Copyedited by: JOURNAL OF CROHN’S AND COLITIS International Journal Devoted to Inflammatory Bowel Diseases Official Journal of the European Crohn’s and Colitis Organisation VOLUME 9, ISSUE 4 APRIL 2015 Contents Editorial Methotrexate in IBD: The Return of the Prodigal Son Thibaut Vaysse, Franck Carbonnel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303 Original Articles Methotrexate for Maintaining Remission in Paediatric Crohn’s Patients with Prior Failure or Intolerance to Thiopurines: A Multicenter Cohort Study Sjoukje-Marije Haisma, Thijs Lijftogt, Angelika Kindermann, Gerard Damen, Lissy de Ridder, Johanna C Escher, M Luisa Mearin, Tim de Meij, Daniëlle Hendriks, Elvira George, Thalia Hummel, Obbe Norbruis, Patrick van Rheenen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305 Optimal Doses of Methotrexate Combined with Anti-TNF Therapy to Maintain Clinical Remission in Inflammatory Bowel Disease Ruben J Colman, David T Rubin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 312 Vulval Crohn’s Disease: A Clinical Study of 22 Patients Zainab Laftah, Clare Bailey, Shirin Zaheri, Jane Setterfield, Lucinda Claire Fuller, Fiona Lewis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 318 Incidence, Management, and Course of Cancer in Patients with Inflammatory Bowel Disease Alicia Algaba, Iván Guerra, Ignacio Marín-Jiménez, Elvira Quintanilla, Pilar López-Serrano, María Concepción García-Sánchez, Begoña Casis, Carlos Taxonera, Ignacio Moral, María Chaparro, Daniel Martín-Rodríguez, María Dolores Martín-Arranz, Noemí Manceñido, Luis Menchén, Antonio López-Sanromán, Ángel Castaño, Fernando Bermejo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 326 Early Childhood Measles Vaccinations are not Associated with Paediatric IBD: A Population-based Analysis Souradet Y Shaw, James F Blanchard, Charles N Bernstein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334 Segmental Sigmoid Polyposis as a Colonoscopic Indicator of an Ileosigmoid Fistula in Crohn’s Ileitis Burton I. Korelitz, Raja Taunk, Vivek Kesar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 The Mucosa-associated Microbiota of PSC Patients is Characterized by Low Diversity and Low Abundance of Uncultured Clostridiales II Noortje G. Rossen, Susana Fuentes, Kirsten Boonstra, Geert R. D’Haens, Hans G. Heilig, Erwin G. Zoetendal, Willem M. de Vos, Cyriel Y. Ponsioen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 342 Benefit of Infliximab Reintroduction after Successive Failure of Infliximab and Adalimumab in Crohn’s Disease C Gagniere, L Beaugerie, B Pariente, P Seksik, A. Amiot, V Abitbol, M Allez, J Cosnes, H Sokol . . . . . . . . . . 349 Review Article Introducing Vedolizumab to Clinical Practice: Who, When, and How? RV Bryant, WJ Sandborn, SPL Travis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 356 Letters to the Editor Fecal Microbiota Transplantation for Recurrent C. difficile Infection in a Patient with Chronic Refractory Ulcerative Colitis Annalisa Aratari,Giovanni Cammarota, Claudio Papi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 367 The Culprit in Obscure Gastrointestinal Bleeding: Intestinal Cavernous Haemangioma in a Patient with Ulcerative Colitis Jing Sun, Jianfeng Gong, Weiming Zhu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 368