DRUG DISCOVERY ‘15 TELFORD INTERNATIONAL CONFERENCE CENTRE 2ND - 3RD SEPTEMBER 2015 www.elrig.org #ELRIGDD15 CHEMISTRY INNOVATION IN LEAD DISCOVERY Wednesday September 2nd Room: Beckbury The need to create chemical leads for ever more challenging biological targets has led to a need for increased chemical innovation in lead discovery. Recent innovations include the generation of high quality hits outside classical ‘small molecule’ chemical space, the application of emerging synthetic methods and design principles to deliver diverse compound libraries, and greater consideration of conformational and kinetic profiles of potential hits. This session will highlight scientific approaches that increase chemical innovation in lead discovery which, together with novel partnership approaches, may deliver high quality leads for today’s challenging drug targets. CHAIRS: Dr Darren McKerrecher, AstraZeneca. Paul Wyatt, University of Dundee TIME SPEAKER TITLE 9:10 - 9:15 Session Chairs Introduction and Welcome 9:15 - 10:00 Keynote Speaker: Damian Young Baylor College of Medicine Using Diversity-Oriented Synthesis to Enable Fragment-Based Lead Discovery 10:00 - 10:30 Frederick Goldberg AstraZeneca Design of Novel Building Blocks to Enhance Drug Discovery 10:30 - 11:00 COFFEE BREAK 11:00 - 11:30 Paul Wyatt University of Dundee 11:30 - 12:00 Phenotypic Drug Discovery: With A Lot of Help From Our Friends! POSTER TASTERS 12:00 - 12:30 SNAPSHOT PRESENTATIONS 12:30 - 14:00 LUNCH - EXHIBITION - POSTERS PLENARY KEYNOTE: ROOM - IRONBRIDGE 14:00 - 15:00 David Thomas Traffick Therapeutiques/Thérapeutiques, Inc Tackling Protein Trafficking Diseases 15:00 - 15:30 Mike Waring AstraZeneca Structure-Kinetic Relationships: Investigating the Molecular Basis for Optimising Drug-Target Residence Time 15:30 - 16:00 James Murray Vernalis (R&D) Ltd All in Good Time, Exploiting Residence Time to Improve Fragment Based Drug Discovery 16:00 - 16:30 Christian Heinis Ecole Polytechnique Fédérale de Lausanne Phage Selection of Bicyclic Peptides for Therapeutic Application 16:30 - 17:00 POSTER SESSION 17:00 - 18:00 POSTERS - NETWORKING - DRINKS RECEPTION
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