A Systematic Review of the current Immunotherapy and Antiviral Agents in Treatment of Ebola Virus Outbreak. Introduction: Ebola hemorrhagic fever is a severe, systemic viral disease affecting humans and non-human primates, with case fatality rates of up to 90%. Currently, neither a specific treatment nor a vaccine licensed for use in humans is available1,2 Aims: To examine the efficacy and safety of current immunotherapy and antiviral agents against Ebola outbreak. Methods: Systematic reviews of the current literature were carried out from November 2004 to November 2014 through the use of Wiley Online Library, PubMed Central PMC, CINHAL, Cochrane Library, Biomed Central, Medline, and Science Direct. Results: Three papers have been identified in this current systematic review. The results showed that several immunotherapy and antiviral agents have been tested including BCX44303, ZMapp4 and TKM-Ebola. These agents can provide effective protection in nonhuman primates and in limited numbers of human patients. Conclusions: This study showed that immunotherapy and antiviral agents are effective in the treatment of Ebola virus infection in non-human primates. As a result the drug (ZMapp) was used to treat a limited numbers of humans who were infected by Ebola and they survived. As the outbreak continues to spread there is no time to conduct traditional clinical efficacy and safety trail before use in human subjects. Moreover the efficacy of drugs can’t be accurately judged due to the heterogeneity of participants. Further clinical trails are essential as a prophylactic measure against any future outbreaks. Dr. Mahmood M Hardan, Dr.Susan Plummer, Mr.Peter Milburn Canterbury Christ Church University References 1-Hoenen T, Groseth A, Feldmann H, Current Ebola Vaccines: PMC julay 2012; 12 (7): 859-872. 2- Marzi A, Feldman H,Ebola virus vaccines: an overview of current approaches:PubMed, 2014 Apr;13(4):521-31. 3-Marburg and Ebola hemorrhagic fevers--pathogens, epidemiology and therapy:PubMed;2014 Sep;37(9):324-30. 4-Gray C, Addo M, Schmidir R,A Dead-End Host: Is There a Way Out? A Position Piece on the Ebola Virus Outbreak by the International Union of Immunology Societies;2014; 5: 562..