monoclonals. Setting the pace for antibody industry.
Setting the pace for antibody industry. Medix Biochemica revolutionized the industry by starting the industrial scale manufacturing of monoclonal antibodies nearly 30 years ago. Since then, we have become one of the leading antibody suppliers for the IVD industry recognized for excellent product quality and delivery process. The MedixMAB monoclonal antibodies are manufactured in vitro using the Hollow Fiber-technology and serum- or protein-free culture media. Antibodies are purified by affinity chromatography and fully characterized ensuring the uniform product quality of every batch. Our production capacity caters to even the most demanding needs of the diagnostic industry. Asematie 13, FI-02700 Kauniainen, Finland Tel.: +358 9 547 680, Fax: +358 9 505 3441, E-mail: [email protected] Visit our web site at www.medixbiochemica.com Copyright © 2011 Medix Biochemica. All rights reserved. Actim and MedixMAB are trademarks or registered trademarks of Medix Biochemica. Medix Biochemica reserves the right to make changes and improvements to any of the products described in this document without prior notice. MM00014-01 06/2011 monoclonals. When you want the best. CAR D I O VA S C U LA R Creatine kinase (CK) is a dimeric enzyme consisting of two subunits, which can be either B (brain type) or M (muscle type). CK-MB is used for diagnosis of myocardinal infarction. NEW D-Dimer is a small degradation product of cross-linked fibrin. D-Dimer is released in the blood during fibrinolysis and it is used to diagnose pulmonary embolia and deep vein thrombosis. UPCOMING Fatty-acid-binding proteins (FABP) are a family of carrier proteins for fatty acids and other lipophilic substances. Heart-FABP (FABP3) can be used as a diagnostic marker in the early phase of acute myocardial infarction. Clone Buffer Conc. Ref.No Anti-h CK-MB Anti-h CK-MB 7501 7502 SPRN SPRN 2 mg/ml 100085 5 mg/ml 100086 Anti-h D-Dimer Anti-h D-Dimer Anti-h D-Dimer 1401 1402 1403 SPTN 5 mg/ml 100204 SPTNZ 5 mg/ml 100205 SPTN 5 mg/ml 100228 Anti-h FABP3 Anti-h FABP3 Anti-h FABP3 2302 2303 2304 SPTN SPTN SPTN 1701 1702 1703 SPTN 5 mg/ml 100266 SPTN 5 mg/ml 100267 SPTNZ 5 mg/ml 100268 Myoglobin is an intracellular protein Anti-h Myoglobin Anti-h Myoglobin Anti-h Myoglobin Anti-h Myoglobin 7001 7004 7005 7005 SPR SP SPTN SPTN 1 mg/ml 1 mg/ml 1 mg/ml 5 mg/ml 100075 100076 100077 100078 SPRN SPTN SPTN SPTN 5 mg/ml 5 mg/ml 1 mg/ml 5 mg/ml 100129 100181 100125 100180 Pregnancy associated plasma protein A (PAPP-A) is a promising new PIPELINE marker for diagnosing problems during pregnancy as well as acute coronary syndromes. Troponins form a complex (Troponin C, I and T) and are involved in muscle contraction. Troponin levels can be used as a test of several different heart disorders, including myocardial infarction. Samples available in 2011. Anti-h cTnI Anti-h cTnI Anti-h cTnI Anti-h cTnI 9701 9703 9705 9707 SP SP SPR 1 mg/ml 100035 1 mg/ml 100037 5 mg/ml 100066 Chorionic Gonadotropin (hCG) is a Anti-hCG beta Anti-hCG beta Anti-hCG beta Anti-hCG Anti-hCG beta Anti-hCG beta Anti-hCG beta Anti-hCG beta 5004 5006 5008 5009 5011 5012 5014 5016 SP SP SP SP SPRN SPRN SPTN SPRN 1 mg/ml 5 mg/ml 5 mg/ml 5 mg/ml 1 mg/ml 1 mg/ml 5 mg/ml 5 mg/ml Anti-h FSH 6602 SP 5 mg/ml 100067 sexes. LH is measured to detect abnormalities in sexual development and reproductive functions. Anti-h LH Anti-h LH Anti-h LH Anti-h LH 5301 5302 5303 5304 SP SP SPRN SP 5 mg/ml 1 mg/ml 1 mg/ml 5 mg/ml 100016 100018 100019 100022 NEW Progesterone is a steroid hormone needed for normal reproduction. Progesterone levels are monitored during pregnancy and as indication of ovarian cancer. Anti-Progesterone Anti-Progesterone Anti-Progesterone Anti-Progesterone 1801 1802 1803 1805 SPTNZ SPTNZ SPTNZ SPRNZ 5 mg/ml 5 mg/ml 5 mg/ml 5 mg/ml 100248 100249 100250 100252 Prolactin (PRL) or Luteotropic hormone (LTH) is a peptide hormone Anti-h PRL Anti-h PRL 5601 5602 SP SP 1 mg/ml 100038 1 mg/ml 100040 Anti-h SHBG Anti-h SHBG Anti-h SHBG 6001 6002 6007 SP SP SP 1 mg/ml 100050 1 mg/ml 100051 1 mg/ml 100052 glycoprotein hormone produced in pregnancy and commonly utilized for early pregnancy testing. Testing for hCG may also be done when diagnosing or monitoring some tumors. Clone Buffer Conc. C-peptide is produced when proinsulin is split into insulin and C-peptide. C-peptide can be used to help determine how much insulin the patient’s pancreas is still producing. Anti-h C-Peptide Anti-h C-Peptide UPCOMING Glycated hemoglobin (HbA1c) is measured primarily to identify Anti-h HbA1c the average plasma glucose concentration over prolonged periods of time. Higher levels are found in people with persistently elevated blood sugar, as in diabetes. w 9101 9103 2403 SPTN SPRN SPTN Ref.No 5 mg/ml 100113 5 mg/ml 100114 5 mg/ml 100301 100004 100005 100006 100008 100009 100010 100011 100013 regulates the development, growth, pubertal maturation, and reproductive processes of the body. It is used to diagnose problems in the reproductive system. Luteinizing hormone (LH or lutropin) is essential for reproduction in both primarily associated with lactation. Prolactin is usually measured when checking for pituitary tumors or the cause of abnormal milk production. Sex hormone-binding globulin (SHBG) binds to sex hormones, specifically Dia b e t e s Ref.No Anti-h Alpha Subunit 5501 Anti-h Alpha Subunit 5503 Anti-h Alpha Subunit 6601 Follicle-stimulating hormone (FSH) Anti-h MPO Anti-h MPO Anti-h MPO Clone Buffer Conc. The alpha subunit of LH, FSH, TSH, and hCG is identical. The biological activity of these hormones is evoked by the specific beta subunit. 5 mg/ml 100292 5 mg/ml 100293 5 mg/ml 100294 NEW Myeloperoxidase (MPO) is an enzymatic mediator of inflammatory cascades and microbial killing. Higher serum levels of MPO have been associated with cardiovascular diseases. transporting oxygen in the cardiac and skeletal muscle cells. Myoglobin is one of the earliest biomarkers of cardiac injury. FERTILIT Y testosterone and estradiol. Abnormally low or high SHBG levels are used to diagnose several nonphysiological conditions. PIPELINE Testosterone is the principal male sex hormone and an anabolic steroid. Testosterone plays a key role in the development of male reproductive tissues as well as secondary sexual characteristics. Samples available in 2011. I NFE C T I O U S DIS EA SES Chlamydia trachomatis is an intracellular pathogen and can cause numerous disease states in both men and women, such as urethritis, proctitis, trachoma, and infertility. PIPELINE Hepatitis B virus (HBV) causes liver inflammation, and chronic hepatitis B may eventually cause liver cirrhosis and liver cancer. The first detectable viral antigen to appear during infection is hepatitis B surface antigen (HBsAg). Influenza A is the most common cause of Clone Buffer Conc. Ref.No Anti-Chlamydia Trachomatis 6701 SP 1 mg/ml 100068 Anti-Chlamydia Trachomatis 6703 SPRN 1 mg/ml 100069 Anti-Chlamydia Trachomatis 6709 SP 5 mg/ml 100073 Samples available in 2011. Anti-Influenza A Anti-Influenza A Anti-Influenza A 7304 SPRN 5 mg/ml 100081 7305 SPRN 5 mg/ml 100082 7307 SPTN 5 mg/ml 100083 Influenza B causes also seasonal epidemics but it is only known to infect humans and seals. This limited host range is apparently responsible for the lack of Influenza B caused pandemics. Anti-Influenza B 9901 SPTNE 10 mg/ml 100117 NEW Respiratory Syncytial Virus (RSV) causes respiratory tract infections. It is the Anti-RSV Anti-RSV Anti-RSV 1201 SPTN 10 mg/ml 100198 1202 SPTN 5 mg/ml 100199 1203 SPTN 5 mg/ml 100200 influeza, flu pandemics and most epidemics. Influenza A virus causes influenza in birds and some mammals. major cause of lower respiratory tract infection and hospital visits during infancy and childhood. The group A streptococcus bacterium (Streptococcus pyogenes, or GAS) is a bacterium often found in the throat Samples available in 2011. NEW Adiponectin is a protein hormone that modulates a number of metabolic processes, that may lead to type 2 diabetes, obesity, atherosclerosis, and non-alcoholic fatty liver disease. NEW Apolipoprotein A1 (ApoA1) is a major component of the high-density lipoproteins (HDL) complex. ApoA1 helps to clear cholesterol from arteries. Apo A-I has been suggested as a better discrimination of coronary artery disease than HDL. UPCOMING Apolipoprotein B (ApoB) is the primary apolipoprotein of low-density lipoproteins (LDL), which is responsible for carrying cholesterol to tissues. High levels of ApoB can lead to plaques that cause atherosclerosis. Clone Buffer Conc. Ref.No Anti-h Adiponectin Anti-h Adiponectin Anti-h Adiponectin 1901 1902 1903 SPTN SPTN SPTN 5 mg/ml 100255 5 mg/ml 100256 5 mg/ml 100257 Anti-h ApoA1 Anti-h ApoA1 2001 2002 SPTN SPTN 5 mg/ml 100263 5 mg/ml 100264 Anti-h ApoB 2101 SPTN 5 mg/ml 100261 Ref.No Anti-h IgA 8203 SPRN Immunoglobulin E (IgE) plays an important role in allergy and defence against parasites. IgE is a class of antibody that has only been found in mammals. Anti-h IgE Anti-h IgE Anti-h IgE 8510 8516 8518 SPTN 1 mg/ml 100104 SPTN 1 mg/ml 100105 SPRNE 1 mg/ml 100106 Immunoglobulin G (IgG) antibodies are involved in the secondary immune response. IgG is a monomeric immunoglobulin consisting of four subclasses and constituting 75% of serum immunoglobulins in humans. Anti-h IgG 7701 SPRN 5 mg/ml 100087 Immunoglobulin M (IgM) is involved in primary immune response. IgM is a basic antibody that first appears in response to exposure to antigen and indicates recent infection in patient’s serum. Anti-h IgM 7408 SPRN 5 mg/ml 100084 SPECIFIC PR OTE IN S 5 mg/ml 100101 Clone Buffer Conc. Ref.No Anti-h Albumin Anti-h Albumin 6501 6502 SPRN SP 1 mg/ml 100063 2 mg/ml 100064 Anti-h AAT Anti-h AAT 1002 1003 SPTN SPTN 5 mg/ml 100209 5 mg/ml 100210 Anti-h CRP Anti-h CRP Anti-h CRP Anti-h CRP Anti-h CRP 6402 6403 6404 6405 6407 SPTN SPTN SP SP SPTN 5 mg/ml 5 mg/ml 2 mg/ml 1 mg/ml 5 mg/ml Ferritin is a protein that binds and stores iron. It releases iron in controlled fashion normally preventing iron deficiency and iron overload in humans. The amount of ferritin in the seum is measured in relation to some chronic diseases and anemia. Anti-h Ferritin Anti-h Ferritin 8803 8806 SPRN SPTN 5 mg/ml 100111 5 mg/ml 100112 Growth hormone (GH) is a single-chain Anti-h GH Anti-h GH 5801 5802 SP SP 1 mg/ml 100041 1 mg/ml 100042 UPCOMING Me ta b olism Clone Buffer Conc. Immunoglobulin A (IgA) is an antibody which plays a critical role in mucosal immunity. IgA has two subclasses (IgA1 and IgA2) and can exist in a dimeric form called secretory IgA (sIgA). Albumin normally constitutes about 60% of human plasma proteins and is produced in the liver. It is important in regulating blood volume, and also serves as carriers for molecules in blood. PIPELINE and on the skin. Most GAS infections are relatively mild illnesses but occasionally these bacteria can cause severe and life-threatening diseases. SEROLO G Y Alpha 1-Antitrypsin (AAT) is a glycoprotein that protect the lungs from destructive actions of blood enzymes, generally known as serum trypsin inhibitor. Disorders of this protein include AAT-deficiency, a hereditary disorder leading to a chronic uninhibited tissue breakdown. C-reactive protein (CRP) is a protein found in the blood and the levels rise in response to inflammation. CRP values are useful in determining disease progress or the effectiveness of treatments. polypeptide hormone. Growth hormone is used clinically to diagnose and treat children’s growth disorders and adult growth hormone deficiency. 100145 100146 100058 100062 100147 PIPELINE Interleukin-6 (IL-6) acts as both pro-inflammatory and anti-inflammatory cytokine. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer’s Disease, cancer, and rheumatoid arthritis. TUM OR Samples available in 2011. NEW Interleukin-8 (IL-8) is a chemokine which serves as a chemical signal that attracts neutrophils at the site of inflammation. IL-8 is a promising marker for many clinical conditions with inflammations. Anti-h IL-8 UPCOMING Serum amyloid A (SAA) is associated with HDL during inflammatory states. The blood level of SAA increases dramatically in response to tissue injury and inflammation. Anti-h SAA Anti-h SAA Anti-h SAA Anti-h SAA T HY R O I D PIPELINE Thyroglobulin is used in the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroid-stimulating hormone (TSH or thyrotropin) is a peptide hormone which regulates the endocrine function of the thyroid gland. Abnormal TSH levels may lead to hyperthyroidism or hypothyroidism. Thyroxine (T4) is the major hormone produced by the thyroid gland. Thyroxine is a prohormone and a reservoir for the active thyroid hormone (T3). Thyroxine is measured from blood to diagnose thyroid disorders. 1501 2201 2202 2203 2204 SPTN SPTN SPTNZ SPTN SPTN 5 mg/ml 100218 5 mg/ml 5 mg/ml 5 mg/ml 5 mg/ml Clone Buffer Conc. 100279 100288 100289 100290 Ref.No Samples available in 2011. Anti-h TSH Anti-h TSH Anti-h TSH Anti-h TSH Anti-h TSH Anti-h TSH Anti-h TSH Anti-h TSH Anti-h TSH 5401 5403 5404 5404 5405 5407 5407 5408 5409 SP SP SP SP SP SPTN SPTN SPTN SPTNE 1 mg/ml 5 mg/ml 1 mg/ml 5 mg/ml 1 mg/ml 1 mg/ml 5 mg/ml 1 mg/ml 5 mg/ml 100023 100024 100025 100026 100030 100032 100254 100033 100034 Anti-Thyroxine 6901 SPTN 1 mg/ml 100074 Clone Buffer Conc. Ref.No Alpha-fetoprotein (AFP) is a major plasma protein produced by fetus. AFP is measured in pregnancy as a screening test for a subset of developmental abnormalities. It is also used as a biomarker to detect a subset of tumors. Anti-h AFP Anti-h AFP 5107 5108 SP SP 1 mg/ml 100014 5 mg/ml 100015 Carcinoembryonic antigen (CEA) is normally produced during fetal development. It has been used as a tumor marker for colorectal cancer and several carcinomas. Anti-h CEA Anti-h CEA Anti-h CEA Anti-h CEA Anti-h CEA 5905 5909 5910 5911 5912 SP SP SPTN SP SP 1 mg/ml 1 mg/ml 5 mg/ml 1 mg/ml 1 mg/ml 100044 100046 100047 100048 100049 NEW CYFRA21-1 is a fragment of Cytokeratin 19. Serum CYFRA21-1 has been used as a tumor marker of different origins and especially in nonsmall cell lung cancer. Anti-h CYFRA21-1 Anti-h CYFRA21-1 Anti-h CYFRA21-1 Anti-h CYFRA21-1 1602 1603 1604 1605 SPTNZ SPTNZ SPTN SPTN 5 mg/ml 5 mg/ml 5 mg/ml 5 mg/ml 100220 100221 100222 100223 Hemoglobin (Hb) is the iron-containing oxygen-transport metalloprotein in the red blood cells. Hemoglobin carriers oxygen from the lungs to the body tissue. Changes from the normal values usually indicate abnormalities, such as anemia. Anti-h Hemoglobin Anti-h Hemoglobin 7202 7204 SPR SP 5 mg/ml 100079 5 mg/ml 100080 Pepsinogen (PG) is the pro-form of pepsin. It is produced in the stomach and secreted into the gastric lumen, but a small amount also into the blood. Alterations in the serum pepsinogen concentration may indicate gastric abnormalities. Anti-h PG I Anti-h PG I Anti-h PG I Anti-h PG I Anti-h PG II Anti-h PG II Anti-h PG II 8003 8009 8015 8016 8101 8102 8103 SPRN SPTN SPRN SPRN SPTN SPRN SPTN 1 mg/ml 1 mg/ml 1 mg/ml 1 mg/ml 1 mg/ml 1 mg/ml 1 mg/ml Prostate-specific antigen (PSA) is a Anti-h PSA Anti-h PSA Anti-h PSA 8301 8311 8312 SPRN SPRN SPRN 5 mg/ml 100102 1 mg/ml 100103 5 mg/ml 100139 Anti-h NSE Anti-h NSE 9601 9602 SPTN SPTN 1 mg/ml 100115 1 mg/ml 100116 protein produced by the cells of the prostate gland. PSA is often elevated in the presence of prostate cancer and in other prostate disorders. Neuron-specific enolase (NSE) has been detected in patients with certain tumors, namely: neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma. 100092 100093 100094 100095 100096 100098 100099 BUFFERS SP: 0.9 % NaCI, 0.1 % NaN3 as a preservative SPRN6.0: 37 mM citrate, 125 mM phosphate, pH 6.0, 0.9 % NaCI, 0.1 % NaN3 as a preservative SPRN6.5: 29 mM citrate, 142 mM phosphate, pH 6.5, 0.9 % NaCI, 0.1 % NaN3 as a preservative SPR: 37 mM citrate, 125 mM phosphate, pH 6.0, 0.1 % NaN3 as a preservative SPTN: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.1 % NaN3 as a preservative SPTNE: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 25 % ethylene glycol SPTNZ: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.05 % sulfobetaine, 0.1 % NaN3 as a preservative CONCENTRATION mg/ml (+/- 10 %) All product specifications can be found on the Internet: www.medixbiochemica.com
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