The:Mount:Sinai: Postdoc:Periodical Monthly:newsletter,:May:2015 In this issue: Page 1: Future:Leaders:for:Women:in:Research::Interview:with: Dr.:Susmita:Sahoo,:PhD ;y)Delaine)Ceholski Future:Leaders:for:Women:in: Research::Interview:with:Dr':Susmita: Sahoo:of:the:Cardiovascular:Research: This) monthK) we) were) fortunate) to) interview) Dr2) Susmita) SahooK) PhD) of) the) Cardiovascular) Research) Center) WCVRC?)at)Mount)Sinai2)Dr2)Sahoo)is)a)newly)minted)assistant)professor)and)has)been)with)the)CVRC)for)less) Center:at:Mount:Sinai than)A)year2)In)this)interviewK)we)find)out)what)it’s)like)and)what)it)takes)to)obtain)an)academic)position)in)the) current)academic)job)environment2 VD:vaccines::a:potential:cure:for: A2)Where)did)you)do)your)PhD0 cancer? Page 2: Nonzinvasive:ultrasound:waves:as:a: potential:treatment:for:Alzheimer3s : Upcoming:event:notices:and:the: Postdoc:Executive:CozChair:Corner I) received) my) PhD) from) the) Indian) Institute) of) TechnologyK) MumbaiK) IndiaK) in) ;iotechnology) and) ;ioengineering2)My)mentors)were)Drs2)G2K2)Suraishkumar)and)K2K2)Rao2)I)am)grateful)to)them)for)nurturing) the)creativity)required)to)generate)scientific)ideasK)fostering)my)independence)and)inculcating)the)importance) of)communication)skills)early)in)my)career2) Page 3: L2)Where)and)with)who)did)you)do)your)postdoc)and)for)how)long0 Ebola:Survivor:Discovers:Virus:in:Eye Interview:with:Nikos:TzavarasA: member:of:the:Sinai:Consulting:Club Page 4: Periodical:Word:Search::SpringI My)postdoctoral)training)was)rather)unconventional2)Upon)obtaining)my)degreeK)I)joined)a)small)biotech)start) upK) ;ioElectroMed) Corporation2) !fter) working) for) the) company) for) about) a) yearK) I) left) and) joined) the) laboratory) of) Dr2) Efrat) Levy) at) the) Nathan) Kline) InstituteK) OrangeburgK) NY2) I) learned) to) integrate) basic) mechanisms)of)cellular)biology)into)a)complex)disease)milieu2)!fter)about)three)yearsK)I)secured)a)position) working) with) Dr2) Douglas) Losordo’s) team2) He) is) an) internationally) recognized) cardiologist) and) a) physician) scientist) and) a) proponent) of) stem) cell) therapy) for) ischemic) cardiovascular) diseases2) This) was) my) final) postdoc)trainingK)which)lasted)for)L)years2) N2)Why)did)you)want)to)become)a)PI)in)an)academic)institution0)Why)did)you)choose)it)over)a)nonqacademic)career0) While) working) for) ;ioElectroMed) CorporationK) I) came) to) realize) my) true) passion) q) to) pursue) an) independent) academic) research) career2) In) an) academic)institutionK)I)am)able)to)be)independent)and)nurture)my)scientific)curiosityK)which)provides)me)with)an)enormous)amount)of)professional) satisfaction2) In) additionK) my) personality) traits) for) career) success) lie) in) an) environment) where) I) can) formulate) my) own) projects) and) enjoy) a) collaborative)setting2 O2)What)was)the)most)difficult)obstacle)that)you)faced)during)your)search)for)a)position0 In)the)final)years)of)my)postdoc)careerK)I)focused)on)building)a)research)identity)separate)from)my)mentors2)I)began)to)study)the)role)of)miniature) vesicles)called)exosomes)secreted)from)stem)cells)in)cardiac)regeneration2)This)field)of)study)was)newly)emerging)and)a)somewhat)risky)move)for) me)because)institutes)tend)to)recruit)new)faculty)whose)research)aligns)with)and)complements)their)existing)programs2 Y2)In)your)opinionK)what)is)the)largest)contributing)factor)to)becoming)a)PI0) I) cannot) attribute) my) success) in) becoming) a) PI) to) one) factor) but) a) convergence) of) many2) I) found) a) great) postdoc) mentor) in) Dr2) Losordo2) His) laboratory) was) an) excellent) environment) where) I) witnessed) and) benefitted) from) his) handsqon) approach) to) leading) an) extensive) team) of) researchersK)techniciansK)and)collaborators2)I)was)also)in)the)company)of)many)hardworking)and)successful)postdocs)who)went)on)to)become)PIsK) which)instilled)positivityK)patience)and)confidence)in)me2)I)learned)the)importance)of)communicationUpublic)speaking)skills2);efore)we)presented)at) scientific) conferencesK) trainees) had) to) give) at) least) three) seminars) where) everyone) was) encouraged) to) critique) the) presentation2) I) learned) the) importance)of)networking)with)peers)and)established)scientists)at)scientific)meetings)who)can)provide)insightK)advice)and)even)job)opportunities2) MoreoverK)I)looked)for)help)in)grant)writing)and)attended)an)excellent)workshop)led)by)Dr2)Richard)McGee)at)Northwestern)where)applications)are) vigorously) reviewed2)I)was) fortunate) to)be)successful) in)my) early) grant) applications) and)started) my) own) small) independent) laboratory)with) one) technician) after) my) postdoc) training) with) Dr2) Losordo2) !t) the) beginning) it) was) a) challenge) to) balance) the) various) aspects) of) managing) a) lab-) financesK)protocol)approvalsK)training)junior)personnelK)grant)writing)and)research)compliances)issuesK)etc2)!s)daunting)as)it)wasK)I)am)glad)I)had) the)opportunity)to)learn2)I)truly)believe)that)all)of)my)efforts)contributed)to)the)success)of)my)first)REA)application)to)the)NIH2) x2)What)advice)can)you)give)to)those)postdocs)who)want)to)pursue)an)academic)career0)Is)there)anything) that)you)would)have)done)differently)given)your)experience0 I)cannot)underscore)the)importance)of)publishingK)developing)your)own)identityK)establishing)your) own)networkK)marketing)your)research)and)creating)a)good)support)system2)Identify)and)address) your)weaknesses)and)build)your)own)niche)q)be)uniqueM)This)is)not)easyq)you)have)to)take)more) responsibilities) outside) of) research) which) are) time) consuming2) ;ut) those) come) with) a) good) reward4)any)additional)thing)that)you)do)will)teach)something)new)and)can)expand)your)network2) SometimesK) there) will) be) setbacksq) but) try) to) use) it) to) feed) your) motivation2) I) always) welcome) criticism) and) strive) for) excellence2) These) attributes) worked) well) with) my) immigrant) background) where) I) had) to) merge) into) a) new) societyK) find) a) balance) between) scientific) excellence) and) employability)and)draw)strength)from)my)failures2)!nother)key)is)to)start)early)Wafter)your)terminal) degree?) to) apply) for) postdoc) grant) applications) and) later) for) fellowqtoqfaculty) transition) awards2) Engage) your) mentorUteam) of) mentors) actively) to) develop) a) comprehensive) career) development) plan) with) specific) shortq) and) longqterm) goals) in) mind2) !ttend) the) early) career) programs) in) professional) conferences) to) understand) the) basic) peerqreview) processK) grantsmanshipK) career) opportunities)etc2);elieve)in)your)unique)abilities)and)don’t)be)afraid)to)take)the)unexpected)path2) Do)the)extra)work)to)build)your)own)package2)It)may)not)be)easyK)but)success)will)come2 The:Mount:Sinai:Postdoc:PeriodicalA:May:bEx! Dr2)Susmita)SahooK)PhD Page:x 3D vaccines: a potential cure for cancer? zyvKatievNolanv Co-Chair Corner zyv”rsxvMerinavVarghesevandvRyanv“ummings Newv advancesv inv cancerv therapyv arev focusingv onv usingv j”v vaccinesv tov harnessvthevbody’svnaturalvimmunevsystemvtovkillvcancervcellsxvUvresearchv groupv ledv byv ”rxv ”avidv Mooneyv fromv thev Schoolv ofv qngineeringv andv Uppliedv Sciencesv atv ?arvardv Universityv hasv recentlyv usedv thisv novelv vaccinev tov delayv tumorv growthv inv micexv “ancerv cellsv developv fromv thev body’sv ownv naturalv cellsv duev tov mutationsv andv increasedv proliferativev ability(vwhichvenablesvtumorvformationxvSincevthevcancervcellsvarevnativev tovthevbodyvtheyvcanvevadevthevnaturalvimmunevresponsevwhichvremovesv foreignvinvadersvandvcontrolsvcellvdeathxv Recentvclinicalvstudiesvhavevfocusedvonvimmunotherapies(vwhichvusevthev bodies’v ownv immunev systemv tov fightv thev cancerxv Previousv workv inv thisv areav hasv utilizedv whitev bloodv cellsv fromv av patient’sv bloodxv Thesev whitev bloodv cellsv arev “programmed”v intov dendriticv cells(v whichv arev capablev ofv identifyingvandvtargetingvpathogensvandvcanvrecognizevandvattackvcancerv cellsxv Thev successesv inv thisv areav havev demonstratedv thev potentialv forv immunotherapiesv butv theyv havev notv yetv achievedv lastingv therapeuticv effectxv ”rxv Mooney’sv labv hasv developedv anv injectablev “self)assembly”v scaffoldv composedv ofv mesoporousv silicav rodsv 1MSRs0xv Thesev MSRsv spontaneouslyvassemblevinvvivovtovformvavporousvstructurevwhich(vthroughv biochemicalv cues(v canv attractv hostv immunev cellsv andv illicitv av targetedv immunevresponsexvThesevbio)scaffoldsvhavevnumerousvapplicationsvinvthev fieldsvofvtargetedvdrugvreleasevandvregenerativevmedicinexvUnothervbenefitv ofv thisv approachv isv thatv thev MSRs’v self)assemblyv meansv patientsv wouldv notv requirev implantationv surgeryv andv therev wouldv bev minimalv woundv damagexv Previousv workv inv thev Mooneyv labv identifiedv thatv scaffoldv implantationvcouldvincreasevsurvivalvbyv89!vinvmicevwhovwouldvotherwisev diev fromv cancerv atv j9v daysxv v Thev latestv studyv foundv thatv injectionv ofv thev j”v vaccinev wasv morev effectivev atv preventingv tumorv growthv andv therebyv affectingvsurvivalvwhenvcomparedvtovavbolusvcontrolxv ”rxv Mooneyv isv hopefulv thatv thisv technologyv willv gov beyondv cancerv treatmentsv andv willv findv applicationsv inv treatingv andv preventingv infectiousv diseasesxv Wantv morev informationEv “heckvoutvwwwxnibibxnihxgovxv 1Imagevfromvwwwxscitechdailyxcom0 ”earvfellowvpostdocs( ?opevyouvarevenjoyingvthevspringw Writingv av grantv isv onev ofv thev importantv skillsv thatv thev Nationalv Postdoctoralv Ussociationv listsv underv thev sixv corev competenciesv forv postdoctoralv fellowsv 1httpAJJwwwxnationalpostdocxorgJpublications)@J competencies0xv zesidesv fundingv yourv project(v thev processv ofv grantv writingv alsov helpsv tov distillv yourv researchv ideasv andv honev yourv writtenv presentationv ofv sciencev tov convincev anv audiencev outsidev yourv labxv Ifv youvhavevnotvappliedvforvyourvownvgrantvyet(vherevarevsomevresourcesv thatvcanvhelpvyouvgetvstartedx Thev Officev ofv Postdoctoralv Uffairsv maintainsv av listv ofv grantsv andv fellowshipsvthatvpostdoctoralvfellowsvcanvapplyvfor)vseevthevlinkvbelowA httpAJJicahnxmssmxeduJeducationJpostdoctoral)trainingJtraining) opportunities)and)resourcesJgrants)and)fellowships %urthervguidelinesvaboutvgrantvapplicationsvcanvbevfoundvatvthevQrantsv andv“ontractsvOfficevwebsiteA httpAJJicahnxmssmxeduJresearchJresourcesJgrants)and)contract)officeJ application)informationv Ifv youv arev interestedv inv tryingv outv somethingv otherv thanv conventionalv fundraisingv approaches(v Mountv Sinaiv recentlyv announcedv supportv forv crowdfunding(vwithvdetailsvavailablevatvthevlinkvbelowA httpAJJicahnxmssmxeduJabout)usJfor)facultyJresearchersJcrowdfunding) as)a)mechanism)to)fund)your)ideas Qoodv luckv withv yourv grantv applicationwv Remember(v thev Officev ofv Postdoctoralv Uffairsv alsov issuesv postdocv recognitionv awardsv forv grant) winningv postdoctoralv fellowsv andv anv annualv fellowshipv forv seniorv womenv postdoctoralv fellowsv 1httpAJJicahnxmssmxeduJeducationJ postdoctoral)trainingJannouncementsJbulletin)board0xv Thev nextv monthlyv Postdocv Socialv willv bev onv Mayv b8th(v @)4v pmv inv thev Icahnv M“v levelxv Thev Postdocv qxecutivev “ommitteev 1Pq“0v isv alsov planningvanvUlumnivSocial(vwherevyouvcanvmeetvandvminglevwithvformerv Sinaiv postdocsv andv learnv aboutv theirv careerv pathsxv Keepv anv eyev onv yourvemailvinboxvorvjoinvourvsocialvmediavpagesvforvupdatesvonvthisx Wishingvyouvthevveryvbestvforvyourvresearchvandvcareervdevelopment( Merina Ryanv“ummingsvandvMerinavVarghesevarevyourvPq“vco)chairsx Non-invasive ultrasound waves as a potential treatment for Alzheimer’s Disease byv”elainev“eholski Ulzheimer’sv diseasev isv av neurodegenerativev disorderv characterizedv byv progressivev cognitivev impairmentv andv memoryv lossxv Thev diseasev isv characterizedvbyvlossvofvbrainvtissuevandvformationvofvplaquesvconsistingvofv deadv cellsv andv amyloid)betav 1Uβ0v proteinxv Microgliav arev residentv macrophagesv ofv thev brainv andv spinalv cordv andv functionv tov eliminatev proteinsv suchv asv Uβxv ?owever(v inv Ulzheimer’sv diseasev thev microgliav arev impairedxvThevQӧtzvgroupvfromvthevQueenslandvzrainvInstitutevinvUustraliav hasv adaptedv av “anadian)developedv techniquev ofv usingv ultrasoundv wavesv andv microbubblesv tov openv thev blood)brainv barrier(v providingv transientv openingsvforvimmunevsystemvcomponentsvtovgetvthroughxvzyvopeningvthev blood)brainv barrierv andv allowingv componentsv ofv thev immunev systemv through(vthevultrasoundvtreatmentvcouldvre)activatevmicrogliaxv Upcoming events: ThevPostdocvWritingvQroupvmeetsvthevjrdv%ridayvofvthevmonthxv“omev andv improvev yourv writing(v editingv andv reviewingv skillswv Whenv andv whereAv%ridaysvatvnoonvinv?essv“entervroomvI9)Ibbv1I9thvfloor0xvThev nextv meetingv isv Junev I8xv Ifv youv havev writingv tov workv on(v letv usv knowv andv bringv av fewv copiesv ofv itv 1I)bv pagev piece(v ideallyv anv abstractv orv / introductionvandvnovresultsvorvmethodsvsections0xvThevgroupvwillvalsov readv “Vsv andv coverv lettersxv Ifv not(v justv bringv yourself(v yourv helpfulv commentsv andv av penwv %ollowv thev ISMMSv PostdocWritingv groupv onv twitterv ’PostdocWritingxv Tov joinv thev mailingv listv visitAv httpAJJ mailmanxmssmxeduJmailmanJlistinfoJpostdoc)writing Thevwritingvseminarvseriesvhappensveveryvbndvmondayvofvthevmonthv fromvS)@pmxv“omevandvimprovevyourvwritingvskillswvWhenvandvwhereAv MondayvJunev5vatvSvpmvinvthevUnnembergvbuildingvroomvb@)@Iv1b@thv floor0xv %oodv willv bev servedxv Pleasev RSVPv tov jesicaxlevingstonmacleod’mssmxedux Inv av mousev modelv ofv Ulzheimer’sv vdisease(v thev ultrasoundv treatmentv inv Ways to keep in touch: 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ByjDelainejCeholski L T F C M A J U A M B N S C P H I B T F D M P O L O B R H R X Z D W Q B Z S O I H R E E H Z N Q O R X S O T X S M W R H U K I E F O M A A T U G O R K B S L A L F N I K N N O L Y R A L D B R I A G O D S M F E G A L A F L D Z D D I H P Q N L P Y L L C A T E R P I L L A R X O O E A L R L J R N K O O U E P L Y R F M I X K E D E M Q P F F L G G S M O S S O L B R O V T I E M I L A D Y B U G L Q N N V N N D E P I L U T G Y F E C W J E R T S I Z T G U R ALLERGIES BLOSSOMS DAFFODIL POLLEN SUNSHINE BLOOM CATERPILLAR FLOWERS POLLINATION TULIP BLOSSOM CHERRY LADYBUG RAIN UMBRELLA Calljtojaction? Interestedjinjjoiningjthejperiodical? Getjgreatjexperiencejwriting,jeditingjandj assemblingjissues? [email protected] topicUsuggestions opinionUarticles photos funUfactsU scienceUeventsU Sendjusjyourjcontribution:j [email protected] The Mount Sinai Postdoc Periodical, May 2015 Page 4
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