The new shape of bovine fertility
reprodAction
The new shape of bovine fertility
A revolutionary approach
to fertility
Developed by Ceva – Europe’s leading animal fertility experts
PRID Delta is the easiest,
most comfortable way to optimise cattle fertility.
Designed by our specialised R&D department
with effectiveness and animal comfort in mind,
PRID Delta is a revolutionary device, made
from a polyethylene spin and EVA (Ethyl Vinyl
Acetate), for faster and more consistent release
of progesterone. Once inserted, PRID Delta
provides a controlled release of 1.55g of natural
progesterone–effortlessly and comfortably for
improved results.
reprodAction
The new shape of bovine fertility
Unique new shape design
PRID DELTA has been developed with the objectives to
keep the efficacy of PRID spiral with an improved retention,
tolerance and ease of use.
The triangular shape allows PRID DELTA to distribute pressure more evenly
on the uterine tract with one of its sides completely leaning against the
vagina’s inner walls for both maximal contact surface and animal comfort.
Progesterone release over time by product
T-shape devices
PRID Delta surface area is a key element because it ensures
contact and exchange with vaginal environment. PRID
Delta surface is 155cm2 vs 120cm2 for a T-shape device.
Rectum
Vagina
6
*
Circulating P4 (ng/mL)
5
*
Better tolerance with
optimal retention rate!
More
comfortable!
Controlled release
of progesterone!
PRID Delta minimises local reactions
in the vagina with an optimal retention
rate.
Prid Delta
Local reactions at day 7
Rectum
Cervix
Cervix
Vagina
*
50%
*
*
*
4
*
Vulva
Vulva
*
Pelvis
Bladder
0%
Pelvis
Bladder
3
PRID Delta
T-shape device
1.38g
2
AUC (ng/mL*h): PRID Delta 653
1
vs T-shape device 583, P<0.01
0
0
24
100%
48
72
96
120
Time after intravaginal P4 device insert (h)
144
168
Treatment: P<0.01
Time: P<0.01
Treat*Time: P<0.36
PRID Delta stay in the vagina applying
pressure with one complete branch
on the vaginal wall whereas T-shape
devices stay straight in the vagina
applying pressure with the end of
their branch extremities.
25%
n=319
Retention rate
100%
97,7%
97,2%
50%
0%
n=308
n=317
reprodAction
The new shape of bovine fertility
PRID DELTA, Optimum fertility
for profitable reproduction
PRID DELTA can help cycling
and non-cycling cows and
heifers getting pregnant faster
PRID DELTA can be used to control the oestrous cycle in all cattle
breeds and animal category including mature cows and virgin heifers
Beef cows
Virgin heifers
(beef and dairy)
Positive
effects of
progesterone
The graph below represents the speed in which dairy cows got pregnant after the
use of a synchronisation-based reproductive management using PRID DELTA as
compared to cow inseminated after natural oestrous detection. PRID DELTA use
decreased 6 days in interval to conception compared to untreated controls!
Increases LH pulses, promotes follicular
growth and prepares the uterus for
pregnancy in non-cycling animals
Improves ovulation rates
When associated with prostaglandin provides precise control of luteal phase
Use of eCG* improves
ovulation and pregnancy
results
If using eCG* there is no
need for calf removal
PRID DELTA
CONTROL
P<0,01
70
60
Use of eCG* seem to
improve pregnancy
results in anovular
cows and cows with
lower body scores
Progesterone treatment seem to reduce incidence
of abnormally short-cycles after ovulation
50
Pregnant (%)
Dairy cows
* Equine chorionic gonadothrophin formerly known as PMSG
40
30
Effect of PRID DELTA on lactating cows:
on average saved 6 days open per cow
compared to untreated Controls
20
Standard protocol
10
0
Enzaprost T (PGF2α)
Calving
10
20 30
Days
40
50 60
24h before removal
50 days
D0
Al at Fixed Time:
56h after removal
7 days
in
Triple synchronisation with PRID DELTA in dairy cows
Study number: C614.CLI09.UK
Insemination
or Mating
PRID DELTA
out
0r 48 & 72h after removal
Or at observed heats
D 50
Syncrostim/Syncropart (eCG)
in non cycling animals
reprodAction
The new shape of bovine fertility
PRID DELTA, Optimum fertility for
profitable reproduction
Anticipating interval from calving to conception is highly beneficial to dairy
producers and the value of each day open varies approximately from 2 to 5€.
Both graphs shown below demonstrates the importance of not losing the handle on
days open in a dairy.
By increasing Pregnancy Rate
Each point increase in pregnancy rate is worth about 20€!
Source: Dairy Cattle Reproduction Council (DCRC) and University of Wisconsin –
ReproMoney® Program.
400
Profit
Days open
350
300
Profit (s/cow/year)
Days open
Improving Cattle Reproduction
is profitable!
250
200
150
100
50
0
0%
5%
10%
By shortening average days open
15%
20%
25%
30%
35%
40%
Pregnancy rate (%)
Data from 200 high producing dairy herds (each dot represents a
herd with at least 50 cows in milk)
300
6.00
Cost per extra day open (s)
Dairy herds with shorter average days open (calving to conception interval) tend
to have lower average days in milk (Shown in the graph below, Souza et al., data to be
published in 2012) and greater average milk production, plus more replacement
heifers and faster genetic gains!
5.50
5.00
4.50
4.00
3.50
3.00
2.50
2.00
280
110
120
130
140
150
Averages days open
160
170
De Vries, Proceedings
of the 11th International
Symposium on
veterinary Epidemiology
and Economics, 2006
Days in milk (DIM)
260
By getting cows pregnant faster
240
220
200
DIM= 0.7988*DOPN + 96.1
r = 0.79
180
160
140
80
100
120
140
160
180
Days open (DOPN)
200
220
240
260
Beef herds getting more cows pregnant at beginning of the breeding season tend
to have more cows calving each year and greater average interval from calving to
initiation of breeding season = overall reproduction efficiency is improved, lessen
culls due to reproductive failure and more calves on the ground every year!
By helping heifers to become pregnant!
Heifers calving too old or with excessive body scores due to greater
age tend to have more metabolic problems, lower milk production, and lower fertility
postpartum (Ettema and Santos et al., 2004). Be proactive and get them pregnant
sooner!
reprodAction
The new shape of bovine fertility
PRID DELTA, Optimum fertility for
profitable reproduction
Key benefits:
Synchronisation of oestrous and ovulation
in cycling cattle
Induction and synchronisation of oestrous
in non cycling cattle
Synchronisation of heifers and cows to maximize production goals.
Synchronisation of batches of heifers and cows to allow artificial insemination
use and to improve results of the breeding season in consecutive years.
Allows effective resumption of cyclic ovarian activity in dairy cows with
different anoestrus conditions (presence of small follicles, large-follicle
anovular condition common in modern high producing cows, and follicular
cysts).
Insemination without oestrous detection to avoid failures due to bad oestrous
detection or poor oestrous expression.
Allows resumption of cyclic ovarian activity in case of suckling anoestrus, it
may represent up to 80% of beef cows in some management conditions!
Treatment of unsuccessful inseminated cows coming regularly in oestrous:
repeat breeding.
Reduces problems with abnormally short-cycles in dairy and beef herds.
Allows precise synchronisation of donors and recipients in embryo transfer
and in vitro Fertilisation (IVF) programs.
Synchronisation allows improved interval from insemination to ovulation as
compared to insemination after natural oestrous.
Allows reduction of calving-to-conception interval for maximal milk
production in dairy herds (lower average days in milk) and balanced breeding
season in beef herds (more cows pregnant before middle of breeding season).
reprodAction
The new shape of bovine fertility
How to use PRID DELTA
PRID DELTA
Optimum fertility for
profitable reproduction.
PRID DELTA is intended for single use only. It’s inserted through a unique
applicator, which must be cleaned and disinfected before and after use.
Inserting the applicator: Latex gloves are required at all times when
handling progesterone devices
Comfortable, safe and with a
controlled release
of progesterone
• Bend the device only once before inserting
in the applicator. Ensure the string is in the
appropriate slot.
• Lightly lubricate the distal end of the applicator
with an obstetrical lubricant.
• Clean the animal’s vulva before gently inserting
the applicator in the vagina.
• Once the applicator has reached the end of the
vagina, smoothly press on the handle to release
the device.
• Remove the applicator gently and ensure the
string is outside the vulva.
• Shorten the string according to the animal’s size
if necessary.
For oestrous synchronisation
and Fixed Time Insemination
Efficacious in cycling and non-cycling
mature cows and virgin heifers
At Removal:
• Remove the device by gently pulling on the
exposed string.
Withdrawal period: • Meat and offal: zero days
• Milk: zero days
ST
EP
S
BY
TE
PG
UI
DE
During the treatment, meat, offal and milk can be
delivered for human consumption.
Ask your Ceva representative for StepbyStep Guide
reprodAction
References
De Vries, A. (2004). Economics of delayed replacement when cow performance
is seasonal. Journal of Dairy Science 87, 2947-2958.
De Vries, A. (2006). Determinants of the cost of days open in dairy cattle.
Proceedings of the 11th International Symposium on Veterinary Epidemiology
and Economics, 2006. Available at www.sciquest.org.nz
Ettema, J.F., and J.E.P. Santos. 2004. Impact of age at calving on lactation,
reproduction, health and income in first-parity Holsteins on commercial farms.
J. Dairy Sci. 87:2730-2742.
The dollar value of a pregnancy. The Dollar Signs Behind Reproduction. Putting
a Price on Reproductive Losses. All available at https://www.dcrcouncil.org/
resources/newsletter-articles/economics.aspx
Best timed AI programs endorsed by the Dairy Cattle Reproduction Council
(DCRC) can be found at https://www.dcrcouncil.org/resources/reproductionprotocols.aspx
Physiological classification of anovulatory conditions in cattle. M.C. Wiltbank, A.
Gümen, R. Sartori. Theriogenology 2002; 57:21-52.
An Alteration in the Hypothalamic Action of Estradiol Due to Lack of Progesterone
Exposure Can Cause Follicular Cysts in Cattle. A. Gümen, M.C. Wiltbank. Biol
Reprod 2002; 66:1689-1695.
Length of progesterone exposure needed to resolve large follicle anovular
condition in dairy cows. A. Gümen, M.C. Wiltbank. Theriogenology 2005; 63:202218.
Improving fertility to timed artificial insemination by manipulation of circulating
progesterone concentrations in lactating dairy cattle. M.C. Wiltbank, A.H. Souza,
P.D. Carvalho, R.W. Bender, A.B. Nascimento. Reprod. Fertil. Dev. 24:238-243.
Andersen, K. J., D. G. LeFever, J. S. Brinks, and K. G. Odde. 1991. The use of
reproductive tract scoring in beef heifers. Agri-Practice 12:4.
De Vries, A. Proceedings of the 11th International Symposium on Veterinary
Epidemiology and Economics, 2006. Available at www.sciquest.org.nz.
reprodAction
Reproductive management in Action
Ask your Ceva representative for ReprodAction advice
RBPD1201
prid®delta 1.55g Vaginal delivery system for cattle COMpOSITION: progesterone 1,55 g per device. INDICATIONS: For the control of the œstrus cycle in cows and heifers
including: Synchronisation of œstrous in cycling cattle. To be used in combination with a prostaglandin (pGF2). Induction and synchronisation of œstrous in non cycling
cattle. To be used in combination with a prostaglandin and equine Chorionic Gonadotropin (eCG, in the past called pMSG). CONTRA-INDICATIONS: Do not use in sexually
immature heifers. Do not use before 35 days have passed since previous calving. Do not use in animals suffering from infectious or non-infectious disease of the genital
tract. Do not use in pregnant animals. See section Use during pregnancy and lactation. ADVERSE REACTIONS: During the course of the seven day treatment, the device may
induce a mild local reaction (i.e. inflammation of the vaginal wall). A clinical study carried out with 319 cows and heifers has demonstrated that 25% of animals presented
ropy or cloudy vulvar secretions at the device removal. This local reaction disappears rapidly without any treatment between removal and insemination and does not affect
fertility at inseminations nor pregnancy rates. If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary. DOSAGE, ROUTE
AND METHOD OF ADMINISTRATION: Vaginal use. 1.55 g of progesterone / animal for 7 days. Using an applicator, insert one device into the vagina of the animal. The
intravaginal device should stay in place for 7 days. In cycling cattle, the device has to be used in combination with a prostaglandin, injected 24 hours prior to removal of the
device. In non cycling cattle, an injection of a prostaglandin must be done 24 hours prior to removal of the device and an injection of eCG at the time of removal. The device
is intended for single use only. WITHDRAWAL pERIOD: Meat and offal: zero days. Milk zero days. During the treatment meat, offal and milk can be delivered for human
consumption CATEGORy: List II. pOMV. pRESENTATIONS: cardboard box containing 10 sachets of 1 device. polyethylene box containing 50 sachets of 1 device. Sachet
containing 10 devices. NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER: CEVA SANTE ANIMALE - 10 av. de la Ballastière - 33500 LIBOURNE.
Indications featured here reflect the licensing conditions comprised in the international products SPC and may not reflect the license conditions in individual countries.
For more information about the specific use of this product refer to the SPC of your country.
Ceva Santé Animale S.A. 10, avenue de la Ballastière - B.p. 126 - 33501 Libourne Cedex - France
Tél: +33 (0)5 57 55 40 40 - Fax: +33 (0) 5 57 55 41 98
www.ceva.com - [email protected]