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INTERNATIONAL CONFERENCE
INTERNATIONAL CONFERENCE
BIOCATALYSIS-2015:
BC - 2015
BIOCATALYSIS: FUNDAMENTALS &
APPLICATIONS
FUNDAMENTALS & APPLICATIONS
June 21-26, 2015, Moscow Region, Russian Federation
Preliminary Scientific Program
June 21, 2015
10.30 - 13.30. Arrival and Registration of participants
13.30 - 14.30. Lunch
15.00. Opening of the Conference
Chairpersons: Prof. Sergey Varfolomeyev and Prof. Vladimir Tishkov
Opening Ceremony Lecture 1
Sergey Varfolomeyev
Department of Chemical Enzymology, Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow,
Russian Federation and N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow,
Russian Federation
Life of molecules at the extreme conditions
Opening Ceremony Lecture 2
Alexander Gabibov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian
Federation and Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Modern Pharmacology: Magic bullet & combinatorial approaches
16.30-17.00. Coffee Break
17.00. Plenary Lecture 1
Vladimir Tishkov
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation;
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation;
Innovations and High Technologies MSU Ltd, Moscow; Russian Federation
Protein engineering. New paradigm for creation of biocatalysts
17.40. Section 1.1. Structural aspects of biocatalysis
Chairpersons: Prof. Alexander Gabibov and Prof. Hideyuki Hayashi
17.40-18.00
Hideyuki Hayashi
Osaka Medical College, Japan
"Super-closed” structure of aspartate aminotransferase unveils the mechanism for the substateinduced transaldimination process
5
18.00-18.20
Tatyana V. Demidkina
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation
Methionine gamma-lyase: structural bases of suicide inactivation by sulfoxides, potential
antimicrobial prodrugs
18.20-18.40
Qingxiao Li
University of Hawaii at Manoa, US
Structural characterization of windmill palm (Trachycarpus fortunei) peroxidase with mass
spectrometry
19.00. Get Together Party
June 22, 2015
10.00. Plenary Lecture 2
Vladimir Popov
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the
Russian Academy of Sciences, Moscow, Russian Federation and Protein Factory of NBICS-Centre of
Kurchatov Institute, Moscow, Russian Federation
Proteins of extremophilic microorganisms
10.40. Section 1.2. General Enzymology
Chairpersons: Prof. Vladimir Muronetz and Prof. Gertz Likhtenshtein
10.40-11.00
Gertz Likhtenshtein
Department of Chemistry Ben-Gurion University Beer-Sheva, Israel
Multielectron processes in chemistry and biology - 45 years of history. In the memory of
Professor A. E. Shilov
11.00-11.20
Vladimir Muronetz
Belozersky Institute of Physicochemical Biology and Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov
Moscow State University, Moscow, Russian Federation
Isoenzymes of glyceraldehyde-3-phosphate dehydrogenase are a convenient model for the
design of catalysts with biotechnological implications
11.20-11.40
Maria Zvereva
Chemistry Faculty and A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State
University, Moscow, Russian Federation
Unique features of telomerase from Hansenula polymorpha.
11.40-12.00
Elena Rodina
Chemistry Faculty and A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State
University, Moscow, Russian Federation and European Molecular Biology Laboratory, Hamburg Outstation
Crystal structure of an essential N-terminal domain of TERT from H. polymorpha
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12.00-12.30. Coffee Break
12.30. Section 1.3. Biocatalysis: catalytic mechanism and
protein engineering of enzymes
Chairpersons: Prof. Vladimir Tishkov and Dr. Maria Zvereva
12.30-12.55
Anastasiya Alekseeva
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation; Department of Chemical Enzymology, M.V. Lomonosov Moscow
State University, Moscow, Russian Federation, Innovations and High Technologies MSU Ltd, Moscow; Russian
Federation
Formate dehydrogenases from eucaryotes
12.55-13.15
Ivan Kargov
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation; Innovations and High Technologies MSU Ltd, Moscow; Russian
Federation
Formate dehydrogenase from Staphylococcus aureus - unusual enzyme in FDH family
13.15-13.35
Elizaveta Gromova
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Murine DNA methyltransferase Dnmt3a: interaction with damaged DNA substrates
13.35-13.55
Olga Kost
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Conformational fingerprinting” of blood angiotensin-converting enzyme in health and disease
14.00-15.00. Lunch
15.00. Plenary Lecture 3
Arkady Sinitsyn
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation
Pilot scale bioconversion of lignocellulosic biomass scale
15.40. Session 2.1. Applied biocatalysis
Chairpersons: Prof. Arkady Sinitsyn and Prof. Alexander Gusakov
15.40-16.00
Alexander Gusakov
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation
Modern approaches for development of highly effective multienzyme preparations for biomass
conversion
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16.00-16.20
Anna Kulminskaya
National Research Centre "Kurchatov Institute", St. Petersburg Institute of Nuclear Physics, Saint-Petersburg,
Russian Federation
Fundamental and applied carbohydrate enzymology: the current status of the field
16.20-16.40
Aleksandra Rojkova
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation; Department of Chemical Enzymology, M.V. Lomonosov Moscow
State University, Moscow, Russian Federation
Penicillium expression systems as a platform for the development of industrial enzymes
16.40-17.00
Evgenia Vlakh
Saint-Petersburg State University, Saint-Petersburg, Russian Federation
Recombinant-xylosidase from Aspergillus awamori X-100 and grindamyl H121 xylanase
immobilized on monolithic columns for combined degradation of xylan
17.00-17.20. Coffee Break
17.20. Section 1.4 Biocatalysis: catalytic mechanism and protein engineering of
enzymes
Chairpersons: Prof. Qingxiao Li and Prof. Elizaveta Gromova
17.20-17.40
Young Je Yoo
Seoul National University, South Korea
Understanding of structural factors for enzyme activity and stability and application to
simultaneous enhancement of enzyme activity and organic solvent stability
17.40-18.00
Rosa Aisina
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Structure and physiological functions of the plasminogen/plasmin system
18.00-18.15
Svetlana Shvetsova
National Research Center «Kurchatov Institute», B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina,
Russian Federation;. St.Petersburg State Polytechnical University, St. Petersburg, Russian Federation; N.D.
Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation and V.N.
Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russian
Federation
Biochemical characterization of the novel 29GH alpha-L-fucosidase from Fusarium
proliferatum LE1
18.15-18.30
Vitaly Koltover
Institute of Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
Nuclear Spin Catalysis in Living Nature
8
18.35-18.50
Galina Zakharova
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation; Department of Chemical Enzymology, M.V. Lomonosov Moscow
State University, Moscow, Russian Federation, Innovations and High Technologies MSU Ltd, Moscow; Russian
Federation
Refolding and protein engineering of tobacco peroxidase
18.50-19.05
Sophia Zarubina
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation; Innovations and High Technologies MSU Ltd, Moscow; Russian
Federation
New multi-point mutants of D-amino acid oxidase from yeast Trigonopsis variabilis
June 23, 2015
10.00-10.35. Plenary Lecture 4
Aleksey Egorov
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Bacterial antimicrobial resistance and ecology problems
10.40. Section 3.1. Analytical application of biocatalysis
Chairpersons: Prof. Aleksey Egorov and Prof. Boris Dzantiev
10.40-11.00
Dzantiev Boris
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation
Nanoparticles in immunoassays: Challenges and solutions
11.00-11.15
Alexandr Urusov
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation
Immunomagnetic sorbents and their use in analytical systems
11.15-11.30
Nadezhda Taranova
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation
Multiplex immunochromatographic assay
11.30-11.50
Ugarova Natalya
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Bioanalytical systems based on Bioluminescence resonance energy transfer using firefly
luciferase
9
11.50-12.10
Ivan Zorov
Department of Chemical Enzymology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation ;
A.N. Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian
Academy of Sciences, Moscow, Russian Federation
Analytical methods in the processes of bioconversion of renewable biomass
12.10-12.30. Coffee Break
12.30. Section 3.2. Analytical application of biocatalysis
Chairpersons: Prof. Natalya Ugarova and Prof. Tatyana Shekhovtsova
12.30-12.50
Natalya Komarova
Research and Production Complex "Technological Center" MIET, Russian Federation
Enzymatic biosensor for detection of explosives developed from a versatile analytical
microsystem
12.50-13.05
Irina Veselova
Department of Analytical Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Оptical biosensing systems for the determination of biologically active compounds
13.05-13.20
Darya Vokhmyanina
Department of Chemical Enzymology and Department of Analytical Chemistry, M.V. Lomonosov Moscow State
University, Moscow, Russian Federation
Bioelectrochemical analysis of exhaled breath condensate as a tool for non-invasive
diagnostics
13.20-13.35
Egor Andreyev
Department of Chemical Enzymology and Department of Analytical Chemistry, M.V. Lomonosov Moscow State
University, Moscow, Russian Federation
Electroanalytical system for microorganism detection in aerosol based on boronate-substitued
polyaniline-modified interdigitated microelectrodes
13.35-13.50
Vita Nikitina
Department of Chemical Enzymology and Department of Analytical Chemistry, M.V. Lomonosov Moscow State
University, Moscow, Russian Federation
Electrochemical synthesis of conducting polyanilineboronic acids for sensing applications
13.50-14.00
Maria Komkova
Department of Chemical Enzymology and Department of Analytical Chemistry, M.V. Lomonosov Moscow State
University, Moscow, Russian Federation
Transition Metal (Fe, Co, Ni, Cu) Hexacyanoferrates in Hydrogen Peroxide Reduction
Electrocatalysis
14.00-15.00. Lunch
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15.00. Plenary Lecture 5
Vytas Švedas
Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physicochemical Biology, M.V. Lomonosov
Moscow State University, Moscow, Russian Federation
Bioinformatic analysis of binding sites in protein superfamilies for design of selective
inhibitors of enzymes from pathogens
15.30. Session 1.5. Bioinformatics and computation methods in biocatalysis
Chairpersons: Prof. Vytas Svedas and Prof. Alexander Nemukhin
15.30-16.00
Patrik Masson
Kazan Federal University, Neuropharmacology laboratory, Kazan, Russian Federation
Slow, and slow tight-binding inhibition of enzymes: Reversible, quasi-irreversible, and
irreversible mechanisms
16.00-16.20
Alexander Nemukhin
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Chemical Transformations in the Active Sites of Cholinesterases Modeled by Quantum-Based
Simulations
16.20-16.40
Sofya Lushchekina
Emanuel Institute of Biochemical Physics, Moscow, Russian Federation; Chemistry Department, M.V. Lomonosov
Moscow State University, MoscowRussian Federation; Kazan Federal University, Kazan, Russian Federation
Polymorphism of human butyrylcholinesterase gene: molecular modelling of structure,
dynamics and catalytic activity of allelozymes
16.40-17.00
Ekaterina Kots
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Catalytic cycle of aspartoacylase by the results of molecular dynamics and QM/MM
simulations
17.00-17.20
Maria Khrenova
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Modeling GTP hydrolysis in Ras-GAP
17.20-17.40
Bella Grigorenko
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Modeling C-di-GMP Hydrolysis by Phosphodiesterases with the EAL Domain
17.40 – 18.00 Coffee Break
17.40-19.00 Poster Session
11
June 24, 2015
10.00. Plenary Lecture 6
Alain Friboulet
Génie Enzymatique et Cellulaire, Sorbonne Université – Université de Technologie de Compiègne – CNRS,
Compiègne cedex, France
Catalytic antibodies: chemically laboratory-induced catalysts, randomly selected entities,
environmentally-induced or constitutive physiopathological biocatalysts?
10.40. Section 5.1. Enzymes, ribozymes and proteins as drugs and vaccines.
Chairpersons: Prof. Alain Friboulet and Prof. Thomas Haertle
10.40-11.10
Thomas Haertle
Fonctions et Interactions des Protéines, BIA, Inst.Ntl Res. Agronomique, Nantes, France
Inhibition of viral development by basic and basified proteins.
11.10-11.40
Alexander V. Maksimenko
Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex,
Moscow, Russian Federation
Orchestrator of vascular homeostasis and protector of vessel wall is endothelial glycocalyx.
Modern and future tasks for sequential researches
11.40-12.00
Lubov Filatova
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Endolysins of staphylococcal phages: physicochemical properties and approaches towards
stabilization
12.00-12.20
Edrei Cruz
Laboratorio de Revaloracion de Residuos. Cinvestav Unidad Saltillo, Mexico
Alliinase, the biocatalyst of garlic
12.20-12.40 Coffee Break
12.40. Section 7. Nanomedicine
Chairpersons:
12.40-13.00
Vladimir Izumrudov
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
Supercharged polycations and (bio)polyelectrolyte complexes
13.00-13.20
Nataliya Feoktistova
Chemistry Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
pNIPAM-based porous thermo-sensitive microgels for drug delivery
12
13.20-13.40
Mariya Volokitina
Saint-Petersburg State University, Saint-Petersburg, Russian Federation
Study of enzymatic degradation of PLA and PLA-nanoparticles
11.00 – 18.00
Parallel Session
3rd International school "NANO-2015"
"Nanomaterials and Nanotechnologies in Life Systems.
Safety and Nanomedicine"
Chairpersons: Prof. Natalia Klyachko and Dr. Elena Zaitseva
Program to be pended
14.00-15.00 Lunch
15.00. Co-symposium "Esterase status for diagnostics and prognosis
of OPC intoxications"
Co-chairmen: Prof. C. Dishovsky, G. Makhaeva, Prof. I. Kurochkin.
C. Dishovsky, Professor of Toxicology
Military Medical Academy, Sofia, Bulgaria
About the project " Esterase status for diagnostics and prognosis of OPC intoxications "
N.P. Boltneva, N.V. Kovaleva, E.V. Rudakova, G.F. Makhaeva
Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russian
Federation; e-mail: [email protected]
Comparative study of esterase status of rodents and humans for exposure assessment to
organophosphorus compounds.
E.V. Rudakova, G.F. Makhaeva
Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russia
Tel./Fax:+7 (496) 524 95 08; E-mail: [email protected]
Mice blood neuropathy target esterase as biochemical marker for exposure to neuropathic
organophosphorus compounds.
G.F. Makhaeva1, E.V. Rudakova1, C. Dishovsky2
1
Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432, Russian
Federation; E-mail: [email protected]
2
Military Medical Academy, Sofia, Bulgaria
Esterase status as a complex biomarker of exposure to organophosphorus compounds.
I. N. Kurochkin, Professor
Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation
Layer-by-layer electrochemical biosensors for blood esterase assay
A.V. Eremenko
Institute of Biochemical Physics Russian Academy od Sciences, Moscow, Russian Federation
Portable biosensor system for choline esterases assay.
N.L. Nechaeva, PhD student
13
Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation
SERS-platform for detection of marker proteins and enzymatic activity.
T.A. Prokopkina, 4th year student
Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation
Ag-based SERS substrates for cholinesterase activity detection.
R. Guliev, PhD student,
Institute of Biochemical Physics Russian Academy od Sciences, Moscow, Russian Federation
Multiparametric statistical methods for the analysis of correlations between esterase activity
and genetic polymorphism of esterases.
16.30 – 16.45 Coffee Break
June 25, 2015
10.00-18.00. Co-symposium "Nanoplasmonics: sensoric and biosensoric
applications"
Co-chairmen: Prof. A. Lagarkov and Prof. I. Kurochkin.
12.00-12.15 и 16.00-16.15 Coffee Break
Program to be pended
For other participants
10.00 Excursion
14.00-15.00 Lunch
June 26, 2015
10.00. Closing of Conference
Chairpersons: Prof. Sergey Varfolomeyev and Prof. Vladimir Tishkov
15.00. Departure of participants
14