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First and Last name: Hasan Alniss
Academic degree and position: Assistant Professor, PhD
Specialty: Pharmaceutical Chemistry and Drug Design
Institution: An-Najah National University- Department of Pharmacy
City and Country: Nablus-Palestine
E-mail: [email protected]
Telephone: 00970 9 2345113
Int number: 2128
Fax: 00970 9 2349739
P.O.Box: 7
Biography:
Dr. Hasan Alniss was born in 1978 in Palestine. He obtained his B.Sc. in Pharmacy from AnNajah National University (2001). He then spent five years working for the Palestinian
Ministry of Health as a pharmacist before obtaining his M.Sc. in Pharmaceutical Analysis
(2007) and a PhD in Pharmaceutical Chemistry (2011) from the University of StrathclydeUK. Dr. Alniss took up his position at An-Najah National University as an assistant professor
of Pharmaceutical Chemistry in 2011.
Teaching courses:
Dr. Alniss is involved in teaching undergraduate pharmacy students and supervising the
postgraduate M.Sc. students. Taught courses include:
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Organic Chemistry
Medicinal Chemistry
Organic Chemistry Labs
Quality Control
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Research interests:
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Biophysical characterization of ligand-DNA associations by using different analytical
techniques
Synthesis of DNA binding agents.
Molecular modeling of ligand-nucleic acids interactions.
Pharmaceutical analysis.
Development of non viral gene delivery vehicles.
Dr. Alniss’s research interests are varied from the organic synthesis of DNA binding
agents to the computer aided drug design and biophysical characterization of ligand-DNA
complexes using different analytical techniques such as NMR spectroscopy, isothermal
titration calorimetry (ITC), circular dichroism (CD), electrospray ionization mass
spectrometry (ESI-MS) & molecular modeling (MM).
Publications:
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Rationalizing sequence selection by ligand assemblies in the DNA minor groove: the
case for thiazotropsin A. Hasan Y. Alniss, Nahoum G. Anthony, Abedawn I. Khalaf,
Simon P. Mackay, Colin J. Suckling, Roger D. Waigh, Nial J. Wheate and John A.
Parkinson. Chem. Sci., 2012, 3, 711-722.
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Prerequisite dimer formation governs molecular recognition for the thiazotropsin
class of DNA minor groove binders. Marie-Virginie Salvia, Fiona Addison, Hasan Y.
Alniss, Niklaas J. Buurmad, Abedawn I. Khalaf, Simon P. Mackay, Nahoum G.
Anthony, Colin J. Suckling, Maxim P. Evstigneev, Adrián Hernandez Santiage, Roger
D. Waigh and John A. Parkinson (2012). (Submitted to J. Phys. Chem. Lett.)
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Ranking ligand affinity for the DNA minor groove by experiment and simulation.
Wittayanarakul K, Anthony NG, Treesuwan W, Hannongbua S, Alniss H, Khalaf AI,
Suckling CJ, Parkinson JA and MacKay SP. Med. Chem. Lett. Med. Chem. Lett.,
2010, 1 (8), 376–380.
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A detailed binding free energy study of 2:1 ligand-DNA complex formation by
experiment and simulation. Treesuwan W, Wittayanarakul K, Anthony NG, Huchet G,
Alniss H, Hannongbua S, Khalaf AI, Suckling CJ, Parkinson JA and Mackay SP
Physical Chemistry Chemical Physics, 2009, 11, 10682-10693.
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