Wellbeing Through Technology Alma SweatX No Sweat, No Smell Alma SweatX No Sweat, No Smell Lasting Results by Combined Technologies Immediate Improvement & No Side Effects No Toxin No Pain 2 Agenda Hyperhidrosis & Body Odor The Need Sweat Glands Currently Available Treatments Treatment Goals & Clinical Challenges Alma SweatX Before & After Pictures Alma’s Proprietary Technologies Clinical Protocol Alma’s Hyperhidrosis System Alma SweatX VS Competitors 3 Hyperhidrosis HYPERHIDROSIS DISEASE SEVERITY SCALE (HDSS) Never noticeable and never interferes with my daily activities Tolerable but sometimes interferes with my daily activities Barely tolerable and frequently interferes with my daily activities Intolerable and always interferes with my daily activities 4 Body Odor 5 The Need 6 Sweat Glands Excessive Sweating - Hyperhidrosis Eccrine Sweat Glands Located over the Entire Body surface Body Odor – Osmidrosis Apocrine Sweat Glands Limited in their distribution to Axillary, and Genital Region At a Depth of 2-4 mm At a Depth of 6-8 mm Pass through the Dermis and Epidermis, open up and empty directly to the skin Associated with Hair Follicles and open up at the hair follicles Mainly a mixture of Water and Salts Produce a thick fluid, which in contact with Bacteria on the skin’s surface 7 Sweat Glands Excessive Sweating - Hyperhidrosis Eccrine Sweat Glands Located over the Entire Body surface Body Odor – Osmidrosis Apocrine Sweat Glands Limited in their distribution to Axillary, and Genital Region At a Depth of 2-4 mm At a Depth of 6-8 mm Pass through the Dermis and Epidermis, open up and empty directly to the skin Associated with Hair Follicles and open up at the hair follicles Mainly a mixture of Water and Salts Produce a thick fluid, which in contact with Bacteria on the skin’s surface 8 Botox Botox – Inhibits release of ACh (chemical signals from the nerves) that stimulate the sweat glands Procedure Needle is used to inject tiny amounts of Botox every 1 to 2 cm Some sweat glands may be missed, as a result the patient may continue to experience some sweating Protocol Every 6 months Time In a clinical study, the median duration of response in BOTOX ® patients was 6.7 months Anesthesia Numbing Cream / Vibration/ Ice The actual treatment takes about 10 to 15 minutes Pain Injection-site pain and Bleeding BOTOX ® Side Effect Side effects of BOTOX® include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems Cost 800$ - 1,200$ 9 miraDry miraDry – Energy to eliminate the Sweat Glands. “Cellular Thermolysis occurs at 550 - 600 C” Procedure Microwave Device working Stationary with Vacuum Some sweat glands may be missed, as a result the patient may continue to experience some sweating Protocol Time 2 Treatments are typically recommended, 3 months apart Anesthesia The area is numbed After Treatment - pain medication and use of ice packs for a few days Pain 60 minutes, with treatment itself taking approximately 40 minutes Side Effect Localized soreness or swelling is normal, and typically clears within a few weeks Painful Cost 3,000$ short-term altered sensation in the skin of their underarms or upper arms 10 Hyperhidrosis - Treatment Goals Deactivate Eccrine & Apocrine Sweat Glands Taking care of Hyperhidrosis & Body Odor *The underarms house less than 2% of the body’s sweat glands 11 Hyperhidrosis - Clinical Challenges Selectively Deactivate Eccrine & Apocrine Glands Treatment must include Selective & Focused & Effective Energy Focused Energy 12 Alma SweatX No Sweat, No Smell Lasting Results by Combined Technologies Immediate Improvement & No Side Effects No Toxin No Pain 13 Alma SweatX - Patient #1 Before Iodine Test Right Left After 4 Treatments Iodine Test Right Left After 3 Months Follow Up Iodine Test Right Left Courtesy of Prof. Pinson. Moscow 14 Alma SweatX - Patient #2 Before Iodine Test Right Left After Right Left Courtesy of Prof. Pinson. Moscow 3 Months Follow Up Iodine Test 15 Alma SweatX - Patient #3 Before Iodine Test Right Left After 4 Treatments Iodine Test Right Left After 3 Months Follow Up Iodine Test Right Left Courtesy of Prof. Pinson. Moscow 16 Alma SweatX - Patient #4 Before Iodine Test Right Left After 4 Treatments Iodine Test Right Left After 3 Months Follow Up Iodine Test Right Left Courtesy of Prof. Pinson. Moscow 17 Alma SweatX - Patient #5 Before Iodine Test Right Left After 4 Treatments Iodine Test Right Left After 3 Months Follow Up Iodine Test Right Left Courtesy of Prof. Pinson. Moscow 18 Alma SweatX - Patient #6 Before Iodine Test Right Left After 4 Treatments Iodine Test Right Left After Right Left Courtesy of Prof. Pinson. Moscow 6 Months Follow Up Iodine Test 19 Alma SweatX - Patient #7 Before Iodine Test Right Left After After 1Treatment Iodine Test Right Left Courtesy of Prof. Pinson. Moscow 20 Alma’s Proprietary UniPolar & CoaxiPolar Technology DIELECTRIC HEATING Selective & Effective Heating Electrical Field of 40.68 MHz creates Rotation of Water Molecules within the tissue The Rotation creates Friction Effective Heat via Friction Sweat Glands Mainly a mixture of Water Selective & Effective 21 Alma’s Proprietary UniPolar & CoaxiPolar Technology IMPEDANCE MATCHING Powerful Heating Body Impedance is ~300 ohms Perfect Matching for RF is 50 ohms Alma Matching the Impedance to a minimum reflection – Decreases Reflection & Increases Transmissio Powerful Energy in order to Deactivate Sweat Glands Powerful Heating 22 Alma’s Proprietary CoaxiPolar Technology COAXIPOLAR Focused Heating Transmits 40.68 MHz RF transmissions up to 6mm Depth CoaxiPolar works Via a Coaxial Electrodes Increase and Maintain the Skin temperature in 40-48°C without causing any patient discomfort 23 Alma’s Proprietary UniPolar Technology UNIPOLAR Focused Heating Transmits 40.68 MHz RF transmissions up to 20mm Depth UniPolar works Via a Single Electrode Increase and Maintain the Skin temperature in 40-48°C without causing any patient discomfort 24 Alma’s Proprietary New Technology NEW – UNIPOLAR & COAXIPOLAR PRO Focused Heating Dynamic Phase Control - Control Depth of Heat Heating the Relevant Layer for greater Treatment Control Phase Control Sweat Glands located in Multiple Depths Focused Heating 25 UniPolar & CoaxiPolar LASTING RESULTS BY COMBINED TECHNOLOGIES UniPolar Pro CoaxiPolar Pro Alma Sweat X Selective & Effective & Focused Heating to Deactivate Eccrine and Apocrine Sweat Glands 26 Cooling Tip & Thermometer • Easy Handling • No Preparation • No Anesthesia • Cooling of Skin Surface • No Disposables CoaxiPolar Pro UniPolar Pro Thermometer C° or F° 27 Alma SweatX Treatment CLINICAL PROTOCOL UniPolar Pro 6 min for Axilla CoaxiPolar Pro 4 min for Axilla Only 20 min. Treatment 2-4 Treatments TR1 TR2 TR3 28 Alma’s Hyperhidrosis System Alma SweatX Hyperhidrosis & Osmidrosis No Pain No Side Effects User Friendly Interface No Disposables 29 Alma SweatX BENEFITS OF WORKING WITH ALMA Highest ROI Easy to Delegate No Disposables Short Treatment 30 Alma SweatX VS Competitors Alma Sweat X miraDry Botox Treat Hyperhidrosis Treat Body Odor - Osmidrosis Lasting Results Immediate Improvement Selectively Deactivate Sweat Glands No Pain No Anesthesia No Side Effects Short Treatment No Possible Misses No Recovery Time Easy to Delegate No Disposables No Toxin 31 THANK YOU