DRUG DISCOVERY ‘15 TELFORD INTERNATIONAL CONFERENCE CENTRE 2ND - 3RD SEPTEMBER 2015 www.elrig.org #ELRIGDD15 NEW BIOLOGICAL DRUGS & TECHNOLOGIES Thursday September 3rd Room: Wenlock The continuing success of biological drugs, in particular monoclonal antibodies but increasingly also other modalities such as peptides, conjugates and multi-selective agents, will be considered in this session. Alongside this, technologies for discovering, optimising and characterising biopharmaceuticals will be discussed. The session will also explore the interface between biological and small molecule drugs: can information from biological drugs help us design better small molecule drugs? how are drugs at the interface of both areas, such as cyclic peptides and small molecule conjugates to peptides, proteins and antibodies, defining novel drug classes? CHAIRS: Katy Kettleborough, MRC Technology. Dr. Lutz Jermutus, MedImmune TIME 9:10 - 9:15 SPEAKER Session Chairs TITLE Introduction and Welcome 9:15 - 10:00 Keynote Speaker: Philipp Holliger MRC Laboratory of Molecular Biology Towards a New Class of Biotherapeutics Based on Synthetic Genetic Polymers 10:00 - 10:30 Dan Teufel Bicycle Therapeutics Development of Cytotoxic Bicyclic Peptide Drug Conjugates and Applications in Molecular Targeted Cancer Therapy 10:30 - 11:00 COFFEE 11:00 - 11:30 Tom Crabbe UCB How Information From the Study of Antibody Function Can be Used in the Discovery of Novel Small Molecule Therapeutics 11:30 - 12:00 POSTER 12:00 - 12:30 SNAPSHOT 12:30 - 14:00 LUNCH - EXHIBITION PLENARY KEYNOTE: ROOM - IRONBRIDGE 14:00 - 15:00 Professor Tracy Hussell The Development of New Therapeutics for respiratory inflammation Manchester Collaborative Centre for Inflammation Research 15:00 - 15:30 Volker Schellenberger Amunix XTEN Protein Polymer for Half-Life Extension and Tumor Drug Delivery 15:30 - 16:00 Bent Jakobsen Adaptimmune Fine-Tuned T Cell Receptors for Cancer Immunotherapy 16:00 - 16:30 John Hartley University College London PBD-Based Antibody Drug Conjugates 16:30 - 17:00 CLOSE OF CONFERENCE - with prize