The Science Behind the Solutions
UNCLASSIFIED The Science Behind the Solutions Research and Grant Opportunities April 27, 2015 Dr. Eric Moore Division Chief Advanced and Emerging Threats Chemical and Biological Technologies Department (J9CB) Defense Threat Reduction Agency & USSTRATCOM Center for Combating WMD & Standing Joint Force Headquarters-Elimination (Distribution Statement A: Approved for public release: distribution unlimited) UNCLASSIFIED UNCLASSIFIED THE DTRA/SCC MISSION To safeguard the US and its Allies from Weapons of Mass Destruction ▪ Chemical ▪ Biological ▪ Radiological ▪ Nuclear ▪ High-Yield Explosives by providing capabilities to reduce, eliminate and counter the threat, and mitigate its consequences. UNCLASSIFIED 2 UNCLASSIFIED RESEARCH AND DEVELOPMENT OVERVIEW Counter WMD Technologies Nuclear Technologies • Nuclear threat detection • Nuclear forensics • System survivability (Rad Hard, EMP) • Nuclear weapons effects • Monitoring and verification technologies • CWMD terrorism technologies • Persistent ISR for WMD • Defeat concepts • Test facilities and technology • Deployable sensors Information Sciences and Applications • 24/7 Technical Reachback • Hazard and Effects Modeling • Advanced Analytics and Situational Awareness Basic and Fundamental Research • STEM workforce development • 6.1 grants to Universities Chemical and Biological Technologies • Medical countermeasures • Disease surveillance, threat detection, and point of need diagnostics • Threat activity sensing and reporting • Rapid Response and Restoration S&T 3 UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Diagnostics, Detection, Disease Sur veillance Information and Analysis Translational Medicine Advanced and Emerging Threats Physical Science and Technology UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Diagnostics, Detection & Disease Sur veillance PROJECT AREAS Biosurveillance Ecosystem (BSVE) Data sources & analytic tools Chem-Bio Detection Wearable Technologies Host-Based Biomarker Identification/Verification/Validation Field Forward Diagnostics Genetic Sequencing for Clinical Microbial/Viral Diagnostics UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Translational Medicine VACCINES & THERAPEUTICS FOCUS AREAS Viral: Ebola & Marburg; EEEV, VEEV, WEEV Bacterial: Bacillus anthracis, Francisella tularensis, Burkholderia mallei & pseudomallei, C. Burnetii, Yersina pestis Toxins: Ricin, Botulinum Neurotoxin Platform Technologies: Animal Model Development, Ex vivo mimetics, Flexible Manufacturing, Adjuvants and Stabilization UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Advanced and Emerging Threats EXAMPLE PROJECT AREAS Catalytic bioscavengers of nerve agents Centrally-acting reactivators of acetylcholinesterase, neuroprotectants ADMET Center to enhance drug discovery/development efforts Host response to chemical toxicants, human toxicity estimates and predictive toxicology Characterization and predictive environmental fate of chemical and biological agents, especially particulates Relevant understanding of routes of exposure and the blood-brain barrier Automatic threat response, including nano- and micromotors UNCLASSIFIED UNCLASSIFIED THE SCIENCE BEHIND THE SOLUTIONS Some of our government partners include: ▪ Department of Health and Human Services (HHS) ▪ Food and Drug Administration (FDA) ▪ Biomedical Advanced Research and Development Authority (BARDA) ▪ U.S. Army Medical Research and Materiel Command (USMRMC) Our partners also include non-government entities and universities such as: ▪ GlaxoSmithKline ▪ George Mason University ▪ Duke University UNCLASSIFIED 8 UNCLASSIFIED WHERE TO FIND BUSINESS OPPORTUNITIES https://www.fbo.gov/ http://www.grants.gov UNCLASSIFIED UNCLASSIFIED TIPS FOR STRONG PROPOSALS Carefully review BAA and Amendment Plan ahead and allow time for peer reviews and corrections Revolutionary advancements over existing state of technology required Ability to achieve program milestones is critical Partnering is encouraged UNCLASSIFIED UNCLASSIFIED BUILDING A COMPETITIVE PROPOSAL Concept Definition ✓ Why is the approach revolutionary? ✓ Challenges ✓ Potential solutions ✓ Risk mitigation Supporting Technical Analysis ✓ Previous experimental evidence ✓ Technical and quantitative rationale for ability to meet metrics Clarity is Key Research Plan ✓ Specific, quantitative, intermediate milestones ✓ How will progress be assessed? Management Plan ✓ Plan for coordination and roles of all members ✓ Risk management approaches UNCLASSIFIED UNCLASSIFIED ? Questions For more information visit: http://www.dtra.mil/Home.aspx http://www.acq.osd.mil/cp/ http://www.dtra.mil/Missions/ChemicalBiologicalDefense/ChemicalBiologicalDefenseHome.aspx To read more about some of our current scientific progress: http://www.dvidshub.net/publication/538/jsto-in-the-news UNCLASSIFIED 12 UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED UNCLASSIFIED BACKUPS UNCLASSIFIED UNCLASSIFIED J9 CB BASIC RESEARCH FOCUS AREAS Innovative materials Approaches to predict or trigger technological surprise Understanding and characterizing threat agents Novel approaches to sensing Novel countermeasures BUILDING THE FOUNDATION FOR TOMORROW’S CBDP UNCLASSIFIED 15 UNCLASSIFIED ADDRESSING KEY MISSION AREAS Diagnostics, Detection & Disease Sur veillance MISSION Deliver cutting edge Integrated Early Warning, Information Management and Applied Analytic capabilities to the warfighter; virtually connect them to these capabilities and other system users for rapid situational awareness, course of action (CoA) analysis and decision support. UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Translational Medicine MISSION Develop vaccines and therapeutics to mitigate the threat of biological warfare agents UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Advanced and Emerging Threats • • • MISSION Deliver novel concepts and technologies to address current and emerging chemical and biological threats to protect the lives of our warfighters UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Information & Analysis • • • MISSION Provide and use Chemical Biological Radiological Nuclear information and analysis capabilities to enable and support operational & programmatic decision-making. UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Information & Analysis PROJECT AREAS Collective Protection System Performance Model Individual Protection System Performance Model Decontamination System Performance Model UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Physical Science & Technology • • • MISSION Providing tomorrow’s solutions today to build next generation chemical and biological defense capabilities for decontamination and protective materials, and ensuring transition of prototypes to advanced developers serving warfighter needs through advanced demonstrations and exercises. UNCLASSIFIED UNCLASSIFIED ADDRESSING KEY MISSION AREAS Physical Science & Technology FOCUS AREAS Protective Materials – e.g. Second Skin and Ammonia Breakthrough Filters Hazard Mitigation – e.g. Material and Equipment Restoration (HaMMER) decontamination system (DFoS) Demonstrations – e.g. Consequence Management Bioresiliency (TaCBRD) Materials and Imaging Sciences – e.g. Better Biosensors, Nanomaterials for drug delivery, Robust Biomimetic Materials & Devices UNCLASSIFIED UNCLASSIFIED DTRA RDT&E Summary • Responds to top national and DOD priorities in CWMD • Supports the strategic deterrent by enhancing system survivability, nuclear forensics, and targeting effectiveness • Provides DoD’s primary support to USSOCOM for WMD-T Future Capabilities • Leverages DTRA’s combat support role to provide unique WMD expertise directly to our warfighters • Infuses WMD-related research into over 100 of our top universities • Well connected to DoD, Interagency and international partners DTRA’s steady-state S&T efforts create the expertise and capabilities required for agile responses to urgent operational needs 23 UNCLASSIFIED UNCLASSIFIED THE THREATS ARE REAL Chemical ▪ Traditional Chemical Warfare Agents ▪ Toxic Industrial Materials and Toxic Industrial Chemicals ▪ Emerging and Non-traditional Agents Biological ▪ Traditional Biological Threat Agents ▪ Emerging Diseases ▪ Enhanced Threats UNCLASSIFIED 24 UNCLASSIFIED J9CB APPROACH Science & Technology Investment Strategies SENSE SHAPE SHIELD SUSTAIN UNCLASSIFIED 25 UNCLASSIFIED DRIVERS OF SUCCESS Innovation Strategy Performance Warfighter Product Collaboration We work with other agencies, academia and the science community. UNCLASSIFIED 26 UNCLASSIFIED DTRA J9CB Mission Lead DoD science and technology to anticipate, defend, and safeguard against chemical and biological threats for the warfighter and the nation Warfighter Driven Innovation Driven Strategy Driven Product Driven Performance Driven Collaboration Driven Warfighter Delivered MISSION UNCLASSIFIED 27
© Copyright 2024