BioSpine
© Helge Leiberg, 2012
th
International Congress
Biotechnologies
for Spinal Surgery
PROGRAMME
April 8–11
2015
BioSpine
Table of Contents
Organisation and Imprint . ..........................................................................................
4
Welcome Note of the Congress Chair ........................................................................
5
Committees ............................................................................................................... 6
Invited Speakers.........................................................................................................
7
Programme Overview
Wednesday and Thursday, April 8 and 9, 2015 ............................
Friday and Saturday, April 10 and 11, 2015 . ................................
8
9
Scientific Programme
Wednesday, April 8, 2015.............................................................
Thursday, April 9, 2015 . ..............................................................
Friday, April 10, 2015....................................................................
Saturday, April 11, 2015 ..............................................................
10
11
16
22
Poster Exhibition ........................................................................................................
24
Sponsors, Exhibitors and Media Cooperation..............................................................
26
Social Programme .....................................................................................................
29
General Information....................................................................................................
30
General Hints for Authors and Presenters . .................................................................
33
Index of Authors and Chairs . .....................................................................................
34
City Map . ............................................................................................................... 35
3
Organisation and Imprint
Venue
Langenbeck-Virchow-Haus
Luisenstrasse 58/59
10117 Berlin (DE)
Date
April 8–11, 2015
Organiser
Regenerate Europe e. V.
Congress Chair
Prof. h. c. Dr. med. Hans Jörg Meisel
BG Clinic Bergmannstrost
Department of Neurosurgery
Merseburger Strasse 165
06112 Halle a. d. Saale (DE)
Congress Secretaries
Claudia Hoßbach
Yvonne Minkus
Congress Organisation
Conventus Congressmanagement & Marketing GmbH
Nadia Al-Hamadi/Roxelane Görls
Carl-Pulfrich-Strasse 1
07745 Jena (DE)
Phone +49 3641 31 16-315/-312
Fax +49 3641 31 16-243
[email protected]
www.conventus.de
Design/Layout
Layout www.krea.tif–design.de
Print N.N.
Circulation N.N.
Editorial DeadlineFebruary 19, 2015
4
Welcome Note of the Congress Chair
Dear colleagues and friends,
On behalf of the Organizing Committee and the Advisory Board, I am pleased to welcome you
in Berlin from April 8–11, 2015 to participate in our 5th Biospine congress.
BioSpine has set itself the task to act as a catalyst between clinicians, scientists and industrial partners, to support doctors’ curiosity and demand for new information, and at the
same time to request that industrial partners elucidate product information with appropriate
scientific scrutiny. Biomaterials in spine surgery have moved far beyond the role of “bone
void fillers” like it used to be 10 years ago. That evolution has resulted in products that are
now characterized as growth factors, cell products and combined products; each of which
might follow various regulations to meet clinical use approval. BioSpine was initiated to give
insights into technology development, has the aim to impart understanding and acceptance,
but also wants to sharpen a critical view.
Nevertheless there are still noticeable differences regarding both the quality of academic
support and the efficiency of introducing new products to the market. In particular, the clinical knowledge contribution from the medical point of view remains limited and will require
ongoing support from the academics as well as from industry to sustain progress and improve
therapeutic options.
BioSpine not only shows openness to the end-consumer, the surgeon, but further recognizes
the importance of incorporating the scientist into a common dialogue in order to provide
parallel direction for future industrial research.
Science subsists from the lively exchange of information. Join us for this fantastic opportunity,
for fruitful conversations, for vigorous discussions and the mutual exchange of knowledge.
I cordially welcome you all to attend the BioSpine congress in Berlin.
Yours
Hans Jörg Meisel
5
Committees
Organizing Committee
Aldemar A. Hegewald (Mannheim/DE)
Christoph Josten (Leipzig/DE)
Jean-Charles Le Huec (Bordeaux/FR)
Michael Piccirillo (Zurich/CH)
Michael Rauschmann (Frankfurt a. M./DE)
Advisory Board
Kenneth Cheung (Hong Kong/CN)
Finn Bjarke Christensen (Aarhus/DK)
Lisa Ferrara (Atlanta, GA/US)
Jörg Franke (Dortmund/DE)
Timothy Ganey (Atlanta, GA/US)
Robert Gunzburg (Antwerp/BE)
Marco N. Helder (Amsterdam/NL)
Frank Kandziora (Frankfurt a. M./DE)
H. Michael Mayer (Munich/DE)
Björn P. Meij (Utrecht/NL)
Michael Ogon (Vienna/AT)
Jong-Beom Park (Uijeongbu/KR)
Theodoor H. Smit (Amsterdam/NL)
Petr Suchomel (Liberec/CZ)
Marek Szpalski (Brussels/BE)
Gianluca Vadalà (Rome/IT)
Péter P. Varga (Budapest/HU)
Jeffrey Wang (Los Angeles, CA/US)
Hans-Joachim Wilke (Ulm/DE)
Michael Winking (Osnabrück/DE)
6
Invited Speakers
Mauro Alini (Davos/CH)
Lorin Michael Benneker (Bern/CH)*
Ulrich Berlemann (Thun/CH)
Marike Broekman (Utrecht/NL)
Finn Bjarke Christensen (Copenhagen/DK)
Vincenzo Denaro (Rome/IT)
Jörg Franke (Dortmund/DE)
Timothy Ganey (Atlanta, GA/US)
Roger Härtl (New York, NY/US)
Aldemar A. Hegewald (Mannheim/DE)
Paul Heini (Bern/CH)
Marco N. Helder (Amsterdam/NL)
Christoph Josten (Leipzig/DE)
Jean-Charles Le Huec (Bordeaux/FR)
H. Michael Mayer (Munich/DE)
Björn P. Meij (Utrecht/NL)
Felix Michnacs (Reutlingen/DE)
Susanne Miettinen (Tampere/FI)
Susanne Müller (Leipzig/DE)
Michael Ogon (Vienna/AT)
Wilco C. Peul (Leiden/NL)
Kai Pinkernell (Bergisch Gladbach/DE)
Michael Rauschmann (Frankfurt a. M./DE)
Jens Reinhardt (Frankfurt a. M./DE)*
Rui L. Reis (Braga/PT)
Dino Samartzis (Hong Kong/CN)
Dariusz Śladowski (Warsaw/PL)
Claudius Thomé (Innsbruck/AT)
Marianna A. Tryfonidou (Utrecht/NL)
Gianluca Vadalà (Rome/IT)
Hans-Joachim Wilke (Ulm/DE)
* inquired
7
Programme Overview
Wednesday, April 8, 2015
Lecture Hall
Thursday, April 9, 2015
Rudolf Virchow
Rudolf Virchow
Lecture Hall
17:00–17:30
08:30–09:30
08:30–09:30
Congress Opening
Quick Fire Session 1
Quick Fire Session 2
17:30–19:00
Surgeons and Scientists:
A Symbiosis in Spine
Research
p. 11
p. 11
10:00–10:30
p. 10
Special Lecture
p. 12
19:00–20:00
10:30–11:30
10:30–11:30
Welcome Reception
Best Strategies for the
Ageing Spine
The most important Bone
Grafts & Biologics: New
Approaches to Spinal
p. 29
p. 12 Fusion: Part 1
p. 13
12:00–13:30
12:00–13:30
Personalized Medicine:
Integrating Patients
Biology into Surgical
Planning
The most important Bone
Grafts & Biologics: New
Approaches to Spinal
Fusion: Part 2
p. 13
p. 13
Poster Exhibition
p. 24
14:30–16:15
14:30–16:15
Animal Models for IVDD
Programme by International
Study Groups for Bone and
Disc Regeneration: Part 1
p. 14
p. 15
16:30–17:45
16:30–17:45
Reducing Operative
Programme by International
Trauma: New Strategies in Study Groups for Bone and
minimal invasive Spine
Disc Regeneration: Part 2
Surgery
p. 15
8
p. 15
Programme Overview
Friday, April 10, 2015
Saturday, April 11, 2015
Lecture Hall
Rudolf Virchow
Lecture Hall
08:30–09:30
08:30–09:30
08:30–09:30
Quick Fire Session 3
Quick Fire Session 4
Quick Fire Session 5
p. 16
p. 16
p. 22
10:00–11:00
10:00–11:00
10:00–11:00
Available Bone Cements:
the Surgeons Expertise
Recent Cell Therapies for
Intervertebral Disc
Regeneration: Part 1
Nucleus Pulposus
Implants
p. 18
p. 17
p. 22
11:15–12:30
11:30–13:00
11:30–13:00
Fusion and Non-Fusion
Techniques
Recent Cell Therapies for
Intervertebral Disc
Regeneration: Part 2
Treatment of Anulus
Fibrosus Defects
p. 23
p. 18
p. 18
12:30–13:00
Summary & Farewell
Poster Exhibition
p. 24
14:30–16:00
14:30–16:00
Key
Imitating Nature:
Innovative Biomaterials
and Implants: Part 1
Regulatory Aspects of
Biological Therapeutics
Panel Discussion
Keynote BioSpine
Spine Session
Special Lecture
p. 20
p. 19
Workshop
BioSpine Session
International Study Groups
16:30–17:30
16:30–17:45
Quick Fire Session
Imitating Nature:
Innovative Biomaterials
and Implants: Part 2
What the patient should
know: Chances & Risks
associated with Biological
Therapeutics
Poster Exhibition
Social Programme
p. 20
p. 21
from 19:30
Social Evening
p. 29
9
Scientific Programme • Wednesday, April 8, 2015
17:00–17:30
Lecture Hall
Congress Opening
Vincenzo Denaro (Rome/IT), Hans Jörg Meisel (Halle a. d. Saale/DE)
17:30–19:00
Lecture Hall
Moderators
Panel Discussion
Surgeons and Scientists: A Symbiosis in Spine Research
Dino Samartzis (Hong Kong/CN), Jean-Charles Le Huec (Bordeaux/FR)
Roger Härtl (New York, NY/US)
Björn P. Meij (Utrecht/NL)
Wilco C. Peul (Leiden/NL)
Rui L. Reis (Braga/PT)
19:00–20:00 Foyer
Welcome Reception (see p. 29)
10
Scientific Programme • Thursday, April 9, 2015
08:30–09:30
Lecture Hall
Moderator Quick Fire Session 1
08:30
12
Biomaterials: a good alternative to bone grafts for spine fusion
Giovanni Barbanti Brodano (Bologna/IT)
08:40
62
Histological analysis of bone regeneration with different doses of
rhBMP-2 in an ovine lumbar interbody fusion model
Katharina Siegrist (Leipzig/DE)
08:50
23
Implant surface design regulates mesenchymal stem cell fate and
production of an osteogenic environment
Barbara Boyan (Richmond, VA/US)
09:00
45
Is osteogenic differentiation of human intervertebral disc cells a
possibility for spinal fusion?
Sarah Turner (Oswestry/GB)
09:10
53
The impact of surface geometry at the bone interface for improving
screw fixation: a biomechanical evaluation of a novel screw design
Bradley Segebarth (Charlotte, NC/US)
09:20
61
Using the RealSpine system: surgical simulation for training and
usability testing
Werner Korb (Leipzig/DE)
08:30–09:30
Rudolf Virchow
Moderator Quick Fire Session 2
08:30
21
An in vitro investigation into bone inhibition in non-unions caused by
intervertebral disc cells
Benjamin Gantenbein (Bern/CH)
08:40
40
Intradiscal injection of BMP-7 does not have regenerative effects in a
canine spontaneous disc degeneration model
Marianna A. Tryfonidou (Utrecht/NL)
Giovanni Barbanti Brodano (Bologna/IT)
Benjamin Gantenbein (Bern/CH)
11
Scientific Programme • Thursday, April 9, 2015
08:50
2
Regeneration of impaired intervertebral discs by a newly designed
hydrogel system in combination with AMSC in the ovine model
Andrea Friedmann (Leipzig/DE)
09:00
36
Human umbilical cord blood cell administration reduces behavioral
deficit after severe spinal cord injury
Sergey I. Ryabov (Moscow/RU)
09:10
7
Biomimetic polyurethane scaffold for nucleus pulposus replacement
Zhen Li (Davos/CH)
09:20
65
WNT signal pathway analysis in human adipose derived mesenchymal
stem cells – Is gender important?
Alexandra Stolzing (Loughborough/GB)
09:30–10:00
Coffee break
10:00–10:30
Lecture Hall
Ethics of Innovation in Regenerative Medicine and Spinal Surgery
Marike Broekman (Utrecht/NL)
10:30–11:30
Lecture Hall
Moderator
Best Strategies for the Ageing Spine
10:30
Role and relevance of the disc in fractures of the elder people
Christoph Josten (Leipzig/DE)
11:00
41
Preclinical intradiscal application of celecoxib loaded hydrogels in a
canine spontaneous intervertebral disc degeneration model
Marianna A. Tryfonidou (Utrecht/NL)
11:15
20
Range of motion in segmental versus nonsegmental UHWMPE
sublaminar wire growth guidance type constructs for early onset
scoliosis correction
Alex Roth (Maastricht/NL)
12
Christoph Josten (Leipzig/DE)
Scientific Programme • Thursday, April 9, 2015
10:30–11:30
Rudolf Virchow
Moderator
The most important Bone Grafts & Biologics:
New Approaches to Spinal Fusion – Part 1
Jean-Charles Le Huec (Bordeaux/FR)
10:30
64
Augmentation of pedicle screws with a self-curing elastomeric material
Werner Schmölz (Innsbruck/AT)
10:50
The most important Bone Grafts & Biologics – New Approaches to
Spinal Fusion*
Lorin Michael Benneker (Bern/CH)
11:10
From autologous iliac crest to last bone substitutes materials: what is proven today for daily practice
Jean-Charles Le Huec (Bordeaux/FR)
11:30–12:00
Coffee break
12:00–13:30
Rudolf Virchow
Moderator
The most important Bone Grafts & Biologics:
New Approaches to Spinal Fusion – Part 2
Jean-Charles Le Huec (Bordeaux/FR)
12:00
Interbody cage biomechanics and its impact on biology
Finn Bjarke Christensen (Aarhus/DK)
12:30
TM – a special metal in a specific shape for cages without the need of additional biologics or bone
Jörg Franke (Dortmund/DE)
13:00
Bone reconstruction in tumor surgery
Giovanni Barbanti Brodano (Bologna/IT)
12:00–13:30
Lecture Hall
Moderator
Personalized Medicine – Integrating Patients Biology into Surgical
Planning
Dino Samartzis (Hong Kong/CN)
12:00 Personalized Medicine – Integrating Patients Biology into Surgical Planning*
Aldemar A. Hegewald (Mannheim/DE)
*title tbd
13
Scientific Programme • Thursday, April 9, 2015
12:15 Novel diagnostic and prognostic methods for disc degeneration
and low back pain
Dino Samartzis (Hong Kong/CN)
12:45
19
The effect of scoliosis implant design parameters on whole spine
mechanical behavior
Jacobus Arts (Maastricht/NL)
13:00
15
Biomechanical assessment of different surgical procedures in the
lumbar spine by computer simulation
Karin Gruber (Koblenz/DE)
13:15
14
Computer simulation and navigation in a novel concept for
individualized dynamic stabilization of the spine
Michael Kosterhon (Koblenz/DE)
13:30–14:30
Lunch break and poster exhibition (see p. 24)
14:30–16:15
Lecture Hall
Moderator
Animal Models for IVDD
14:30
The dog as animal model for translating new regenerative treatments
for intervertebral disc degeneration
Björn P. Meij (Utrecht/NL)
15:00
51
Animal Model 2.0: the loaded disc culture system
Kaj Emanuel (Amsterdam/NL)
15:15
28
A reproducible disc degeneration scale in a large animal model
Gianluca Vadalà (Rome/IT)
15:30
66
The ovine mechanical far lateral disc herniation model
Felix Göhre (Halle a. d. Saale/DE)
15:45
67
In vivo models for the spine: the VUmc goat models
Pieter-Paul A. Vergroesen (Amsterdam/NL)
16:00
68
Why using bioreactors for whole organ cultures of intervertebral discs?
Marianna Peroglio (Davos/CH)
14
Björn P. Meij (Utrecht/NL)
Scientific Programme • Thursday, April 9, 2015
14:30–16:15
Rudolf Virchow
Moderator
Programme by International Study Groups for Bone and Disc
Regeneration – Part 1
Dino Samartzis (Hong Kong/CN)
Consortium Marianna A. Tryfonidou (Utrecht/NL)
Consortium Mauro Alini (Davos/CH)
Consortium Timothey Ganey (Atlanta, GA/US)
Consortium Susanne Miettinen (Tampere/FI)
16:15–16:30
Coffee break
16:30–17:45
Rudolf Virchow
Moderator
Programme by International Study Groups for Bone and Disc
Regeneration – Part 2
Dino Samartzis (Hong Kong/CN)
Consortium Marco N. Helder (Amsterdam/NL)
Consortium Gianluca Vadalà (Rome/IT)
16:30–17:45
Lecture Hall Moderator
Reducing Operative Trauma: New Strategies in minimal invasive
Spine Surgery
H. Michael Mayer (Munich/DE)
16:30
Reducing Operative Trauma: New Strategies in minimal invasive
Spine Surgery*
Wilco C. Peul (Leiden/NL)
17:00
18
Neuromonitorisation in prevention of motor-deficit during pediatric
spine surgeries
Mirza Biscevic (Sarajevo/BH)
17:15
Minimally invasive treatment strategies in degenerative lumbar spinal
stenosis
H. Michael Mayer (Munich/DE)
17:30
Minimally invasive tubular decompression avoids fusion surgery in
patients with lumbar stenosis and spondylolisthesis
Roger Härtl (New York, NY/US)
*title tbd
15
Scientific Programme • Friday, April 10, 2015
08:30–09:30
Lecture Hall
Moderator Quick Fire Session 3
08:30
63
Trabecular metal – How does it support bone ingrowth?
Claude Rieker (Winterthur/CH)
08:40
24
Repair of anulus fibrosus repair with genipin-enhanced fibrin hydrogel
and silk membrane-fleece
Daniela A. Frauchiger (Bern/CH)
08:50
29
A new alternative to expandable screws: expandable peek shell
Teyfik Demir (Ankara/TR)
09:00
32
In-situ photopolymerized composite-hydrogel for minimally-invasive
nucleus pulposus replacement
Andreas Schmocker (Lausanne/CH)
09:10
43
A biodegradable glue for annulus repair: evaluation of strength and
endurance
Pieter-Paul A. Vergroesen (Amsterdam/NL)
09:20
52
Titanium truss structures as conduits for bone healing through
multiplanar stress distribution
Lisa Ferrara (Southport, NC/US)
08:30–09:30
Rudolf Virchow
Moderator Quick Fire Session 4
08:30
6
Influence of disc degeneration on the efficacy of stem cell treatment:
an ex-vivo study
Marianna Peroglio (Davos/CH)
08:40
25
Intervertebral disc regeneration: the role of MSCs recruitment by
hyaluronan-based delivery of stromal cell-derived factor-1 in matrix
production improvement
Catarina Leite Pereira (Porto/PT)
16
Lisa Ferrara (Southport, NC/US)
Cornelia Neidlinger-Wilke (Ulm/DE)
Scientific Programme • Friday, April 10, 2015
08:50
27
Does mesenchymal stem cell therapy have the potential to control
inflammation in a pro-inflammatory intervertebral disc organ culture
system?
Cornelia Neidlinger-Wilke (Ulm/DE)
09:00
16
Local treatment of inflammation and degeneration of intervertebral
Disc – ex vivo study of anti-inflammatory drug delivery system based
on Chitosan/Poly-(γ-Glutamic acid) nanoparticles
Graciosa Q. Teixeira (Porto/PT)
09:10
22
Bovine coccygeal intervertebral discs contain multipotent Tie2+ cells
which can differentiate into osteogenic and adipogenic lineages
Adel Tekari (Bern/CH)
09:20
50
Riboflavin cross-linked collagen gel for the repair of annular defects in
intervertebral discs: an in vivo study
Peter Grunert (Vienna/AT)
09:30–10:00
Coffee break
10:00–11:00
Lecture Hall
Moderator
Available Bone Cements – the Surgeons Expertise
10:00
70
Bone cement in spinal surgery – A lost decade?
Paul Heini (Bern/CH)
10:30
13
Is hyperosmosis a better environment to maintain Nucleus Pulposus
Progenitor Cells (NPPC)?
Benjamin Gantenbein (Bern/CH)
10:45
Bone void fillers in vertebro- and kyphoplasties – a survey
Michael Rauschmann (Frankfurt a. M./DE)
Paul Heini (Bern/CH)
17
Scientific Programme • Friday, April 10, 2015
10:00–11:00
Rudolf Virchow
Moderator
Recent Cell Therapies for Intervertebral Disc Regeneration – Part 1
10:00
The evolution of cell based therapies for the treatment of intervertebral
disc degeneration
Marianna A. Tryfonidou (Utrecht/NL)
10:20
72
Cellular therapies for the intervertebral disc – Do we know enough?
Marco N. Helder (Amsterdam/NL)
10:40
New approaches for stem cell mediated intervertebral disc
regeneration
Gianluca Vadalà (Rome/IT)
11:00–11:30
Coffee break
11:30–13:00
Rudolf Virchow
Moderator
Recent Cell Therapies for Intervertebral Disc Regeneration – Part 2
11:30
Intervertebral disc innovation; biologic and biogenic insights
Timothy Ganey (Atlanta, GA/US)
12:00
73
Endogenous cell homing for intervertebral disc regeneration
Mauro Alini (Davos/CH)
12:30
A combined phase I/II prospective randomized clinical trial using an
in-situ polymerizable hydrogel seeded with autologous disc cells for
IVD regeneration – study design – and first safety results
Felix Michnacs (Reutlingen/DE)
11:30–13:00
Lecture Hall
Moderator
Fusion and Non-Fusion Techniques
11:30
Fusion and non-fusion technologies – literature review and personal
experience
Michael Ogon (Vienna/AT)
18
Marianna A. Tryfonidou (Utrecht/NL)
Marianna A. Tryfonidou (Utrecht/NL)
Michael Ogon (Vienna/AT)
Scientific Programme • Friday, April 10, 2015
12:00
34
Efficacy of different grafts in anterior cervical discectomy and fusion
surgery (comparison regarding the rate of fusion, bone ingrowth and
fusion speed)
Matjaz Vorsic (Maribor/SI)
12:15
54
Four-year clinical and radiographic results of a semi-constrained total
disc replacement
Lubomir Jurák (Liberec/CZ)
12:30
46
Pedicle screw concept with shape memory components for improved
bone anchorage
Mario Leimert (Dresden/DE)
12:45
58
Biomechanical analysis and histological evaluation of a new
PEEK-silver zeolite composite biomaterial in spine
Dan C. George (New Milford, CT/US)
13:00–14:30
Lunch break and poster exhibition (see p. 24)
14:30–16:00
Rudolf Virchow
Moderator
Regulatory Aspects of Biological Therapeutics
14:30
ATMP the European perspective
Dariusz Śladowski (Warsaw/PL)
15:00
Key regulatory aspects for commercialization of cellular therapeutics
Kai Pinkernell (Bergisch Gladbach/DE)
15:15
71
TETEC AG – ATMP manufacturing in a regulated market
Felix Michnacs (Reutlingen/DE)
15:30
Regulatory Aspects of Biological Therapeutics*
Jens Reinhardt (Frankfurt a. M./DE)
15:45
The Translational Centre for Regenerative Medicine as an organism:
development of an ATMP at the academic facility
Susanne Müller (Leipzig/DE)
Kai Pinkernell (Bergisch Gladbach/DE)
*title tbd
19
Scientific Programme • Friday, April 10, 2015
14:30–16:00
Lecture Hall
Moderator
Imitating Nature – Innovative Biomaterials and Implants – Part 1
14:30
Observations of mechanical transduction and a biologic induction
Lisa Ferrara (South Port, NC/US)
14:45
Prescriptive topology as a mimetic material enhancement
Timothy Ganey (Atlanta, GA/US)
15:00
Imitating Nature – Innovative Biomaterials and Implants*
Rui L. Reis (Braga/PT)
15:30
59
Bimolecular based heparin and self-assembling hydrogel for cartilage
tissue engineering applications
Carlos E. Semino (Barcelona/ES)
16:00–16:30
Coffee break
16:30–17:30
Lecture Hall
Moderator
Imitating Nature – Innovative Biomaterials and Implants – Part 2
16:30
Imitating Nature – Innovative Biomaterials and Implants*
Wilco C. Peul (Leiden/NL)
16:50
74
Philosophy of cementaugmentated pedicle screws – Indications,
technique, pearls and pitfalls
Michael Rauschmann (Frankfurt a. M./DE)
17:10
75
Correction of adult scoliosis deformity using carbon fiber composite
rod instrumentation in spinal fusion. Preliminary prospective results of
an 84 patient series
Paul Fayada (Saint-Pol-sur-Ternoise/FR)
*title tbd
20
Hans-Joachim Wilke (Ulm/DE)
Hans-Joachim Wilke (Ulm/DE)
Scientific Programme • Friday, April 10, 2015
16:30–17:45
Rudolf Virchow
Moderator
What the patient should know – Chances & Risks associated with
Biological Therapeutics
Claudius Thomé (Innsbruck/AT)
16:30
Informed consent for novel spinal therapies
Claudius Thomé (Innsbruck/AT)
17:00
48
Balancing bone resorption and overzealous bone growth in Anterior
Lumbar Interbody Fusion (ALIF) with RhBMP-2 in the sheep model:
A question of dose and/or concentration?
Gerlinde S. Heil (Halle a. d. Saale/DE)
17:15
56
Long time follow up after posterior lumbar interbody fusion with bone
morphogenetic protein-2
Christian Hohaus (Halle a. d. Saale/DE)
17:30
What the patient should know – Chances & Risks associated with
Biological Therapeutics*
Johannes Seeger (Leipzig/DE)
from 19:30 Social Evenig (see p. 29)
*title tbd
21
Scientific Programme • Saturday, April 11, 2015
08:30–09:30
Lecture Hall
Moderator Quick Fire Session 5
08:30
26
Bupivacaine induces death of rabbit intervertebral disc cells via
ROS-mediated lysosomal membrane permeabilization
Xian-Yi Cai (Wuhan/CN)
08:40
31
Synthetic phytoestrogens and the native flax plant extract from Linum
usitatissimum effect human bone cells in vitro
Victor Bügel (Rostock/DE)
08:50
33
Cost effectiveness of doubling the estimated sample size for medical products/
devices in spine Clinical Investigation (CI) generates lower incremental costs
Jacques Tshiang (Freiburg/DE)
09:00
37
Is bacterial infection connected to degenerative disc disease?
Tomaz Velnar (Maribor/SI)
09:10
11
Non-viral gene delivery of Growth and Differentiation Factor 6 (GDF6)
to whole bovine intervertebral disc
Rahel D. May (Bern/CH)
09:20 Amniotic tissue in regenerative medical applications
Thomas J. Koob (Atlanta, GA/US)
09:30–10:00
Coffee break
10:00–11:00
Lecture Hall
Moderator
Nucleus Pulposus Implants
10:00
60
Nucleus augmentation with NuCore® Injectable Nucleus – previous
experience and long-term follow-up
Ulrich Berlemann (Bern/CH)
10:20
Biological approaches for nucleus repair and regeneration
Roger Härtl (New York, NY/US)
10:40
Ideas and mechanical requirements of nucleus implants
Hans-Joachim Wilke (Ulm/DE)
11:00–11:15
Coffee break
22
Rahel D. May (Bern/CH)
Roger Härtl (New York, NY/US)
Scientific Programme • Saturday, April 11, 2015
11:15–12:30
Lecture Hall
Moderator
Treatment of Anulus Fibrosus Defects
11:15
Current and possible future options for anular closure
Claudius Thomé (Innsbruck/AT)
11:45
Principles and biomechanical challenges of anulus sealing
Hans-Joachim Wilke (Ulm/DE)
12:00
57
Autologous disc chondrocyte transplantation in lumbar spine disc
degeneration disease – a prospective, controlled, randomized study
Florian Didrigkeit (Halle a. d. Saale/DE)
12:15
49
Tissue-engineered intervertebral discs – In vivo outcome in the rodent
spine
Peter Grunert (Vienna/AT)
12:30–13:00
Lecture Hall
Summary and Farewell
Dino Samartzis (Hong Kong/CN)
Hans Jörg Meisel (Halle a. d. Saale/DE)
Claudius Thomé (Innsbruck/AT)
23
Poster Exhibition
The poster session will not be chaired. However, the presenting author gets the chance to
present his poster to an interested audience during the lunch breaks on Thursday, April 9
and Friday, April 10, 2015.
5
Outcome of posterior spinal fixation with pedicle screws and rods system in thoracolumbar spinal fractures
Khan Kashif Mahmood (Karachi/PK)
9
An in vivo model for Intervertebral Disc Regeneration
Carla Cunha, Sofia Lamas, Mário A. Barbosa (Porto/PT)
10 ACRON cage: A novel cage design and implantation technique for lumbar
spinal fusion.
Ronald J. Sabitzer (Vienna/AT)
30
Minimally Invasive Oblique Lumbar Interbody Fusion at L25: Benefits and
Complications
Jin Sung Kim, Kyeong Sik Ryu, Jung Woo Hur, Won Suh Choi (Seoul/KR)
39
The amount of organic phosphates (like DPG) existing in blood is determining factor of mammal’s bulk
Ramin Amirmardfar (Tabriz/IR)
42 Could heavy degradable sutures replace metal wires in fixating unstable injuries of the cervical spine in the young pediatric population?
Kamal Hamoud, Janan Abbas (Tiberias/IL)
76 Spinal fusion and a conflict of needs ovret time: carbon composite compared
to traditional review.
Robert Lange, Vittoria Brighenti (Zurich/CH), Paul Fayada (Saint-Pol-sur-Ternoise/FR)
Steve Hansen (Fontaine lès-Dijon/FR)
24
FUSION
IN
Bone in-growth through the
Trabecular Metal Material
(Artistic Representation)
3-D
TM Ardis®
Interbody System
TM-S
Cervical Fusion Device
Trabecular Metal Material
™
Helps 3-D bone in-growth throughout the device
as a result of its interconnected porous structure.
Traditional Material
Traditional Material
Trabecular Metal Material
No bone on-growth
or in-growth
No bone in-growth and boney
on-growth on textured surface only
Bone in-growth through
the device
with textured surface
Three-dimensional fusion
Trabecular Metal Material is designed for
bone in-growth and three-dimensional fusion.
Zimmer Spine
+33 5 56 00 18 20
zimmer.com
© 2015 Zimmer Spine SAS
Lit. N° 06.02726.012 - Ed. 01/2015
(Ref: ZS-SA0871)
Sponsors, Exhibitors and Media Cooperation
Bronze Sponsors
Biomet Europe/LANX s.r.l. (Medolla/IT)
Depuy Synthes (Norderstedt/DE)
DiFusionTechnologies, Inc. (Georgetown, TX/US)
Zimmer Spine (Bordeaux/FR)
Sponsor of Congress Bags
Ziehm Imaging GmbH (Nuremberg/DE)
Sponsor of Name Badges and Lanyards
Biomet Europe/LANX s.r.l. (Medolla/IT)
Sponsor of Poster Exhibition
Fehling Instruments GmbH & Co. KG (Karlstein/DE)
Exhibitors
Aureus Medical GmbH (Munich/DE)
Biomet Europe/LANX s.r.l. (Medolla/IT)
Depuy Synthes (Norderstedt/DE)
DiFUSION Technologies, Inc. (Georgetown, TX/US)
Intrinsic Therapeutics (Woburn, MA/US)
Königsee Implantate GmbH (Allendorf/DE)
Medtronic GmbH (Meerbusch/DE)
Ranier Technology Ltd. (Cambridge/GB)
RTI Surgical/Tutogen Medical GmbH (Neukirchen a. Brand/DE)
Titan Spine Europe (Laichingen/DE)
Zimmer Spine (Bordeaux/FR)
Media Cooperation
BIBA Medicals LDT (London/GB) • “Spinal News”
Biermann Verlag (Cologne/DE) • “Orthopädische Nachrichten”
Deutscher Ärzte-Verlag GmbH (Cologne/DE)
“OUP - Zeitschrift für die orthopädische und unfallchirurgische Praxis”
Reflex Verlag GmbH (Berlin/DE) • “Wirbelsäule & Rücken”
Thieme Publishers (New York, NY/US) • “Global Spine Journal“
Trillium GmbH (Grafrath/DE) • “Trillium Diagnostik”
26
State at printing
27
28
Social Programme
Welcome Reception
Right after the exciting panel discussion we would like to
invite you to our Welcome Reception with some drinks
and snacks within the industrial exhibition.
Chatting, relaxing, amusing – Enjoy a networking evening
in a relaxed atmosphere!
Date
Time
Location
Fee
Wednesday, April 8, 2015
from 19:00 hrs
© CandyBox Images Fotolia
Industrial exhibition (venue)
included for participants, accompanying person 15 EUR
Social Evening The social evening will take place in the Soho House
Berlin that has a long and versatile history. Join us for
a memorable evening in the former Politisches Büro,
where the GDR Central Committee used to meet.
Follow the tracks from former GDR presidents Wilhelm
Pieck and Walter Ulbricht and savour delicious meals,
have a drink at the circular bar and enjoy the view from
the balcony over the Berlin Mitte district.
Date
Time
Location
Fee
© Soho House Berlin
Friday, April 10, 2015
from 19:30 hrs
Soho House Berlin
Torstrasse 1
10119 Berlin (DE)
75 EUR
29
General Information
Registration
Registration for the congress is required. Please register online at www.biospine.org.
Registration can also be made via fax or mail.
Registration Fees
Regular
Postgraduate Student*
Undergraduate Student*
from January 5, 2015
600 EUR
450 EUR
250 EUR
Welcome Reception, April 8, 2015
Participant
Accompanying Person
included
15 EUR
Social Evening, April 10, 2015 75 EUR
* Please send a confirmation of your status either to [email protected], Fax +49 3641 31 16-244 or by
mail to Conventus GmbH indicating the keyword: BioSpine 2015 • Carl-Pulfrich-Strasse 1 • 07745 Jena (DE).
Payment and Confirmation of Payment
An invoice or confirmation of registration will be sent to you via postal or electronic mail within
14 days. This invoice is a valid invoice which may be submitted to the local tax and revenue
office. All fees are due upon receipt of invoice/registration confirmation. Payment transfers
must include participant’s name and invoice number. Payment is also accepted by credit card
(Master-/Eurocard, American Express, VISA).
General Terms and Conditions
Please find our General Terms and Conditions at www.biospine.org.
Accommodation
We reserved a contingent of rooms at special rates in different categories.
Further information on accommodation is provided at www.biospine.org.
30
General Information
Travel to Berlin
Lufthansa Group Ticket
Partner Airlines offer a comprehensive global route network linking
major cities around the world. We offer special prices and conditions to participants, visitors, exhibitors, invited guests as well as
employees of the contracting partner and their travel companions.
To make a reservation, please go to www.lufthansa.com/event-booking_en and enter the
access code DEZEMGD in the “Access to Your Special Lufthansa Offer” area. This will open
an online booking platform that will automatically calculate the discount offered or provide
you with an even better offer if another promotional fare is available.
NOTE: Pop-ups must be enabled otherwise the booking platform window will not open.
These promotional fares are also available through your IATA/ARC travel agent. Travel agents
can obtain ticketing instructions by sending an email to [email protected] and providing the access code as a reference.
DB German Rail Event Ticket
In cooperation with DB German Rail and Conventus you travel safely and
conveniently to the BioSpine 2015.
The price for your event ticket of a return trip* to Berlin is:
2nd class 99 EUR (for a defined train connection)
1st class159 EUR (for a defined train connection)
2nd class139 EUR (for all trains)
1st class199 EUR (for all trains)
* Changes and reimbursement before the first day of validity are 15 EUR excluded from the first day of validity
onwards. Passengers restrict themselves to a particular train and travel times.
Please find more detailed information on conditions and booking at www.biospine.org.
31
General Information
Certification
The 5th International Congress on Biotechnologies for Spinal Surgery (BioSpine) is accredited by the European Accreditation Council for Continuing Medical Education (EACCME).
The congress is being granted with 15 European CME credits (ECMEC).
Additionally an application has been made to the Medical Chamber of Berlin.
Please remember to sign the list of attendants (with barcode, if required or applicable) at the
Check-In.
Internet Corner & WIFI Access
Vouchers for WIFI can be purchased at the Check-In for 4,95 EUR/24 hrs.
Congress Language
The congress language is English.
32
General Hints for Authors and Presenters
Submitting your Presentation/Technical Information
Please prepare your presentation in 4:3 aspect ratio. A presentation notebook with a PDF
reader and MS Office PowerPoint 2007 will be provided. The use of personal notebooks is
possible upon agreement. However, it may interrupt the flow of the programme in the lecture
hall. Please provide an adapter for VGA if necessary. A notebook, presenter and laser pointer
are available at the speaker’s podium in the lecture hall. A technical supervisor will help you.
Speakers’ Preparation
Please submit your presentation to our technical staff in the room where you will have you
talk, no later than 90 minutes before the presentation begins. You may view and/or edit your
presentation. For submission, please use a USB flash drive.
Poster Exhibition
Posters should be no larger than DIN A0 portrait format (84.1 cm x 118.9 cm). Poster boards
are 120 cm x 150 cm (portrait format). They are only to be used with the designated pins.
Poster boards will be numbered. All posters have to be mounted on Thursday, April 9, 2015
until 13:00 hrs and have to be removed by Friday, April 10, 2015 until 17:00 hrs.
© fotolia.com/AlienCat/yetishooter
9. Jahrestagung der Deutschen Gesellschaft für Biomechanik (DGfB)
Biomechanik biologischer Gewebe (Knochen, Knorpel, Bänder, Meniskus, Organe)
Biomaterialien, Implantate, Prothesen
Tribologie (Prothetik, Knorpel, Meniskus)
Biomechanik des Bewegungsapparates
und weitere
6.–8. Mai 2015 • Bonn
Informationen, Anmeldung und Programm:
www.biomechanik-kongress.de
33
Index of Authors and Chairs
A
Abbas, J.
Alini, M.
Amirmardfar, R.
Arts, J.
24
15, 18
24
14
B
Barbanti Brodano, G. 11, 13
Barbosa, M.
24
Benneker, L. M.
13
Berlemann, U.
22
Biscevic, M.
15
Bjarke, F.
13
Boyan, B.
11
Brighenti, V.
24
Broekman, M.
12
Bügel, V.
22
C
Cai, X.-Y.
Choi, W. S.
Cunha, C.
22
24
24
D
Demir, T.
Denaro, V.
Didrigkeit, F.
16
10
23
E
Emanuel, K.
14
F
Fayada, P.
Ferrara, L.
Franke, J.
Frauchiger, D. A.
Friedmann, A.
G
Ganey, T.
Gantenbein, B.
George, D. C.
Göhre, F.
Gruber, K.
Grunert, P.
34
20, 24
16, 20
13
16
12
15, 18, 20
11, 17
19, 26
14
14
17, 23
H
Hamoud, K.
24
Hansen, S.
24
Härtl, R.
10, 15, 22
Hegewald, A. A.
13
Heil, G. S.
21
Heini, P.
17
Helder, M. N.
15, 18
Hohaus, C.
21
Hur, J. W.
24
J
Josten, C.
Jurák, L.
12
19
K
Khan, K. M.
Kim, J. S.
Koob, T. J. Korb, W.
Kosterhon, M.
24
24
22
11
14
L
Lamas, S.
Lange, R.
Le Huec, J.-C.
Leimert, M.
Leite Pereira, C.
Li, Z.
24
24
10, 13
19
16
12
M
Mayer, H. M.
Meij, B. P.
Meisel, H. J.
Michnacs, F.
Miettinen, S.
Müller, S.
15
10, 14
10, 23
18, 19
15
19
P
Peroglio, M.
Peul, W. C.
Pinkernell, K.
R
Rauschmann, M.
Reinhardt, J.
Reis, R. L.
Rieker, C.
Roth, A.
Ryabov, S. I.
Ryu, K. S.
S
Sabitzer, R. J.
Samartzis, D.
Schmocker, A.
Schmölz, W.
Seeger, J.
Segebarth, B.
Siegrist, K.
Śladowski, D.
Stolzing, A.
T
Teixeira, G. Q.
Tekari, A.
Thomé, C.
Tryfonidou, M. A.
Tshiang, J.
Turner, S.
14, 16
10, 15, 20
19
17, 20
19
10, 20
16
12
12
24
24
10, 13, 14
15, 23
16
13
21
11
11
19
12
17
17
21, 23
11, 12
15, 18
22
11
N
Neidlinger-Wilke, C. 16, 17
V
Vadalà, G.
14, 15, 18
Velnar, T.
22
Vergroesen, P.-P. A. 14, 16
Vorsic, M.
19
O
Ogon, M.
W
Wilke, H.-J. 17, 20, 22, 23
18
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© Bezirksamt Mitte von Berlin, Stadtentwicklungsamt – Kataster und Vermessung
35
BioSpine
International Congress
Biotechnologies
for Spinal Surgery
© Sergey Novikov • shutterstock.com