Title: A Human Tumor Genome Project: From Sequence to Structure

Title: Fluorescent Carbogenic Nanoparticles
Dr. Marta Krysmann
Lecturer
University of Central Lancashire,
School of Pharmacy and Biomedical Sciences,
United Kingdom
Abstract
Photoluminescent nano-systems have attracted much attention in last years from both academia and industry.
They are widely used in everyday life as well as in highly specialized implementations such as optical
analysis, photonics, chemical sensing, molecular tracing and cellular imaging. Recent advances in the field
have expanded the library of available fluorescent materials (typically dyes, polymers or proteins) to include
semiconductor nanocrystals (so called Quantum Dots) and carbogenic photoluminescent nanostructures
(C-Dots). The latter class of materials share properties typical to the metal-containing Quantum Dots, with
the advantage of being nontoxic and highly biocompatible. C-Dots essentially hold great promise for various
biological and biomedical applications. Current research efforts are focused on the development of
well-defined carbon based nanostructures with tunable size and functionalities and optimum fluorescent
capabilities. Up to date, the synthetic strategies have focused on ‘top down’ and ‘bottom down’ approaches.
The first strategy is based on nano-fragmentation of carbon source while the second one involves mild
pyrolysis of organic molecular precursors. Most recently, emphasis is given to explore C-Dot based systems
that exhibit dual photoluminescent emission. Those materials can selectively detect the presence of toxic
compound even in minute quantities, while showing supreme bioimaging capabilities. Literature: Chem.
Mater (2012), 24, 6-8, JACS (2012), 134, 747-750, J. Mater. Chem. (2012), 22, 16219, Green Chem. (2012),
14, 3141, Chemistry of Materials J. Mater. Chem. (2012), 22, 23327, CARBON (2013), 61, 640-643,
Chem.Com. (2015), 23, 4902
Biography
Dr. Marta Krysmann, is a Lecturer in Chemistry and a leader of the Nanopharmaceutics Laboratory at
University of Central Lancashire in Preston, UK. She joined UCLan in 2013. Dr Krysmann studied for the
MSc level in Bioorganic Chemistry at Adam Mickiewicz University in Poland. During her studies, she went
for Socrates-Erasmus Programme at Lund’s University in Sweden where she completed her diploma work in
Physical Chemistry. After she accomplished her PhD at University of Reading in the UK, she took up the
position of Research Associate at Cornell University in the USA. Marta’s main research interests lie in
development of fluorescent materials as biological tracers. She focusses mainly on carbogenic nanoparticles
and quantum dots as light emitting nanomaterials and MRI probes. She is also working on bioconjugates for
drug delivery and nanomaterials with long lasting antimicrobial properties.