DRUG DISCOVERY ‘15
TELFORD INTERNATIONAL
CONFERENCE CENTRE
2ND - 3RD SEPTEMBER 2015
www.elrig.org
#ELRIGDD15
CHEMISTRY INNOVATION IN LEAD DISCOVERY
Wednesday September 2nd
Room: Beckbury
The need to create chemical leads for ever more challenging biological targets has led to a need for increased
chemical innovation in lead discovery. Recent innovations include the generation of high quality hits outside
classical ‘small molecule’ chemical space, the application of emerging synthetic methods and design principles to
deliver diverse compound libraries, and greater consideration of conformational and kinetic profiles of potential hits.
This session will highlight scientific approaches that increase chemical innovation in lead discovery which, together
with novel partnership approaches, may deliver high quality leads for today’s challenging drug targets.
CHAIRS: Dr Darren McKerrecher, AstraZeneca. Paul Wyatt, University of Dundee
TIME
SPEAKER
TITLE
9:10 - 9:15
Session Chairs
Introduction and Welcome
9:15 - 10:00
Keynote Speaker: Damian Young
Baylor College of Medicine
Using Diversity-Oriented Synthesis to Enable
Fragment-Based Lead Discovery
10:00 - 10:30
Frederick Goldberg
AstraZeneca
Design of Novel Building Blocks to Enhance Drug
Discovery
10:30 - 11:00 COFFEE BREAK
11:00 - 11:30 Paul Wyatt
University of Dundee
11:30 - 12:00
Phenotypic Drug Discovery: With A Lot of Help From
Our Friends!
POSTER TASTERS
12:00 - 12:30 SNAPSHOT PRESENTATIONS
12:30 - 14:00 LUNCH - EXHIBITION - POSTERS
PLENARY KEYNOTE: ROOM - IRONBRIDGE
14:00 - 15:00 David Thomas
Traffick Therapeutiques/Thérapeutiques, Inc
Tackling Protein Trafficking Diseases
15:00 - 15:30 Mike Waring
AstraZeneca
Structure-Kinetic Relationships: Investigating the
Molecular Basis for Optimising Drug-Target Residence
Time
15:30 - 16:00 James Murray
Vernalis (R&D) Ltd
All in Good Time, Exploiting Residence Time to Improve
Fragment Based Drug Discovery
16:00 - 16:30 Christian Heinis
Ecole Polytechnique Fédérale de Lausanne
Phage Selection of Bicyclic Peptides for
Therapeutic Application
16:30 - 17:00 POSTER SESSION
17:00 - 18:00 POSTERS - NETWORKING - DRINKS RECEPTION