Long-lasting net treatment for the control of malaria vectors

Long-lasting net treatment for the control
of malaria vectors
Highly effective treatment for new or used
mosquito nets and curtains
Can withstand a minimum of 20 washes and still
remain effective
Water-based, low odor formulation
Treatment kit available for individual use
READ THE LABEL BEFORE YOU BUY: USE PESTICIDES SAFELY.
ICON® 10CS contains lambda-cyhalothrin
ICON® is a registered trademark of Syngenta Group Company
© Syngenta 2007
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CH-4002 Basel, Switzerland
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Email: [email protected]
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such as is expressly set forth herein. UNDER NO CIRCUMSTANCES SHALL SYNGENTA AND ITS AFFILIATES BE LIABLE
FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THEIR PRODUCTS.
No statements or recommendations contained herein are to be construed as inducements to infringe any relevant
patent now or hereafter in existence. ©2005 Syngenta. Syngenta Crop Protection AG, Basel, Switzerland
Long-lasting treatment
for mosquito nets
and curtains
Knockdown of Aedes aegypti
Knockdown
of exposure
Aedes aegypti
after
3-minute
to washed
aftertreated
3-minute
exposure
to washed
nets
with
ICON Maxx
nets treated with ICON Maxx
What is ICON Maxx?
ICON® Maxx is the new and innovative long-
This continual drive to improve the lives of those at
ICON Maxx is an insecticide treatment designed to convert existing
lasting treatment for mosquito nets and curtains
risk of vector borne disease throughout the world has
or new untreated mosquito nets into long-lasting insecticide-treated nets.
offering protection against mosquitoes and
led to the development of ICON Maxx, an individual
It is based on the WHO-approved capsule suspension formulation of
malaria.
long-lasting insecticide net treatment.
lambda-cyhalothrin, ICON 10CS, plus a polymer binding agent.
An ICON Maxx treatment is easy to apply
Insecticide-treated nets are a widely supported tool
The advanced capsule suspension technology used in ICON 10CS allows
and will withstand at least 20 washes whilst
used in malaria prevention and vector control
the controlled release of insecticide over time. The addition of the
maintaining effectiveness.
campaigns worldwide. They can be used either alone
polymer binder helps retain the capsules on the net fiber during washing.
or in combination with other key vector control
This innovative combination provides protection from mosquitoes for at
For many years Syngenta and its legacy companies ICI
measures such as indoor residual spraying (IRS) with
least 20 washes.
and Zeneca Public Health have been at the forefront
ICON 10CS as part of an integrated approach to
of developing new and innovative solutions for
disease prevention.
to the introduction of products for indoor residual
Sleeping under a bed net protects the user from
spraying, mosquito net treatment, space spraying and
mosquito bites by either repelling or killing them.
Performance of ICON Maxx
mosquito larviciding.
This reduces the risk of malaria transmission
The efficacy of ICON Maxx treated nets has been determined in indepen-
and provides the user with an improved sleeping
dent laboratory studies. Tunnel tests (see Figure 1) undertaken by the
experience through reduced disturbance.
London School of Hygiene and Tropical Medicine demonstrate that after
20 washes, nets treated with ICON Maxx still provide effective control
However, many nets untreated by insecticide remain
of Anopheles gambiae mosquitoes (Yates and Rowland, 2007).
in the field, leaving the user at increased risk of
contracting malaria.
Further studies in Tanzania also demonstrate the effectiveness of
ICON Maxx treated nets (see Figure 2). Anopheles gambiae were exposed to
Withstands at least 20 washes
Can be used to treat new or used nets
Kills mosquitoes in addition to repelling
further improves the safety profile of the product. ICON 10CS is in a
low WHO hazard category – class 3 – unlikely to present acute hazard
in normal use.
them
A water-based low-odor formulation
Available as a convenient treatment kit
containing everything required to treat
The Maxx binding agent is considered to meet US EPA criteria as a low risk
polymer (represents minimal or no risk to man).
Label recommendations should be followed at all times.
a net.
25 washes
30 washes
gambiae
Figure 2. exposure
Mortalityto
ofwashed
An. gambiae
following
following
to washed
ICON
Maxxexposure
treated nets
ICON Maxx treated nets
et al, 2007).
environmental safety profile. The encapsulated nature of the formulation
20 washes
% blood feeding
% mortality
Figure 2. Mortality of An.
inhibition
treated nets is exceeding the WHOPES criteria of 80% mortality (Rowland
ICON 10CS used in ICON Maxx has an excellent toxicological and
30 washes
30 washes
0
% mortality
% mortality
treatment
25 washes
25 washes
20
The results show that even after 25 washes the efficacy of ICON Maxx
Safety Profile
20 washes
20 washes
100
100
Figure 1. Efficacy of nets treated
80
80 with ICON Maxx against An. gambiae
60 in Tunnel assays
After 30 washes
60
After
After 20
30 washes
washes
Unwashed
40
After 20 washes
100
Unwashed
40
20
80
20
0
600
After 30 washes
% blood feeding
% mortality
After 20 washes
inhibition
% blood
feeding
% mortality
Unwashed
40
inhibition
% mortality
Long-lasting effect from a single
90
90
95
Figure 1. Efficacy of nets treated
Figure
1. Efficacy
of netsAn.
treated
with
ICON
Maxx against
gambiae
with
ICONassays
Maxx against An. gambiae
in
Tunnel
in Tunnel assays
washed nets for three minutes and assessed for mortality after 24 hours.
MAIN BENEFITS OF
ICON MAXX FOR USERS
95
95
100
Knockdown of Aedes aegypti
after 3-minute exposure to washed
nets treated with ICON Maxx
90
The treatment of the nets is a simple and easy process that can be undertaken in the field or factory.
the control of insect vectors of disease. This has led
% knockdown
% knockdown % knockdown
Introducing ICON Maxx
100
100
100
100
80
80
60
60
40
40
100
20
20
80
0
0
60
Figure 2. Mortality of An. gambiae
following exposure to washed
ICON Maxx treated nets
21 washes
21 washes
25 washes
25 washes
40 An.gambiae mortality at 24 hrs after 3 minute
exposure
in cone
test at 24 hrs after 3 minute
An.gambiae
mortality
Line denotes efficacy criteria as set by WHOPES
20 exposure in cone test
Line denotes efficacy criteria as set by WHOPES
0
21 washes
25 washes
References
An.gambiae
mortality
24 hrs after
3 minute
Yates, A and
Rowland,
Mat(2007)
Evaluation
exposure in cone test
of a Long Lasting
Insecticidal
Net
(LLIN)
Treatment
Line denotes efficacy criteria as set by WHOPES
produced by Syngenta. Unpublished
Rowland M, Mosha F, Magesa S, Lyimo I,
Tungu P, Malima R, Maxwell C and Yates A
(2007) Evaluation of ICON Maxx long lasting
insecticide net treatment in experimental huts in
Tanzania. Unpublished
An ICON capsule bound to a mosquito net