1. No category

Synthesis and spectroscopic characterization of gallic acid and some
of its azo complexes
Mamdouh S. Masoud a, Sawsan S. Hagagg a, Alaa E. Ali b, , Nessma M. Nasr c
a
Chemistry Department, Faculty of Science, Alexandria University,
Alexandria, Egypt
b
Chemistry Department, Faculty of Science, Damanhour University,
Damanhour, Egypt
c
Science Park for Pharmaceuticals, Faculty of Pharmacy, Alexandria
University, Alexandria, Egypt
abstract
A series of gallic acid and azo gallic acid complexes were prepared and characterized
by elemental analysis,IR, electronic spectra and magnetic susceptibility. The
complexes were of different geometries: Octahedral,Tetrahedral and Square Planar.
ESR was studied for copper complexes. All of the prepared complexes were of
isotropic nature. The thermal analyses of the complexes were studied by DTA and
DSC techniques. The thermodynamic parameters and the thermal transitions, such as
glass transitions, crystallization and melting temperatures for some ligands and their
complexes were evaluated and discussed.
The entropy change values, DS#, showed that the transition states are more ordered
than the reacting complexes. The biological activities of some ligands and their
complexes are tested against Gram positive and Gram negative bacteria. The results
showed that some complexes have a well considerable activity against different
organisms.
Keywords:
Gallic acid complexes
Azo derivatives
IR
UV spectroscopy
Biological activity
Thermal analysis
Published In: Elsevier B.V.
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Solvatochromaticity and pH dependence of the electronic absorption spectra of
some purines and pyrimidines and their metal complexes
Mamdouh S. Masouda, Medhat A. Shakerb, Alaa E. Ali b, , Gehan S. Elasal b
a Chemistry Department, Faculty of Science, Alexandria University, Egypt
b Chemistry Department, Faculty of Science, Damanhour University, Egypt
abstract
The solvatochromic responses of uric acid (Ua), 6-amino-2-thiouracil (ATU) and a
series of their complexes dissolved in ten solvents of different polarity have been
measured. The solvent-dependent UV/Vis spectroscopic absorption maxima, _max,
are assigned to the corresponding electronic transitions and analyzed using SPSS
program, regression analysis and Kamlet and Taft methods.
The observed solvatochromism is discussed using various solute–solvent interaction
mechanisms. The electronic absorption spectra of ATU were investigated in aqueous
buffer solutions of varying pH and utilized for the determination of dissociation
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Keywords:
Uric
6-Amino-2-thiouracil
Complexes
Solvatochromic
Dissociation constants
pH-effect
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Synthesis, computational, spectroscopic, thermal and antimicrobial activity
studies on some metal–urate complexes
Mamdouh S. Masoud a, Medhat A. Shaker b, Alaa E. Ali b, , Gehan S. Elasal b
a
b
Chemistry Department, Faculty of Science, Alexandria University, Egypt
Chemistry Department, Faculty of Science, Damanhour University, Egypt
abstract
New sixteen uric acid metal complexes of different stoichiometry, stereo-chemistries
and modes of interactions were synthesized using different metals Cr, Mn, Fe, Co,
Ni, Cu, Cd, UO2, Na and K. The synthesized complexes were characterized by
elemental analysis, spectral (IR, UV–Vis and ESR) methods, thermal
analysis (TG, DTA and DSC) and magnetic susceptibility studies. Molecular
modeling calculations were used to characterize the ligation sites of the free ligand.
Furthermore, quantum chemical parameters of uric acid such as the energies of
highest occupied molecular orbital (EHOMO), energies of lowest unoccupied
molecular orbital (ELUMO), the separation energy (_E = ELUMO −
EHOMO), the absolute electronegativity, _, the chemical potential, Pi, the absolute
hardness, _ and the softness (_) were obtained for uric acid.
Eight different microbial categories were used to study the antimicrobial activity of
the free ligand and ten of its complexes. The results indicate that the ligand and its
metal complexes possess antimicrobial properties.
The stoichiometry of iron–uric acid complex was studied by using different
spectrophotometric methods.
Keywords:
Uric
Complexes
Synthesis
Spectroscopy
Thermal analysis
Computational
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Solvatochromic behavior of the electronic absorption spectra of gallic acid and
some of its azo derivatives
a,
Mamdouh S. Masoud
, Sawsan S. Hagagg a, Alaa E. Ali b, Nessma M. Nasr c
a
Chemistry Department, Faculty of Science, Alexandria University,
Alexandria, Egypt
b
Chemistry Department, Faculty of Science, Damanhour University,
Damanhour, Egypt
c
Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
abstract
The electronic absorption spectra of gallic acid and its azo derivatives have been
studied in various solvents of different polarities. Multiple regression techniques
were applied to calculate the regression and correlation coefficients based on an
equation that relates the wavenumbers of the absorption band maxima (_max
−) to the solvent parameters; refractive index (n), dielectric constant (D), empirical
Kamlet–Taft solvent parameters, _*(dipolarity/polarizability), ˛ (solvent hydrogenbond donor acidity) and ˇ (solvent hydrogen-bond acceptor basicity). The fitting
coefficient obtained from this analysis allows estimating the contribution of each
type of interactions relative to total spectral shifts in solution.
The dependence of _max − on the solvent parameters indicates that the obtained
bands are affected by specific and non-specific solute-solvent interactions.
Keywords:
Gallic acid
Solvent effect
Kamlet–Taft equation
Azo complexes
Refractive index
Dielectric constant
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Spectral, Coordination and Thermal Properties of
5-Arylidene Thiobarbituric Acids
Mamdouh S. Masoud a, Adel El-Marghany b, Adel Orabi c ,
Alaa E. Ali d
, Reham Sayed b.
a
Chemistry Department, Faculty of Science, Alexandria University, Egypt.
b
Chemistry Department, Faculty of Education, Suez Canal University, Egypt.
c
Chemistry Department, Faculty of Science, Suez Canal University, Egypt.
d
Chemistry Department, Faculty of Science, Damanhour University, Egypt.
Abstract
Synthesis of 5-arylidine thiobarbituric acids containing different functional groups
with variable electronic characters were described and their Co+2, Ni+2 and Cu+2
complexes. The stereochemistry and mode of bonding of 5-(substituted benzylidine)2- TBA complexes were achieved based on elemental analysis, spectral (UV-VIS,
IR, 1HNMR, MS), magnetic susceptibility and conductivity measurements. The
ligands were of bidentate and tridentate bonding through S, N and O of pyrimidine
nucleolus.
All complexes were of octahedral configuration. The thermal data of the complexes
pointed to their stability. The mechanism of the thermal decomposition is discussed.
The thermodynamic parameters of the dissociation steps were evaluated and
discussed.
Keywords: 5-arylidine thiobarbituric acids, complexes, NMR, Thermal analysis
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Solvatochromaticity and pH dependence of the electronic absorption spectra of
some purines and pyrimidines and their metal complexes
Mamdouh S. Masouda, Medhat A. Shakerb, Alaa E. Ali b,∗, Gehan S. Elasalb
a
b
Chemistry Department, Faculty of Science, Alexandria University, Egypt
Chemistry Department, Faculty of Science, Damanhour University, Egypt
abstract
The solvatochromic responses of uric acid (Ua), 6-amino-2-thiouracil (ATU) and a
series of their complexes dissolved in ten solvents of different polarity have been
measured. The solvent-dependent UV/Vis spectroscopic absorption maxima, _max,
are assigned to the corresponding electronic transitions and analyzed using SPSS
program, regression analysis and Kamlet and Taft methods.
The observed solvatochromism is discussed using various solute–solvent interaction
mechanisms. The electronic absorption spectra of ATU were investigated in aqueous
buffer solutions of varying pH and utilized for the determination of dissociation
constants. The ranges of pH, where individual ionic species are predominant have
been determined.
Keywords:
Uric
6-Amino-2-thiouracil
Complexes
Solvatochromic
Dissociation constants
pH-effect
published in
Spectrochimica Acta Part A 79 (2011) 538–547
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