Wen-Yih Isaac Tseng 曾文毅, M.D., Ph.D.
Center for Optoelectronic Medicine 光電醫學研究中心
National Taiwan University Medical College 國立臺灣大學醫學院
1 Jen-Ai Road, Sec 1, Taipei 10051, Taiwan 臺北市仁愛路一段一號
Phone: 886-2-2312-3456 ext. 88758
Fax: 886-2-2392-6922
Cell phone: 0928-826720
Email: [email protected]
Education
Massachusetts Institute of Technology 美國麻省理工學院
Ph.D., Department of Nuclear Engineering, 1998 February.
核子工程系放射科學博士
Cambridge, MA
National Taiwan University 國立臺灣大學醫學院
M.D., College of Medicine, 1987 December
學士後醫學系醫學士
National Tsinghua University 國立清華大學
B.S., Department of Nuclear Engineering, 1980 June
核子工程學系學士
Taipei, Taiwan
Hsinchu, Taiwan
Experience
National Taiwan University 國立臺灣大學
2014 August – now
Chief Director, National Taiwan University Molecular Imaging Center
台灣大學分子生醫影像中心主任
2007 August - now
Professor, Center for Optoelectronic Biomedicine,
Adjunct Professor in the Institute of Biomedical Engineering, Institute of Brain and Mind
Sciences, and Department of Radiology;
National Tsinghua University, Department of Biomedical Engineering and Environmental
Sciences;
National Health Research Institute, Section of Medical Engineering
國立臺灣大學醫學院光電生物醫學研究中心專任教授
國立臺灣大學醫學工程研究所腦與心智科學研究所暨放射線科合聘教授
國立清華大學生醫工程與環境科學系兼任教授
國家衛生研究院醫工組兼任研究員
2003 August – 2007 August
Associate Professor, Center for Optoelectronic Biomedicine,
Adjunct Associate Professor in the Institute of Biomedical Engineering, and
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Department of Radiology;
National Tsinghua University, Department of Biomedical Engineering and Environmental
Sciences;
National Health Research Institute, Section of Medical Engineering
國立臺灣大學醫學院光電生物醫學研究中心專任副教授
國立臺灣大學醫學工程研究所暨放射線科合聘副教授
國立清華大學生醫工程與環境科學系兼任副教授
國家衛生研究院醫工組兼任副研究員
1999 August – 2003 July
Assistant Professor, Center for Optoelectronic Medicine
國立臺灣大學醫學院光電醫學研究中心專任助理教授
National Taiwan University Hospital 臺大醫院
1999 August – 2012 August
Attending Doctor, Department of Medical Imaging
臺大醫院影像醫學部主治醫師
1992 - 1993
Attending Doctor, Department of Medical Imaging
臺大醫院影像醫學部主治醫師
1988 - 1992
Resident, Department of Medical Imaging
臺大醫院影像醫學部住院醫師
MGH-NMR Center, Harvard Medical School 美國哈佛醫學院麻省綜合醫院
1998 September – 1999 August
Instructor in Radiology, Massachusetts General Hospital
美國哈佛醫學院麻省綜合醫院放射線科講師
1998 February - 1999 August
Post-Doctoral Research Fellow
美國哈佛醫學院麻省綜合醫院放射線科博士後研究
1994 - 1997
Research Assistant 研究助理
Massachusetts Institute of Technology 美國麻省理工學院
1993 - 1996
Teaching Assistant 助教
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Chen, Y.J., Fan, C.C., Lo, Y.C., Hsu, Y.C., Hwang, T.J., Liu, C.M., Chien, Y.L., Hsieh, M.H., Liu, C.C.,
Hwu, H.G., Tseng, W.Y.I.*. Automatic whole brain tract-based analysis using predefined tracts in a
diffusion spectrum imaging template and an accurate registration strategy. Human Brain
Mapping, accepted.
Hsu, Y.C., Lo, Y.C., Chen, Y.J., Wedeen, V.J., Tseng, W.Y.I.*. NTU-DSI-122: A diffusion spectrum
imaging template with high anatomical matching to the ICBM-152 space. Human Brain Mapping,
accepted.
Lin, H.Y., Ni, H.C., Lai, M.C., Tseng, W.Y.I., Gau, S.S.F.*. Regional brain volume differences between
males with and without autism spectrum disorder are highly age-dependent. Molecular Autism,
accepted.
Chien, H.Y., Gau, S.S.F.*, Hsu, Y.C., Chen, Y.J., Lo, Y.C., Shih, Y.C., and Tseng, W.Y.I.*. Altered Cortical
Thickness and Tract Integrity of the Mirror Neuron System and Associated Social Communication
in Autism Spectrum Disorder. Autism Research, accepted.
Lin, H.Y., Tseng, W.Y.I., Lai, M.C., Matsuo, K., Gau, S.S.*. Altered resting-state frontoparietal control
network in children with attention-deficit hyperactivity disorder. Journal of International
Neuropsychological Society, accepted.
Hsieh, P.C., Tseng, M.T., Chao, C.C., Lin, Y.H., Tseng, W.Y.I., Liu, K.H., Chiang, M.C., Hsieh, S.T.*.
Imaging signatures of altered brain responses in small-fiber neuropathy: reduced functional
connectivity of the limbic system after peripheral nerve degeneration. Pain, accepted.
Tseng, C.E.J., Chien, Y.L., Liu, C.M., Wang, H.L. S., Hwu, H.G.*, Tseng, W.Y.I.*. Altered cortical
structures and tract integrity of the mirror neuron system and association with symptoms in
schizophrenia. Psychiatric Research: Neuroimaging, accepted.
Chiang, H.L., Chen, Y.J., Gau, S.F.S.*, Tseng, W.Y.I.*. Altered white matter tract property related to
impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attentiondeficit hyperactivity disorder. Journal of Psychiatry and Neuroscience, accepted.
Chien, H.Y., Lin, H.Y., Lai, M.C., Gau, S.S.F.*, and Tseng, W.Y.I. Hyperconnectivity of the right
posterior temporo-parietal junction predicts social difficulties in boys with autism spectrum
disorder. Autism Research, accepted.
Wu C.H., Hwang T.J., Chen Y.J., Hsu Y.C., Lo Y.C., Liu C.M., Hwu H.G.*, Chen C.M., Tseng W.Y.I.*.
Altered integrity of the right arcuate fasciculus as a trait marker of schizophrenia: A sibling study
using tractography-based analysis of the whole brain. Human Brain Mapping, accepted.
Wu, C.H., Hwang, T.J., Chen, P.J., Chou, T.L.*, Hsu, Y.C., Liu, C.M., Wang, H.L., Chen, C.M., Hua,
M.S., Hwu, H.G., and Tseng, W.Y.I.*. Reduced structural integrity and functional lateralization of
the dorsal language pathway correlate with hallucinations in schizophrenia: a combined diffusion
spectrum imaging and functional magnetic resonance imaging study, Psychiatric Research
Neuroimaging, accepted.
Chang, Y.L.*, Chen, T.F., Shih, Y.C., Chiu, M.J., Yan, S.H., Tseng, W.Y.I.. Regional cingulum disruption,
not gray matter atrophy, detects cognitive changes in amnestic mild cognitive impairment
subtypes. Journal of Alzheimer’s Disease, accepted.
Gau, S.S.*, W.L. Tseng, Tseng, W.Y.I., Y.H. Wu, Lo, Y.C. Association between microstructural
integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function
as mediators. Psychological Medicine, accepted.
Wu, Y.H., Gau, S.S.F.*, Lo, Y.C., Tseng, W.Y.I.*. 2014. White matter tract integrity of frontostriatal
circuit in attention deficit hyperactivity disorder: association with attention performance and
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symptoms. Human Brain Mapping; 35(1):199-212.
Yu, R., Chien, Y.L., Wang, H.L.S., Liu, C.M., Liu, C.C., Hwang, T.J., Hsieh, M.H., Hwu, H.G.*, Tseng,
W.Y.I.*. 2014. Frequency specific alternations in the amplitude of low-frequency fluctuations in
schizophrenia. Hum Brain Mapp. 35(2):627-37.
Lin, Y.C., Shih, Y.C., Tseng, W.Y.I., Chu, Y.H., Chen, T.F., Tang, P.F., Chiu, M.J. 2014. Cingulum
correlates of cognitive functions in patients with mild cognitive impairment and early
Alzheimer's disease: A diffusion spectrum imaging study. Brain Topography, accepted.
Matsuo K., Chen, S.H.A., Liu, C.M., Liu, C.C., Hwang, T.J., Hsieh, M.H. , Chien, Y.L., Hwu, H.G.,
Tseng, W.Y.I.*. Stable signatures of schizophrenia in the cortical-subcortical-cerebellar network
using fMRI of verbal working memory. Schizophrenia Research 2013;151:133–140.
Yeh, F.C., Verstynen, T.D., Wang, Y., Fernandez-Miranda, J.C. and Tseng, W.Y.I.*. Deterministic
diffusion fiber tracking improved by quantitative anisotropy. PLOS One; 8(11):e80713.
Yeh, F.C. and Tseng, W.Y.I.*. Sparse solution of fiber orientation distribution function by diffusion
decomposition. PLOS One; 8(10):e75747.
Lin , H.Y., Gau, S.S.F.*, Huang-Gu, S.L., Shang, C.Y., Wu, Y.H. and Tseng, W.Y.I.*. Neural substrates
of behavioral variability in attention deficit hyperactivity disorder: based on ex-Gaussian reaction
time distribution and diffusion spectrum imaging tractography. Psychological Medicine,
2013;9:1-14.
Yeh, F.C., Tseng, W.Y.I.*. Diffusion MRI connectometry examines fiber pathways with reduced
connectivity in individual patients with chronic stroke, Neuroimage Clin. 2013 Jun 29;2:912-21.
Tseng, M.T., Chiang, M.C., Kong, Y., Chao, C.C., Tseng, W.Y.I., Hsieh, S.T.*. Effect of aging on the
cerebral processing of thermal pain in the human brain. Pain 2013; 154(10):2120-9.
Lo, Y.C., Chou, T.L., Fan, L.Y., Gau, S.S.F., Chiu, Y.N., Tseng, W.Y.I.*. Altered structure-function
relations of language processing in adolescents with high-functioning autism: A combined
diffusion and functional MRI study. Autism Research; 2013;6(6):561-70.
Yu, R., Hsieh, M.H., Wang, H.L.S., Liu, C.M., Liu, C.C., Hwang, T.J., Chien, Y.L., Hwu, H.G.*, Tseng,
W.Y.I.*. Frequency dependent alterations in regional homogeneity of baseline brain activity in
schizophrenia, PLoS One. 2013;8(3):e57516.
Kuo, L.W., Chiang, W.Y., Yeh, F.C., Wedeen, V.J., Tseng, W.Y.I.*. Diffusion Spectrum MRI Using Bodycentered-cubic and Half-sphere Sampling Schemes, J Neurosci Methods. 2013;212(1):143-55.
Tseng, C.E.J., Tseng, W.Y.I.*, Lo, Y.C., Tozer, D. Has arterial spin labeling removed the need for
contrast enhanced perfusion studies? Journal of Neuroscience and Neuroengineering, 2013;
accepted.
Shang, C.Y., Wu, Y.H., Gau, S.S.*, Tseng, W.Y.I.*.. Disturbed microstructural integrity of the
frontostriatal fiber pathways and executive dysfunction in children with attention deficit
hyperactivity disorder. Psychological Medicine; 2013;43(5):1093-107.
Pan, M.K., Huang, S.C., Lo, Y.C., Yang, C.C., Tzen, K.Y., Cheng, T.W., Yang, C.C., Hua, M.S.,
Stephenson, D.A., Lee, M.J.*, Tseng, W.Y.I.*.. Microstructural integrity of cerebral fiber tracts in
hereditary spastic paraparesis with SPG11-mutation. American Journal of Neuroradiology,
2013;34(5):990-6.
Tseng, M.T., Chiang, M.C., Chao, C.C., Tseng, W.Y.I., Hsieh, S.T.*. fMRI evidence of degenerationinduced neuropathic pain in diabetes: enhanced limbic and striatal activations. Human Brain
Mapping, 2013;34(10):2733-46.
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