Drug
Levaquin
levofloxacin
Patient Education
Generic Name: levofloxacin (oral)
Brand Names: Levaquin, Levaquin Leva-Pak
What is the most important information I should know about levofloxacin?
You should not use this medication if you are allergic to levofloxacin or similar antibiotics
such as ciprofloxacin (Cipro), gemifloxacin (Factive), moxifloxacin (Avelox), ofloxacin (Floxin),
norfloxacin (Noroxin), and others.
Before taking levofloxacin, tell your doctor if you have kidney or liver disease, muscle weakness or
trouble breathing, joint problems, seizures, diabetes, myasthenia gravis, a history of head injury of
brain tumor, a condition called pseudotumor cerebri, low levels of potassium in your blood, a
personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an
antibiotic.
Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine
(Videx) powder or chewable tablets within 2 hours before or after you take levofloxacin.
Levofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to
muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely
to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or
lung transplant. Stop taking levofloxacin and call your doctor at once if you have sudden pain,
swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you
receive medical care or instructions.
What is levofloxacin?
Levofloxacin is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones).
Levofloxacin fights bacteria in the body.
Levofloxacin is used to treat bacterial infections of the skin, sinuses, kidneys, bladder, or prostate.
Levofloxacin is also used to treat bacterial infections that cause bronchitis or pneumonia, and to treat
people who have been exposed to anthrax or plague.
Levofloxacin may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking levofloxacin?
You should not use this medication if you are allergic to levofloxacin or other
fluoroquinolones such as ciprofloxacin (Cipro), gemifloxacin (Factive), moxifloxacin (Avelox),
ofloxacin (Floxin), norfloxacin (Noroxin), and others.
To make sure you can safely take levofloxacin, tell your doctor if you have any of these other
conditions:
myasthenia gravis;
a heart rhythm disorder, especially if you take amiodarone (Cordarone, Pacerone), dofetilide
(Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Procan, Pronestyl),
propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);
a history of allergic reaction to an antibiotic;
joint problems;
kidney or liver disease;
seizures or epilepsy;
a history of head injury or brain tumor;
a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches,
vision loss, or other symptoms);
diabetes;
muscle weakness or trouble breathing;
low levels of potassium in your blood (hypokalemia); or
a personal or family history of Long QT syndrome.
FDA pregnancy category C: It is not known whether levofloxacin is harmful to an unborn
baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Levofloxacin can pass into breast milk and may harm a nursing baby. Do not use this
medication without telling your doctor if you are breast-feeding a baby.
Levofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to
muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely
to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or
lung transplant. Stop taking levofloxacin and call your doctor at once if you have sudden pain,
swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you
receive medical care or instructions.
Do not share this medication with another person (especially a child), even if they have the
same symptoms you have.
How should I take levofloxacin?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer
than recommended. Follow the directions on your prescription label.
Take levofloxacin with a full glass of water (8 ounces). Drink several extra glasses of fluid
each day while you are taking levofloxacin. You may take levofloxacin tablets with or without food.
Take levofloxacin oral solution (liquid) on an empty stomach 1 hour before or 2 hours after
meals. Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table
spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Take this medication for the full prescribed length of time. Your symptoms may improve
before the infection is completely cleared. Skipping doses may also increase your risk of further
infection that is resistant to antibiotics. Levofloxacin will not treat a viral infection such as the
common cold or flu.
This medication can cause you to have a false positive drug screening test. If you provide a urine
sample for drug screening, tell the laboratory staff that you are taking levofloxacin.
Store at room temperature away from moisture and heat. Do not allow the liquid medicine to
freeze.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your
next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose
symptoms may include loss of balance or coordination, drooping eyelids, weakness, decreased
activity, trouble breathing, sweating, tremors, or seizure (convulsions).
What should I avoid while taking levofloxacin?
You may be taking certain other medicines that should not be taken at the same time as
levofloxacin. Avoid taking the following medicines within 2 hours before or after you take
levofloxacin. These other medicines can make levofloxacin much less effective when taken at the
same time:
antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids), or the ulcer
medicine sucralfate (Carafate);
didanosine (Videx) powder or chewable tablets; or
vitamin or mineral supplements that contain iron or zinc.
Avoid exposure to sunlight or tanning beds. Levofloxacin can make you sunburn more easily.
Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Call your
doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have
diarrhea that is watery or bloody, stop taking levofloxacin and call your doctor. Do not use antidiarrhea medicine unless your doctor tells you to.
What are the possible side effects of levofloxacin?
Get emergency medical help if you have any of these signs of an allergic reaction: hives;
difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using levofloxacin and call your doctor at once if you have a serious side effect such as:
chest pain and severe dizziness, fainting, fast or pounding heartbeats;
sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of
movement in any of your joints;
diarrhea that is watery or bloody;
confusion, hallucinations, depression, tremors, feeling restless or anxious, unusual thoughts or
behavior, insomnia, nightmares, seizure (convulsions);
severe headache, ringing in your ears, nausea, vision problems, pain behind your eyes;
pale skin, fever, weakness, easy bruising or bleeding;
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice
(yellowing of the skin or eyes);
urinating less than usual or not at all;
numbness, burning pain, or tingly feeling in your hands or feet;
the first sign of any skin rash, no matter how mild; or
severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin
pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and
causes blistering and peeling.
Less serious side effects may include:
mild diarrhea, constipation, vomiting;
sleep problems (insomnia);
mild headache or dizziness; or
vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice
about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect levofloxacin?
Tell your doctor about all other medicines you use, especially:
a blood thinner such as warfarin (Coumadin, Jantoven);
insulin or oral diabetes medication;
theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin,
Pediazole), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or
desipramine (Norpramin);
anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);
medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol
(Inapsine), or ondansetron (Zofran);
medicines to treat psychiatric disorders, such as clozapine (FazaClo, Clozaril), haloperidol (Haldol),
pimozide (Orap), ziprasidone (Geodon), and others;
migraine headache medicine such as sumatriptan (Imitrex, Treximet);
narcotic medication such as methadone (Methadose, Diskets, Dolophine);
an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen
(Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia,
Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic),
and others; or
a steroid medicine (prednisone and others).
This list is not complete and other drugs may interact with levofloxacin. Tell your doctor about all
medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do
not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about levofloxacin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines
with others, and use this medication only for the indication prescribed.
Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01. Revision Date: 5/14/2012.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete,
but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for
use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United
States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational
resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a
supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for
a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate
for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information
Multum provides.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic
reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Substantial effort has been made to ensure that the information provided by Epocrates is accurate and up-to-date, but this information is not
intended to cover all possible uses, precautions, or other considerations relating to the therapies covered. Epocrates does not advocate or
endorse the use of any drug or other therapy and does not diagnose patients. Healthcare professionals should use their professional judgment in
using this information, and this information should not be considered a substitute for the care and professional judgment provided by a
licensed healthcare practitioner. This information if provided on an "as is" basis, and Epocrates and its affiliates, agents and licensors assume
no responsibility for any aspect of healthcare administered with the aid of this information or any other use of the information.
Copyright © 2013 Epocrates, Inc. All Rights Reserved.
Epocrates® Online is a trademark of Epocrates Inc, in the U.S. and elsewhere.