基本資料表
姓名：羅怡卿教授（Yi-Ching Lo）
現任：高雄醫學大學藥理學科教授兼學務長
學歷：私立高雄醫學院醫學研究所博士
專長：神經退化疾病研究及藥物開發、中草藥藥理學、環境毒理藥理學
教授科目：藥理學；實驗藥理學及研究設計
聯絡地址：807 高雄市三民區十全一路 100 號
高雄醫學大學醫學系藥理學科
電話/傳真：07-3121101 轉 2139#19/07-3234686
Email: [email protected]
*榮獲 98 學年度教學優良教師
*榮獲 100 學年度教學優良教師
期刊論文：(近五年)
1. Tseng, Y.T., Chang, F.R., Lo, Y.C. * (2014) The Chinese herbal formula Liuwei
dihuang protects dopaminergic neurons against Parkinson's toxin through enhancing
antioxidative defense and preventing apoptotic death. Phytomedicine. 21(5):724-33
2. Hsu, H.T., Tseng, Y.T., Hsu, Y.Y., Cheng, K.I., Chou, S.H., Lo, Y.C.* (2014) Propofol
Attenuates Lipopolysaccharide-Induced Reactive Oxygen Species Production Through
Activation of Nrf2/GSH and Suppression of NADPH Oxidase in Human Alveolar
Epithelial Cells. Inflammation [Epub ahead of print]
3. Hsu, Y.Y., Jong, Y.J., Lin, Y.T., Tseng, Y.T., Hsu, S.H., Lo, Y.C. * (2014) Nanomolar
Naloxone Attenuates Neurotoxicity Induced by Oxidative Stress and Survival Motor
Neuron Protein Deficiency. Neurotox Res 25(3):262-70
4. Cheung, So. E., Lo, Y.C., Chen, L.T., Kao, C.A., Wu, S.N. (2014) High effectiveness
of triptolide, an active diterpenoid triepoxide, in suppressing Kir-channel currents from
human glioma cells. Eur J Pharmacol.738(5):332-41
5. Kuo, F.C., Wu, C.Y., Kuo, C.H., Wu, C.F., Lu, C.Y., Chen, Y.H., Chen, C.Y., Lo,
Y.C., Wu, M.T., Hu, H.M. (2014) The Utilization of a New Immunochromatographic
Test in Detection of Helicobacter pylori Antibody from Maternal and Umbilical Cord
Serum. Biomed Res Int.
6. Liu, C.M., Fan, Y.C., Lo, Y.C., Wu, B.N., Yeh, J.L., Chen, I.J. (2014) Cyclic
guanosine monophosphate-enhancing reduces androgenic extracellular regulated
protein
kinases-phosphorylation/Rho
kinase
II-activation
in
benign
prostate
hyperplasia. Int J Urol. 21(1): 87-29
7. Hsu, Y.Y., Tseng, Y.T., Lo, Y.C. * (2013) Berberine, a natural antidiabetes drug,
attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. Toxicol
Appl Pharmacol. 272(3):787-796.
8. Chen, C.S., Tseng, Y.T., Hsu, Y.Y., Lo, Y.C*. (2013) Nrf2-Keap1 Antioxidant
Defense and Cell Survival signaling are up-regulated by 17β-Estradiol in
Homocysteine-treated
Dopaminergic
SH-SY5Y
Cells.
Neuroendocrinology.
97(3):232-41
9. Kuo, F.C., Tseng, Y.T., Wu, S.R., Wu, M.T., Lo, Y.C. * (2013) Melamine activates
NFκB/COX-2/PGE2 pathway and increases NADPH oxidase-dependent ROS
production in macrophages and human embryonic kidney cells. Toxicol In Vitro.
27(6):1603-11
10. Lo, Y.C.* Shih, Y.T., Tseng, Y.T., Hsu, H.T (2012) Neuroprotective effects of
San-Huang-Xie-Xin-Tang in the MPP+/MPTP models of Parkinson’s disease in vitro
and in vivo. Evid Based Complement Alternat Med. Article ID 501032.
11. Hsu, Y.Y., Chen, C.S., Wu, S.N., Jong, Y.J., Lo, Y.C.* (2012) Berberine activates Nrf2
nuclear translocation and protects against oxidative damage via a phosphatidy- linositol
3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells. Eur J Pharm
Sci. 46, 415-25
12. Hsu, Y.Y., Jong, Y.J., Tsai, H.H., Tseng, Y.T., An, L.M., Lo, Y.C.* (2012) Triptolide
increases SMN transcript and protein levels in human SMA fibroblasts and improves
survival in SMA-like mice. Br J Pharmacol. 166,1114-26
13. Tseng,
Y.T.,
Hsu,
Y.Y.,
Shih,
Y.T.,
Lo,Y.C.*
(2012)
Paeonol
Attenuates
Microglia-Mediated Inflammation and Oxidative Stress-Induced Neurotoxicity in Rat
Primary Microglia and Cortical Neurons. Shock. 37,312-8
14. Wu, S.N., Lo, Y.C., Chen, B.S., Wu, F.T., So, E.C. (2012) Possible effects of reduced
conductance in delayed-rectifier K(+) current on neuronal firing. Mov Disord.
27(12):1581-2
15. Wu, S.N., Hsu, M.C., Liao, Y.K., Wu, F.T., Jong, Y.J., Lo, Y.C. (2012) Evidence for
inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+)
currents in motor neuron-like cells Evid Based Complement Alternat Med. Article ID
148403
16. Wu, S.N., Lo, Y.C., Chen, B.S., Cheung, So E, Chen, L.T. (2012) Contribution of
blocked potassium current conductance and increased conductance of persistent sodium
current to the afterdischarge in myelinated neuron. Muscle Nerve. 46(2):297-9
17. Wu, S.N.*, Lo, Y.C., Shen, A.Y., Chen, B.S. (2011) Contribution of non-inactivating
Na+ current induced by oxidizing agents to the firing behavior of neuronal action
potentials: experimental and theoretical studies from NG108-15 neuronal cells. Chin J
Physiol. 54,19-29
18. Wu, S.N.*, Chen, B.S., Lo, Y.C. (2011) Evidence for aconitine-induced inhibition of
delayed rectifier K(+) current in Jurkat T-lymphocytes. Toxicology. 289,11-8
19. Wu, S.N.*, Huang, H.C., Yeh, C.C., Yang, W.H., Lo, Y.C. (2011) Inhibitory effect of
memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents
in pituitary GH3 cells. Biochem Biophys Res Commun. 405,508-13
20. Liu, Y, Lo, Y. C., Qian, L, Crews, F. T., Wilson, B, Chen, H. L., Wu, H. M., Chen, S.H.,
Wei, K., Lu, R. B., Ali, S., Hong, J. S. * (2011) Verapamil protects dopaminergic
neuron damage through a novel anti-inflammatory mechanism by inhibition of
microglial activation. Neuropharmacology. 60,373-80
21. Shih, Y. T., Chen, I. J., Wu, Y. C., Lo, Y. C*. (2011) San-Huang-Xie-Xin-Tang protects
against activated microglia- and 6-OHDA-induced toxicity in neuronal SH-SY5Y cells.
Evid Based Complement Alternat Med. Article ID 429384.
22. Shih, Y. T., Chen, P. S., Wu, C. H., Tseng, Y. T., Wu, Y. C.*, Lo, Y. C.* (2010)
Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement
of oxidative stress and suppression of the antioxidant protective system. Free Radic Bio
Med. 49, 1471-9
23. Chen, B.S., Lo, Y.C., Lius, Y.C., Wu, S.N. * (2010) Effects of transient receptor
potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley
neuron during exposure to sinusoidal external voltage. Chin J Physiol. 53(6),423-9
24. Hsu, S. H., Lai, M. C., Er, T. K., Yang, S. N., Hung, C. H., Tsai, H. H., Lin, Y. C.,
Chang, J. G., Lo, Y. C., Jong, Y. J.* (2010) Ubiquitin carboxyl-terminal hydrolase L1
(UCHL1) regulates the level of SMN expression through ubiquitination in primary
spinal muscular atrophy fibroblasts. Clin Chim Acta. 411, 1920-8.
25. Hsu, Y. Y., Liu, C. M., Tsai, H. H,, Jong, Y. J., Chen, I. J., Lo, Y. C*. (2010) KMUP-1
attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: Roles of PKG,
PI3K/Akt and Bcl-2/Bax pathways. Toxicology. 268, 46-54.
26. Shih, Y. T., Hsu, Y. Y., Chang, F. R., Wu, Y. C., Lo, Y. C.*. (2010) 6-Hydroxycleroda
-3,13-dien-15,16-olide protects neuronal cells from lipopolysaccharide-induced
neurotoxicity through the inhibition of microglia-mediated inflammation. Planta Med.
76, 120-7.
27. Chen, B. S., Lo, Y. C., Peng, H., Hsu, T. I., Wu, S. N*. (2009) Effects of ranolazine, a
novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor
GH(3) cells and NG108-15 neuronal cells. J Pharmacol Sci,110, 295-305.
28. Wu, S. N*., Chen, B. S., Hsu, T. I., Peng, H., Wu, Y. H., Lo, Y. C. (2009) Analytical
studies of rapidly inactivating and noninactivating sodium currents in differentiated
NG108-15 neuronal cells. J Theor Biol, 259, 828-36.
29. Lo, Y. C.*, Shih, Y. T., Wu, D. C., Lee, Y. C. (2009) In vitro effects of Helicobacter
pylori-induced infection in gastric epithelial AGS cells on microglia-mediated toxicity
in neuroblastoma SH-SY5Y cells. Inflamm Res, 58, 329-35.
30. Liu, C. M., Lo, Y. C., Tai, M. H., Wu, B. N., Wu, W. J., Chou, Y. H., Chai, C. Y.,
Huang, C. H., Chen, I. J*. (2009) Piperazine-designed alpha(1A)/alpha(1D)adrenoceptor blocker KMUP-1 and doxazosin provide down-regulation of androgen
receptor and PSA in prostatic LNCaP cells growth and specifically in xenografts.
Prostate, 69, 610-623
31. Wu, S.N.*, Wu, Y.H., Chen, B.S., Lo, Y.C., Liu, Y.C. (2009) Underlying mechanism of
actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on
action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons.
Toxicology. 258, 70-7.
研討會論文：
1.
Lo, Y.C.*, Tseng, Y.T. (2014) Loganin protects motor neuron against survival motor
neuron protein deficiency. 17th World Congress of Basic & Clinical Pharmacology
2.
Tseng, Y.T., Lo, Y.C.* (2014) Resveratrol attenuates inflammation and oxidative stress
in carbon black nanoparticles-treated A549 human lung epithelial cells. 5th FIP
Pharmaceutical Sciences World Congress
3.
Hsu, H.T., Tseng, Y.T., Hsu, Y.Y., Cheng K.I., Chou, S.H., Lo, Y.C.* (2013)
Anti-inflammation and Nrf2-mediated antioxidant defense contribute to propofol
protection in LPS-treated A549 cells. 2013 Annual Meeting of Taiwan Society of
Anesthesiologists.
4.
Tseng, Y.T., Hsu, Y.Y., Jong, Y.J., Lo, Y.C.* (2013) Herbal Drugs Development
Platform for Spinal Muscular Atrophy. International Conference of Traditional and
Complementary Medicine on Health 2013.
5.
Hsu, Y.Y., Lo, Y.C.* (2013) Targeting Nrf2 signaling in oxidative stress-induced
neurotoxicity and neurite degeneration in experimental diabetic neuropathy by
antidiabetes drug berberine. International Conference of Traditional and
Complementary Medicine on Health 2013.
6.
Lo, Y.C.*, Tseng, Y.T. Liang, W.F., Jong, Y.J. (2013) Therapeutic potential of Liuwei
dihuang wang, a traditional Chinese Medicine, for spinal muscular atrophy in vitro and
in vivo. Experimental Biology 2013
7.
Liang, W.F., Tseng, Y.T., Jong, Y.J., Lo, Y.C.* (2013) Liuwei Dihuang Wang Protects
NSC34 Cells against Smn Deficiency. The 28th Joint Annual Conference of
Biomedical Sciences.
8.
Lin, W.J., Tseng, Y.T., Chen, C.S., Lo, Y.C.* (2013) Protective effect of loganin
against MPP+-induced neurotoxicity. The 28th Joint Annual Conference of Biomedical
Sciences.
9.
Lo, Y.C.*, Tseng, Y.T. (2012) Neuroprotective effects of Liuwei dihung wan in the
MPP+/MPTP models of Parkinson’s disease in vitro and in vivo. 6th European
Congress of Pharmacology.
10. Wong,W.J., Lo, Y.C.* (2012) Dextromethorphan Protects Against NanoparticlesInduced Inflammation and Oxidative Stress in Alveolar Epithelial Cells and
Macrophages. The 27th Joint Annual Conference of Biomedical Sciences.
11. Chen, C.S., Hsu, Y.Y., Shih, Y.T., Lo, Y. C.* (2011) Estrogen prevents
homocysteine-induced oxidative stress and cell death in human neuronal cell line
SH-SY5Y. World Psychiatry Association Regional Meeting.
12. Lo, Y. C.*,Tseng, Y.T. (2011) LiuWei Dihuang Wan and its main component paeonol
attenuate neuronal damage induced by inflammation and oxidative stress in rat primary
microglia and cortical neurons. 8th IBRO World Congress of Neuroscience.
13. Tseng, Y.T., Shih, Y.T., Lo, Y. C.* (2011) Protective effects of paeonol on
microglia-mediated inflammation and oxidative stress-induced neurotoxicity. The 26th
Joint Annual Conference of Biomedical Sciences.
14. Lo, Y. C.*, Tsai, H.H., Hsu, Y.Y., Jong, Y.J. (2011) Triptolide increases SMN protein
production by up-regulating splicing enhancer proteins and promoting SMN2 exon 7
inclusion in human SMN1-depleted skin fibroblasts and SMA-like mice. The 26th Joint
Annual Conference of Biomedical Sciences.
15. Lo, Y. C*., Shih, Y. T. (2010) San-Huang-Xie-Xin-Tang protects against
MPTP-induced dopaminergic neurotoxicity via inhibition of oxidative stress and
apoptosis. The 16th IUPHAR WorldCongress of Basis and Clinical Pharmacology.
16. Lin, Y. T., Tsai, H. H., Hsu, S. H., Jong, Y. J., Lo, Y. C.* (2010) Protective Effect of
Naloxone on H2O2 induced Cytotoxicity in Mouse Motor Neuronal NSC-34 Cells.
The 25th Joint Annual Conference of Biomedical Sciences.
17. Shih, Y. T., Wu, C. H., Tsai, H. H., Hsu Y. Y. and Lo, Y. C*. (2009) Effects of
arecoline, the main alkaloid of areca nut, on microglia and neuronal cells. The 9th
World Congress on Inflammation.
18. Hsu, Y. Y., Shih, Y. T., Lin, Y. T. and Lo, Y. C*. (2009) 6-hydroxycleroda-3,13dien-15,16-olide attenuates lipopolysaccharide-induced inflammation in microglia. The
9th World Congress on Inflammation.
19. Lo, Y. C*., Shih, Y. T. (2009) San-Huang-Xie-Xin-Tang inhibits inflammation,
oxidative stress and apoptosis in rat primary cultured microglia and neuron. The 9th
World Congress on Inflammation.
20. Wu, C. H., Shih, Y. T., Hsu, Y. Y., Tsai, H. H., Liu, C. M. and Lo, Y. C.* (2009)
Arecoline Induces Microglia-Mediated Inflammation and COX-2-Related
Neurotoxicity. The 24th Joint Annual Conference of Biomedical Sciences.
21. Wu, S. R., Hsu, Y. Y., Shih, Y. T., Lo, Y. C.* (2009) Melamine Activates
COX-2/NF-kB Signaling Pathway in Macrophage-like Cells. The 24th Joint Annual
Conference of Biomedical Sciences.
22. Lo, Y. C.*, Shih, Y. T. (2008) San-Huang-Xie-Xin-Tang protects against
microglia-mediated neurotoxicity: an in vitro model for anti-inflammatory herbal
medicine. The 8th World Conference on Clinical Pharmacology and Therapeutics.
23. Lo, Y. C*., Liu, C. M., Chen C. T., Chen, I. J. (2008) Dual inhibition of KMUP-1A on
cyclooxygenase-2 and 5-lipoxygenase in human oral squamous cell carcinoma. World
Cancer Congress 2008.
24. Hsu Y. Y., Shih Y. T., Chang F. R., Wu, Y. C., Lo Y. C*. (2008) Effects of PL3 on
Microglia-activated Neurotoxicity: a Diterpene Extracted from Formosan Polyalthia
longifolia var. pendula. The 23th Joint Annual Conference of Biomedical Sciences.
25. Lu, C. Y., Wang J. Y., Hsieh J. S., Lo, Y. C., Jan, C. M., Lee C. T. (2008) The Influence
of Glutamine in Postoperative Gastrointestinal Cancer Patients --- A Randomized
Controlled Study. 台灣消化系醫學會(第三十八屆)暨台灣消化系內視鏡醫學會(第
十七次)聯合學術演講年會.
26. Wu, D. C. *, Kuo F. C., Shih, Y. T., Tsai, H. H., Lo, Y. C. (2008) Helicobacter pylori
and gastrointestinal cancer cell line: the role of tumor suppressor gene and Cag A. 台
灣消化系醫學會(第三十八屆)暨台灣消化系內視鏡醫學會(第十七次)聯合學術演
講年會.
27. Tsai, H. H., Liu, C. M., Shih, Y. T., Jhong, H. S., Chen, I. J., Lo, Y. C*. (2007)
Protective effects of San-Hunag-Xie-Xin-Tang in pulmonary arterial hypertension:
anti-inflammation and vasodilation. The 22th Joint Annual Conference of Biomedical
Sciences.
28. Lin, Y. C., Hsu, Y. Y., Lo, Y. C*. (2007) Neuroprotective effects of GLNVA on
LPS-activated microglia- and 6-OHDA- induced dopaminergic neuronal cell death.
The 22th Joint Annual Conference of Biomedical Sciences.
29. Chen, C. Y., Lo, Y. C., Wu, B. N., Lo, W. L., Kuo, S. Y., Lin, R. J. (2007)
Isoobtusilactone a induces apoptosis of human non-small cell lung cancer a549:
involvement of proliferation inhibition, cell-cycle dysregulation, reactive oxygen
species (ros) and p53-mediated pathways. The 22th Joint Annual Conference of
Biomedical Sciences.
30. Lo, Y. C., Lin, Y. C. (2007) Neuroprotective effects of GLNVA on
inflammation-induced dopaminergic neuronal cell death. The 23th International
Symposium on Cerebral Blood Flow,Metabolism & Function (Brain’07)
31. Hsieh, P. W., Wu, C.C., Chiang, S.Z., Lo, Y. C., Wu, Y. C. (2007) Potent inhibitory
effects of 2-benzoylaminobenzoic acid analogues on cyclooxygenase activity and
expressionpotent inhibitory effects of 2-benzoylaminobenzoic acid analogues on
cyclooxygenase activity and expression. Southeast Asian Western Pacific (SEAWP)
Regional Federation of Pharmacologists and the Australasian
32. Lo, Y. C., Shih, Y. S., Tsai, S. H., Wu, D.C., Jan, C. M., Wang, W. M., Yu, F. J., Wu,
J.Y., Kuo, F. C., Hu, H.M. (2007) Evaluation of p27 and cagA role on the Helicobacter
pylori infection to GI tract cancer cell line. 台灣內科醫學會 96 年年會暨學術研討會
研究計劃
年度
計劃名稱
起迄年月
補助機構
補助金額
99
地黃丸之神經保護作用
990801~1000731
國科會
900,000
1000801~1010731
國科會
900,000
1010801~1020731
國科會
900,000
及機轉探討:建立治療
神經發炎及神經退化的
傳統中藥開發平台
(1/3 年)
100
地黃丸之神經保護作用
及機轉探討:建立治療
神經發炎及神經退化的
傳統中藥開發平台
(2/3 年)
101
地黃丸之神經保護作用
及機轉探討:建立治療
神經發炎及神經退化的
傳統中藥開發平台
(3/3 年)
102
神經退化性疾病之多重
1020801~1030731
國科會
1,250,000
1030801~1040731
國科會
1,250,000
標的治療藥物開發：傳
統中藥、天然物及化學
成物 (1/3)
103
神經退化性疾病之多重
標的治療藥物開發：傳
統中藥、天然物及化學
成物 (2/3)
羅怡卿教授個人網頁 http://pharmacology.kmu.edu.tw/Lo2009/index.htm