medical Interest, January 13; State Associations and
Examinations and Llcensure, January 20; Meetings Outside the United States, January 27;
AMA Officials, April 7
Obituaries.3174
C. P. Richter, by P. R.
Books
McHugti; J. C. Eggleston, by R. H. Heptinstall
.3176
Hopkins
(Harvey, Brieger, Abrams, McKusick) Reviewed byD. C. Smith
A Model of Its Kind, vol 2: A Pictorial History of Medicine at Johns Hopkins
(Harvey, Brieger, Abrams, McKusick) Reviewed by D. C. Smith
The Principles and Practice of Medicine (Harvey, Johns, McKusick, Owens, Ross, eds)
Reviewed by F. D. Gray, Jr
Mendelian Inheritance in Man (McKusick) Reviewed by A. G. Motulsky
Living With Radiation (Wagner, Ketchum) Reviewed by R. Wilson
Reasoning In Medicine (Albert, Munson, Resnik) Reviewed by K. Patrick
A Model of Its Kind, vol 1 : A Centennial History of Medicine at Johns
Medical Decision Making (Sox, Blatt,
•,
INTERNATIONAL ADVISORY COMMITTEE
Reference Directories
US Meetings
«
Harold G. Jacobson, MD, Bronx, NY
Robert J. Joynt, MD, PhD, Rochester, NY
Mark S. Litwin, MD, Boston, Mass
Gordon K. MacLeod, MD, Pittsburgh, Pa
Daniel J. McCarty, MD, Milwaukee, Wis
William W. McLendon, MD, Chapel Hill, NC
Arno G. Motulsky, MD, Seattle, Wash
Claude H. Organ, Jr, MD, Oakland, Calif
Edmund D. Pellegrino, MD, Washington, DC
Robert E. Rakel, MD, Houston, Tex
Thomas P. Stossel, MD, Boston, Mass
3098
JAMA 100 Years Ago
License to Practice
Kenneth A. Arndt, MD, Boston, Mass
Byron J. Bailey, MD, Galveston, Tex
Robert J. Blendon, ScD, Boston, Mass
James E. Dalen, MD, Tucson, Ariz
Lois DeBakey, PhD, Houston, Tex
R. Gordon Douglas, Jr, MD, New York, NY
William H. Foege, MD, Atlanta, Ga
Renée C Fox, PhD, Philadelphia, Pa
Daniel X. Freedman, MD, Los Angeles, Calif
Vincent A. Fulginltl, MD, New Orleans, La
Morton F. Goldberg, MD, Chicago, III
Marilyn Heins, MD, Tucson, Ariz
King K. Holmes, MD, PhD, Seattle, Wash
Traumatic Injury of the Brachial Plexus: Should Radiotherapy Be Postponed? D.-J. Lee, D. Mattox
The Exchange
EDITORIAL BOARD
Higgins) Reviewed by K. Patrick
Books Received
Prof Luigl Allegra, JAMA-ltaly
Dr Michèle Deker, JAMA-France
Yulchlro Goto, MD JAMA-Japan
Dr J. K. Jain, JAMA-lndia
Prof Dr Mod Max Just, JAMA-Switzerland
Prof Dr Ivan Lambió, JAMA-Yugoslavia
Yong Kak Lee, MD, FACS JAMA-South Korea
Dr Mehmet Pekus, JAMA-Turkey
4
Prof David Todd, JAMA-Southeast Asia
Dr Zhang Hongkai, JAMA-Peoples Republic of China
Dr Pierre-Francois Unger, JAMA-Switzerland
AMA Officers
President: James E. Davis, MD*
President-Elect: Alan R. Nelson, MD"
Immediate Past President: William S. Hotchkiss, MD
Secretary-Treasurer: George L. Collins, Jr, MD*
Speaker, House of Delegates: John L. Clowe, MD
Vice-Speaker, House of Delegates: Daniel H. Johnson, Jr, MD
AMA Trustees
Timothy E. Baldwin, MD (Resident); Lonnie R. Bristow, MD; Rufus
K. Broadaway. MD; George L. Collins, Jr, MD* (Secretary); John
H. Dawson, MD; Ray W. Gifford, Jr, MD; Robert E. McAfee, MD*;
Joseph T Painter, MD* (Vice-Chairman); Rebecca J. Patchin
(Student); John J. Ring, MD* (Chairman); Raymond Scalettar,
MD; Jerald R. Schenken, MD*; C. John Tupper, MD; Frank B.
Walker, MD
"Executive Committee
Executive Vice President: James H. Sammons, MD
Senior Deputy Executive Vice President: James S. Todd, MD
Deputy Executive Vice President: Kenneth E. Monroe
Assistant Executive Vice President: Theodore R. Chilcoat, Jr
Assistant Executive Vice President: M. Roy Schwarz, MD
Vice President, Publishing: John T Baker
Vice President, Scientific Information: George D. Lundberg,
MD
Director, Publication Production and Printing Division:
Richey
Director, Advertising Sales and Promotion Services Division:
Dennis Joseph Dennehy
Director, Circulation-Fulfillment Division: Lee A. Parent
Director, Advertising Communications: Thomas J. Carroll
Director, Advertising Services: Raymond Christian
Norman D.
Osleriana.3182
Classified Advertising.3185
CME Corner.3198
ADVERTISING OFFICES: Eastern: 600 Third Ave, Suite 700,
New York, NY 10016 (Manager: Robert C. Corcoran [212-
867-6640]; Representatives: Alice Harvey-Herman, Cliff Vanderhoof; Midwest/Farwest: 535 N Dearborn St, Chicago, IL 60610
Index to Advertisers.3198
(Manager: Thomas J. Carroll [312-280-7162]; Representative:
Daniel T Mjölsness); Classified Advertising: Leah Wnukowski
(312-280-7190)
JAMA Journal Club Reading Assignments.3198
ADVERTISING PRINCIPLES-Advertisements in this issue have
been reviewed to comply with the principles governing advertis¬
ing in AMA publications.
on
Instructions for Authors.seeMayi2,i989,P262i.
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A copy of these
principles
is available
request. The appearance of advertising in AMA publications
is not an AMA
guarantee or endorsement of the product
product by the manufacturer.
claims made for the
or
the