Table of Contents The Journal of Immunology VOL. 194 | NO. 6 | March 15, 2015 | Pages 2451–2956 IN MEMORIAM 2451 Herman N. Eisen, M.D. (1918–2014) Scholar, Gentleman, and AAI President (1968–1969) Arup K. Chakraborty and Emil R. Unanue IN THIS ISSUE 2453 Murky Impact of miR-182 See article p. 2635 Ly6C Labels Antiviral T Cell Subsets See article p. 2746 Not Your Momma’s Macrophage See article p. 2786 Fishing for AGS Models See article p. 2819 SHIP1 Schools NK Cells See article p. 2847 BRIEF REVIEWS 2455 Interfering with Immunity: Detrimental Role of Type I IFNs during Infection Sebastian A. Stifter and Carl G. Feng CUTTING EDGE 2467 Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a+ NK Cells Nicole Marquardt, Vivien B e ziat, Sanna Nystro¨m, Julia Hengst, Martin A. Ivarsson, Eliisa Keka¨la¨inen, Helene Johansson, Jenny Mjo¨sberg, Magnus Westgren, Tim O. Lankisch, Heiner Wedemeyer, Ewa C. Ellis, Hans-Gustaf Ljunggren, Jakob Micha€ elsson, and Niklas K. Bjo¨rkstro¨m 2472 Cutting Edge: NF-kB p65 and c-Rel Control Epidermal Development and Immune Homeostasis in the Skin Yenkel Grinberg-Bleyer, Teruki Dainichi, Hyunju Oh, Nicole Heise, Ulf Klein, Roland M. Schmid, Matthew S. Hayden, and Sankar Ghosh 2477 Cutting Edge: STAT6 Signaling in Eosinophils Is Necessary for Development of Allergic Airway Inflammation Kindra Stokes, Nelson M. LaMarche, Nasif Islam, Amie Wood, Weishan Huang, and Avery August On the cover: Virus-induced inflammation produces skeletal muscle fiber calcification (alizarin red staining) in C3H mice following peripheral inoculation with a neurotropic picornavirus. Watson, N. B., K. M. Schneider, and P. T. Massa. 2015. SHP-1–dependent macrophage differentiation exacerbates virus-induced myositis. J. Immunol. 194: 2796–2809. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/ membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf). Reprints of individual articles are available only from authors. Periodicals postage paid at Bethesda, MD 20814-3994, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in advance to The Journal of Immunology, Subscription Department, 9650 Rockville Pike, Bethesda, MD 20814-3994. Copyright Ó 2015 by The American Association of Immunologists, Inc. 2482 Cutting Edge: Circulating Plasmablasts Induce the Differentiation of Human T Follicular Helper Cells via IL-6 Production Konstantia-Maria Chavele, Eve Merry, and Michael R. Ehrenstein AUTOIMMUNITY 2487 CD73 Plays a Protective Role in Collagen-Induced Arthritis Pavel Chrobak, Roxanne Charlebois, Pavel Rejtar, Rana El Bikai, Bertrand Allard, and John Stagg 2493 A Comparative Analysis of Multiple Sclerosis–Relevant Anti-Inflammatory Properties of Ethyl Pyruvate and Dimethyl Fumarate Djordje Miljkovi c, Jana Bla zevski, Filip Petkovi c, Neda Djedovi c, Miljana Mom cilovi c, Suzana Stanisavljevi c, Bojan Jevti c, Marija Mostarica Stojkovi c, and Ivan Spasojevi c 2504 Cell-Intrinsic Expression of TLR9 in Autoreactive B Cells Constrains BCR/TLR7-Dependent Responses Kerstin Nu¨ndel, Nathaniel M. Green, Arthur L. Shaffer, Krishna L. Moody, Patricia Busto, Dan Eilat, Kensuke Miyake, Michael A. Oropallo, Michael P. Cancro, and Ann Marshak-Rothstein 2513 Placental Growth Factor-1 and -2 Induce Hyperplasia and Invasiveness of Primary Rheumatoid Synoviocytes Seung-Ah Yoo, Ji-Hwan Park, Seong-Hye Hwang, Sang-Min Oh, Saseong Lee, Valeria Cicatiello, Sangchul Rho, Sandro De Falco, Daehee Hwang, Chul-Soo Cho, and Wan-Uk Kim 2522 Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis Dorothee Schwinge, Antonella Carambia, Alexander Quaas, Till Krech, Claudia Wegscheid, Gisa Tiegs, Immo Prinz, Ansgar W. Lohse, Johannes Herkel, and Christoph Schramm 2531 High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific Human CD4+ T Cells Anne Eugster, Annett Lindner, Mara Catani, Anne-Kristin Heninger, Andreas Dahl, Sylvia Klemroth, Denise Ku¨hn, Sevina Dietz, Marc Bickle, Anette-Gabrielle Ziegler, and Ezio Bonifacio 2539 Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis Sabrina Haag, Jonatan Tuncel, Soley Thordardottir, Daniel E. Mason, Anthony C. Y. Yau, Doreen Dobritzsch, Johan Ba¨cklund, Eric C. Peters, and Rikard Holmdahl CLINICAL AND HUMAN IMMUNOLOGY 2551 Immunodeficiency and Autoimmune Enterocolopathy Linked to NFAT5 Haploinsufficiency Brigid S. Boland, Christella E. Widjaja, Asoka Banno, Bing Zhang, Stephanie H. Kim, Samantha Stoven, Michael R. Peterson, Marilyn C. Jones, H. Irene Su, Sheila E. Crowe, Jack D. Bui, Samuel B. Ho, Yoshinaga Okugawa, Ajay Goel, Eric V. Marietta, Mahdieh Khosroheidari, Kristen Jepsen, Jose Aramburu, Cristina L opez-Rodr´iguez, William J. Sandborn, Joseph A. Murray, Olivier Harismendy, and John T. Chang 2561 Bone Marrow Plasma Cells Are a Primary Source of Serum HIV-1–Specific Antibodies in Chronically Infected Individuals Jairo M. Montezuma-Rusca, Susan Moir, Lela Kardava, Clarisa M. Buckner, Aaron Louie, Leo J. Y. Kim, Brian H. Santich, Wei Wang, Olivia R. Fankuchen, Gabriella Diaz, Janine R. Daub, Sergio D. Rosenzweig, Tae-Wook Chun, Yuxing Li, Raul C. Braylan, Katherine R. Calvo, and Anthony S. Fauci 2569 Extracorporeal Photopheresis Promotes IL-1b Production Erhan Yakut, Christopher Jakobs, Adriana Peric, Gabriela Michel, Nelli Baal, Gregor Bein, Bernhard Bru¨ne, Veit Hornung, and Holger Hackstein IMMUNE REGULATION 2578 Contact-Dependent Depletion of Hydrogen Peroxide by Catalase Is a Novel Mechanism of Myeloid-Derived Suppressor Cell Induction Operating in Human Hepatic Stellate Cells Yazid J. Resheq, Ka-Kit Li, Stephen T. Ward, Annika Wilhelm, Abhilok Garg, Stuart M. Curbishley, Miroslava Blahova, Henning W. Zimmermann, Regina Jitschin, Dimitrios Mougiakakos, Andreas Mackensen, Chris J. Weston, and David H. Adams 2587 Quantitative Reduction of the TCR Adapter Protein SLP-76 Unbalances Immunity and Immune Regulation Owen M. Siggs, Lisa A. Miosge, Stephen R. Daley, Kelly Asquith, Paul S. Foster, Adrian Liston, and Christopher C. Goodnow 2596 Core Fucosylation of IgG B Cell Receptor Is Required for Antigen Recognition and Antibody Production Wenzhe Li, Rui Yu, Biao Ma, Yan Yang, Xinyan Jiao, Yang Liu, Hongyu Cao, Weijie Dong, Linhua Liu, Keli Ma, Tomohiko Fukuda, Qingping Liu, Tonghui Ma, Zhongfu Wang, Jianguo Gu, Jianing Zhang, and Naoyuki Taniguchi 2607 Requirement for Autophagy in the Long-Term Persistence but not Initial Formation of Memory B cells Min Chen, Srikanth Kodali, Albert Jang, Le Kuai, and Jin Wang IMMUNE SYSTEM DEVELOPMENT 2616 CXCL13 Responsiveness but Not CXCR5 Expression by Late Transitional B Cells Initiates Splenic White Pulp Formation Harold R. Neely and Martin F. Flajnik 2624 Dickkopf-3 Acts as a Modulator of B Cell Fate and Function Julia Ludwig, Giuseppina Federico, Sandra Prokosch, Gu¨nter Ku¨blbeck, Sabine Schmitt, Alexandra Klevenz, Hermann-Josef Gro¨ne, Lars Nitschke, and Bernd Arnold 2635 miR-182 Is Largely Dispensable for Adaptive Immunity: Lack of Correlation between Expression and Function Joseph N. Pucella, Wei-Feng Yen, Myoungjoo V. Kim, Joris van der Veeken, Nicholas D. Socci, Yukiko Naito, Ming O. Li, Naoharu Iwai, and Jayanta Chaudhuri 2643 Differential Roles for Bim and Nur77 in Thymocyte Clonal Deletion Induced by Ubiquitous Self-Antigen Qian Nancy Hu and Troy A. Baldwin IMMUNOGENETICS 2654 Genome-Wide Transcriptional Analyses of Islet-Specific CD4+ T Cells Identify Idd9 Genes Controlling Diabetogenic T Cell Function Gregory J. Berry, Christine Frielle, Thaiphi Luu, Anna C. Salzberg, Daniel B. Rainbow, Linda S. Wicker, and Hanspeter Waldner 2664 IL2RA Genetic Variants Reduce IL-2–Dependent Responses and Aggravate Human Cutaneous Leishmaniasis Pablo R. S. Oliveira, H e lia Dessein, Audrey Romano, Sandrine Cabantous, Maria E. F. de Brito, Ferrucio Santoro, Maira G. R. Pitta, Val e ria Pereira, Lain C. Pontes-de-Carvalho, Virmondes Rodrigues, Jr., Sima Rafati, Laurent Argiro, and Alain J. Dessein IMMUNOTHERAPY AND VACCINES 2673 Hydroxypropyl-b-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen Motoyasu Onishi, Koji Ozasa, Kouji Kobiyama, Keiichi Ohata, Mitsutaka Kitano, Keiichi Taniguchi, Tomoyuki Homma, Masanori Kobayashi, Akihiko Sato, Yuko Katakai, Yasuhiro Yasutomi, Edward Wijaya, Yoshinobu Igarashi, Noriyuki Nakatsu, Wataru Ise, Takeshi Inoue, Hiroshi Yamada, Alexis Vandenbon, Daron M. Standley, Tomohiro Kurosaki, Cevayir Coban, Taiki Aoshi, Etsushi Kuroda, and Ken J. Ishii 2683 Immunoprevention of Chemical Carcinogenesis through Early Recognition of Oncogene Mutations Tahseen H. Nasti, Kyle J. Rudemiller, J. Barry Cochran, Hee Kyung Kim, Yuko Tsuruta, Naomi S. Fineberg, Mohammad Athar, Craig A. Elmets, and Laura Timares 2696 Criteria for Dendritic Cell Receptor Selection for Efficient Antibody-Targeted Vaccination Anika Reuter, Scott E. Panozza, Christophe Macri, Claire Dumont, Jessica Li, Haiyin Liu, Elodie Segura, Javier Vega-Ramos, Nishma Gupta, Irina Caminschi, Jose A. Villadangos, Angus P. R. Johnston, and Justine D. Mintern INFECTIOUS DISEASE AND HOST RESPONSE 2706 Filarial Infection Modulates the Immune Response to Mycobacterium tuberculosis through Expansion of CD4+ IL-4 Memory T Cells Soumya Chatterjee, Carolyn E. Clark, Enrico Lugli, Mario Roederer, and Thomas B. Nutman 2715 Antibody-Mediated Response of NKG2Cbright NK Cells against Human Cytomegalovirus Marcel Costa-Garcia, Andrea Vera, Manuela Moraru, Carlos Vilches, Miguel L opez-Botet, and Aura Muntasell 2725 T Cell Expansion Is the Limiting Factor of Virus Control in Mice with Attenuated TCR Signaling: Implications for Human Immunodeficiency Kristina M. Hillen, Ruth Gather, Anselm Enders, Hanspeter Pircher, Peter Aichele, Paul Fisch, Britta Blumenthal, Wolfgang W. Schamel, Tobias Straub, Christopher C. Goodnow, and Stephan Ehl 2735 MyD88 in Macrophages Is Critical for Abscess Resolution in Staphylococcal Skin Infection Reinhild Feuerstein, Maximilian Seidl, Marco Prinz, and Philipp Henneke 2746 Functional Heterogeneity in the CD4+ T Cell Response to Murine g-Herpesvirus 68 Zhuting Hu, Marcia A. Blackman, Kenneth M. Kaye, and Edward J. Usherwood 2757 Set7 Facilitates Hepatitis C Virus Replication via Enzymatic Activity–Dependent Attenuation of the IFN-Related Pathway Tao Han, Yushun Wan, Jun Wang, Peng Zhao, Yue Yuan, Li Wang, Yinglong She, Ruth Broering, Mengji Lu, Linbai Ye, and Ying Zhu INNATE IMMUNITY AND INFLAMMATION 2769 HIV-1 Single-Stranded RNA Induces CXCL13 Secretion in Human Monocytes via TLR7 Activation and Plasmacytoid Dendritic Cell–Derived Type I IFN Kristen W. Cohen, Anne-Sophie Dugast, Galit Alter, M. Juliana McElrath, and Leonidas Stamatatos 2776 The Cyclopentenone Prostaglandin 15d-PGJ2 Inhibits the NLRP1 and NLRP3 Inflammasomes Nolan K. Maier, Stephen H. Leppla, and Mahtab Moayeri 2786 Granzyme B Expression Is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to Antibody-Dependent Cellular Cytotoxicity Saranya Elavazhagan, Kavin Fatehchand, Vikram Santhanam, Huiqing Fang, Li Ren, Shalini Gautam, Brenda Reader, Xiaokui Mo, Carolyn Cheney, Edward Briercheck, John P. Vasilakos, Gregory N. Dietsch, Robert M. Hershberg, Michael Caligiuri, John C. Byrd, Jonathan P. Butchar, and Susheela Tridandapani 2796 SHP-1–Dependent Macrophage Differentiation Exacerbates Virus-Induced Myositis Neva B. Watson, Karin M. Schneider, and Paul T. Massa 2810 Estradiol Promotes M1-like Macrophage Activation through Cadherin-11 To Aggravate Temporomandibular Joint Inflammation in Rats Xiao-Xing Kou, Chen-Shuang Li, Dan-Qing He, Xue-Dong Wang, Ting Hao, Zhen Meng, Yan-Heng Zhou, and Ye-Hua Gan 2819 Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutieres Syndrome Paul R. Kasher, Emma M. Jenkinson, Val e rie Briolat, David Gent, Catherine Morrissey, Leo A. H. Zeef, Gillian I. Rice, Jean-Pierre Levraud, and Yanick J. Crow 2826 TRAF4-SMURF2–Mediated DAZAP2 Degradation Is Critical for IL-25 Signaling and Allergic Airway Inflammation Jarod A. Zepp, Ling Wu, Wen Qian, Wenjun Ouyang, Mark Aronica, Serpil Erzurum, and Xiaoxia Li 2838 Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip Yiqi Liu, Qian Zhang, Yuanyuan Ding, Xia Li, Dezhi Zhao, Kai Zhao, Zhenhong Guo, and Xuetao Cao 2847 SHIP1 Intrinsically Regulates NK Cell Signaling and Education, Resulting in Tolerance of an MHC Class I–Mismatched Bone Marrow Graft in Mice Matthew Gumbleton, Eric Vivier, and William G. Kerr 2855 Protein Kinase Ca Regulates the Expression of Complement Receptor Ig in Human Monocyte–Derived Macrophages Yuefang Ma, Kanchana Usuwanthim, Usma Munawara, Alex Quach, Nick N. Gorgani, Catherine A. Abbott, Charles S. Hii, and Antonio Ferrante 2862 RelB/p50 Complexes Regulate Cytokine-Induced YKL-40 Expression Reetika Bhardwaj, Jessie W. Yester, Sandeep K. Singh, Debolina D. Biswas, Michael J. Surace, Michael R. Waters, Kurt F. Hauser, Zhenqiang Yao, Brendan F. Boyce, and Tomasz Kordula MOLECULAR AND STRUCTURAL IMMUNOLOGY 2871 CD28 Inhibits T Cell Adhesion by Recruiting CAPRI to the Plasma Membrane Marianne Strazza, Inbar Azoulay-Alfaguter, Bryan Dun, Jairo Baquero-Buitrago, and Adam Mor 2878 FOXO1 Mediates RANKL-Induced Osteoclast Formation and Activity Yu Wang, Guangyu Dong, Hyeran Helen Jeon, Mohamad Elazizi, Lan B. La, Alhassan Hameedaldeen, E Xiao, Chen Tian, Sarah Alsadun, Yongwon Choi, and Dana T. Graves MUCOSAL IMMUNOLOGY 2888 IkBNS Regulates Murine Th17 Differentiation during Gut Inflammation and Infection Michaela Annemann, Zuobai Wang, Carlos Plaza-Sirvent, Rainer Glauben, Marc Schuster, Frida Ewald Sander, Panagiota Mamareli, Anja A. Ku¨hl, Britta Siegmund, Matthias Lochner, and Ingo Schmitz TRANSPLANTATION 2899 Transient Blockade of Delta-like Notch Ligands Prevents Allograft Rejection Mediated by Cellular and Humoral Mechanisms in a Mouse Model of Heart Transplantation Sherri Wood, Jiane Feng, Jooho Chung, Vedran Radojcic, Ashley R. Sandy-Sloat, Ann Friedman, Amy Shelton, Minhong Yan, Christian W. Siebel, D. Keith Bishop, and Ivan Maillard 2909 Genetic Investigation of MHC-Independent Missing-Self Recognition by Mouse NK Cells Using an In Vivo Bone Marrow Transplantation Model Peter Chen, Oscar A. Aguilar, Mir Munir A. Rahim, David S. J. Allan, Jason H. Fine, Christina L. Kirkham, Jaehun Ma, Miho Tanaka, Megan M. Tu, Andrew Wight, Vicky Kartsogiannis, Matthew T. Gillespie, Andrew P. Makrigiannis, and James R. Carlyle TUMOR IMMUNOLOGY 2919 Organ-Specific Microenvironment Modifies Diverse Functional and Phenotypic Characteristics of Leukemia-Associated Macrophages in Mouse T Cell Acute Lymphoblastic Leukemia Sha-Yan Chen, Xiao Yang, Wen-Li Feng, Jin-Feng Liao, Li-Na Wang, Li Feng, Yong-Min Lin, Qian Ren, and Guo-Guang Zheng 2930 PRL-3 Mediates the Protein Maturation of ULBP2 by Regulating the Tyrosine Phosphorylation of HSP60 Wai-Hang Leung, Queenie P. Vong, Wenwei Lin, David Bouck, Susanne Wendt, Erin Sullivan, Ying Li, Rafijul Bari, Taosheng Chen, and Wing Leung 2942 Bortezomib Inhibits Expression of TGF-b1, IL-10, and CXCR4, Resulting in Decreased Survival and Migration of Cutaneous T Cell Lymphoma Cells Tzu-Pei Chang, Vladimir Poltoratsky, and Ivana Vancurova 2954 AUTHOR INDEX