SIEMIONOW SPINE SURGERY Kris Siemionow, MD Chicago, Illinois Cervical Spondylotic Myelopathy Correspondence should be addressed to: K. B. Siemionow, M.D. Assistant Professor of Orthopaedics and Neurosurgery University of Illinois, Chicago Email: [email protected] SIEMIONOW SPINE SURGERY www.kbspine.com Dr. Krzysztof (Kris) B. Siemionow MD is Assistant Professor of Orthopaedics and Neurosurgery at the University of Illinois in Chicago. Dr. Siemionow completed fellowships in Spine Surgery and he specializes in the surgical management of spinal conditions affecting the neck, spine, and back in adults, children, and adolescents. Dr. Siemionow is Board Certified by the American Board of Orthopaedic Surgery. Dr. Siemionow completed a residency in Orthopaedic Surgery at the Cleveland Clinic in Cleveland, Ohio, ranked one of the top hospitals in the nation by US News. While in Cleveland, Dr. Siemionow completed a combined orthopedic/neurosurgical spine fellowship at the Cleveland Clinic Spine Institute. After completing residency, Dr. Siemionow and his family moved to Chicago. In Chicago, Dr. Siemionow completed fellowship training in Adult Spine Surgery at Rush University Medical Center and a Pediatric Spine Fellowship at the Shriners Hospital for Children. Dr. Siemionow participates in an annual spine surgery mission to Uganda, East Africa, where he treats both children and adults suffering from spinal trauma, scoliosis, tumors, and infection. Dr. Siemionow has published numerous scientific articles pertaining to spine surgery and basic science spine research. He was awarded an NIH grant to study, “ The effects of inflammation on glial fibrillary acidic protein expression in satellite cells of the dorsal root ganglion.” Some of his current research is focused on the aging spine, the effects of less invasive surgical techniques, and robotic spine surgery. Dr. Siemionow has been awarded several patents for developing devices and technologies used in nerve and spine surgery. Currently he is working on applications for terahertz electromagnetic waves with scientists at Case Western Reserve University. 2 SIEMIONOW SPINE SURGERY www.kbspine.com Cervical Spondylotic Myelopathy Introduction You might have been diagnosed with cervical spondylotic myelopathy or CSM by your doctor. What is CSM? Cervical spondylotic myelopathy is a slowly progressive process resulting from age related spinal degeneration that can lead to significant functional disability and, in some cases, paralysis. It is now well established, that CSM is the result of a reduction in the space available for the spinal cord in the spinal canal. This causes pressure on the spinal cord itself and results in damage to the blood supply, nerves, and the nerve cells that form the spinal cord. [1, 2]. CSM is the most common type of spinal cord dysfunction affecting individuals over 55 years of age[2-4]. The most common reason for the reduction in spinal cord diameter is age related degeneration of the spinal joints and discs. These joints wear out just like other joints in the body and form bone spurs, the discs decrease in height and bulge. With time, the combination of these factors results in narrowing of the passage for the spinal cord. Without definitive surgical treatment, progressive deterioration is common. Conservative treatment is generally ineffective, and surgical intervention remains the most reliable and predictable method to halt further neurologic deterioration. 3 SIEMIONOW SPINE SURGERY www.kbspine.com MRI of the cervical spine. The arrows are showing spinal cord compression caused by degenerative changes. In this case the discs are collapsed and bulging and the ligaments are thick and buckled. 4 SIEMIONOW SPINE SURGERY www.kbspine.com History The natural history of cervical myelopathy is best summarized as a gradual, progressive worsening of symptoms and decline in functional status. The most common pattern is a stepwise progression of symptoms followed by periods of stable or worsening function and in rare instances, improvement[5, 6]. In a review of 120 patients, Clarke and Robinson identified a slow pattern of stepwise decline in function with intervals of stable neurologic function in 50% of patients, and a rapid pattern with stable intervals in 25% of patients[6]. In contrast, 20% of patients had a slow, continuous progression of symptoms without a stable period, while 5% were found to have a rapid deterioration of neurologic function. Lees and Turner similarly defined stepwise neurological dysfunction with quiescent intervals.[5] The authors additionally demonstrated that patients with long standing disease (>10 years) were more likely to be severely disabled than those earlier in the disease process. Causes The cause of cervical myelopathy is often multifactorial, but can be categorized into mechanical and vascular etiologies. [7]. Spinal cord compression can arise from birth defects, progressive degenerative changes, acute cervical disc herniation, hardening of ligaments (OPLL) or cervical deformity (kyphosis/translation). Congenital(present at birth), or developmental canal stenosis may be an underlying contributor to many, but not all, patients with symptomatic disease. A congenitally narrow canal provides less space than a normally open canal to accommodate for compressing strucutres or deformity. Progressive cervical degeneration (spondylosis), a common cause of CSM, contributes to compression by progressive cervical disc disease, degeneration of the facet( small joints located in the back of the spinal column) joints, degeneration of the joints of Luschka or uncinate joints(located outside of the disc), formation of bone spurs 5 SIEMIONOW SPINE SURGERY www.kbspine.com (ostephytes), and thickening or infolding of the ligaments (like ligamentum flavum)[8, 9]. Additionally, compression can arise from other structures such as acute disc herniations or ligament calcification. All of these compressive structures act as a space-occupying mass within the fixed volume of the cervical spinal canal. Cross section through spinal column of a cadaver demonstrating bone spurs(white arrow) and ligament thickening and buckling(black arrow). These changes contribute to spinal cord compression. 6 SIEMIONOW SPINE SURGERY www.kbspine.com Cervical deformities such subaxial subluxation, seen in rheumatoid disease, can contribute to CSM by further diminishing the spinal canal volume. Deformities such as cervical kyphosis may result in a mechanical stretch to the spinal cord and subsequent CSM symptoms. These mechanical factors may be worsened by neck motion resulting in repetitive trauma to the cervical cord. In addition to pure mechanical effects on the spinal cord, CSM symptoms may also be due to spinal cord ischemia(lack of sufficient blood flow). These ischemic changes are likely secondary to direct compression or direct spinal cord stretch and may lead to further nerve cell injury.[10] 7 SIEMIONOW SPINE SURGERY www.kbspine.com They may account for the stepwise progression of symptoms seen in patients with otherwise stable radiographic findings. Maintenance of spinal cord blood flow, possibly through collateral circulation, may explain how some patients remain asymptomatic despite significant cord compression or deformation. Clinical Presentation Due to its wide spectrum of causes, this degenerative process results in various clinical presentations. In the early stages, neck pain is a common complaint, with cervical 8 SIEMIONOW SPINE SURGERY www.kbspine.com radiculopathy(pain radiating down the arm) and myelopathy seen in more advanced disease. Some patients report neck pain as a significant component of their symptoms, while others have little or no such symptoms[11]. Numbness or paresthesias in the hands, that is often associated with a loss of hand coordination, is another common complaint. This may be manifested as an inability to distinguish items such as coins in ones pocket, or an inability to perform delicate tasks such as tying shoes or buttoning a shirt[4]. Complaints of difficulty with writing, or an unexplained change in handwriting are also common[8]. Patients may report that they cannot tell the temperature of water, although they can tell that their hand is submersed[12]. Patients may complain of arm pain, which is most commonly travels down one of the arms (radiculopathy). [11]. Concomitant radiculopathy is one of the most common presenting symptoms and may be seen in more than 40% of patients with CSM [13, 14].10,18. The same degenerative changes that contribute to central stenosis and result in spinal cord compression, such as a bone spur or herniated disc, may impinge on the neural foramen causing nerve root compression and the resultant radiculopathy. The presence of a concomitant radiculopathy can influence both treatment decision making as well as surgical planning. Problems with walking are very common and are often one of the first signs of spinal cord compression. Gait disturbance such as a loss of balance or unsteadiness when walking are the most common lower extremity complaints reported by patients with CSM and myelopathy should be considered in the differential diagnosis of a patient with a history of multiple, unexplained falls [14, 15]. Hip muscle weakness can be profound in these patients and may contribute to difficulty with getting out of a chair[8]. Additionally, a number of patients with CSM may present with primary complaints of low back and leg pain symptoms, often due to associated lumbar nerve compression. Although the 9 SIEMIONOW SPINE SURGERY www.kbspine.com frequency of symptomatic lumbar nerve compression is unknown, the incidence of anatomic stenosis has been reported to be 5 to 25% of patients.[16, 17]. In advanced cases of CSM, patients may have bladder or bowel impairment – symptoms that are usually associated with a poor prognosis for recovery[18]. Urinary symptoms vary and may consist of urinary frequency, urgency, incontinence, or urinary retention. The incidence of these symptoms varies with 15 to 50% being reported in the literature [19, 20]. Bladder dysfunction was demonstrated in 15% and bowel dysfunction in 18% out of 269 patients with CSM[19]. In a clinical series involving CSM patients older than age 55, 20% exhibited bladder dysfunction with urinary retention of varying degrees[21, 22]. The “presence of neurogenic bladder was closely correlated with severe leg symptoms”[23]. Other Causes Mimicking CSM Diagnosing CSM is a challenge that requires a high degree of clinical suspicion. There are other diseases that can mimic CSM. Complaints of difficulty with ambulating and reduced hand dexterity should alert the examining physician to the possibility of an underlying myelopathy. There are several other conditions that can mimic CSM on initial presentation such as multiple sclerosis, ALS(Lou Gehrig’s disease), or polio among others. [44, 45]. Most of these conditions can easily be distinguished from CSM based on characteristic MRI findings which document spinal cord compression. Treatment If you were diagnosed with CSM then you need to consult a spine surgeon. Make sure that your surgeon is board certified and has completed a fellowship in spine surgery. Since CSM is a progressive problem, early surgical intervention is warranted in a patient who presents with significant spinal cord compression and symptoms. In patients with radiographic evidence of canal narrowing, with or without cord compromise, and only 10 SIEMIONOW SPINE SURGERY www.kbspine.com mild symptoms, such as neck stiffness and no radicular or myelopathic symptoms, initial conservative management with close follow-up is appropriate and has shown equivalent results to operative treatment.[46] Nonsurgical treatments for patients with mild symptoms include cervical immobilization, pain medication, and physical therapy. There is often apprehension associated with nonsurgical management , for both the patient and the physician since it has been reported that symptomatic patients may deteriorate neurologically during conservative treatment, causing many to advocate earlier surgical intervention[47]. Many have also advocated surgical management in asymptomatic patients to prevent spinal cord injury from minor trauma despite the lack of evidence to support this recommendation. There is no strong clinical evidence (grade I, II, or III) to support prophylactic spinal cord decompression and, therefore, asymptomatic patients are best managed through serial clinical examination. Surgical treatment for patients with moderate to severe symptoms is often recommended. A number of treatment options exist – anterior decompression and fusion, posterior laminectomy, posterior laminaplasty, posterior laminectomy and fusion, and combined anterior and posterior procedures. Alignment of the spine, location of cord compression (front vs back), flexibility of the spine, the presence of deformity(angulation), the number of levels involved, and surgeon preference all influence decision making. Deciding the approach, number of levels, fusion vs nonfusion techniques remain controversial, with little widespread agreement. Each has demonstrated potential benefits and as well as risks. Overall, outcomes of surgical decompression, among symptomatic patients, have been demonstrated to be superior to nonoperative treatment in functional status, pain relief, and neurological status.[48] Negative predictors of postoperative recovery include: poorer preoperative neurological status, longer duration of symptoms, and advance patient age.[8] 11 SIEMIONOW SPINE SURGERY www.kbspine.com Summary Cervical spondylotic myelopathy is a slowly progressive process resulting from age related degenerative changes in the spine that can lead to significant functional disability. Once myelopathic symptoms are present, most patients with will require surgery to decompress the spinal cord and prevent further functional deterioration. 12 SIEMIONOW SPINE SURGERY www.kbspine.com References 1. 2. . 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. Fehlings MG, S.G., A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury. Spine 23:2730-2737, 1998. WF:, Y., Cervical spondylotic myelopathy: a common cause of spinal cord dysfunction in older persons. Am Fam Physician 62:1064-1070, 1073, 2000 Dillin W, B.R., Cuckler J, et al:, Cervical radiculopathy. A review. Spine 11:988991, 1986. Bernhardt M, H.R., Blume HW, et al: , Cervical spondylotic myelopathy. J Bone Joint Surg Am 75:119-128, 1993. Lees F, T.J., Natural history and prognosis of cervical spondylosis. BMJ 1963;2:1607-1610. Clarke E, R.P., Cervical myelopathy: A complication of cervical spondylosis. Brain 1956;79:483-510. HH:, B., Cervical spondylosis and myelopathy. Instr Course Lect 44:81-97, 1995. Bohlman HH, E.S., The pathophysiology of cervical spondylosis and myelopathy. Spine 13(7):843-846, 1988. L:, B., Adverse Mechanical Tension in the Central Nervous System (ed 2). 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Emery SE, B.H., Bolesta MJ, et al: , Anterior cervical decompression and arthrodesis for the treatment of cervical spondylotic myelopathy: two to seventeen-year follow-up. J Bone Joint Surg Am 69:21513 SIEMIONOW SPINE SURGERY www.kbspine.com 219, 1987. 19. Hukuda S, M.T., Ogata M, et al: , Operations for cervical spondylotic myelopathy. J Bone Joint Surg Br 67:609-615, 1985. 20. Lunsford LD, B.D., Zorub D: , Anterior surgery for cervical disc disease. Part 2. J Neurosurg 53:12-19, 1980. 21. Epstein N, E.J., Carras R. , Cervical spondylostenosis and related disorders in patients over 65: Current managment and diagnosis techniques. Orthotransactions 11:15, 1987. 22. W., D., Clinical Syndromes in Cervical Myelopathy. Rothman-Simeone The Spine 5th edition. Philadelphia, Saunders Elsevier, 2006. pp 784-794. . 23. Mochida K, S.K., Andou M., Urodynamic and electrophysiologic study of the urinary disturbances caused by cervical myelopathy. J Spinal Disord. 1996 Apr;9(2):141-5. 24. Newton HB, R.G., Lhermitte’s sign as a presenting symptom of primary spinal cord tumor. J Neurooncol 29(2):183-188, 1996. 25. Small JM, D.W., Watkins RG: , Clinical syndromes in cervical myelopathy, in: Herkowitz H, Garfin SR, Balderson RA, et al (eds): The Spine (ed 4). Philadelphia, PA, W.B. Saunders Co., 1999, pp 465-474. 26. Dillin WH, W.R., Clinical syndromes in cervical myelopathy. Cervical disc disease, in Rothman RH, Simeone FA (eds): The Spine (ed 3). Philadelphia, PA, WB Saunders, 1992, pp 560-570. 27. Houten J., E.T., Cervical Spondylotic Myelopathy and Radiculopathy: Natural History and Clinical Presentation. The Cervical Spine. Editor Charles Clark. (4th ed.). pp 735. Philadelphia 2005. 28. Good DC, C.J., Wacaser L.: , “Numb, clumsy hands” and high cervical spondylosis. Surg Neurol 22(3):285-291, 1984. 29. Watson JC, B.W., Smith MM, et al: , Hyperactive pectoralis reflex as an indicator of upper cervical spinal cord compression: report of 15 cases. J Neurosurg 86(1):159-161, 1997. 30. Shimizu T, S.H., Shirakura K., Scapulohumeral reflex (Shimizu). Its clinical significance and testing maneuver. Spine. 1993 Nov;18(15):2182-90. . 31. Law MD Jr, B.M., White AA 3rd: , Evaluation and management of cervical spondylotic myelopathy. Instr Course Lect 44:99-110, 1995. 32. Heller J., P.F., Gill S., Anatomy of the Cervical Spine. The Cervical Spine. Editor Charles Clark. (4th ed.). pp 1-35. Philadelphia 2005. 33. Rhee JM, H.T., Heflin J., Incidence of Physical Signs in Cervical Myelopathy: A Prospective Controlled Study. Presented at the CSRS Annual Meeting in San Francisco, CA. 2007. 34. Matsunaga S, S.T., Taketomi E, et al: , The natural course of myelopathy caused by ossification of the posterior longitudinal ligament in the cervical spine. Clin Orthop Relat Res 305:168-177, 1994. 14 SIEMIONOW SPINE SURGERY www.kbspine.com 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. Jr:, A.J., The clinical manifestations of spondylochondrosis (spondylosis) of the cervical spine. Ann Surg 141:872-889, 1955. Wilkinson HA, L.M., Ferris EJ:, Clinical-radiographic correlations in cervical spondylosis. J Neurosurg 30:213-218, 1969. Al-Mefty O, H.L., Middleton TH, et al: , Myelopathic cervical spondylotic lesions demonstrated by magnetic resonance imaging. J Neurosurg 68:217-222, 1988. Matsuda Y, M.K., Tada K, Yasuda A, Nakayama T, Murakami H, Matsuo M., Increased MR signal intensity due to cervical myelopathy. Analysis of 29 surgical cases.J Neurosurg. 1991 Jun;74(6):887-92. Boden SD, M.P., Davis DO, et al: , Abnormal magnetic resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 72(8):1178-1184, 1990. S, N., The pathogenesis of the spinal cord disorder associated with cervical spondylosis. Brain, 1972;95: 87-100. Naderi S, Ö.S., Pamir MN, Özek MM, Erzen C: , Cervical spondylotic myelopathy: surgical results and factors affecting prognosis. Neurosurgery 43:43–50, 1998. Benzel EC, L.J., Kesterson L, Hadden T., Cervical laminectomy and dentate ligament section for cervical spondylotic myelopathy. J Spinal Disord. 1991 Sep;4(3):286-95. Ranawat CS, O.L.P., Pellicci P, Tsairis P, Marchisello P, Dorr L., Cervical spine fusion in rheumatoid arthritis. J Bone Joint Surg Am. 1979 Oct;61(7):1003-10. Lapsiwala S., T.G., Myelopathy: Diagnosis and Differential Diagnosis. The Cervical Spine. Editor Charles Clark. (4th ed.). pp 199-219. Philadelphia 2005. WF., Y., Cervical spondylotic myelopathy: a common cause of spinal cord dysfunction in older persons. Am Fam Physician. 2000 Sep 1;62(5):1064-70, 1073. Review. Kadanka, Z., et al., Approaches to spondylotic cervical myelopathy: conservative versus surgical results in a 3-year follow-up study. Spine, 2002. 27(20): p. 220510; discussion 2210-1. AH., R., Myelopathy due to cervical spondylosis treated by collar immobilization. Neurology 1966;16:951-4. Sampath, P., et al., Outcome of patients treated for cervical myelopathy. A prospective, multicenter study with independent clinical review. Spine, 2000. 25(6): p. 670-6. 15 SIEMIONOW SPINE SURGERY www.kbspine.com 16 SIEMIONOW SPINE SURGERY www.kbspine.com Figure Legend Figure 1. Sagittal T2 weighted MRI showing compression of the spinal cord at C3-C4 with increased signal in the cord (arrow) indicative of myelomalacia. 17 SIEMIONOW SPINE SURGERY www.kbspine.com NOTES 18
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