1. No category

B J C British Journal of Cancer
VOLUME 77 SUPPLEMENT 1 1998
INTERNATIONAL SYMPOSIUM ON METASTASES IN HEAD AND NECK CANCER
15-18 JANUARY 1998 , KIEL , GERMANY
Contents
Experimental oncology
Diagnosis of metastases
Neck dissection
Miscellaneous
Carcinoma of unknown primary
Malignant melanoma
Prognostic factors
Advanced neck metastases, Recurrences
Hyperthermia, Radiotherapy
Radiochemotherapy
Complications of neck dissection
Distant metastases
Immunology, Gene therapy
Pain therapy, Treatment of lymphoedema,
Psychological aspects of cancer patients
Tumour markers, Virus, Neck dissection,
Miscellaneous (Posters)
Author index
Abstract Nos
1.1-1.45
2.1-2.8
3.1-3.16
4.1-4.29
5.1-5.7
6.1-6.6
7.1-7.12
8.1-8.5
9.3-9.4
10.2-10.3
11.1-11.6
12.1-12.9
13.1-13.5
14.1-14.12
15.1-15.18
16.1-16.7
Page Nos
17.1-17.32
1-11
12-17
18-24
25-26
27-28
29-31
32-33
34
35-36
37-39
40-41
42-44
45-47
48-49
50-57
59-60
VOLUME 77 NUMBER 2 JANUARY 1998
EXPERIMENTAL ONCOLOGY
Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor
in breast cancer cells
Z Chen, A Ko, J Yang and VC Jordan
All-trans retinoic acid (ATRA)-Induced apoptosis is preceded by G, arrest in human MCF-7
breast cancer cells
R Mangiarotti, M Danova, R Alberici and C Pellicciari
Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of
the uterine cervix
AMF Kersernaekers, J Hermans, GJ Fleuren and MJ van de Vijver
Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated
to glutathione
K Bamouin, I Leier, G Jedlitschky, A Pourtier-Manzanedo, J König, W-D Lehmann and D
Keppler
181
186
192
201
N-methylformamide induces changes on adhesive properties and lung-colonizing potential
of M14 melanoma cells
D Del Bufalo, C Leonetti, B Bucci, Camedeo, R Falcioni, A Biroccio and G Zupi
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of
P388 cells in vitro
AT McGown, G Jayson, GR Pettit, MS Haran, TH Ward and D Crowther
Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable
quinazoline thymidylate synthase inhibitor, in preclinical models
GW Aherne, E Ward, N Lawrence, D Dobinson, SJ Clarke, H Musgrove, F Sutcliffe, T
Stephens and AL Jackman
Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo
L Webster, RJ Hodgkiss and GD Wilson
A regulatory role for porphobilinogen deaminase (PBG D) In g-aminolaevulinic acid (gALA)-induced photosensitization?
SL Gibson, Dj Cupriks, JJ Havens, ML Nguyen and R Hilf
Stochastic modelling of tumorigenesis in p53 deficient mice
JH Mao, KA Lindsay, A Balmain and TE Wheldon
Wilms' tumour-suppressor protein isoforms have opposite effects on lgf2 expression in
primary embryonic cells, independently of p53 genotype
A Duarte, A Caricasole, Cf Graham and A Ward
Comparison of DNA copy number changes in malignant mesothelioma, adenocarcinoma
and large-cell anaplastic carcinoma of the lung
A-M Björkqvist, L Tammilehto, S Nordling, M Nurminen, S Anttila, KMattson and S
Knuutila
Allelic loss on chromosome 10q in human lung cancer: association with tumour progression
and metastatic phenotype
S Petersen, G Wolf, U Bockmühl, K Gellert, M Dietel and I Petersen
Comparison of p53 and DNA content abnormalities in adenocarcinoma of the oesophagus
and gastric cardia
CM Gleeson, JM Sloan, DT McManus, P Maxwell, K Arthur JA McGuigan, AJ Ritchie and
SEH Russell
Generation of metastatic variants by transfection of a rat non-metastatic epithelial cell line
with genomic DNA from rat prostatic carcinoma cells
Y Ke, C Beesley, P Smith, R Barraclough, P Rudland and CS Foster
Alterations in plasminogen activation correlate with epithelial cell dysplasia grading in
colorectal adenomas
P Protiva, I Sordat, P Chaubert, E Saraga, C Trán-Thang, 8 Sordat, AL Blum and G Dorta
Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of
regions of consensus copy number change
B Summersgill, H Goker, S Weber-Hall, R Huddart, A Horwich and J Shipley
CLINICAL ONCOLOGY
p53 protein expression in nephroblastomas: a predictor of poor prognosis
D Govender, P Harital, GP Hadley and R Chetty
High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer
TD Bui, T O'Brien, J Crew, D Cranston and AL Harris
Are serial measurements of CA1 9-9 useful in predicting response to chemotherapy in
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253
260
270
277
287
297
305
314
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325
patients with inoperable adenocarcinoma of the pancreas?
H Gogas, FJ Lofts, TRJ Evans, S Daryanani and JL Mansi
Treatment and outcome of patients with extragonadal germ cell tumours - the Norwegian
Radium Hospital's experience 1979-94
S Dueland, AE Stenwig, A Heilo, J Hoie, S Ous and SD Fossá
Clinical course and prognostic factors following bone recurrence from breast cancer
RE Coleman, P Smith and RD Rubens
Schedule-selective biochemical modulation of 5-fluorouracii in advanced colorectal cancer:
a multicentric phase II study
C Aschele, A Guglielmi, GL Frassineti, C Milandri, D Amaddri, R Labianca, M Vinci, L
Tixi, C Caroti, E Ciferri, E Verdi,R Rosso and A Sobrero
A phase II study of paciltaxel in heavily pretreated patients with small-cell lung cancer
EF Smit, E Fokkema, B Biesma, HJM Groan, W Snoek and PE Postmus
CALENDAR
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VOLUME 77 SUPPLEMENT 2
What are the critical issues when investigating new chemotherapies for colorectal cancer?
Proceedings of a Zeneca-sponsored satellite symposia held at the ECCO 9 Conference,
Hamburg, 17 September 1997
Multidisciplinary case teams: an approach to the future management of advanced colorectal
cancer
BD Minsky
Assessing patients' needs and preferences in the management of advanced colorectal cancer
K Redmond
Measuring quality of life: impact of chemotherapy for advanced colorectal cancer.
Experience from two recent large phase Ill trials
H Anderson and MK Palmer
Mature results from three large controlled studies with raltitrexed (Tomudex)
D Cunningham
The establishment of a large collaborative trial programme in the adjuvant treatment of
colon cancer
J Wils
New developments in cancer treatment with the novel thymidylate synthase inhibitor
raltitrexed ('Tomudex')
G Blackledge
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VOLUME 77 NUMBER 3 FEBRUARY 1998
EXPERIMENTAL ONCOLOGY
99m Tc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated
protein
NH Hendrikse, EJF Franssen, WTA van der Graaf, C Meijer, DA Piers, W Vaalburg and
EGE de Vries
353
CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug
resistance-associated protein
WJM Jansen, TM Hulscher, J van Ark-Otte, G Giaccone, HM Pinedo and E Boven
In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum
complex AMD473
J Holford, SY Sharp, BA Murrer, Mabrams and LR Kelland
Effects of p53 mutants derived from lung carcinomas on the p53-responsive element
(p53RE) of the MDM2 gene
VG Gorgoulis, PV Zacharatos, E Manolis, JA lkonomopoulos, A Darnalas, C
Lamprinopoulos, GZ Rassidakis,
VZoumpourlis, A Kotsinas, AN Rassidakis, TD Halazonetis and C Kittas
Differential cytotoxicity of [1231] IUdR, [125] IUdR and [131] IUdR to human glioma
cells in monolayer or spheroid culture: effect of proliferative heterogeneity and radiation
cross-fire
A Neshasteh-Riz, RJ Mairs, WJ Angerson, PD Stanton, JR Reeves, R Rampling, J Owens
and TE Wheldon
Characterization of native fluorescence from DMBA-treated hamster cheek pouch buccal
mucosa for measuring tissue transformation
N Vengadesan, P Aruna and S Ganesan
Transforming growth factor beta 1 and sodium butyrate differentially modulate urokinase
plasminogen activator and plasminogen activator inhibitor-1 in human breast normal and
cancer cells
X Dong- Le Bourhis, V Lambrecht and B Boilly
Taxol-mediated augmentation of CD95 ligand-induced apoptosis of human malignant
glioma cells: association with bcl-2 phosphorylation but neither activation of p53 nor G2/M
cell cycle arrest
W Roth, B Wagenknecht, C Grimmel, J Dichgans and M Weller
Use of the comet assay for assessment of drug resistance and its modulation in vivo
P Huang, PL Olive and RE Durand
Aberrant FHIT transcripts in hepatocellular carcinomas
Y-J Chen, P-H Chen and J-G Chang
Comparison of flow cytometric DNA content analysis in fresh and paraffin-embedded
ovarian neoplasms: a prospective study
Sanaa Eissa, A Khalifa, M Laban, A Elian and WE Bolton
Persistent induction of nitric oxide synthase in tumours from mice treated with the antitumour agent 5,6-dimethylxanthenone-4-acetic acid
E Moilanen, LL Thomsen, DW Miles, L Happerfield, RG Knowles and S Moncada
Stimulation of the apoptotic response as a basis for the therapeutic synergism of lonidamine
and cisplatin in combination in human tumour xenografts
M De Cesare, G Pratesi, A Giusti, D Polizzi and F Zunino
Stimulation of tumour angiogenesis by proximal wounds: spatial and temporal analysis by
MRI
R Abramovitch, M Marikovsky, G Meir and M Neeman
The ubiquitin-proteasome pathway in cancer
V Spataro,C Norbury and AL Harris
Telomerase activation in nasopharyngeal carcinomas
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404
412
417
421
426
434
440
448
456
RYS Cheng. PW Yuen, JM Nicholls, Z Zheng, W Wei, JST Sham, XH Yang, L Cao, DP
Huang and SW Tsao
Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours
HL McLeod, J Sludden, GI Murray, RA Keenan, Al Davidson, K Park, M Koruth and J
Cassidy
CLINICAL ONCOLOGY
Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon
cancers
T Goi, A Yamaguchi, G Nakagawara, T Urano, H Shiku and K Furukawa
Evaluation of pleural CYFRA 21-1 and carcinoembryonic antigen in the diagnosis of
malignant pleural effusions
G Salama, M Miédougé, P Rouzaud, M-A Mauduyt M-C Pujazon, C Vincent, P Carles and
G Serre
Emergency admission for cancer: a matter of survival?
M Porta, E Femandez, J Belloc, N Malats, M Gallén and J Alonso
Relevance of age on survival of 341 patients with multiple myeloma treated with
conventional chemotherapy: updated results of the MM87 prospective randomized protocol
A Riccardi, 0 Mora, S Brugnatelli, C Tinelli, R Spanedda, A De Paoli, L Barbarano, M Di
Stasi, C Bergonzi, M Giordano, C Delfini, G Nicoletti, E Rinaldi, L Piccinini, D Valentini
and E Ascari for the Cooperative Group of Study and Treatment of Multiple Myeloma
PS2 mRNA expression adds prognostic information to node status for 6-year survival in
breast cancer
AM Thompson, RA Elton, RA Hawkins, U Chetty and CM Steel
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer
SA Ridge, J Sludden, X Wei, A Sapone, 0 Brown, S Hardy, P Canney. P FernandezSalguero, FJ Gonzalez, J Cassidy and HL McLeod
EPIDEMIOLOGY
Parakeets, canaries, finches, parrots and lung cancer: no association
A Morabia, S Stellman, LH Lumey and EL Wynder
The association between naevi and melanoma in populations with different levels of sun
exposure:a joint case-control study of melanoma in the UK and Australia
V Bataille, A Grulich, P Sasieni, A Swerdlow, J Newton Bishop, W McCarthy, P Hersey
and J Cuzick
A 15-year series of gastrointestinal non-Hodgkin's lymphomas. a population-based study
M Ducreux, M-C Boutron, F Piard, P-M Carli and J Faivre
CALENDAR
461
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VOLUME 77 SUPPLEMENT 3 1998
Trends in cancer incidence and mortality
in Scotland: description and possible explanations
AJ Swerdlow, I dos Santos Silva, A Reid, Z Qiao, DH Brewster
and J Arrundale
Trends in cancer incidence and mortality in Scotland: description and
possible explanations
1
Appendix: Figures
Appendix: Tables
17
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VOLUME 77 NUMBER 4 FEBRUARY 1998
EXPERIMENTAL ONCOLOGY
Frequent and heterogenous expression of cyclin-dependent kinase inhibitor WAF1/ p21
protein and mRNA in urothelial carcinoma
S Clasen, WA Schuiz, C-D Gerharz, M-0 Grimm, F Christoph and BJ Schmitz-Dráger
Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas
JF Marshall, DC Rutherford, L Happerfield, A Hanby, ACE McCartney, J Newton-Bishop
and IR Hart
Expression of alfav integrins and vitronectin receptor identity in breast cancer cells
T Meyer, JF Marshall and IR Hart
Design, characterization and anti-tumour cytotoxicity of a panel of recombinant,
mammalian ribonuclease-based immunotoxins
MP Deonarain and AA Epenetos
Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance
to DNA-damaging agents but not to anti-microtubule anti-cancer agents
Y Iwadate, M Tagawa, S Fujimoto, M Hirose, H Namba, K Sueyoshi, S Sakiyama and A
Yamaura.
Cytogenetic abnormalities in Langerhans cell histiocytosis
DR Betts, KE Leibundgut, A Feldges, HJ Plüss and FK Niggli
Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in
cisplatin sensitivity of head and neck cancer cell lines
MJP Welters, AMJ Fichtinger-Schepman, RA Baan, MJ Flens, RJ Scheper and BJM
Braakhuis
Altered ß-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells
S Ranganathan, CA Benetatos, PJ Colarusso, DW Dexter and GR Hudes
Inhibitors of aromatase prevent degradation of the enzyme in cultured human tumour cells
N Harada and 0 Hatano
Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during
initiation of rat colon carcinogenesis
CJ Barnes, IL Cameron, WE Hardman and M Lee
Suppression by pravastatin, an inhibitor of p21 ras Isoprenylation, of hepatocarcinogenesis
induced by N-nitrosomorpholine in Sprague-Dawley rats
M Tatsuta, H Lishi, M Baba, K Iseki, H Yano, H Uehara, R Yamamoto and A Nakaizumi
Detection of the DCC gene product in normal and malignant colorectal tissues and its
relation to a codon 201 mutation
CA Schmitt, KR Thaler, BM Wittig, H Kaulen, K-H Meyer zum Büschenfelde and WG
Dippold
Development of a new metastatic human breast carcinoma xenograft line
RR Mehta, JM Graves, A Shilkaitis and TK Das Gupta
Aberrant expression and phosphorylation of ß-catenin in human colorectal cancer
T Takayama, H Shiozaki, Y Doki, H Oka, M Inoue, M Yamamoto, S Tamura, S Shibamoto,
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F Ito and M Monden
CLINICAL ONCOLOGY
Radiation-induced micronucleus induction in lymphocytes; identifies a high frequency of
radiosensitive cases among breast cancer patients: a test for predisposition?
D Scott, JBP Barber, EL Levine, W Burrill and SA Roberts
Prognostic role of clinical, pathological and biological characteristics in patients with
locally advanced breast cancer
AH Honkoop, PJ van Diest, JS de Jong, SC Linn, G Giaccone, K Hoekman, J Wagstaff and
HM Pinedo
Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate
modulation of P-glycoprotein-mediated drug resistance in the first-line management of
small-cell lung carcinoma
L Wood, M Palmer, J Hewitt, R Urtasun, E Bruera, E Rapp and JF Thaell
Comparative studies on the expression of somatostatin receptor subtypes, outcome of
octreotide scintigraphy and response to octreotide treatment in patients with carcinoid
tumours
0 Nilsson, L Kölby, B Wängberg, A Wigander, H Billig, L William-Olsson, M Fjälling, E
Forssell-Aronsson and H Ahlman
TNP-470 inhibits collateralization to complement the anti-tumour effect of hepatic artery
ligation
T Mugitani, H Taniguchi, A Takada, A Yamaguchi, M Masuyama, M Hoshima and T
Takahashi
Comparison between radiation-induced cell cycle delay in lymphocytes and radiotherapy
response in head and neck cancer
R Tell, T Heiden, F Granath, A-L Borg, S Skog and R Lewensohn
Imbalance between serum matrix metalloprotei nase-2 and its inhibitor as a predictor of
recurrence of urothelial cancer
K Gohji, N Fujimoto, J Ohkawa, A Fujii and M Nakajima
Therapeutic effect of interleukin 12 on mouse haemangiosarcomas is not associated with
an increased anti-tumour cytotoxic T-lymphocyte activity
C Vizier, A Rosato, F Calderazzo, L Quintieri, P Fruscella, R Wainstok de Calmanovici, A
Mantovani, A Vecchi, P Zanovello and D Collavo
Prognostic value of ERBB-1, VEG F, cyclin A, FOS, JUN and MYC in patients with
squamous cell lung carcinomas M Volm, W Rittgen and P Drings
Short-term cellular effects induced by castration therapy in relation to clinical outcome in
prostate cancer
P Stattin,P Westin,J-E Damber and A Bergh
LETTERS TO THE EDITOR
BOOK REVIEW
CALENDAR
614
621
627
632
638
643
650
656
663
670
676
679
680
VOLUME 77 NUMBER 5 MARCH 1998
REVIEW
Biological therapy: approaches in colorectal cancer. Strategies to enhance
683
carcinoenibryonic antigen (CEA) as an immunogenic target
AP Zbar, NR Lemoine, M Wadhwa, H Thomas, D Snary and Wa Kmiot
EXPERIMENTAL ONCOLOGY
Comparative evaluation by semiquantitative reverse transcriptase polymerase chain reaction
of MDR1, MRP and GSTp gene expression in breast carcinomas
R Lacave, F Coulet, S Ricci, E Touboul, A Flahault, JG Rateau, D Cesari, JP Lefranc and
JF Bernaudin
The effect of different chemotherapeutic agents on the enrichment of DNA mismatch
repair-deficient tumour cells
D Fink, S Nebel, PS Norris, S Aebi, HK Kim, M Haas and SB Howell
NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by
NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones
P Joseph and AK Jaiswal
K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer
M Sagawa, Y Saito S Fujimura and RI Linnoila
Differential expression of matrix metalloproteinases in activated c-rasHo-transfected
immortalized human keratinocytes
LC Meade –Tollin, P Boukamp, NEFusenig, CPR Bowen, TC Tsang and GT Bowden
The effects of n6 polyunsaturated fatty acids on the expression of nm-23 in human cancer
cells
WG Jiang, S Hiscox, RP Bryce, DF Horrobin and RE Mansel
Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is
enhanced by N-(2-hydroxyphenyi)all-trans retinamide
MJ Campbell, M Dawson and HP Koeffler
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro antitumour activity
TD Bradshaw, S Wrigley, D-F Shi, RJ Schultz, KD Paull and MFG Stevens
Cytotoxity of (alfa-particle-emitting astatine-211 -labelled antibody in tumour spheroids: no
effect of hyperthermia
ML,Hauck, RH Larsen, PC Welsh and MR Zalutsky
Molecular pathogenesis of sporadic duodenal cancer
A Achille, A Baron, G Zamboni, S Orlandini, G Bogina, C Bassi, C lacono and A Scarpa
Characterization of keratin and cell cycle protein expression in cell lines from squamous
intraepithelial lesions progressing towards a malignant phenotype
S Hietanen, K Syrjänen and S Syrjänen
CLINICAL ONCOLOGY
p53 mutation is a poor prognositc indicator for survival in patients with hepatocellular
carcinoma undergoing surgical tumour ablation
K Honda, E Sbisá, A Tullo, PA Papeo, C Saccone, S Poole, M Pignatelli, RR Mitry, S
Ding, A Isla, A Davies
and A Habib
Prognostic significance of cyclin E and p53 protein overexpression in carcinoma of the
renal pelvis and ureter
M Furihata, Y 0htsuki, H Sonobe, T Shuin, A Yamamoto, N Terao and M Kuwahara
Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also
with increased proliferative activity
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724
731
739
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760
766
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789
H-J van Slooten, MJ van de Vifver, CJH van de Velde and JH van Dierendonck
Allelic imbalance at chromosome 17p13.3 (YNZ22) in breast cancer is independent of p53
mutation or p53 overexpression and is associated with poor prognosis at medium-term
follow-up
AM Thompson, DN Crichton, RA Elton, MF Clay, U Chetty and M Steel
Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with
nonsmall-cell lung cancer: correlation with histological expression of ICAM-1 and tumour
stage
A Grothey, P Heistermann, S Philippou and R Voigtmann
Dose-limiting neurotoxicity in a phase I study of penclomedine (NSC 388720, CRC 88-04),
a synthetic
alfa-picoline derivative, administered intravenously
DI Jodrell, A Bowman, M Stewart, N Dunlop, R French, A MacLellan, J Cummings and JF
Smyth
Spatial temporal patterns in childhood leukaemia: further evidence for an infectious origin
FE Alexander, P Boyle, P-M Carli, JW Coebergh, GJ Draper, A Ekbom, F Levi, PA
McKinney, W McWhirter, C Magnani, J Michaelis, JH 0lsen, R Peris-Bonet, E Petridou, E
Pukkala and L Vatten on behalf of the EUROCLUS project
EPIDEMIOLOGY
Spatial clustering of childhood leukaemia: summary results for the EUROCLUS project
FE Alexander, P Boyle, P-M Carli, JW Coebergh, GJ Draper, A Ekbom, F Levi, PA
McKinney, W McWhirter, J Michaelis, R Peris-Bonet, E Petridou, V Pompe-Kirn, I Plisko,
E Pukkala, M Rahu, H Storm, B Terracini, L Vatten and N Wray on behalf of the
EUROCLUS project
Childhood cancer and paternal employment in agriculture: the role of pesticides
NT Fear, E Roman, G Reeves and B Pannett
The use of videotaped information in cancer genetic counselling: a randomized evaluation
study
A Cull, H Miller, T Porterfield, J Mackay, EDC Anderson, CM Steel and RA Elton
Determinants of risk of invasive cervical cancer in young women
F Parazzini, L Chatenoud, C La Vecchia, E Negri, S Franceschi and G Bolis
Geographical distribution of birth places of children with cancer in the UK
EA Gilman and EG Knox
LETTERS TO THE EDITOR
p53 and angiogenesis in non-small-cell lung cancer
A Giatromanolaki and MI Koukourakis
p53 and angiogenesis in non-smali-cell lung cancer - Reply
G Fontanini
CALENDAR
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VOLUME 77 NUMBER 6 MARCH 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Epidermal growth factor receptor activation in androgen-independent but not androgenstimulated growth of human prostatic carcinoma cells
ER Sherwood, JL Van Dongen, CG Wood, S Liao, JM Kozlowski and C Lee
The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia
855
862
is disrupted in cells expressing HPV18 E7 oncoprotein
Ø Amellem, JA Sandvik, T Stokke and EO Pettersen
Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells
ASE Ojugo, PMJ McSheehy, M Stubbs, G Alder, CL Bashford, RJ Maxwell, MO Leach,
IR Judson and JR Griffiths
Captopril inhibits tumour growth in a xenograft model of human renal cell carcinoma
S-I Hii, DL Nicol, DC Gotley, LC Thompson, MK Green and JR Jonsson
Timing of recombinant human granulocyte colony-stimulating factor administration on
neutropenia induced by cyclophosphamide in normal mice
M Misaki, Y Ueyama, G Tsukamoto and T Matsumura
Syndecan-1 is up-regulated in ras-transformed intestinal epithelial cells
ZM Wong, B Choo, M Li, DJ Carey, DF Cano-Gauci and RN Buick
Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human
melanoma
EK Rofstad and T Danielsen
/Expression of Ret/PTC11, -2, -3, -A3 and -4 in German papillary thyroid carcinoma
B Mayr E Pötter, P Goretzki, J Rüschoff, W Dietmaier, C Hoang- Vu, H Dralle and G
Brabant
Interleukin 6 and its relationship to clinical parameters in patients with malignant pleural
mesothelioma
T Nakano, AP Chahinian, M Shinjo, A Tonomura, M Miyake, N Togawa, K Ninomiya and
K Higashino
N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal
cancer patients
AL Hubbard, C Moyes, AH Wyllie, CAD Smith and DJ Harrison
Systematic heterogeneity and prognostic significance of cell proliferation in colorectal
cancer
R Palmqvist, A Öberg, C Bergström, JN Rutegard, B Zackrisson and R Stenling
Assay of matrix metalloproteinases types 1, 2, 3 and 9 in breast cancer
AG Remacle, A Noél, C Duggan, E McDermott, N O'Higgins, JM Foidart and MJ Duffy
Prognostic significance of urokinase-type plasminogen activator and plasminogen activator
inhibitor-1 in primary breast cancer
A Knoop, PA Andreasen, JA Andersen, S Hansen, A-V Laenkholm, ACW Simonsen, J
Andersen, J Overgaard and C Rose
Correlation between basic fibroblast growth factor immunostaining of stromal cells and
stromelysin-3 mRNA expression in human breast carcinoma
C Linder, P Bystrom, G Engel, G Auer, U Aspenblad, H Strander and S Linder
Heterogeneity in microvascular density in lung tumours - comparison with normal bronchus
AM Schor, S Pazouki, J Morris, RL Smither, LM Chandrachud and N Pendleton
Absence of RAS and p53 mutations in thyroid carcinomas of children after Chernobyl in
contrast to adult thyroid tumours B Suchy, V Waldmann, S Klugbauer and HM Rabes
Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from
platelets: significance for VEGF measurements and cancer biology
RE Banks, MA Forbes, SE Kinsey, A Stanley, E Ingham, C Walters and PJ Selby
The photodynamic response of two rodent tumour models to four zinc (II)-substituted
phthalocya-nines
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JE Cruse-Sawyer, J Griffiths, B Dixon and SB Brown
CLINICAL ONCOLOGY
Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5fluorouracil associated cardiotoxicity
C-H Köhne, P Thuss-Patience, M Friedrich, PT Daniel, A Kretzschmar T Benter B Bauer R
Dietz and B Dórken
The pharmacokinetics and metabolism of ifosfamide during bolus and infusional
administration: a randomized cross-over study
JM Singer, JM Hartley, C Brennan, PWNicholson and RL Souhami
Subjective health estimations (SHE) in patients with advanced breast cancer: an adapted
utility conept for clinical trials
C Hürny, B van Wegberg, M Bacchi, J Bernhard, B Thúrlimann, 0 Real, L Perey, H
Bonnefoi and A Coates
Soluble interleukin-2 receptors (sIL-2R) in Hodgkin's disease: outcome and clinical
implications
S Viviani, E Camerini, V Bonfante, A Santoro, M Baizarotti, M Fornier, L Devizzi, P
Verderio, P Valagussa and G Bonadonna
Vascular endothelial growth factor (VEGF) nRNA isoform expression pattern is correlated
with liver metastasis and poor prognosis in colon cancer
T Tokunaga, Y 0shika, Y Abe, Y Ozeki, S Sadahiro, H Kijima, T Tsuchida, H Yamazaki, Y
Ueyama, N Tamaoki and M Nakamura
Microsatellite instability in female non-small-cell lung cancer patients with familial
clustering of malignancy
K Suzuki, T Ogura, T Yokose, I Sekine, K Nagai, T Kodama, K Mukai, Y Nishiwaki and H
Esumi
The value of serum a-N-acetylgalactosaminidase measurement for the assessment of
tumour response to radio- and photodynamic therapy
M Korbelik, VR Naraparaju and N Yamamoto
Cross-reactivity between Candida albicans and human ovarian carcinoma as revealed by
monoclonal antibodies PA10F and C6
J Schneider, D Moragues, N Martínez, H Romero, E Jimenez and J Pontón
Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's
sarcoma
C Abels, S Karrer, W Bäumler, AE Goetz, M Landthaler and R-M Szeimies
CALENDAR
VOLUME 77 NUMBER 7 APRIL 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Chromosome division figures reveal genomic instability in tumorigenesis of human colon
mucosa
RG Steinbeck
Two Li-Fraumeni syndrome families with novel germline p53 mutations: loss of the wildtype p53 allele in only 50% of tumours
Z Sedlacek, R Kodet, V Kriz, E Seemanova, P Vodvarka, P Wilgenbus, J Mares, A Poustka
and P Goetz
Enhanced expression of cytochrome P450 in stomach cancer
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992
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1009
1015
1021
1025
1027
1034
1040
GI Murray, MC Taylor, MD Burke and WT Melvin
Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative
Hodgkin's disease
1045
AA Armstrong, L Shield, A Gallagher and RF Jarrett
Evaluation of FHIT gene alterations in ovarian cancer
F Buttitta, A Marchetti, 0 Radi, G Bertacca, S Pellegrini, A Gadducci, AR Genazzani and G
Bevilacqua
Expression of HGF/SF in mesotheioma cell lines and its effects on cell motility,
proliferation and morphology
P Harvey, A Warn, S Dobbin, N Arakaki, Y Daikuhara, MC Jaurand and RM Warn
Mutations of K-ras oncogene in human adrenal tumours in Taiwan
S-R Lin, JH Tsai, YC Yang and SC Lee
The role of transforming growth factor alpha production and ErbB-2 overexpression in
induction of tumorigenicity of lung epithelial cells
A W Hamburger, A Femandes, M Murakami and BI Gerwin
Interleukin 2 restores CD3-γ chain expression but fails to generate tumour-specific lytic
activity in tumour-infiltrating lymphocytes derived from human colorectal hepatic
metastases
KF Yoong and DH Adams
Complex karyotypes in flow cytometrically DNA-diploid squamous cell carcinomas of the
head and neck
J Akervall, Y Jin, B Baldetorp, F Mertens and J Wennerberg
Expression of y -glutamylcysteine synthetase (y-GCS) and multidrug resistance-associated
protein (MRP), but not human canalicular multispecific organic anion transporter
(cMOAT), genes correlates with exposure of human lung cancers to platinum drugs
T Oguri, Y Fujiwara, T Isobe, 0 Katoh, H Watanabe and M Yamakido
Endogenous antioxidant enzymes and glutathione S-transferase in protection of
mesothelioma cells against hydrogen peroxide and epirubicin toxicity
K Kinnula, K Linnainmaa, KO Raivio and VL Kinnula
The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and
radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-a-initiated
apoptosis
J Delic, P Masdehors, S Ömura, J-M Cosset, J Dumont, J-L Binet and H Magdelénat
The ratio of initial/residual DNA damage predicts intrinsic radlosensitivity in seven cervix
carcinoma cell lines
B Marples, D Longhurst, AM Eastham and CML West
Intratumour injection of immunoglobulins labelled with the alfa-particle emitter 211 At:
analyses of tumour retention, microdistribution and growth delay
RH Larsen and ØS Bruland
Linomide blocks anglogenesis by breast carcinoma vascular endothelial growth factor
transfectants
M Ziche, S Donnini, L Morbidelli, A Parenti, G Gasparini and F Ledda
CLINICAL ONCOLOGY
Mutations in residues of TP53 that directly contact DNA predict poor outcome in human
primary breast cancer
EMJJ Berns, IL van Staveren, MP Look, M Smid, JGM Klijn and JA Foekens
1048
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1060
1066
1072
1082
1089
1097
1103
1108
1115
1123
1130
1137
The prognostic value of CD44 isoform expression in endometrial cancer
C Tempfer, G Haeusler, A Kaider, L Hefler, E Hanzal, A Reinthaller G Breitenecker and
Ch Kainz
Independent prognostic Importance of microvessel density in endometrial carcinoma
1140
HB Salvesen, OE lversen and LA Akslen
1145
Anthracycline doses in patients with liver dysfunction: do UK oncologists follow current
recommendations?
NA Dobbs and CJ Twelves
1149
FEP regimen (epidoxorubicin, etoposide and cisplatin) In advanced gastric cancer, with or
without low-dose GM-CSF: an Italian Trial in Medical Oncology (ITMO) study
E Bajetta, M Di Bartolomeo, C Carnaghi, R Buzzoni, L Mariani V Gebbia, G Comella, G
Pinotti G lanniello, G Schieppati, AM Bochicchio and L Maiorino
1155
Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic
breast cancer
M Lehnert, K Mross, J Schueller, B Thuerlimann, N Kroeger and H Kupper
NM23-Hl immunostaining is inversely associated with tumour staging but not overall
1164
survival or disease recurrence in colorectal carcinomas
PY Cheah, X Cao, KW Eu and F Seow-Choen
Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with
1169
lymph node status and anglogenesis
S Kakolyris, L Kaklamanis, K Engels, SB Fox, M Taylor, ID Hickson, KC Gatter and AL
Harris
EPIDEMIOLOGY
Seasonal variations in the presentation and growth of thyroid cancer
1174
LA Akslen and RB Sothern
Testicular cancer risk and maternal parity: a population-based cohort study
1180
T Westergaard, PK Andersen, JB Pedersen, M Frisch, JH Olsen and M Melbye
Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt
1186
R Bedwani, E Renganathan, F El Kwhsky, C Braga, HH Abul Seif, T Abul Azm, A Zaki, S
Franceschi, P Boffetta and C La Vecchia
High incidence of classical Kaposi's sarcoma in Iceland and the Faroe Islands
1190
H Hjaigrim, H Tulinius, J Dalberg, S Hardarson, M Frisch and M Melbye
High suicide mortality soon after diagnosis among cancer patients in central Italy
1194
E Crocetti, S Arniani, S Acciai, A Barchielli and E Buiatti
CALENDAR
1197
VOLUME 77 NUMBER 8 APRIL 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
A missense mutation in the BRAC2 gene in three siblings with ovarian cancer
S Roth, P Kristo, A Auranen, M Shayeghi, S Seal, N Collins, R Barfoot, N Rahman, PJ
Klemi, S Grénman,
L Sarantaus, H Nevanlinna, R Butzow, A Ashworth, MR Stratton, and LA Aaltonen
Putative markers for the detection of breast carcinoma cells in blood
EM Eltahir DS Mallinson, GD Birnie, C Hagan, WD George and AD Purushotham
1199
1203
The promoting effect of tumour necrosis factor a in radiation-induced cell transformation
RF Guo and YF Gong
The response of Dunning R3327 prostatic adenocarcinoma to IL-2, histamine and radiation
S Johansson, M Landström, K Hellstrand and R Henriksson
Late G, accumulation after 2 Gy of y-lrradiation is related to endogenous Raf-1 protein
expression and intrinsic radiosensitivity in human cells
HM Warenius, M Jones, MD Jones, PG Browning, LA Seabra and CCM Thompson
The antiproliferative activity of all-trans-retinoic acid catabolites and isomers is
differentially modulated by liarozole-fumarate in MCF-7 human breast cancer cells
J Van heusden, W Wouters, FCS Ramaekers, MDWG Krekels, L Dillen, M Borgers and G
Smets
Transfection of COS-1 cells with DT-diaphorase cDNA: role of a base change at position
609
V Misra,HJ Klamut and AM Rauth
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells
and effect on anti-tumour activity of bioreductive agents
GP Doherty, MK Leith, X Wang, TJ Curphey and A Begleiter
Prognostic significance of methyl-p-hydroxy-phenyllactate-esterase activity in laryngeal
squamous cell carcinoma
M Maurizi, G Ferrandina, G Almadori, G Scambia, G Cadoni, G DAgostino, FG Serra, M
Piantelli, S Mancuso and FO Ranelletti
Down-regulated expression of transforming growth factor beta 1 mRNA in endometrial
carcinoma
E Perlino, G Loverro, E Maiorano, T Giannini, A Cazzolla, A Napoli, MG Fiore, R Ricco,
E Marra
and L Selvaggi
The detection of K-ras mutations in colorectal cancer using the amplification-refractory
mutation system
JC Fox, J England, P White, G Ellison, K Callaghan, NR Charlesworth, J Hehir, TL
MCCarthy, J Smith-Ravin, IC Talbot, D Snaty JMA Northover, CR Newton and S Little
Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with
squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of
the skin
AL Krunic, DR Garrod, S Madani, MD Buchanan and RE Clark
CLINICAL ONCOLOGY
Randomlized phase II trial of BCDT [carmustine (BCNU), cisplatin, dacarbazine (DTIC)
and tamoxifen] with or without interferon alpha (IFN-alfa) and interieukin (IL-2) in patients
with metastatic melanoma
SRD Johnston, DO Constenia, J Moore, H Atkinson, RP A Hern, G Dadian, PG Riches and
ME Gore
Adjuvant therapy for melanoma: how should we respond to high-dose interferon?
PG de Takats, MV Williams and R Hawkins
Recombinant human granulocyte colony-stimulating factor (filgrastim) following high-dose
chemotherapy and peripheral blood progenitor cell rescue in high-grade non-Hodgkin's
lymphoma:clinical benefits at no extra cost
SM Lee, JA Radford, L Dobson, T Huq, WDJ Ryder, R Pettengell, GR Morgenstern, JH
1208
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Scarffe and D Crowther
Late effects of treatment for early-stage Hodgkin's disease
JD Brierley, AJ Rathmell, MK Gospodarowicz, SB Sutcliffe, A Munro, R Tsang and M
Pintilie
Survival in renal cell carcinoma - a randomized evaluation of tamoxifen vs interieukin 2,
alfa-interferon (leucocyte) and tamoxifen
R Henriksson, S Nilsson, S Colleen, P Wersdäll, M Helsing, R Zimmerman and K Engman
Are cytokine responses in renal cell cancer the product of placebo effect of treatment or true
biotherapy? What trials are needed now?
RTD Oliver
Improving survival in recurrent medulloblastoma: earlier detection, better treatment or still
an impasse?
E Bouffet, F Doz, MC Demaille, P Tron, H Roche, D Plantaz, A Thyss, JL Stephan, 0
Lejars, E Sariban, M Buclon, M Zúcker, M Brunat-Mentigny, JL Bernard and JC Gentet
Cytokeratin 20 mRNA in peripheral venous blood of colorectal carcinoma patients
NO Funaki, J Tanaka, G Ohshio, H Onodera, S Maelani and M Imamura
Apparent lack of prognostic value of M113-11 index in anal carcinomas treated by
radiotherapy
AS Allal, L Alonso-Pentzke and S Remadi
Chromosomal imbalances in primary and metastatic pancreatic carcinoma as detected by
interphase cytogenetics: basic findings and clinical aspects
N Zojer, M Fiegl, L Müllauer, A Chott, S Roka, J Ackermann, M Raderer, H Kaufmann, A
Reiner, H Huber and J Drach
Who and what influences delayed presentation in breast cancer?
CC Burgess, AJ Ramirez, MA Richards and SB Love
Combined intravenous and intraperitoneal chemotherapy with fluorouracil + leucovorin vs
fluorouracil + levamisole for adjuvant therapy of resected colon carcinoma
W Scheithauer, G V Kornek, A Marczell, J Karner, G Salern, R Greiner, D Burger, F
Stöger, J Ritschel, E Kovats, HM Vischer, B Schneeweiss and D Depisch
Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer
C Bokemeyer, CC Berger, JT Hartmann, C Kilmannsberger, H-J Schmoll, MA Kuczyk and
L Kanz
Predicting che motherapeutic response to small-cell lung cancer of platinum compounds by
thallium-201 single-photon emission computerized tomography
Y Tokuchi, H lsobe, H Takekawa, T Hanada, T Ishida, S Ogura, K ltoh, M Furudate, K
Saito and Y Kawakami
CALENDAR
VOLUME 77 NUMBER 9 MAY 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells
by modifying the functions of vascular endothelial cells
H Nagayasu, J-i Hamada, T Kawano, S Konaka, D Nakata, T Shibata, M Arisue, M
Hosokawa, N Takeichi and T Moriuchi
Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in
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1378
cisplatin-sensitive and -resistant human ovarian cancer cells
N Zaffaroni, R Silvestrini, L Orlandi, A Bearzatto, D Gornati and R Villa
Reduction of tumour oxygenation during and after photodynamic therapy in vivo: effects of
fluence rate
TM Sitnik, JA Hampton and BW Henderson
Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon
cancer cells
AW Boddie Jr, A Constantinou, C Williams and A Reed
Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain
of human HER2/neu
GP Adams, R Schier. AM McCall, RS Crawford, EJ Wolf, LM Weiner and JD Marks
Immune atimulatory potential of B7.1 and B7.2 retrovirally transduced melanoma cells:
suppression by interleukin 10
R Dummer, F-Y Yue, J Pavlovic, R Geertsen, C Döhring, K Moelling and G Burg
Hepatocyte growth factor-stimulated renal tubular mitogenesis: effects on expression of cmyc, c-fos, c-met, JEGF and JHL tumour-suppressor and related genes
SC Clifford, K Czapla, FM Richards, DJ O'Donoghue and EH Maher
Wt-p53 action in human leukaemia cell lines corresponding to different stages of
differentiation
MG Rizzo, A Zepparoni, B Cristolanelli, R Scardigli, M Crescenzi, G Blandino, S
Guiliacci, S Ferrari, S Soddu and A Sacchi
Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive
carcinoma of the breast
KL Marsh and JM Varley
SupraMolecular BioVectors (SMBV) improve antisense inhibition of erbB-2 expression
C Allal, S Sitou, R Kravtzoff, N Soulet, G Soula and G Favre
Down-regulation of Fas gene expression in colon cancer is not a result of allelic loss or
gene rearrangement
LM Butler, PJ Hewett, W Butler and PA Cowled
Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by
immunohistochemistry
KL Marsh and JM Varley
Immunohistochemical detection of DNA topoisomerase IIα, P-glycoprotein and multidrug
resistance protein (MRP) in small-cell and non-small-cell lung cancer
J Kreisholt, M Sorensen, PB Jensen, BS Nielsen, CB Andersen and M Sehested
CLINICAL ONCOLOGY
Randomized trial comparing protracted infusion of 5-fluorouracil with weekly doxorubicin
and cyclophosphamide with a monthly bolus FAC regimen in metastatic breast carcinoma
(SPM90)
J-Y Pierga, M Jouve, B Asselain, A Livartowski, P Beuzeboc, V Diéras, S Scholl, T
Dorval, T Palagié, E García-Giralt and P Pouillart
Bolus/ infusional 5-fluorouracil and folinic acid. A report on two prospective, cosecutive
phase II studies with 5-fluorouracil dose escalation
MJ Mackean, J Cassidy, Dl Jodrell, J Paul, NS Reed, PA Canney, H Yosef, T Habeshaw,
AG Robertson, A Mclnnes and CJ Twelves
Initial high anti-emitic efficacy of granisetron with dexamethasone is not maintained over
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1439
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1469
1474
1480
1487
repeated cycles
R de Wit, H van den Berg, J Burghouts, J Nortier, P Slee, C Rodenburg, J Keizer, M
Fonteyn, J Verweij and J Wils
Elevated plasma levels of transforming growth factor (TGF)-ß1 and TGF-ß2-in patients
with disseminated malignant melanoma
K Krasagakis, D Thölke, B Farthmann, J Eberle, U Mansmann and CE Orfanos
Prognostic value of urokinase plasminogen activator in primary breast carcinoma:
comparison of two immunoassay methods
C Bouchet, F Spyratos, K Hacëne, L Durcos, V Bécette and J Oglobine
Cell proliferation measured by MIB1 and timing of surgery for breast cancer
LS Cooper, CE Gillett, P Smith, IS Fentiman and DM Barnes
EPIDEMIOLOGY
Hypertension, obesity and their medications in relation to renal cell carcinoma
J-M Yuan, JE Castelao, M Gago-Dominguez, RK Ross and MC Yu
Survival analysis of 5595 head and neck cancers - results of conventional treatment in a
high-risk population
DN Rao, PD Schroff, G Chattopadhyay and KA Dinshaw
Breast cancer in Norway 1970-1993: a population-based study on incidence, mortality and
survival
H Wang, SØ Thoresen and S Tretli
The effects of interaction between familial and reproductive factors on breast cancer risk: a
combined analysis of seven case-control studies
N Andrieu, T Smith, S Duffy DG Zaridke, R Renaud, T Rohan, M Gerber, E Luporsi, M
Lé, HP Lee,Y Lifanova and NE Day
Segregation analysis of epithelial ovarian cancer in Finland
A Auranen and L Iselius
CALENDAR
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1542
VOLUME 77 NUMBER 10 MAY 1998
CONTENTS
REVIEW
Health economics and quality of life in cancer trials: report based on a UKCCCR workshop
R Fitzpatrick and L Davies
EXPERIMENTAL ONCOLOGY
Alteration of oestradiol metabolism in myc oncogene-transfected mouse mammary
epithelial cells
NT Telang, F Arcuri, OM Granata, HL Bradlow, MP Osborne and L Castagnetta
Temperature sensitivity of human wild-type and mutant p53 proteins expressed in vivo
F Ponchel and J Milner
Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell
tumour cell lines
H Burger, K Nooter, AWM Boersma, CJ Kortland and G Stoter
p53 Mutations in non-small-cell lung cancers occurring in individuals without a past history
of active smoking
Y Takagi, H 0sada, T Kuroishi, T Mitsudomi M Kondo, T Niimi, S Saji, AF Gazdar, T
Takahashi, JD Minna and T Takahashi
Analysis of p53, p16 MTS1 p21 WAF1 and H-ras in archived bladder tumours from
1543
1549
1555
1562
1568
1573
workers exposed to aromatic amines
TSorlie, G Martel-Planche, P Hainaut, J Lewalter, R Holm, A-L Borresen-Dale and R
Montesano
1580
Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the
transmembrane pH gradient
SV Kozin and LEGerweck
Increased plasminogen binding is associated with metastatic breast cancer cells: differential 1586
expression of plasminogen binding proteins
M Ranson, NM Andronicos, MJ O' Mullane and MS Baker
1598
In vitro testing of calcium channel blockers and cytotoxic chemotherapy in B-cell lowgrade non-Hodgkin's lymphoma
J Shamash, AH Salam, DC Davies, A Williams, S Joel and TA Lister
1604
Allelic imbalance and instability of microsatellite loci on chromosome 1 p in human nonsmall-cell lung cancer
AV Gasparian, KKLakfionov MS-0 Belialova, NA Pirogova, AG Tatopyan and IB
Zborovskaya
y-Linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to
1612
'normal' rat astrocytes
S Vartak, R McCaw, CS Davis, MEC Robbins and AA Spector
The influence of hypoxia and pH on aminolaevulinic acid-induced photodynamic therapy in 1621
bladder cancer cells in vitro
L Wyld, MWR Reed and NJ Brown
Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to 1628
colon cancer
L Cristóväo, MC Lechner, P Fidalgo, CN Leitäo, FC Mira and J Rueff
Telomerase activity in 144 brain tumours
1633
T Sano, A Asai, K Mishima, T Fujimaki and T Kirino
Semi-quantitation of urokinase plasminogen activator and its receptor in breast carcinomas 1638
by immunocytochemistry
S Kennedy, MJ Duffy, C Duggan, C Barnes, R Rafferty and MD Kramer
Mutation analysis of the c-mos proto-oncogene in human ovarian teratomas
1642
KAF de Foy, SA Gayther, WH Colledge, S Crockett, IV Scott, MJ Evans and BAJ Ponder
Reduced cellular accumulation of topotecan: a novel mechanism of resistance in human
1645
ovarian cancer cell line
J Ma, M Maliepaard, K Nooter, WJ Loos, HJ Kolker, J Verweij, G Stoter and JHM
Schellens
CLINICAL ONCOLOGY
Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to
1653
endocrine therapy
RA McClelland, DL Manning, JMW Gee, P Willsher, JFR Robertson, IO Ellis, RIW
Blamey and RI Nicholson
The effect of 3-week tamoxifen treatment on oestrogen receptor levels in primary breast
1657
tumours:a flow cytometric study
I Brotherick, DA Browell, BK Shenton, M Egan, WJ Cunliffe, LA Webb, LG Lunt, JR
Young and MJ Higgs
Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma:
1661
An immunohistochemical study of clinical outcome in a series of 252 patients with longterm follow-up
FA Mauri, 0 Caffo, S Veronese, P Verderio, P Boracchi, M Bonzanini, N Rossi, G Perrone,
P Dalla Palma and M Barbareschi
Plasma insulin-like growth factor in primary breast cancer patients treated with adjuvant
Chemotherapy
J-Ph Peyrat, F Révillion and J Bonneterre
High-dose therapy including carboplatin adjusted for renal function in patients with
relapsed or refractory germ cell tumour: outcome and prognostic factors
MPA Lyttelton, ES Newlands, C Giles, M Bower, A Guirnaraes, S O'Reilly, GJS Rustin, D
Samson and EJ Kanfer
Cisplatin dose rate as a risk factor for nephrotoxicity in children
R Skinner, ADJ Pearson, MW English, L Price, RA Wyllie, MG Coulthard and AW Craft
Comparison of antiemetic efficacy of granisetron and ondansetron in Oriental patients: a
randomized crossover study
RTP Poon and LWC Chow
Neuromuscular toxicities of paclitaxel 210 mg m-2 by 3-hour infusion
H Kunitoh, N Saijo, K Furuse, K Noda and M Ogawa
Treatment-induced mucositis: an old problem with new remedies
RP Symonds
Different patterns of stromal and cancer cell thymidine phosphorylase reactivity in nonsmall-cell lung cancer: impact on tumour neoangiogenesis and survival
MI Koukourakis, A Giantromanolaki, S Kakolyris, KJ O'Byrne, N Apostolikas, J Skarlatos,
KC Gatter and AL Harris
In oesophageal squamous cell carcinoma vascular endothelial growth factor is associated
with p53 mutation, advanced stage and poor prognosis
S Uchida, Y Shimada, G Watanabe, H Tanaka, 1 Shibagaki, T Miyahara, S Ishigami, S Arii
and M lmamura
LETTERS TO THE EDITOR
CALENDAR
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VOLUME 77 NUMBER 11 JUNE 1998
CONTENTS
MEETING REPORT
Beatson International Cancer Conference - Cancer: from Pedigree to Protein
VG Brunton and N Keith
EXPERIMENTAL ONCOLOGY
Influence of exogenous RARα gene on MDR1 expression and P-glycoprotein function in
human and rodent cell lines
TP Stromskaya, EY Rybalkina, AA Shtil, TN Zabotina, NA Filippova and AA
Stavrovskaya
The contribution of lactic acid to acidification of tumours: studies of variant cells lacking
lactate dehydrogenase
M Yarnagata, K Hasuda, TStamato and IF Tannock
Multidrug resistance phenotype in leukaemic cells from patients with acute myelocytic
leukaemia can be detected with 99Tcm.MIBI
A Gruber, 1Areström, D Xu, J Liliemark, SA Larsson and H Jacobsson
1715
1718
1726
1732
Combined effect of navelbine with medroxyprogesterone acetate against human breast
carcinoma MCF-7 cells in vitro
K Sugiyama, M Shimiku, T Akiyama, H Ishida, M 0kabe, T Tamaoki and S Akinaga
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in
primary mouse keratinocytes
B Ortel, N Chen, J Brissette, GP Dotto, E Maytin and T Hasan
31 P-magnetic resonance spectroscopy and 2 H-magnetic resonance imaging studies of a
panel of early-generation transplanted murine tumour models
SP Robinson, A van den Boogaart, Ri Maxwell, JR Griffiths, E Hamilton and JC Waterton
Magnetic resonance imaging and spectroscopy of combretastatin A 4 prodrug-induced
disruption of tumour perfusion and energetic status
DA Beauregard, PE Thelwall, DJ Chaplin, SA Hill, GE Adams and KM Brindle
Modulation of P450-dependent ifosfamide pharmacokinctics: a better understanding of drug
activation in vivo
EGC Brain, LJ Yu, K Gustafsson, P Drewes and W Waxman
Selective activation of oncogenic Ha-ras-induced apoptosis in NIH / 3T3 cells
H-S Liu, C-Y Chen, C-H Lee and Y-I Chou
Loss of heterozygosity of 3p markers in neuroblastoma tumours implicate a tumoursuppressor locus distal to the FHIT gene
K Ejeskär, H Aburatani, J Abrahamsson, P Kogner and T Martinsson
Epidermal growth factor receptor expression in primary cultured human colorectal
carcinoma cells
W-M Tong, A Ellinger, Y Sheinin and HS Cross
Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion
molecules and adhesion to extracellular matrices without loss of cell viability
NH Hasan, GE Adams, MC Joiner, JF Marshall and IR Hart
Sticky and smelly issues: lessons on tumour cell and leucocyte trafficking, gene and
immunotherapy of cancer
AB Alexandroff, CA Mclntyre, JC Porter, JZeuthen, RG Vile and DD Taub
The oestrogen-like effect of 4-hydroxytamoxifen on Induction of transforming growth
factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen
receptor
AS Levenson, DA Tonetti and VC Jordan
Serum soluble interieukin-2 receptor level as a prognostic indicator in gastric cancer
B Nakata, K Hirakawa-YS Chung, Y Kato, Y Yamashita, A Inui, YArimoto, K Maeda, N
Onoda, T Sawada and M Sowa
Synthesis and breakdown of fibrillar collagens: concomitant phenomena in ovarian cancer
M Santala, J Risteli, L Risteli, U Puistola, BM Kacinski, ER Stanley and A Kauppila
Proliferation and apoptosis in malignant and normal cells In B-cell non-Hodgkin's
lymphomas
T Stokke, H Holte, L Smedshammer, EB Smeland, 0 Kaalhus and HB Steen
Tumour cell proliferation, but not apoptosis, predicts survival in B-cell non-Hodgkin's
lymphomas
T Stokke, EB Smeland, S Kvaloy and H Holte
Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for
prognostic significance
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RAEM Tollenaar, JHJM van Krieken, H-J van Slooten, DJ Bruinvels, KMJ Nelemans, LJ
van den Broek, J Hermans and JH van Dierendonck
Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal
cancer
U Kressner, B Glimelius, R Bergström, L Pahlman, A Larsson and G Lindmark
The Helicobacter pylori fatty acid cis-9,10-methyleneoctadecanoic acid stimulates protein
kinase C and increases DNA synthesis of gastric HM02 cells
W Bail, B Obst, S Wagner and KF Sewing
Serum concentrations of soluble adhesion molecules in patients with colorectal cancer
G Velikova, RE Banks, A Gearing, 1 Hemingway, MA Forbes, SR Preston, NR Hall, M
Jones, J Wyatt, K Miller, U Ward, J AI-Maskatti, SM Singh, PJ Finan, NS Ambrose, JN
Primrose and PJ Selby
Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer
L Kaklamanis, A Savage, R Whitehouse, I Doussis-Anagnostopoulou, S Biddolph, P
Tsiotos, N Mortensen, KC Gatter and AL Harris
Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with
suspected ovarian cancer
A Obermair, C Tempter, L Hefler, 0 Preyer, A Kaider, R Zeillinger, S Leodolter and C
Kainz
Antibodies to heat-shock protein 27 are associated with improved survival in patients with
breast cancer
SE Conroy, PD Sasieni, VAmin, DY Wang, P Smith, IS Fentiman and DS Latchman
An identical novel mutation in BRCA l and a common haplotype in familial ovarian cancer
in non-Ashkenazi Jews
L Theodor, R Bar-Sade, A Kruglikova, G Ben-Baruch, S Risel, R Shiri-Sverdlov, G Hirsh
Yechezkel, B Modan, MZ Papa, G Rechavi and E Friedman
Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma
transplanted into rat liver
PH Móller, K lvarsson, U Stenram, M Radnell and K-G Tranberg
Cytogenetic and FISH analyses of pancreatic carcinoma reveal breaks in 18q11 with
consistent loss of 18q12-qter and frequent gain of 18p
M Höglund, L Gorunova, TJonson, S Dawiskiba, A Andrén-Sandberg, G Stenman and B
Johansson
Do mast cells help to induce angiogenesis in B-cell non-Hodgkin's lymphomas?
D Ribatti, B Nico, A Vacca, A Marzullo, N Calvi, L Roncali and F Dammacco
CLINICAL ONCOLOGY
Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the antimelanoma lytic activity in peripheral blood of patients with a good clinical performance
status: a clinical phase 1 study
P Möller, Y Sun, T Dorbic, S Alijagic, A Makki, K Jurgovsky, M Schroff, BM Henz, B
Wittig and D Shadendorf
Mitotic rate and S-phase fraction as prognostic factors in stage 1 cutaneous malignant
melanoma
JM Karjalainen, MJ Eskelinen, S Nordling, PK Lipponen, EM Alhava and V-M Kosma
Consensus standards for the process of cancer care: a modified expert panel method applied
to head and neck cancer
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MA Birchall and the South and West Expert Tumour Panel for Head and Neck Cancer
Prognostic value of histological and biological markers in pharyngeal squamous cell
carcinoma: a case-control study
M Guerry, L Vabre, M Talbot, G Mamelle, AM Leridant, C Hill, J Bosq, B Luboinski and
F Janot
A phase 1 trial of docetaxel and 5-day continuous infusion of 5-fluorouracil in patients with
advanced or recurrent breast cancer
M Ando, T Watanabe, Y Sasaki, D-F Ying, Y Omuro, N Katsumata, M Narabayashi, Y
Tokue, H Fuji, T lgarashi, H Wakita, T Ohisu, K ltoh, I Adachi and T Taguchi
Time trends in breast cancer survival: experience in a single centre, 1975-89
MJ Bradbum, DG Altman, P Smith, IS Fentiman and RD Rubens
Cyclophosphamide, methotrexate and infusional 5-fluorouracil (infusional CMF) in
metastatic breast cancer
KJ O'Byrne, MI Koukourakis, MP Saunders, AJ Salisbury, R Isaacs, S Varcoe, M Taylor,
TS Ganesan, AL Harris and DC Talbot
In vivo stimulation of IL-12 secretion by subcutaneous low-dose IL-2 in metastatic cancer
patients
P Lissoni, L Fumagalli, F Rovelli, F Brivio, G Di Felice and F Majorca
Phase II trial of carboplatin plus oral etoposide for elderly patients with small-cell lung
cancer
K Matsui, N Masuda, M Fukuoka, T Yana, T Hirashima, T Korniya, M Kobayashi, M
Kawahara, S Atagi, M 0gawara, S Negoro, S Kudoh and KFuruse
A pilot study of MVP (mitomycin-C, vinblastine and cisplatin) chemotherapy in small-cell
lung cancer
TF Hickish, lE Smith, MC Nicolson, S Ashley, K Priest, L Spencer, A Norman, G
Middleton and MER O'Brien
Prognostic value of genomic damage in non-small-cell lung cancer
C de Juan, P Iniesta, FJ Vega, MA Peinado, C Femandez, T Caldés, M José Massa, JA
López, A Sánchez, AJ Torres, JL Balibrea and M Benito
Abnormalities in plasma and red blood cell fatty acid profiles of patients with colorectal
cancer
L Baró, J-C Hermoso, M-C Nuñez, J-A Jiménez-Rios and A Gil
Weekly etoposide, epirubicin, cisplatin, 5-fluorouracil and leucovorin: an effective
chemotherapy in advanced gastric cancer
KH Chi, Y Chao, WKChan, SS Lo, SYChen, SH Yen, KYChen, CW Wu, SD Lee and
WY Lui
Clinical photodynamic therapy for superficial cancer in the oesophagus and the bronchi:
514 nm compared with 630 nm light irradiation after sensitization with Photofrin II
P Grosjean, G Wagnieres, C Fontolliet, H van den Bergh and P Monnier
Effect of subcutaneous recombinant human erythropoetin in cancer patients receiving
radiotherapy: final report of a randomized, open-labelled, phase II trial
PJ Sweeney, D Nicolae, L Ignacio, L Chen, M Roach III, W Wara, KC Marcus and S
Vijayakumar
Comparison of chromosomal aberrations detected by fluorescence in situ hybridization with
clinical parameters, DNA ploidy and Ki 67 expression in renal cell carcinoma
Y Wada, M lgawa, H Shiina, K Shigeno, H Yokogi, S Urakami, T Yoneda and R
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Maruyama
Demonstration of hepatic steatosis by computerized tomography in patients receiving 5fluorouracil-based therapy for advanced colorectal cancer
PD Peppercorn, RH Reznek, P Wilson, ML Slevin and RK Gupta
Can manipulation of a pelvic tumour influence the serum level of cancer antigen 125 and
cancer-associated serum antigen?
0 Kierkegaard, 0 Mogensen, B Mogensen and S Ahrons
Psychological predictors of attendance at annual breast screening examinations
MV Burton, R Warren, D Price and H Earl
Phase I study of the mitomycin C analogue BMS-181174
VM Macaulay, K.J O'Byrne, JA Green, PA Philip, L McKinley, FP LaCreta, B Winograd,
TS Ganesan, AL Harris and DC Talbot
EPIDEMIOLOGY
Past exposure to hepatitis B virus as a risk factor for hepatocellular carcinoma In patients
with chronic liver disease
S Okada, T Sato, T Okusaka, H Ishii, M lkeda, H Nakasuka, H Kosakamoto, M Yoshimori
and K Wakabayashi
Hepatitis C virus, non-Hodgkin's lymphomas and hepatocellular carcinoma
S De Vita, V Zagonel, A Russo, M Rupolo, R Cannizzaro, G Chiara, M Boiocchi, A
Carbone and S Franceschi
Individual patient data meta-analyses in cancer
M Clarke, L Stewart, J-P Pignon and L Bijnens
No association between a polymorphism in the steroid metabolism gene CYP17 and risk of
breast cancer
AM Dunning, CS Healey, PDP Pharoah, NA Foster, JM Lipscombe, KL Redman, DF
Easton, NE Day and BAJ Ponder
Occupational exposures, animal exposure and smoking as risk factors for hairy cell
leukaemia evaluated in a case-control study
M Nordstróm, L Hardell, A Magnuson, H Hagberg and A Rask-Andersen
Divergent changes in survival for histological types of non-small-cell lung cancer in the
southeastern area of The Netherlands since 1975
MLG Janssen-Heijnen, RM Schipper, PJJM Klinkhamer, MA Crommelin, WJ Mooi and JWW Coebergh
BOOK REVIEW
LETTER TO THE EDITOR
CALENDAR
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VOLUME 77 NUMBER 12 JUNE 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Toxicity to neuroblastoma cells and spheroids of benzyiguanidine conjugated to
radionuclides with short-range emissions
SH Cunningham, RJ Mairs, TE Wheldon, PC Welsh, G Vaidyanathan and MR Zalutsky
Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under
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2069
flow conditions: role of platelet glycoproteins P-selectin and GPIlb-IIIA
R Dardik, N Savion, Y Kaufmann and D Varon
2076
Amplification and expression of the ABC transporters ARA and MRP in a series of
multidrug- resistant leukaemia cell sublines
GM O'Neill, GB Peters, RM Harvie, HB MacKenzie, S Henness and RA Davey
Regulation of interferon responses in medulloblastoma cells by interferon regulatory factor- 2081
1 and –2
KC Park, K Shimiku, T Hayakawa and N Tanaka
Anti-proliferative activity and mechanism of action of titanocene dichloride
2088
CV Christodoulou, AG Elippoulos, LS Young, L Hodgkins, DR Ferry and DJ Kerr
2098
Interstitial photodynamic therapy with the second-generation photosensitizer
bacteriochlorin a in a rat model for liver metastases
JP Rovers, JJ Schuitmaker, AL Vahrmeijer, JH van Dierendonck and OT Terpstra
Electrochemotherapy on liver tumours in rabbits
2104
LH Ramirez, S Orlowski, D An, G Bindoula, R Dzodic, P Ardouin, C Bognel, J Belehradek
Jr, J-N Munck and LM Mir
Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of 2112
tumours
RM Phillips, PM Loadman and BP Cronin
Differential expression of vascular endothelial growth factor mRNA vs protein isoform
2120
expression in human breast cancer and relationship to e1F-4E
PAE Scott, K Smith, R Poulsom, A De Benedetti, R Bicknell and AL Harris
A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis 2129
in MCF-7 tumour cells
KM Eck, L Yuan, L Duffy, PT Ram, S Ayettey, I Chen, CS Cohn, JC Reed and SM Hill
Modulation of the insulin-like growth factor-I system by N(4-hydroxyphenyl)-retinamide in 2138
human breast cancer cell lines
RE Favoni, A de Cupis, S Bruno, D Yee, A Ferrera, P Pirani, A Costa and A Decensi
Mutations of the Apc gene in experimental colorectal carcinogenesis induced by
2148
azoxymethane in F344 rats
C De Filippo, G Caderni, M Bazzicalupo, C Briani, A Giannini, M Fazi and P Dolara
Low-level resistance to camptothecin in a human small-cell lung cancer cell line without
2152
reduction in DNA topoisomerase I or drug-induced cleavable complex formation
M Sorensen, M Sehested, IJ Christensen, JK Larsen and PB Jensen
Paracrine effects of hepatocyte growth factor/scatter factor on non-small-cell lung
2162
carcinoma cell lines
S Yi, J-r Chen, J Viallet, RH Schwall, T Nakamura and M-S Tsao
Determinants of CPT-11 and SN-38 activities in human lung cancer cells
2171
J van Ark-Otte, MA Kedde, WJF van der Vijgh, A-MC Dingemans, WJM Jansen, HM
Pinedo, E Boven and G Giaccone
Telomerase activity in benign and malignant human thyroid tissues
2177
A-J Cheng, J-D Lin, T Chang and TI-CV Wang
Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families
2181
JM Boyle, ELD Mitchell, MJ Greaves, SA Roberts, K Tricker E Burt, JM Varley, JM Birch
and DS Scott
Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the
2193
urinary bladder?
JMS Bartlett, AD Watters, SA Ballantyne, JJ Going, KM Grigor and TG Cooke
BRCA l mutations in southern England
DM Eccles, P Englefield, MA Soulby and IG Campbell
Increased microvessel density in mucinous compared with malignant serous and benign
tumours of the ovary
M Orre, M Lotfi -Miri, P Mamers and PAW Rogers
The luminescence immunoassay S-100: a sensitive test to measure circulating S-100B: its
prognostic value in malignant melanoma
JMG Bonfrer, CM Korse, OE Nieweg and EM Rankin
Suppression of tumorigenic and metastatic potentials of human melanoma cell lines by
mutated (143 Val-Ala) p53
S Rauth, A Green, J Kichina and A Shilkaitis
Comparative genomic hybridization and telomerase activity analysis identify two
biologically different groups of 4s neuroblastomas
C Brinkschmidt, C Poremba, H Christiansen, R Simon, KL Scháfer, HJ Terpe, F Lampert,
W Boecker and B Dockhorn-Dworniczak
Alterations of TP53 in microdissected transitional cell carcinoma of the human urinary
bladder: high frequency of TP53 accumulation in the absence of detected mutations is
associated with poor prognosis
R Abdel-Fattah, C Challen, TRL Griffiths, MC Robinson, DE Neal and J Lunec
Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2
and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node
metastasis
M Sutinen, T Kainulainen, T Hurskainen, E Vesterlund, JP Alexander CM Overall, T Sorsa
and T Salo
CLINICAL ONCOLOGY
Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase
expression in invasive breast carcinoma
RD Leek, R Landers, SB Fox, F Ng, AL Harris and CE Lewis
Family history and survival in premenopausal breast cancer
SN Mohammed, P Smith, SV Hodgson, IS Fentiman, DW Miles, DM Barnes, RR Millis
and RD Rubens
Doxorubicin vs epirubicin, report of a second-line randomized phase II / III study in
advanced breast cancer
M Bontenbal, M Andersson, J Wildiers, G Cocconi, J Jassem, R Paridaens, N Rotmensz, R
Sylvester, HT Mouridsen, JGM Klijn and AT van Oosterom on behalf of the EORTC
Breast Cancer Cooperative Group
Tamoxifen reduces plasma homocysteine levels in healthy women
M Cattaneo, L Baglietto, ML Zighetti, D Bettega, C Robertson, A Costa, PM Mannucci and
A Decensi
Predictive value of topoisomerase 11α and other prognostic factors for epirubicin
chemotherapy in advanced breast cancer
TAH Järvinen, K Holli, T Kuukas járvi and JJ Isola
VLA2 integrin expression in breast carcinomas evaluated by automated and quantitative
Immunohistochemistry
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C Charpin, S Garcia, D Bergeret, L Andrac, N Horschowski, R Choux and MN Lavaut
Improved cure rate in children with B-cell acute lymphoblastic leukaemia (B-ALL) and
stage IV B-cell non-Hodgkin's lymphoma (B-NHL) - results of the UKCCSG 9003 protocol
A Atra, M Gerrard, R Hobson, JD Imeson, SAshley and CR Pinkerton on behalf of the
UKCCSG
Pulmonary toxicity after granulocyte colony-stimulating factor-combined chemotherapy for
Non-Hodgkin's lymphoma
N Yokose, K Ogata, H Tamura, E An, K Nakamura, K Kamikubo, S Kudoh, K Dan and T
Nomura
Early stem cell transplantation for chronic lymphocytic leukaemia: a chance for cure?
P Dreger, N von Neuhoff, R Kuse, R Sonnen, B Glass, L Uharek, R Schoch, H Löffler and
N Schmitz
Combined analysis of differentiation inhibitory factor nm23-H1 and nm23-H2 as prognostic
factors in acute myeloid leukaemia
N Wakimoto, A Yokoyama, J Okabe-Kado, N Nagata, K Motoyoshi and Y Honma
High-dose cyclosporin with etoposide - toxicity and pharmacokinetic interaction in children
with solid tumours
G Bisogno, F Cowie, A Boddy, HD Thomas, G Dick and CR Pinkerton
Unresectable localized neuroblastoma: improved survival after primary chemotherapy
including carboplatin-etoposide
H Rubie, J Michon, D Plantaz, MC Peyroulet, C Coze, D Frappaz, P Chastagner, MC
Baranzelli, F Méchinaud, P Boutard, P Lutz, Y Perel, G Leverger, L de Lumley, F Millot JL
Stéphan, G Margueritte and 0 Hartmann for the Neuroblastoma Study Group of the Société
Francaise d'Oncologie Pédiatrique
(SFOP)
A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in
children
SP Lowis, L Price, ADJ Pearson, DR Newell and M Cole
Dose escalation with repeated intrathecal injections of 131 l-labelled MAbs for the
treatment of central nervous system malignancies
JT Kemshead, K Hopkins, B Pizer, V Papanastassiou, H Coakham, J Bullimore and C
Chandler
Demonstration of increased collagen synthesis in irradiated human skin in vivo
P Autio, T Saarto, M Tenhunen, 1 Elomaa, J Risteli and T Lahtinen
Effective treatment of cutaneous and subcutaneous malignant tumours by
electrochemotherapy
LM Mir, LF Glass, G Sersa, J Teissié, C Domenge, D Miklavcic, MJ Jaroszeski, S
Orlowski, DS Reintgen, Z Rudolf, M Belehradek, R Gilbert, M-P Rols, J Belehradek Jr,
JM Bachaud, R DeConti, B Stabuc, M Cemazar, P Coninx and R Heller
Aberrant crypt foci in patients with colorectal cancer
L Roncucci, S Modica, M Pedroni, MG Tamassia, M Ghidoni, L Losi, R Fante, C Di
Gregorio, A Manenti, L Gafa and M Ponz de Leon
Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological
parameters in colorectal cancer
L Masramon, R Arribas, S Tórtola, M Perucho and MA Peinado
Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical
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features and outcome of Hodgkin's disease patients
K Warzocha, J Bienvenu, P Ribeiro, 1 Moullet, C Dumontet, EM Neidhardt-Berard, B
Coiffier and G Salles
A phase I / II study of multicyclic dose-intensive chemotherapy supported with G-CSF, or
G-CSF and haematopoietic progenitor cells in whole blood, in two consecutive cohorts of
patients
R de Wit, WHJ Kruit, CHJ Lamers, MB van't Veer, AA Luyten, V van Beurden, M
Harteveld, ASTh Planting, PIM Schmitz, G Stoter, RLH Bolhuis and J Verweij
Cisplatin-vindesine-mitomycin (MVP) vs cisplatin-ifosfamide-vinorelbine (PIN) vs
carboplatin-vinorel-bine (CaN) in patients with advanced non-small-cell lung cancer
(NSCLC): a FONICAP randomized phase II study
E Baldini, C Tibaldi, A Ardizzoni, F Salvati, A Antilli, L Portalone, S Barbera, F Romano,
F De Marinis, MR Migliorino, MA Noseda, U Borghini, M Crippa, G Ferrara, M Raimondi,
M Fioretti, M Bandera, MC Pennucci, G Galeasso, GC Cacciani, G Lepidini, G Sunseri, C
Lanfranco, M Rinaldi, R Lionetto, PF Conte and R Rosso for the Italian Lung Cancer Task
Force (FONICAP)
The in vitro radiosensitivity of human head and neck cancers
T Björk-Eriksson, CML West, E Karlsson, NJ Slevin, SE Davidson, RD James and C
Mercke
A multicentre phase II study of carboplatin and prolonged oral etoposide in the treatment of
cancer of unknown primary site (CUPS)
E Warner, R Goel, J Chang, W Chow, S Verma, J Dancey, E Franssen, H Dulude, M
Girouard, J Correia and G Gallant
Predictors of patients' mental adjustment to cancer: patient characteristics and social support
TAkechi, H Okamura, S Varnawaki and Y Uchitomi
Prostate-specific antigen in the cerebrospinal fluid leads to diagnosis of solitary cauda
equina metastasis: a unique case report and review of the literature
B Schaller, A Merlo, E Kirsch, K Lehmann, PR Huber, P Lyrer, AJ Steck and 0 GratzI
CALENDAR
AUTHOR INDEX
KEYWORD INDEX
VOLUME 77 SUPPLEMENT 4 JUNE 1998
Colorectal Cancer, Lung Cancer... Hopes and Reality
Proceedings of a Sanofi-sponsored satellite symposium held at the ECCO 9 conference,
Hamburg, 14 September 1997
CONTENTS
Oxaliplatin (L-OHP): a new reality in colorectal cancer
H Bleiberg
Oxaliplatin in practice
J-L Misset
Ongoing and unsaid on oxaliplatin: the hope
E Cvitkovic
Exploiting tumour hypoxia and overcoming mutant p53 with tirapazamine
JM Brown
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Tirapazamine-cisplatin: the synergy
U Gatzemeier, G Rodriguez, J Treat, V Miller, R von Roemeling, J Viallet and A Rey
Advances in the management of malignancy-associated hyperuricaemia
HH Mahmoud, G Leverger, C Patte, E Harvey and F Lascombes
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VOLUME 78 NUMBER 1 JULY 1998
CONTENTS
CLINICAL ONCOLOGY
123-I-labelled vasoactive intestinal peptide receptor scintigraphy in patients with colorectal
cancer
M Raderer, M Kurtaran, M Hejha, F Vorbeck, P Angelberger W Scheithauer and I
Virgolini
A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and
colorectal cancer
T Gulliford, J English, KW Colston, P Menday, S Moller and RC Coombes
Microencapsulated octreotide pamoate in advanced gastrointestinal and pancreatic cancer:
a phase study
SI Helle, J Geisler, JP Poulsen, K Hestdal, K Meadows, W Collins, KM Tveit, A Viste,
JMP Holly and PE Lonning
Pulmonary function after treatment for acute lymphoblastic leukaemia in childhood
K Nysom, K Holm, JH 0lsen, H Hertz and B Hesse
Clinical benefit from palliative chemotherapy in non-small-cell lung cancer extends to the
elderly and those with poor prognostic factors
TF Hickish, lE Smith, MER O'Brien, S Ashley and G Middleton
Phase II and pharmacokinetic study of paclitaxel therapy for unresectable hepatocellular
carcinoma patients
Y Chao, W-K Chan, MJ Birkhofer, OY-P Hu, S-S Wang, Y-S Huang, M Liu, J WhangPeng, K-H Chi, W-Y Lui and S-D Lee
Elevated pretreatment serum levels of soluble vascular cell adhesion molecule 1 and lactate
dehydrogenase as predictors of survival in cutaneous metastatic malignant melanoma
A Franzke, M Probst-Kepper, J Buer, S Duensing, R Hoffmann, F Wittke, M Volkenandt,
A Ganser and J Atzpodien
Is prostatic intraepithelial neoplasia in the transition/central zone a true precursor of cancer?
A long-term retrospective study in Norway
S Harvei, FJ Skjorten, TE Robsahm, A Berner and S Tretli
EXPERIMENTAL THERAPEUTICS
Cell cycle phase influences tumour cell sensitivity to aminolaevulinic acid-induced
photodynamic therapy in vitro
L Wyld, 0 Smith, J Lawry, MWR Reed and NJ Brown
Localized hypothermia: impact on oxygenation, microregional perfusion, metabolic and
bioenergetic status of subcutaneous rat tumours
DK Kelleher, C Nauth, 0 Thews, W Krueger and P Vaupel
Thymidylate synthase expression and activity: relation to S-phase parameters and 5fluorouracil sensitivity
J-F Mirjolet, M Barberi-Heyob, J-L Merlin, S Marchal, M-C Etienne, G Milano and P Bey
1
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28
34
40
46
50
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Mutations in the TP53 gene and protein expression of p53, MDM 2 and p21/WAF-1 in
primary cervical carcinomas with no or low human papillomavirus load
A Helland, F Karlsen, EU Due, R Holm, G Kristensen and A-L Borresen-Dale
Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are
constantly associated with loss of heterozygosity in the FHIT locus
A Marchetti, S Pellegrini, G Sozzi, G Bertacca, P Gaeta, F Buttitta, V Carnicelli, P Griseri,
A Chella, CA Angeletti, M Pierotti and G Bevilacqua
Effects of retinoic acid and fenretinide on the c-erbB-2 expression, growth and cisplatin
sensitivity of breast cancer cells
ThW Grunt, E Dittrich, M Offierdinger, SM Schneider, Ch Dittrich and H Huber
Oestradiol regulation of the components of the plasminogen-plasmin system in MDA-MB231 human breast cancer cells stably expressing the oestrogen receptor
AS Levenson, HC Kwaan, KM Svoboda, IM Weiss, S Sakurai and VC Jordan
Enzyme-linked immunosorbent assay of epidermal growth factor receptor in lung cancer:
comparisons with immunohistochemistry, clinicopathological features and prognosis
P Pteiffer, E Nexo, SM Bentzen, PP Clausen, K Andersen and C Rose
Bax expression has prognostic significance that is enhanced when combined with AgNOR
counts in glottic carcinomas
X Xie, OPF Clausen, P De Angelis and M Boysen
Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma
S Glüer, C Schelp, N Madry, D von Schweinitz, M Eckhardt and R Gerardy-Schahn
The suppression of fibroblast growth factor 2/fibroblast growth factor 4-dependent tumour
Anglogenesis and growth by the anti-growth factor activity of dextran derivative (CMDB7)
R Bagheri-Yarmand, Y Kourbali, C Mabilat, JF Mortere, A Marlin, H Lu, C Soria, J
Jozefonvicz and M Crépin
EPIDEMIOLOGY
Seasonal variations in the onset of childhood leukaemia and lymphoma
RMC Westerbeek, V Blair, 0B Eden, AM Kelsey, RF Stevens, AM Will, GM Taylor and
JM Birch
Gastric cancer risk in relation to Helicobacter pylori Infection and subtypes of intestinal
metaplasia
M-S Wu, C-T Shun, W-C Lee, C-J Chen, H-P Wang, W-J Lee, J-C Sheu and J-T Lin
Intake of nitrate and nitrite and the risk of gastric cancer: a prospective cohort study
AJM van Loon, AAM Botterweck, RA Goldbohm, HAM Brants, JD van Klaveren and PA
van den Brant
Smoking and risk of colorectal cancer
P Knekt, M Hakama, R Järvinen, E Pukkala and M Heliövaara
CALENDAR
VOLUME 78 SUPPLEMENT 1 1998
Joint British Association and Irish Association
Cancer Research Meeting
21-24 June 1998
Trinity College, Dublin
Contents
Abstract Nos
69
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96
100
106
111
119
125
129
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Page
Nos
Invited papers
S1-S16
The Tom Connors Lecture
S1
The Walter Hubert Lecture
S2
The Frank Rose Memorial Lecture
S7
IACR Lecture
S16
BACR/Zeneca Young Scientist Award Lecture
Oral presentations
1.1-8.10
Poster presentations
P1-P187
Author index
Keyword index
VOLUME 78 NUMBER 2 JULY 1998
CONTENTS
ABSTRACTS
Cancer cure: drugs, genes or surgery?
REVIEW
Where to go with new expensive treatments in NSCLC
A Webb and MER O'Brien
EXPERIMENTAL ONCOLOGY
A dual hypoxic marker technique for measuring oxygenation change within individual
tumors
RV Iyer, E Kim, RF Schneider and JD Chapman
Quantification and prognostic relevance of angiogenic parameters in invasive cervical
cancer
W Tjalma, E Van Marck, J Weyler, L Dirix, A Van Daele, G Goovaerts, G Albertyn and P
van Dam
Lack of a role for MRP1 in platinum drug resistance in human ovarian cancer cell lines
SY Sharp, V Smith, S Hobbs and LR Kelland
Antigen specificity and tumour targeting efficiency of a human carcinoembryonic antigenspecific scFv and affinity-matured derivatives
H Jackson, L Bacon, RB Pedley, E Derbyshire, A Field, J Osboum and D Allen
Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and
reduce immunogenicity
M Chinol, P Casalini, M Maggiolo, S Canevari, ES Omodeo, P Caliceti, FM Veronese, M
Cremonesi, F Chiolerio, E Nardone, AG Siccardi and G Paganelli
Neoplastic progression of breast epithelial cells - a molecular analysis
WZ Wei, R Pauley, D Lichlyter, H Soule, W-P Shi, G Calaf, J Russo and RF Jones
Prognostic value of cathepsin D expression and association with histomorphological
subtypes in breast cancer
A Lösch, C Tempfer, P Kohlberger, EA Joura, M Denk, B Zajic, G Breitenecker and C
Kainz
Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent
cervical cancer
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RAF Crawford, C Caldwell, RK lles, D Lowe, JH Shepherd and T Chard
Matrix metalloproteinase-1 is induced by epidermal growth factor in human bladder tumour
cell lines and is detectable in urine of patients with bladder tumours
JE Nutt, JK Mellon, K Oureshi and J Lunec
Restricted expression of oncofetal fibronectin mRNA in thyroid papillary and anaplastic
carcinoma: an in situ hybridization study
T Takano, F Matsuzuka, A Miyauchi, T Yokozawa, G Liu, S Morita, K Kuma and N
Amino
Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas
and is moderately increased by CD40 ligation
L Xerri, R Bouabdallah, E Devilard, J Hassoun, A-M Stoppa and F Birg
Vascular endothelial growth factor and nitric oxide synthase expression in human lung
cancer and the relation to p53
S Ambs, WP Bennett, WG Merriam, MO Ogunfusika, SM Oser, MA Khan, RT Jones and
CC Harris
CLINICAL ONCOLOGY
Aminoterminal propeptide of type 1 procollagen (PINP) correlates to bone loss and predicts
the efficacy of antiresorptive therapy in pre- and post-menopausal non-metastatic breast
cancer patients
T Saarto, C Blomqvist, J Risteli, L Risteli, S Sama and I Elomaa
Neural network analysis of combined conventional and experimental prognostic markers in
prostate cancer: a pilot study
RNG Naguib, MC Robinson, DE Neal and FC Hamdy
A phase II trial of combination of CPT-11 and cisplatin for advanced non-small-cell lung
cancer
N Masuda, M Fukuoka, A Fujita, Y Kurita, S Tsuchiya, K Nagao, S Negoro, H Nishikawa,
N Katakami, K Nakagawa and H Niitani for the CPT-11 Lung Cancer Study Group
Dose-finding study of irinotecan and cisplatin plus concurrent radiotherapy for unresectable
stage Ill non-small-cell lung cancer
A Yokoyama, Y Kurita, N Saijo, T Tamura, K Noda, K Shimokata and T Matsuda
Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with
Heficobacter pylori
S Miehlke, A Hackelsberger A Meining, R Hatz, N Lehn, P Malfiertheiner, M Stolte and E
Bayerdörffer
Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer
M Benekli, 1H Gü11ü, G Tekuzman, MC Savas, M Hayran, G Hascelik and D Firat
The effects of norethisterone on endometrial abnormalities identified by transvaginal
ultrasound screening of healthy post-menopausal women on tamoxifen or placebo
TJ Powles, T Bourne, S Athanasiou, J Chang, K Grubdck, S Ashley, L Oakes, A Tidy, J
Davey, J Viggers, S Humphries and W Collins
BOOK REVIEWS
LETTERS TO THE EDITOR
CALENDAR
VOLUME 78 SUPPLEMENT 2 1998
British Oncological Association
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Association of Cancer Physicians
Royal College of Radiologists
5-7 July 1998
Nottingham, UK
Contents
Oral presentations
Poster presentations
Author index
Keyword index
Abstract Nos
001-075
P01-P69
Page Nos
3-25
29-46
47-51
52-54
VOLUME 78 NUMBER 3 AUGUST 1998
CONTENTS
OBITUARY
EDITORIAL
Immunotherapy in lung cancer
M AI-Moundhri, M O'Brien and BE Souberbielle
SPECIAL NOTICES
BT backs BACUP to develop the first interactive cancer information service on the internet
Consensus conference on platelet transfusion
EXPERIMENTAL ONCOLOGY
Cytogenetic and molecular genetic demonstration of polyclonality in an acinic cell
carcinoma
C Jin, Y Jin, M Höglund, J Wennerberg, J Akervall, R WiIIén, M Dictor, N Mandahl, F
Mitelman and F Mertens
Ras-related TC21 is activated by mutation in a breast cancer cell line, but infrequently in
breast carcinomas in vivo
KT Barker and MR Crompton
Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination
with plutonium-239
Bl Lord, LB Woolford, L Wang, VA Stones, D McDonald, SA Lorimore, D Papworth, EG
Wright and D Scott
Hydroquinones cause specific mutations and lead to cellular transformation and in vivo
tumorigenesis
P Joseph, AJP Klein-Szanto and AK Jaiswal
Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrugresistant human CCRF-CEM leukaemia cells
SK Syed, RI Christopherson and BD Routogalis
Comparison of the cytotoxic activity of melphalan with L-prolyl-M-L-sarcolysy1-l-pfluorophenylalanine in human tumour cell lines and primary cultures of tumour cells from
patients
R Larsson, S Dhar, H Ehrsson, P Nygren and R Lewensohn
Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with
the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of
serum tumour necrosis factor-alpha and enhancement of anti-tumour activity
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301
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L-M Ching, WL Browne, R Tchemegovski, T Gregory, BC Baguley and BD Palmer
Osteoid osteoma and osteoblastoma with clonal chromosome changes
P Dal Cin, R Sciot, I Samson, I De Wever and H Van den Berghe
Unique activation of matrix metalloproteinase-9 within human liver metastasis from
colorectal cancer
ZS Zeng and JG Guillem
p53 mutations and human papillomavirus DNA in oral squamous cell carcinoma:
correlation with apoptosis
JY Koh, NP Cho, G Kong, JD Lee and K Yoon
Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in
androgen receptor-positive breast tumours
RE Hall, JA Clements, SN Birrell and WD Tilley
CLINICAL ONCOLOGY
A randomized phase 11 trial of inteleukin 2 and inteleukin 2-interferon alpha in advanced
renal cancer
GC Jayson, M Middleton, SM Lee, L Ashcroft and N Thatcher
Paclitaxel and carboplatin in patients with metastatic urothelial cancer: results of a phase 11
trial
CC Zielinski, B Schnack, M Grbovic, T Brodowicz, C Wiltschke, G Steger, H Pflüger and
M Marberger
Therapy effect of either paclitaxel or cyclophosphamide combination treatment in patients
with epithelial ovarian cancer and relation to TP53 gene status
B Smith-Sorensen, J Kaerm, R Holm, A Dorum, C Tropé and A-L Borresen-Dale
The growth law of primary breast cancer as inferred from mammography screening trials
data
D Hart, E Shochat and Z Agur
Interleukin 6 is a cause of flu-like symptoms in treatment with a deoxycytidine analogue
N Masuda, S Negoro, K Takeda, N Kurata, T Kuwabara, S Kobayashi and M Fukuoka
Intensive weekly chemotherapy for locally advanced gastric cancer using 5-fluorouracil,
cisplatin, epidoxorubicin, 6S-leucovorin, glutathione and filgrastim: a report from the
Italian Group for the Study of Digestive Tract Cancer (GISCAD)
S Cascinu, R Labianca, F Graziano, G Pancera, S Barni, L Frontini, G Luporini, R
Cellerino and G Catalano
EPIDEMIOLOGY
Risk of lung cancer associated with residential radon exposure in south-west England:
a case-control study
S Darby, E Whitley, P Sitcocks, B Thakrar, M Green, P Lomas, J Miles, G Reeves, T Fearn
and R Doll
Second primary tumours in more than 2-year disease-free survivors of small-cell lung
cancer in Japan: the role of smoking cessation
M Kawahara, S Ushijima, T Kamimori, N Kodama, M Ogawara, K Matsui, N Masuda, M
Takada, T Sobue and K Furuse
The effect of finasteride on the prostate gland in men with elevated serum prostate-specific
antigen levels
RJ Cote, EC Skinner, CE Salem, SJ Mertes, FZ Stanczyk, BE Henderson, MC Pike and RK
Ross
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360
366
370
375
382
388
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394
409
413
Incidence rates of classical Kaposi's sarcoma and multiple myeloma do not correlate
H Hjalgrim, M Frisch and M Melbye
VOLUME 78 SUPPLEMENT 4 SEPTEMBER 1998
Endocrine options for the treatment of early breast cancer - looking beyond tamoxifen
St. Gallen, Switzerland at the 6th International Conference of Adjuvant Therapy of Primary
Breast Cancer
Thursday 26 February 1998
CONTENTS
Tamoxifen - the treatment of choice. Why look for alternatives?
M Baum
Luteinizing hormone-releasing hormone analogues - the rationale for adjuvant use in
premenopausal women with early breast cancer
W Jonat
Luteinizing hormone-releasing hormone analogues in early breast cancer: updated status of
ongoing clinical trials
M Kaufmann
Aromatase inhibitors and their future role in post-menopausal women with early breast
cancer
PE Lonning
The place of chemotherapy in the treatment of early breast cancer
A Buzdar
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VOLUME 78 NUMBER 6 SEPTEMBER 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Overexpression of the stathmin gene in a subset of human breast cancer
I Biéche, S Lachkar, V Becette, C Cifuentes-Diaz, A Sobel, R Lidereau and PA Curmi
Relationship of nm23 to proteolytic factors, proliferation and motility in breast cancer
tissues and cell lines
RL Russell, AN Pedersen, J Kantor, K Geisinger, R Long, N Zbieranski, A Townsend, B
Shelton, N Brünner and TE Kute
Enhanced expression of the urokinase-type plasminogen activator gene and reduced colony
formation in soft agar by ectopic expression of PU.1 in HT1080 human fibrosarcoma cells
N Kondoh, T Yamada, F Kihara-Negishi, M Yamamoto and T Oikawa
Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble
factor (MMPSF)
TM Leber and FR Balkwill
Uptake and kinetics of 14C-labelled meta-tetrahydroxyphenylchlorin and 5-aminolaevulinic
acid in the C6 rat glioma model
A Obwegeser, R Jakober and H Kostron
In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly
explanted clonogenic human tumour cells and haematopoietic precursor cells
H Depenbrock, R Peter, GT Faircloth, I Manzanares, J Jimeno and AR Hanauske
Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1
inhibitors
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AC McDonald and R Brown
Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of
chemotherapy-induced anaemia
0 Thews, R Koenig, DK Kelleher, J Kulzner and P Vaupel
P-glycoprotein and metallothionein expression and resistance to chemotherapy in
osteosarcoma
SD Shnyder, AJ Hayes, J Pringle and CW Archer
CLINICAL ONCOLOGY
Reinduction therapy with the same cytostatic regimen in patients with advanced colorectal
cancer
M Hejna, GV Kornek, M Raderer, D Depisch, T Brodowicz, WCC Fiebiger and W
Scheithauer
Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth
factor in human colorectal cancer
M Landriscina, A Cassano, C Ratto, R Longo, M Ippoliti, B Palazzotti, F Crucitti and C
Barone
Absence of 185delAG mutation of the BRCA 1 gene and 6174delT mutation of the BRCA2
gene in Ashkenazi Jewish men with prostate cancer
S Lehrer, F Fodor, RG Stock, NN Stone, C Eng, HK Song and M McGovem
The treatment of nephrotic syndrome caused by primary (light chain) amyloid with
vincristine, doxorubicin and dexamethasone
AM Wardley, GC Jayson, DJA Goldsmith, MC Venning, P Ackrill and JH Scarffe
High-dose intensity cyclophosphamide, epidoxorubicin, vincristine and prednisone by
shortened intervals and granulocyte colony-stimulating factor in non-Hodgkin's lymphoma:
a phase II study
P Pronzato, R Lionetto, F Botto, F Pensa and A Tognoni
Cost-effectiveness of recombinant human erythropoietin in the prevention of
chemotherapy-induced anaemia
G Barosi, M Marchetti and NL Liberato
Evidence of significant apoptosis in poorly differentiated ductal carcinoma in situ of the
breast
A Gandhi, PA Holland, WF Knox, CS Potten and NJ Bundred
Long-term survival in node-positive breast cancer treated by locoregional therapy alone
H Joensuu, L Pylkkänen and S Toikkanen
Morphometric grading of invasive ductal breast cancer. I. Thresholds for nuclear grade
P Kronqvist, T Kuopio and Y Collan
Chromosome alterations in breast carcinomas: frequent involvement of DNA losses
includingchromosomes 4q and 21 q
A Schwendel, F Richard, H Langreck, 0 Kaufmann, H Lage, KJ Winzer, 1 Petersen and M
Dietel
A multivariate analysis of tumour biological factors predicting response to cytotoxic
treatment in advanced breast cancer
J Sjöström, S Krajewski, K Franssila, E Niskanen, V-M Wasenius, S Nordling, JC Reed
and C Blomqvist
MAGE, BAGE and GAGE: tumour antigen expression in benign and malignant ovarian
tissue
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AM Gillespie, S Rodgers, AP Wilson, J Tidy, RC Rees, RE Coleman and AK Murray
Tumour hypoxia and vascular density as predictors of metastasis in squamous cell
carcinoma of the uterine cervix
K Sundfor, H Lyng and EK Rofstad
Four cycles of BEP vs four cycles of VIP in patients with intermediate-prognosis metastatic
testicular non-seminoma: a randomized study of the EORTC Genitourinary Tract Cancer
Cooperative Group
R de Wit, G Stoter, DTh Sleijfer, JP Neijt, WW ten Bokkel Huinink, L de Prijck, L Collette
and R Sylvester
Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung
cancer: association of decreased plasminogen activator inhibitor 2 with lymph node
metastasis
H Yoshino, Y Endo, Y Watanabe and T Sasaki
CALENDAR
VOLUME 78 NUMBER 7 OCTOBER 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Role of nitric oxide in pancreatic tumour growth: in vivo and in vitro studies
A Hajri, E Metzger, F Vallat, S Coffy, E Flatter, S Evrard, J Marescaux and Maprahamian
Mechanism of muscle protein degradation induced by a cancer cachectic factor
MJ Lorite, MG Thompson, JL Drake, G Carling and MJ Tisdale
Inhibition by transforming growth factor (34-43)-a, a TGF-α antagonist, of gastric
carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats
M Tatsuta, H lishi, M Baba, R Hirasawa, K Iseki, H Yano, N Sakai, H Uehara and A
Nakaizumi
Autocrine self-elimination of cultured ovarian cancer cells by tumour necrosis factor alpha
(TNF-alpha
I Simonitsch and G Krupitza
Tau expression in model adenocarcinomas correlates with docetaxel sensitivity in tumourbearing mice
R Veitia, M-C Bissery, C Martinez and A Fellous
Establishment of a retinoic acid-resistant human acute promyelocytic leukaemia (APL)
model in human granulocyte-macrophage colony-stimulating factor (hGM-CSF) transgenic
severe combined immunodeficiency (SCID) mice
Y Fukuchi, M Kizaki, K Kinjo, N Awaya, A Muto, M lto, Y Kawai, A Umezawa, J Hata, Y
Ueyama and Y lkeda
Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel
diketopiperazine derivative
IL Dale, W Tuffley, R Callaghan, JA Holmes, K Martin, M Luscombe, P Mistry, H Ryder
AJ Stewart, P Chariton, PR Twentyman and P Bevan
Fraction of radiobiologically hypoxic cells in human melanoma xenografts measured by
using single-cell survival, tumour growth delay and local tumour control as end points
EK Rofstad and K Maseide
CLINICAL ONCOLOGY
Fatigue and radiotherapy: (A) experience in patients undergoing treatment
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EMA Smets, MRM Visser, AFMN Willems-Groot, B Garssen, F Oldenburger, G van
Tienhoven and JCJM de Haes
Fatigue and radiotherapy: (B) experience in patients 9 months following treatment
EMA Smets, MRM Visser, AFMN Willems-Groot, B Garssen, ALJ Schuster-Uitterhoeve
and JCJM de Haes
High-dose chemotherapy followed by reinfusion of selected CD34 peripheral blood cells in
patients with poor-prognosis breast cancer: a randomized multicentre study
C Chabannon, K Cornetta, J-P Lotz, C Rosenfeld, M Shlomchik, S Yanovitch, J-P
Marolleau, G Sledge, G Novakovitch, EF Srour, B Burtness, J Camerlo, G Gravis, J LeeFischer C Faucher, I Chabbert, D Krause, D Maraninchi, B Mills, L Kunkel, F Oldham, D
Blaise and P Viens
Heterozygosity for mutations in the ataxia telangiectasia gene is not a major cause of
radiotherapy complications in breast cancer patients
M Shayeghi, S Seal, J Regan, N Collins, R Barfoot, N Rahman, A Ashton, M Moohan, R
Wooster R Owen, J M Bliss, MR Stratton and J Yarnold
High-dose etoposide with granulocyte colony-stimulating factor for mobilization of
peripheral blood progenitor cells: efficacy and toxicity at three dose levels
EJ Kanfer, D McGuigan, D Samson, Z Abboudi, G Abrahamson, JF Apperley, S Chilcott,
C Craddock, J Davis, C MacDonald, D Macdonald, E Olavarria, N Philpott, GJS Rustin,
MJ Seckl, M Sekhar, S Stern and ES Newlands
Telomerase activity and human papillomavirus in malignant, premalignant and benign
cervical lesions
A Mutirangura, V Sriuranpong, W Termrunggraunglert, D Tresukosol, P
Lertsaguansinchai, N Voravud and S Niruthisard
Microvessel density predicts survival in prostate cancer patients subjected to watchful
waiting
M Borre, BV Offersen, B Nerstrom and J Overgaard
Epithelial proliferation and hormone receptor status in the normal post-menopausal breast
and the effects of hormone replacement therapy
DF Hargreaves, F Knox, R Swindell, CS Potten and NJ Bundred
Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at
multiple sites
K Dolan, J Garde, J Gosney, M Sissons, T Wright, AN Kingsnorth, SJ Walker R Sutton, SJ
Meltzer and JK Field
EPIDEMIOLOGY
The incidence of cancers among second-generation Irish living in England and Wales
S Harding
Seventeen-year evaluation of breast cancer screening: the DOM project, The Netherlands
GAJ Miltenburg, PHM Peeters, J Fracheboud and HJA Collette
Risk of cancer other than Kaposi's sarcoma and non-Hodgkin's lymphoma in persons with
AIDS in Italy
S Franceschi, L Dal Maso, S Arniani, P Crosignani, M Vercelli, L Simonato, F Falcini, R
Zanetti, A Barchielli, D Serraino and G Rezza for the Cancer and AIDS Registry Linkage
Study
Overexpression of p53 in different subtypes of intestinal metaplasia and gastric cancer
M-S Wu, C-T Shun, W-C Lee, C-J Chen, H-P Wang, W-J Lee, J- C Sheu and J-T Lin
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Epidemiology of childhood brain tumours in Yorkshire, UK, 1974-95: geographical
distribution and changing patterns of occurrence
PA McKinney, RC Parslow, SA Lane, CC Bailey, I Lewis, S Picton and RA Cartwright
CALENDAR
VOLUME 78 NUMBER 8 OCTOBER 1998
CONTENTS
EXPERIMENTAL ONCOLOGY
Genomic loci susceptible to replication errors in cancer cells
M Krajinovic, C Richer, I Gorska-Flipot, L Gaboury I Novakovic, D Labuda and D Sinnett
5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2
family proteins
M Eidi Nita, H Nagawa, 0 Tominaga, N Tsuno, S Fujii, S Sasaki, C-G Fu, T Takenoue, T
Tsuruo and T Muto
The relationship between ionizing radiation-induced apoptosis and stem cells in the small
and large intestine CS Potten and HK Grant
Interleulkin 1ß mediates the modulatory effects of monocytes on LNCaP human prostate
cancer cells
Z Culig, A Hobisch, M Herold, A Hittmair, M Thurnher, IE Eder, MV Cronauer, C Rieser,
R Ramoner, G Bartsch,
H Klocker and G Konwalinka
Comparison of benign and malignant follicular thyroid tumours by comparative genomic
hybridization
S Hemmer, V-M Wasenius, S Knuutila, H Joensuu and K Franssila
Selective suppression of cytokine secretion in whole blood cell cultures of patients with
colorectal cancer
H Lahm, M Schindel, L Frikart, J-P Cerottini, A Yilmaz, J-C Givel and JR Fischer
In vitro effect of amifostine on haematopoietic progenitors exposed to carboplatin and nonalkylating antineoplastic drugs: haematoprotection acts as a drug-specific progenitor rescue
L Pierelli, G Scambia, A Fattorossi, G Bonanno, A Battaglia, A Perillo, G Menichella, P
Benedetti Panici, G Leone and S Mancuso
Diuretic response to cyclophosphamide in rats bearing a matrix metalloproteinase-qproducing tumour
Y Mizushima, K Sassa, T Hamazaki, T Fujishita, R Oosaki and M Kobayashi
Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide,
doxorubicin and cisplatin on small-cell lung cancer cell lines
U Zangemeister-Wittke, T Schenker, GH Luedke and RA Stahel
Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer celldependent local anti-tumour response, but induces T-cell-dependent systemic immunity
only against B7-expressing tumours H Chong, G Hutchinson, IR Hart and RG Vile
CLINICAL ONCOLOGY
Superoxide dismutases in relation to the overall survival of colorectal cancer patients
AML Janssen, CB Bosman, CFM Sier, G Grifflioen, FJGM Kubben, CBHW,Lamers,
JHJM van Krieken, CJH van de Velde and HW Verspaget
Hepatic arterial floxuridine as second-line treatment for systemic fluorouracii-resistant
colorectal liver metastases
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1030
1035
1043
1051
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C Fordy, C Glover, MM Davies and TG Allen-Mersh
Fatal bleomycin pulmonary toxicity in the west of Scotland 1991-95: a review of patients
with germ cell tumours
AB Simpson, J Paul, J Graham and SB Kaye
A randomized trial comparing methotrexate and vinblastine (MV) with cisplatin,
methotrexate and vinblastine (CMV) in advanced transitional cell carcinoma: results and a
report on prognostic factors in a Medical Research Council study
GM Mead, M Russell, P Clark, SJ Harland, PG Harper, R Cowan, JT Roberts, BM
Uscinska, GO Griffiths and MKB Parmar on behalf of the MRC Advanced Bladder Cancer
Working Party
Risk and outcome in metastatic malignant melanoma patients receiving DTIC, cisplatin,
BCNU and tamoxifen followed by immunotherapy with interieukin 2 and interferon
alpha2a
R Hoffman, I Müller, K Neuber, S Lassmann, J Buer, M Probst, K Oevermann, A Franzke,
H Kirchner, A Ganser and J Atzpodien
A novel TP53 splicing mutation in a Li-Fraumeni syndrome family: a patient with Wlimstumour is not a mutation carrier
JM Varley, G McGown, M Thorncroft, GRM White, KJ Tricker, AM Kelsey, JM Birch and
DGR Evans
p53 mutation, but not p53 overexpression, correlates with survival in head and neck
squamous cell carcinoma
H Mineta, A Borg, M Dictor, P Wahlberg, J Akervall and J Wennerberg
CD44v3 and v6 variant isoform expression correlates with poor prognosis in early-stage
vulvar cancer
C Tempfer, G Sliutz, G Haeusler, P Speiser, A Reinthaller, G Breitenecker N Vavra and Ch
Kainz
Characterization of soluble E-cadherin as a disease marker in gastric cancer patients
J Gofuku, H Shiozaki, Y Doki, M Inoue, M Hirao, N Fukuchi and M Monden
Neuron-specific enolase and chromogranin A as markers of neuroendocrine tumours
E Baudin, A Gigliotti, M Ducreux, J Ropers, E Comoy, JC Sabourin, JM Bidart, AF
Cailleux, R Bonacci, P Ruffié and M Schlumberger
CYFRA 21-1 serum levels in women with adnexal masses and inflammatory diseases
C Tempfer, L Hefler, H Heinzl, A Loesch, G Gitsch, H Rumpold and C Kainz
Quantitative studies of the kinetics of 5-aminolaevulinic acid-induced fluorescence in
bladder transitional cell carcinoma
SN Datta, CS Loh, AJ MacRobert, SD Whatley and PN Matthews
CALENDAR
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