The Quarterly Journal of Medicine Edited by J. S. CAMERON, P. HUGH-JONES R. HOFFENBERG, P. K. THOMAS A. E. READ, P. SLEIGHT New Series, Volume XLIX, 1980 Volume LXXIII of the Continuous Series OXFORD • AT THE CLARENDON PRESS Oxford University Press, Ely House, London W.I GLASGOW NEW YORK TORONTO MELBOURNE WELLINGTON CAPETOWN IBADAN NAIROBI DARES SALAAM LUSAKA ADDIS ABABA DELHI BOMBAY CALCUTTA MADRAS KARACHI LAHORE DACCA KUALA LUMPUR SINGAPORE HONG KONG TOKYO © O X F O R D UNIVERSITY PRESS 1980 Contents New Series, Vol. XLIX, No. 193 Winter 1980 Mortality and Morbidity in Birmingham during the 1976 Heatwave. By F. P. Ellis, H. P. Prince, G. Lovatt and R. M. Whittington Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome. By Peter Mitchell-Heggs, Kevin Murphy, Keith Minty, Abraham Guz, Susan C. Patterson, Peter S. B. Minty and Rachel M. Rosser Treatment of Acromegaly by Transethmoidal Hypophysectomy. By S. H. Richards and J. P. Thomas Poisoning with Tricyclic and Related Antidepressants—A Ten-Year Review. By I. R. Starkey and A. A. H. Lawson Hyperthyroidism in the Land of Graves: Results of Treatment by Surgery, Radio-iodine and Carbimazole in 837 Cases. By D. Sugrue, M. McEvoy, J. Feely and M. I. Drury Mortality in Crohn's Disease. By John F. Mayberry, Robert G. Newcombe and John Rhodes Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1—report of a further family and a review of the literature. By J. B. Betts, B. P. O'Malley and F. D. Rosenthal An Objective Assessment of the Value of Exercise Training to Patients with Chronic Obstructive Airways Disease. By I. P. F. Mungall and R. Hainsworth The Pathogenesis of Idiopathic Hypercalciuria: Evidence for Renal Tubular Calcium Leak. By F. P. Muldowney, R. Freaney and J. G. Ryan The Natural History of Diabetic Autonomic Neuropathy. By D. J. Ewing, I. W. Campbell and B. F. Clarke Errata 1 9 21 33 51 63 69 77 87 95 109 No. 194, Spring 1980 Intracranial Disease in Non-Hodgkin's Lymphoma. By G. S. Venables, S. J. Proctor, D. Bates, N. E. F. Cartlidge and D. A. Shaw Idiopathic Chronic Ulcerative Enteritis. By P. R. Mills, I. L. Brown and G. Watkinson The Mechanism of Arterial Hypoxia Occurring in Acute Pancreatis. By Desmond Murphy, Allan I. Pack and Clement W. Imrie A Study of Fifty-eight Patients with Renal Scarring Associated with Urinary Tract Infection. By J. C. L. Mihindukulasuriya, Rosalind Maskell and A. Polak 111 133 151 165 iv Contents Surgical Correction of Renovascular Hypertension: Dissociation between Post-operative Changes in Plasma Renin and Blood Pressure. By M. Maskill, R. F. Bing, H. Thurston, P. R. F. Bell and J. D. Swales Variegate Porphyria. By Pertti Mustajoki The Management of Ventricular Septal Rupture Following Myocardial Infarction. By J. Colin Forfar, John B. Irving, Hugh C. Miller, Arthur H. Kitchin and David J. Wheatley The Effects of Viral Infections on Renal Transplants and Their Recipients. By M. J. Warrell, I. Chinn, P. J. Morris and J. O'H. Tobin 179 191 205 219 No. 195, Summer 1980 Renal Manifestations and Abnormal Calcium Metabolism in Sarcoidosis. By Frode K. Romer In Vitro Studies of Duodenal Iron Uptake in Patients with Primary and Secondary Iron Storage Disease. By T. M. Cox and T. J. Peters Food Allergy and Intolerance in 100 Patients—Local and Systemic Effects. By M. H. Lessof, D. G. Wraith, T. G. Merrett, J. Merrett and P. D. Buisseret The Use of Colour Vision Measurement in the Diagnosis of Digoxin Toxicity. By Jeffrey K. Aronson and Alan R. Ford The Impact of Treatment with Levodopa on Parkinson's Disease. By K. M. Shaw, A. J. Lees and G. M. Stern Hereditary Abnormalities of Thyroxine-Binding Globulin Concentration— A Study of 19 Kindreds with Inherited Increase or Decrease of ThyroxineBinding Globulin. By W. A. Burr, D. B. Ramsden and R. Hoffenberg Infective Endocarditis, 1970-1979—A Study of Culture-Positive Cases in St. Thomas' Hospital. By M. T. Moulsdale, S. J. Eykyn and I. Phillips Regression of Lung Size in Adults with Growth Hormone Deficiency. By A. De Troyer, D. Desir and G. Copinschi The Biochemical Diagnosis, Localization and Follow-up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements. By D. H. Jones, J. L. Reid, Carlene A. Hamilton, D. J. Allison, R. B. Welbourn and C. T. Dollery Crohn's Disease: Course, Treatment and Long Term Prognosis. By W. T. Cooke, E. Mallas, P. Prior and R. N. Allan Plasma Renin in Hypertensive Patients: Significance in Relation to Clinical and Other Biochemical Features. By G. I. Russell, R. F. Bing, H. Thurston and J. D. Swales 233 249 259 273 283 295 315 329 341 363 385 No. 196 Autumn 1980 Hypertension Following Renal Transplantation: The Role of the Host's Kidneys. By M. I. McHugh, H. Tanboga, R. Marcen, F. Liano, V. Robson and R. Wilkinson 395 Contents Hypercalcaemia—A Hospital Survey. By R. A. Fisken, D. A. Heath and A. M. Bold Leri's Pleonosteosis. By R. C. Hilton and J. Wentzel The Clinical Spectrum of Campylobacter Fetus Infections: Report of Five Cases and Review of the Literature. By Uwe Schmidt, Herman Chmel, Zigmund Kaminski and Purnendu Sen The Straight Back Syndrome. By M. K. Davies, P. Mackintosh, R. M. Clayton, A. J. F. Page, M. F. Shiu and W. A. Littler Cireadian Variations in Urine Excretion in Chronic Renal Failure. By Pamela Hillier, Martin S. Knapp and Rodney Cove-Smith Prognostic Value of Radionuclide Ventriculography After Myocardial Infarction. By N. G. Dewhurst, W. J. Hannan and A. L. Muir Defect in Plasma Clearance of Bromsulphthalein in Papua New Guineans with Systemic Infections. By G. C. Cook The Association of Physicians of Great Britain and Ireland 1980 SeventyFourth Annual General Meeting v 405 419 431 443 461 479 491 501 Index to Contributors R. N. Crohn's Disease: Course, Treatment and Long Term Prognosis ALLISON, D. J. The Biochemical Diagnosis, Localization and Follow up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements ARONSON, JEFFREY K. The Use of Colour Vision Measurement in the Diagnosis of Digoxin Toxicity BATES, D. Intracranial Disease in Non-Hodgkin's Lymphoma BELL, P. R. F. Surgical Correction of Renovascular Hypertension: Dissociation between Post-operative Changes in Plasma Renin and Blood Pressure BETTS, J. B. Hyperparathyroidism: a prerequisite for Zollinger—Ellison Syndrome in Multiple Endocrine Andomatosis Type 1—Report of a Further Family and a Review of the Literature BING, R. F. Surgical Correction of Renovascular Hypertension: Dissociation between Post-operative Changes in Plasma Renin and Blood Pressure BING, R. F. Plasma Renin in Hypertensive Patients: Significance in Relation to Clinical and Other Biochemical Features BOLD, A. M. Hypercalcaemia—A Hospital Survey BROWN, I. L. Idiopathic Chronic Ulcerative Enteritis BUISSERET, P. D. Food Allergy and Intolerance in 100 Patients—Local and Systemic Effects BURR, W. A. Hereditary Abnormalities of Thyroxine-Binding Globulin Concentration CAMPBELL, I. W. The Natural History of Diabetic Autonomic Neuropathy CARTLIDGE, N. E. F. Intracranial Disease in Non-Hodgkin's Lymphoma CHINN, I. The Effects of Viral Infections on Renal Transplants and Their Recipients CHMEL, HERMAN. The Clinical Spectrum of Campylobacter Fetus Infecttions: Report of Five Cases and Review of the Literature CLAYTON, R. M. The Straight Back Syndrome COOK, G. C. Defect in Plasma Clearance of Bromsulphthalein in Papua New Guineans with Systemic Infections COOKE, W. T. Crohn's Disease: Course, Treatment and Long Term Prognosis COPINSCHL G. Regression of Lung Size in Adults with Growth Hormone Deficiency COVE-SMITH, RODNEY. Circadian Variations in Urine Excretion in Chronic Renal Failure ALLAN, vii 363 341 273 111 179 69 179 385 405 133 259 295 95 111 219 431 443 491 363 329 461 viii Index to Contributors Cox, T. M. In Vitro Studies of Duodenal Iron Uptake in Patients with Primary and Secondary Iron Storage Disease DAVIES, M. K. The Straight Back Syndrome DESIR, D. Regression of Lung Size in Adults with Growth Hormone Deficiency DE TROYER, A. Regression of Lung Size in Adults with Growth Hormone Deficiency DEWHURST, N. G. Prognostic Value in Radionuclide Ventriculography After Myocardial Infarction DOLLERY, C. T. The Biochemical Diagnosis, Localization and Follow up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements DRURY, M. I. Hyperthyroidism in the Land of Graves: Results of Treatment by Surgery, Radio-iodine and Carbimazole in 837 Cases ELLIS, F. P. Mortality and Morbidity in Birmingham during the 1976 Heatwave EWING, D. J. The Natural History of Diabetic Autonomic Neuropathy EYKYN, S. J. Infective Endocarditis, 1970-1979 FEELY, J. Hyperthyroidism in the Land of Graves: Results of Treatment by Surgery, Radio-iodine and Carbimazole in 837 Cases FISKEN, R. A. Hypercalcaemia—A Hospital Survey FORD, ALAN R. The Use of Colour Vision Measurement in the Diagnosis of Digoxin Toxicity FORAR, J.COLIN. The Management of Ventricular Septal Rupture Following Myocardial Infarction FREANEY, R. The Pathogenesis of Idiopathic Hypercalcuria: Evidence for Renal Tubular Calcium Leak Guz, ABRAHAM. Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome HAINSWORTH, R. An Objective Assessment of the Value of Exercise Training to Patients with Chronic Obstructive Airways Disease HAMILTON, CARLENE A. The Biochemical Diagnosis, Localization and Follow up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements HANNAN, W. J. Prognostic Value of Radionuclide Ventriculography After Myocardial Infarction HEATH, D. A. Hypercalcaemia—A Hospital Survey HILLIER, PAMELA Orcadian Variations in Urine Excretion in Chronic Renal Failure HILTON, R. C. Leri's Pleonosteosis HOFFENBERG, R. Hereditary Abnormalities of Thyroxine-Binding Globulin Concentration IMRIE, CLEMENT W. The Mechanism of Arterial Hypoxia Occurring in Acute Pancreatitis 249 443 329 329 479 341 51 1 95 315 51 405 273 205 87 9 77 341 479 405 461 419 295 151 Index to Contributors ix B. The Management of Ventricular Septal Rupture Following Myocardial Infarction 205 JONES, D. H. The Biochemical Diagnosis, Localization and Follow up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements 341 KAMINSKI, ZIGMUND. The Clinical Spectrum of Campylobacter Fetus Infections: Report of Five Cases and Review of the Literature 431 KITCHIN, ARTHUR H. The Management of Ventricular Septal Rupture Following Myocardial Infarction 205 KNAPP, MARTIN S. Circadian Variations in Urine Excretion in Chronic Renal Failure 461 LAWSON, A. A. H. Poisoning with Tricyclic and Related Antidepressants— A Ten-Year Review 33 LEES, A. J. The Impact of Treatment with Levodopa on Parkinson's Disease 283 LESSOF, M. H. Food Allergy and Intolerance in 100 Patients—Local and Systemic Effects 259 LIANO, F. Hypertension Following Renal Transplantation: The Role of the Host's Kidneys 395 LITTLER, W. A. The Straight Back Syndrome 443 LOVATT, G. Mortality and Morbidity in Birmingham during the 1976 Heatwave 1 MACKINTOSH, P. The Straight Back Syndrome 443 MALLAS, E. Crohn's Disease: Course, Treatment and Long Term Prognosis 363 MARCEN, R. Hypertension Following Renal Transplantation: The Role of the Host's Kidneys 395 MASKELL, ROSALIND. A Study of Fifty-eight Patients with Renal Scarring Associated with Urinary Tract Infection 165 MASKILL, M. Surgical Correction of Reno vascular Hypertension: Dissociation between Post-operative Changes in Plasma Renin and Blood Pressure 179 MAYBERRY, JOHN F. Mortality in Crohn's Disease 63 MCEVOY, M. Hyperthyroidism in the Land of Graves: Results of Treatment by Surgery, Radio-iodine and Carbimazole in 837 Cases 51 MCHUGH, M. I. Hypertension Following Renal Transplantation: The Role of the Host's Kidneys 395 MERRETT, J. Food Allergy and Intolerance in 100 Patients—Local and Systemic Effects 259 MERRETT, T. G. Food Allergy and Intolerance in 100 Patients—Local and Systemic Effects 259 MIHINDUKULASURIYA, J. C. L. A Study of Fifty-eight Patients with Renal Scarring Associated with Urinary Tract Infection 165 MILLER, HUGH C. The Management of Ventricular Septal Rupture Following Mycocardial Infarction 205 MILLS, P. R. Idiopathic Chronic Ulcerative Enteritis 133 IRVING, JOHN x Index to Contributors MINTY, KEITH. Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome S. B. Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome MITCHELL-HEGGS, PETER. Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome MORRIS, P. J. The Effects of Viral Infections on Renal Transplants and Their Recipients MOULSDALE, M. T. Infective Endocarditis, 1970-1979 MUIR, A. L. Prognostic Value of Radionuclide Ventriculography After Myocardial Infarction MULDOWNEY, F. P. The Pathogenesis of Idiopathic Hypercalcuria: Evidence for Renal Tubular Calcium Leak MUNGALL, I. P. F. An Objective Assessment of the Value of Exercise Training to Patients with Chronic Obstructive Airways Disease MURPHY, DESMOND. The Mechanism of Arterial Hypoxia Occurring in Acute Pancreatitis MURPHY, KEVTN Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome MUSTAJOKI, PERTTI. Variegate Porphyria NEWCOMBE, ROBERT G. Mortality in Crohn's Disease O'MALLEY, B. P. Hyperparathyroidism: a Prerequisite for ZollingerEllison Syndrome in Multiple Endocrine Adenomatosis Type 1—Report of a Further Family and a Review of the Literature PACK, ALLAN I. The Mechanism of Arterial Hypoxia Occurring in Acute Pancreatitis PAGE, A. J. F. The Straight Back Syndrome PATTERSON, SUSAN C. Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome PETERS, T. J. In Vitro Studies of Duodenal Iron Uptake in Patients with Primary and Secondary Iron Storage Disease PHILLIPS, I. Infective Endocarditis, 1970-1979 POLAK, A. A study of Fifty-eight Patients with Renal Scarring Associated with Urinary Tract Infection PRINCE, H. P. Mortality and Morbidity in Birmingham during the 1976 Heatwave PRIOR, P. Crohn's Disease: Course, Treatment and Long Term Prognosis PROCTOR, S. J. Intracranial Disease in Non-Hodgkin's Lymphoma RAMSDEN, D. B. Hereditary Abnormalities of Thyroxine-Binding Globulin Concentration REID, J. L. The Biochemical Diagnosis, Localization and Follow up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements RHODES, JOHN. Mortality in Crohn's Disease 9 MINTY, PETER 9 9 219 315 479 87 77 151 9 191 63 69 151 443 9 249 315 165 1 363 111 295 341 63 Index to Contributors xi S. H. Treatment of Acromegaly by Transethmoidal Hypophysectomy 21 ROBSON, V. Hypertension Following Renal Transplantation: The Role of the Host's Kidneys 395 R0MER, FRODE K. Renal Manifestations and Abnormal Calcium Metabolism in Sarcoidosis 233 ROSENTHAL, F. D. Hyperparathyroidism: a Prerequisite for ZollingerEllison Syndrome in Multiple Endocrine Adenomatosis Type 1—Report of a Further Family and a Review of the Literature 69 ROSSER, RACHEL M. Diazepam in the Treatment of Dyspnoea in the 'Pink Puffer' Syndrome 9 RUSSELL, G. I. Plasma Renin in Hypertensive Patients: Significance in Relation to Clinical and Other Biochemical Features 385 RYAN, J. G. The Pathogenesis of Idiopathic Hypercalcuria: Evidence for Renal Tubular Calcium Leak 87 SCHMIDT, UWE. The Clinical Spectrum of Campylobacter Fetus Infections: Report of Five Cases and Review of the Literature 431 SEN, PURNENDU. The Clinical Spectrum of Campylobacter Fetus Infections: Report of Five Cases and Review of the Literature 431 SHAW, D. A. Intracranial Disease in Non-Hodgkin's Lymphoma 111 SHAW, K. M. The Impact of Treatment with Levodopa on Parkinson's Disease 283 SHIU, M. F. The Straight Back Syndrome 443 STARKEY, I. R. Poisoning with Tricyclic and Related Antidepressants—A Ten-Year Review 33 STERN, G. M. The Impact of Treatment with Levodopa on Parkinson's Disease 283 SUGRUE, D. Hyperthyroidism in the Land of Graves: Results of Treatment by Surgery, Radio-iodine and Carbimazole in 837 Cases 51 SWALES, J. D. Surgical Correction of Renovascular Hypertension: Dissociation between Post-operative Changes in Plasma Renin and Blood Pressure 179 SWALES, J. D. Plasma Renin in Hypertensive Patients: Significance in Relation to Clinical and Other Biochemical Features 385 TANBOGA, H. Hypertension Following Renal Transplantation: The Role of the Host's Kidneys 395 THOMAS, J. P. Treatment of Acromegaly by Transethmoidal Hypophysectomy 21 THURSTON, H. Surgical Correction of Renovascular Hypertension: Dissociation between Post-operative Changes in Plasma Renin and Blood Pressure 179 THURSTON, H. Plasma Renin in Hypertensive Patients: Significance in Relation to Clinical and Other Biochemical Features 385 TOBIN, J. O'H. The Effects of Viral Infections on Renal Transplants and Their Recipients 219 RICHARDS, xii Index to Contributors G. S. Intracranial Disease in Non-Hodgkin's Lymphoma M. J. The Effects of Viral Infections on Renal Transplants and Their Recipients WATKINSON, G. Idiopathic Chronic Ulcerative Enteritis WELLBOURN, R. B. The Biochemical Diagnosis, Localization and Follow up of Phaeochromocytoma: The Role of Plasma and Urinary Catecholamine Measurements WENTZEL, J. Leri's Pleonosteosis WHEATLEY, DAVID J. The Management of Ventricular Septal Rupture Following Myocardial Infaction WHITTINGTON, R. M. Mortality and Morbidity in Birmingham during the 1976 Heatwave WILKINSON, R. Hypertension Following Renal Transplantation: The Role of the Host's Kidneys WRAITH, D. G. Food Allergy and Intolerance in 100 Patients—Local and Systemic Effects VENABLES, WARRELL, 111 219 133 341 419 205 1 395 259 Index Acromegaly, treatment of, by transethmoidal hypophysectomy, 21 Adenomatosis, multiple endocrine, Type 1, Zollinger-Ellison syndrome in, hyperparathyroidism: a prerequisite for—report of a further family and a review of the literature, 69 Allergy, food, and intolerance in 100 patients— local and systemic effects, 259 Antidepressants, poisoning with tricyclic and related—a ten-year review, 33 Autonomic neuropathy, diabetic, the natural history of, 95 Back, the straight, syndrome, 443 Bromsulphthalein, defect in plasma clearance of, in Papua New Guineans with systemic infections, 491 Campylobacter fetus infections, the clinicaJ spectrum of: report of five cases and review of the literature, 431 Clearance, plasma, defect in, of bromsulphthalein in Papua New Guineans with systemic infections, 491 Crohn's disease: course, treatment and long term prognosis, 363 Crohn's disease, mortality in, 63 Diabetic autonomic neuropathy, the natural history of, 95 Diazepam in the treatment of dyspnoea in the 'Pink Puffer' syndrome, 9 Digoxin toxicity, the diagnosis of, the use of colour vision measurement in, 273 Dyspnoea in the 'Pink Puffer' syndrome, diazepam in the treatment of, 9 Endocarditis, infective, 1970-1979,315 Enteritis, chronic ulcerative, idiopathic, 133 Exercise training, an objective assessment of the value of, to patients with chronic obstructive airways disease, 77 Growth hormone deficiency, regression of lung size in adults with, 329 Heatwave, the 1976, mortality and morbidity during, 1 Hypercalcaemia—a hospital survey, 405 Hypercalciuria, idiopathic, the pathogenesis of: evidence for renal tubular calcium leak, 87 Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1—report of a further family and a review of the literature, 69 Hypertension, renovascular, surgical correction of: dissociation between post-operative changes in plasma renin and blood pressure, 179 Hypertensive patients, plasma renin in: significance in relation to clinical and other biochemical features, 385 Hyperthyroidism in the land of Graves: results of treatment by surgery, radio-iodine and carbimazole in 837 cases, 51 Infarction, myocardial, prognostic value of radionuclide ventriculography after, 479 Infections, systemic, defect in plasma clearance of bromsulphthalein in Papua New Guineans with, 491 Intracranial disease in non-Hodgkin's lymphoma, 111 Iron storage disease, primary and secondary, in vitro studies of duodenal iron uptake in patients with, 249 Lung size in adults, regression of, with growth hormone deficiency, 329 Lymphoma, non-Hodgkin's, intracranial disease in, 111 Myocardial infarction, the management of ventricular septal rupture following, 205 Obstructive airways disease, chronic, an objective assessment of the value of exercise training to patients with, 77 Pancreatitis, acute, the mechanism of arterial hypoxia occurring in, 151 Parkinson's disease, the impact of treatment with levodopa on, 283 Phaeochromocytoma, the biochemical diagnosis, localization and follow up of: the role of plasma and urinary catecholamine measurements, 341 Pleonosteosis, Leri's, 419 Porphyria, variegate, 191 Renal failure, chronic, circadian variations in urine excretion in, 461 Renal transplantation, hypertension following: the role of the host's kidneys, 395 Renal transplants and their recipients, the effects of viral infections on, 219 Renin, plasma, in hypertensive patients: significance in relation to clinical and other biochemical features, 385 Sarcoidosis, renal manifestations and abnormal calcium metabolism in, 233 Thyroxine-binding globulin concentration, Xlll xiv Index hereditary abnormalities of, 295 Urinary tract infection, renal scarring assodated with, a study of fifty-eight patients with, 165 Ventriculography, radionuclide, prognostic value of, after myocardial infarction, 479 Pnnieu m uredi amain oy opoti/swoooe aananxyne Lta., Dorchester and London