UNIVERSITAS INDONESIA EVIDENCE BASED CASE REPORT COMPARISON: TREATMENT CATHETER DRAINAGE AND NEEDLE ASPIRATION FOR LIVER ABSCESS AUTHOR SOFIAN KURNIA MARSAWIDJAYA, MD 1106024501 DEPARTMENT OF INTERNAL MEDICINE DIVISON OF HEPATOLOGY FACULTY OF MEDICINE UNIVERSITY OF INDONESIA JAKARTA 2014 LETTER OF APPROVAL Author NPM Title : Sofian Kurnia Marsawidjaya, MD : 1106024501 : COMPARISON: TREATMENT CATHETER DRAINAGE AND NEEDLE ASPIRATION FOR LIVER ABSCESS Has been approved for presentation at Cipto Mangunkusumo National Reference Hospital In November 2014 Supervisor Andri Sanityoso, Dr.Sp.PD-KGEH,FINASIM Author Sofian KM, Dr. 2 CONTENTS Contents………………………………………………………………………………... 3 Introduction……………………………………………………………………………. 4 Case Presentation………………………………………………………………………. 4 Formulate Question………………………………………………………………….... 5 Search Evidence………………..………………………………………………........... 5 Intervention…………………………………………………………………………….. 6 Outcome………………….………………………………………………………… 10 Conclusion……………………………………………………………………………… 11 References…………………………………………………………………………….. 12 3 INTRODUCTION A liver abscess is a suppurative cavity in the liver resulting from the invasion and multiplication of microorganisms, entering directly from an injury through the blood vessels or by the way of the biliary ductal system. Liver abscesses are most commonly due to pyogenic, amebic or mixed infections. Less commonly these may be fungal in origin. Liver abscess has been recognized since Hippocrates (circa 400 B.C.) who speculated that the prognoses of the patients were related to the type of fluid within the abscess cavity 1 Liver abscess is generally divided into two, there are amoebik liver abscess (ALA) and pyogenic liver abscess (PLA). ALA is extraintestinal amebiasis which one of the most common in the tropics or subtropics, including in Indonesia has many areas endemic for virulent strains of E. histolytica. E. histolytica lives in the human gut commensal, but with poor nutritional status may become pathogenic and cause high morbidity. Amoebic liver abscess is the most common inflammatory lesions liver takes up space. Agents cause is protozoa, Entamoeba Histolyitica. About 10% of the population in the world, there Entamoeba histolytica in their intestines, which can then develop into invasive. Protozoa enter the liver through the portal vein. Amebiasis can occur in various organs but the liver is the organ most commonly for infection of extra-intestinal.2,3,45 Although amebic liver abscess occurs more commonly on a worldwide basis, the pyogenic liver abscess predominates in the United States. Liver abscess is found more commonly in men between 20 and 40 years of age, but can occur at any age. Approximately 60% are solitary and mainly located in the right lobe of the liver, as a result of the streaming of portal blood flow secondary to the fact that the right lobe is predominantly supplied by the superior mesenteric vein, and because most of the hepatic volume is in the right lobe. When multiple abscesses are present, pyogenic or mixed is the most probable type. Patients usually present with a constant dull pain in the right upper quadrant of the abdomen which may be referred to the scapular region or the right shoulder. Research in Indonesia shows ratio of men: women ranged 3:1-22. Age of patients ranged from 20-50 years, especially in young adults, rare in children anak.3,4 About 10% from all people in the world had this infection, but only 10% became clinically. Ultrasound and computed tomography scans are non-invasive, equally sensitive imaging modalities for the detection of amoebic liver abscesses 6,7. Amoeboic liver abscess is handled with chemotherapy using nitromidazole derivate, aspiration or drainage with surgery 4 8 . Metronidazole is the drug of choice for treatment of amoebic liver abscesses followed by a luminal agent to eradicate the asymptomatic carrier state 6. Positive result with metronidazole empirically can conclude to diagnose amoebic liver abscess. The treatment of ALA with or without aspiration in addition to amoebicidal drugs is discussed controversially and therefore the therapeutic approach differs widely.9 Here in this paper we tried to find out the answer determine the beneficial and harmful effects of image-guided percutaneous needle aspiration procedure compared with percutaneus catheter darinage in patients with liver abscess CASE PRESENTATION A 30-year-old woman was admitted to our hospital presenting with abdominal pain in the upper right side which had developed over 3 week. Since one month this patient had been abdominal pain, she felt likes sharpnes, squeezed and he also had fever but on in off not a chilled, and also nausea, vomitus, and malaise. She was not frequently ate in place which low of higiene and sanitation. And also she was not frequently drink a cup of alcohol. She isn’t transgender of sexual, didn’t have tatoo, and not a drug abuser. At presentation, she had a heart rate of 108 beats per minute, blood pressure of 120/70 mmHg, respiratory rate of 22, and a body temperature of 36.9˚C. On abdominal examination, there was found a mass on upper right quadrant, pushpain, Hepar was felt 2 fingers below prosesus xiphoideus and 2 fingers below arcus costae dextra. This patient have loculated ascites, shifting dullnes (+). Biochemical analysis showed leukocyt (7,94 x103 cells/mm3), normocytic anemia (8,13 g/dL, MCV 82 fL), hypoalbuminemia (2,6 g/dL), AntiHIV: Non reactive, HbsAg and anti HCV: non reactive. Normal ECG. Ultrasound abdominal get result absess mass in the right lobe diameters : 13,06 cm x 12,7 cm, suspected abscess hepar. Based on above findings, our patient problems were hepar mass suspect abscess hepar, normocytic anemia, dyspepsia syndrome and hypoalbuminemia. This patients get treatment metronidazole 3x500 mg and cefotaxim 3x1 g iv and this patient also had twice ultrasound guided needle aspiration. 5 FORMULATE QUESTION patient with this case prompted discussion in the practice “are catheter drainage more effective than needle aspiration in patients with liver abscess ?” SEARCH THE EVIDENCE We searched Pubmed because of ease to access, and huge database. We began our search strategy using key words “Needle aspiration AND “cathether darinage” AND “liver abscess”. Since our search produced 23 citations, we further limited to RCT and English language, free charge, resulted in 3 RCT hits for this search. We reviewed the abstracts and found only three relevant RCT that might answer our question. INTERVENTION We did critically appraised three two prospective randomized trials using the method described by Straus et al.6 Table 1 and 2 details our assessment Table 1. Title Authors Publication Sample size Domain Sukhjeet Singh et al, 2013 Treatment of liver abscess: prospective randomized comparison of catheter drainage and needle aspiration Onkar Singh, 2009 Zerem, 2007 Comparative study of catheter drainage and needle aspiration in management of large liver abscesses Singh S, Chaudhary P, Saxena N,Khandelwal S, Poddar D, Biswal U Ann Gastroenterol 2013; 26 (3): 1-8 Singh O ·Gupta S · Moses S · Jain DK Sonographically Guided Percutaneous Catheter Drainage Versus Needle Aspiration in the Management of Pyogenic Liver Abscess Zerem E, Hadzic A Indian J Gastroenterol 2009(May– June):28(3):88–92 AJR 2007; 189:W138– W142 60 patients Patient with liver abscess clinically and 72 patients patients with liver abscess (amebic and 60 patients patients with pyogenic liver abscess 6 radiologically Determinant pigtail catheter drainage (PCD) Comparison percutaneous needle aspiration (PNA) Hospital stay, succes, Volume of the largest cavity, clinical improvement, time for 50% reduction,time for resolution, duration of drainage Outcome pyogenic) percutaneous catheter drainage (PCD) percutaneous needle aspiration (PNA) Duration of hospital stay, duration of iv antibiotics, clinical relief attained, succes rate Sonographically Guided percutaneous catheter drainage percutaneous needle aspiration (PNA) Total hospital stay, succesful treatment, disappearance of abscess Table 2.Validity assessment of the prospective studies Sukhjeet Singh et al, 2013 Yes Onkar Singh, 2009 Yes Zerem, 2007 Was the randomization concealed? Yes Yes Yes Were the groups similar at the start of the trial? Yes Yes Yes Was the follow up of patients sufficiently long and complete? Yes Yes Yes Were all patients analyzed in the groups to which they were randomized? Yes Yes Yes Were patients, clinicians, and study personnel kept blind to treatment? No No No Were groups treated equally, apart from the experimental therapy Yes Yes Yes Was the assignment of patients to treatment randomized? Yes APPLY THE ANSWER All of studies reported significant difference in succes rate in treatment PCD group than PNA. Sukhjeet Singh et al, reported the outcome, Pigtail percutaneous drainage was 7 successful in all the 30 cases. On the other hand, image-guided needle aspiration was successful only in 23 of 30 patients (P=0.006). Out of these 23 patients successfully treated, 9 patients required only one aspiration, 10 required two aspirations, and 4 required three aspirations. The 7 patients who did not show clinical improvement and / or decrease in cavity size despite 3 aspirations were taken as failures. In the PNA group, on comparing the cavity volumes the mean cavity volume in those who were successfully treated was 201.4 cc which was significantly less than those failing treatment; the mean volume being 403.6 cc (P<0.011). The patients in PCD group showed earlier clinical improvement (P=0.039) and 50% decrease in abscess cavity volume (P=0.000) as compared to those who underwent PNA. However, there was no significant difference between the duration of hospital stay or the time required for total or near-total resolution of cavity. Onkar Singh, et al reported that needle aspiration was successful in 31 (86%) out of the 36 patients, after single aspiration in 10, two aspirations in 18, and three aspirations in 3 patients. PCD was successful in 35 (97%) patients. The median duration of catheter insertion was 13 days (range 6–34 days, mean 12.8 days). Mean (SD) duration of intravenous antibiotic (p=0.04) and duration to clinical relief (p=0.02) were shorter in the PCD group. The success rates in the PNA and PCD groups were 86% and 97%, respectively (p=0.2) (Table 2). PCD failed in one case, who had diabetes and multiple pyogenic liver abscesses involving the right liver lobe. He had rupture of abscess during treatment leading to 8 peritonitis and sepsis, and underwent exploration with curettage of abscess cavity along with peritoneal lavage and placement of abdominal drains. The mean (SD) size of abscess at discharge was 3.0 cm in PCD vs. 4.2 cm in PNA group (p=0.88). At 6 months of follow- up, more number of patients treated successfully by PCD (29/35, 83%) had complete sonographic resolution of abscess cavities, compared to patients treated successfully by PNA (14/31, 45%) (p=0.02). There were four recurrences in aspiration group and two in PCD group at 6 months of follow-up. On the other study, Zerem and Hadzic, reported that in the percutaneous needle aspiration group, the average longest diameter of the abscess collection was significantly greater in patients with unsuccessful (97 ± 42 mm) than in patients with successful (62 ± 35 mm) needle aspiration (p = 0.02). Although the average volume of frank pus was larger in patients who underwent unsuccessful percutaneous needle aspiration (178 ± 98 mL) than in those who underwent successful percutaneous needle aspiration (121 ± 96 mL), the difference was not significant (p = 0.14). Intermittent needle aspiration was successful for all patients with abscesses 50 mm in longest diameter or smaller. However, this treatment was unsuccessful for all five patients with multiloculated abscesses. In the PCD group, all patients were successfully treated, clinical features and laboratory abnormalities subsiding (Table 4). In four of six patients with multiloculated ab scesses, catheter drainage was performed twice because drainage was inadequate with the first attempt. Total duration of catheter drainage for each patient in the drainage group ranged from 3 to 25 days with a mean of 11.0 ± 6.4 days. At the end of treatment, the abscess cavity had disappeared completely in 25 of 50 successfully treated patients and had decreased more than 50% in the other 25 patients (Table 4). On final control examination 6 months after the beginning of treatment, abscesses were absent in all successfully treated patients. Hospital stay did not differ significantly between the groups (Mann-Whitney U test; Z = –0.02; p = 0.98) 9 OUTCOME The evidence obtained was reviewed using method that described by the Evidence Based Medicine Working Group before applying to the patients. Three questions below were asked to determine the applicability of the articles. Were the study patients similar to the patient in my practice?-Yes. Our patients had liver abscess that similar to the study patients. Patients in this case obtain antibiotics therapy metronidazole for more ten days, but while the symptoms of fever and abdominal pains is get improvement, patients still there complaints lump in the upper right even though has reduced and still pain if he depth of inspiration. In addition, we also applied inclusion and exclusion criteria and compared demographic baseline of the study to our patient. In this case patient reported got twice needle aspiration. Were all patient-important outcomes considered?-Yes. These studies measured all clinically important outcomes included symptoms relieved Clinical improvement or response to treatment as follows: succes rate (proportion of patients 10 without reduction in liver size), duration of hospital stay, duration of drainage, duration of intravenous antibiotics., Are the likely treatment benefits worth the potential harm and costs? Yes. We found evidence that percutaneous catheter drainege (PCD) added benefits in the management of liver abscess. Percutaneous drainage (either needle aspiration or catheter drainage) with systemic antibiotics has become the preferred treatment for the management of pyogenic liver abscesses.This EBCR found that evidence to support or refute aspiration of the abscess cavity. Accordingly, our findings are conclusive to make a definite recommendation on the benefit of adjunctive therapeutic catheter drainege (PCD). PCD has this obvious advantage over PNA, which may have accounted for quicker clinical recovery, lesser duration of parenteral antibiotics and lesser failure rate among patients treated with PCD. On the other hand, placing a catheter needs more expertise followed by nursing care. CONCLUSION Based on the current evidence, we conclude that this EBCR found evidence to support or refute catheter drainage of the abscess cavity versus needle aspiration in uncomplicated liver abscess. Randomised clinical trials with larger sample sizes and adequate randomisation (generation of the allocation sequence as well as allocation concealment) and blinded outcome assessment of out comes important to patients are urgently needed. Such trials should use uniform measures to assess outcomes. Strict evaluation of adverse events resulting from different interventions employed in the management of amoebic or pyogenic liver abscesses should be included in future trials. 11 REFERENCE 1. Singh, S, et al. Treatment of liver abscess: prospective Randomized comparison of catheter drainage and needle aspiration. Annals of Gastroenterology 2013 2. Julius. Abses Hati. dalam Buku Ajar Ilmu Penyakit Hati,editor: Sulaiman A, Akbar N, Lesmana L, Noer S. Edisi Pertama. Jakarta. Jayabadi, 2007. 487-91 3. Wenas NT, Waleleng BJ. Abses hati pogenik. Dalam: Buku Ajar Ilmu Penyakit Dalam.Editor: Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S.Edisi keempat. Jakarta. 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