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Neurosurgeon:Scientist Pathway in Pediatric Neurosurgery 14th AACNS Meeting, Jeju Island, Korea James T Rutka, MD, PhD, FRCSC Division of Neurosurgery, The University of Toronto Neurosurgeon:Scientists Around the World Can Paediatric Neurosurgeons Be Productive and Competitive Scientists? Excellence in Neurosurgical Research The Next Generation! Abhaya Kulkarni MD,PhD Clinical Epidemiology Clinical Trials Design Gamma Knife in Ped NS JAMA, J Pediatr, Lancet Peter Dirks MD,PhD Vascular Neurosurgery Stem Cells in Brain Tumors Canada’s Top 40 under 40 Nature, Cell, Cancer Research Michael Taylor MD,PhD Molecular Biology of Pediatric Brain Tumors Canada’s Top 40 under 40 Nature Genetics, Cancer Research, Cancer Cell How Did These Neurosurgeons Achieve Excellence in the Lab? 1) They are Neurosurgeons! 2) They devoted substantial time to their research efforts. 3) They published their seminal work in high impact scientific journals. 4) Their clinical areas of interest meshed with their research interests. 5) They are innately interested in doing better for their patients. Excellence in Neurosurgical Research Advice to Paediatric Neurosurgeons • Adequate training in the lab (2 - 5 years) • Focused area of research interest • Research tied to main clinical area of interest • PROTECTED TIME! • Adequate infrastructure, team relationships • Sweat equity • Dogged determination Excellence in Neurosurgical Research: Advice to Residents • Dedicated time in the lab • Timing of lab rotation • Unencumbered by significant call responsibilities • Ideal if research rotation counts towards a higher degree • Best if research is done in a productive lab with infrastructure and good mentors Neurosurgeon:Scientist Pathway: A Practice Sharing Scheme Dr James Drake Clinical Trials Hydrocephalus 2 weeks clinical service Covers Dr Rutka’s patients 2 weeks in lab Runs weekly clinic Formed a partnership: One large clinical neurosurgery practice Busy 2 weeks clinical Protected time research (50%) Dr James Rutka Brain Tumors 2 weeks in lab Runs weekly clinic 2 weeks clinical service Covers Dr Drake’s patients Glioblastoma Multiforme Hallmarks of a Feared Cancer • Nuclear and cytoplasmic pleomorphism • High mitotic index • Vascular endothelial proliferation • Pseudopalisading around Necrosis • Lymphocytic cuffing • Invasion into regions of normal brain Astrocytoma Invasion Building a Model of Astrocytoma Invasion NEJM Dec 2010 BIOCOMPATIBLE BIODEGRADABLE NANOPARTICLE INCORPORATION INTRACELLULAR DELIVERY REPRODUCIBLE SYNTHESIS TARGETING Nanoparticle Delivery Across the BBB with MR-Guided Focused Ultrasound The Future of Nanomedicine and Neurosurgery Establishing the Infrastructure for Neuro-Oncology Research The Arthur and Sonia Labatt Brain Tumour Research Centre James T. Rutka MD, PhD, FRCSC Division of Neurosurgery, Hospital for Sick Children, University of Toronto Sick Kids Brain Tumour Research Centre Now! On September 26th, 2013 A move to the new Peter Gilgan Research Tower at Sick Kids Hospital! Principal Investigators Annie Huang James Rutka Peter Dirks Jane McGlade Cynthia Hawkins Uri Tabori Michael Taylor Gelareh Zadeh Todd Mainprize, Sid Croul, Sunit Das Recent Publications Nature Reviews Neurology 2012 Continental Collaboration! Annual Report of Activities The Neurosurgeon:Scientist Pathway • Paediatric neurosurgeons must continue to do neurosurgical research • Paediatric neurosurgeons have led the field in neurooncology research • Residents must be encouraged to pursue careers in neurosurgery and science with appropriate support • To do research, there is no substitute for protected time • As faculty, we should lead by example Acknowledgements Arthur and Sonia Labatt Brain Tumour Research Centre The University of Toronto Bodour Salhia Hojun Seol Adrienne Weeks Christian Smith Shoichi Nagai Orlando Moreno Betty Kim Warren Chan Kullervo Hynynen Arnold Etame Roberto Diaz Korean – Sick Kids Alumni Reunion WFNS World Congress Meeting Seoul, Sept 2013
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