An Invitation to Health – Chapter 12 Avoiding Addictions Prepared by: Richard C. Krejci, Ph.D. Professor of Public Health Columbia College of SC 3.27.15 Chapter Objectives Describe the harmful effects of addictions on every dimension of health. Identify the risk factors for all addictions. Compare and contrast the reasons students choose to use or not use drugs. Give examples of appropriate and inappropriate use of over-the-counter and prescription medications. Categorize the types of drug dependence, and discuss contributing factors. Identify the common drugs of abuse; their street names; how they are abused; acute effects; and health risks. Describe the treatment methods available for individuals seeking help for drug dependence. Evaluate your drug use history (legal and illegal) and identify strategies to decrease risky behaviors. The Impact of Addictive Behaviors on the Dimensions of Health • Physical Health • Impair organ systems • May cause disease, disability, and premature death • Psychological Health • Addictive behaviors • “self-medicating” • May lead to depression and anxiety, guilt, and shame • Spiritual Health and Environmental Health • Loss of connection with others • Loss or destruction of property due to accidents • Social Health • Withdrawal from social interactions • Isolation • Intellectual Health • Loss of concentration, logic, reasoning, and critical thinking Characteristics Of College Drug Users Risk Factors For Problem Gambling • Male sex. • Gambling at an early age. • A big win earlier in one’s gambling career. • Consistently chasing losses. • Gambling alone. • Feeling depressed before gambling. • Feeling excited and aroused during gambling. • Behaving irrationally during gambling • Poor grades at school. • Other addictive behaviors. • Lower socioeconomic class. • Parents with a gambling or other addiction problem. • A history of delinquency or stealing money to fund gambling. • Skipping class to go gambling. Why Students Use Drugs Genetics/Family History Sexual Identity Parental Attitudes Alcohol Use and/or Race/Ethnicity Gambling Psychological Reasons Why Students Use Drugs Why Students Don’t Use Drugs Spirituality and Religion Academic Engagement Athletics Understanding Drugs and Their Effects Drug Any substance, other than food, that affects bodily functions and structures when taken into the body. Drug Misuse The use of a drug for a purpose (or person) other than that for which it was medically intended. Drug Abuse The excessive use of a drug in a manner inconsistent with accepted medical practice. Understanding Drugs and Their Effects Dosage and Toxicity Dose/response curve Detoxification enzymes (liver) Individual Differences Psychology Anatomy Gender Setting or Environment Six Routes of Taking a Drug Four Types of Drug Interactions Routes of Administration Routes of Administration of Drugs Transdermal Fig. 12.1, p. 379 Drug to Drug Interactions Additive (Drug A + Drug B) Synergistic (Drug A + Drug B > A or B) Be able to define each term Potentiating Antagonistic (Drug A or B) > any drug (Drug A < Drug B) Caffeine and Its Effects Facts • • The most widely used psychotropic (mind-affecting) drug in the world. 80% of Americans drink coffee, our principal caffeine source – an average of 3.5 cups per day. Caffeine and Its Effects General Bodily Effects • Relieves drowsiness, helps in performance of repetitive tasks, and improves the capacity for work. • Improves performance and endurance during prolonged, exhaustive exercise, and to a lesser degree, enhances short-term, highintensity athletic performance. • Improves concentration, reduces fatigue, and sharpens alertness. Caffeine and Its Effects Health Effects • A few cups of coffee per day is safe and may offer some benefits such as lowering the risk for type 2 diabetes, and reducing the likelihood of gallstones, Parkinson’s disease, and colon cancer. High Dosage Effects • Dependence, anxiety, insomnia, rapid breathing, upset stomach and bowels, and dizziness. Table 12-2, p. 392 Caffeine Content in Selected Soft Drinks Drink Company Milligrams of Caffeine in 12 oz. Mountain Dew MDX PepsiCo 120 JOLT Wet Planet 72 Diet Pepsi Max PepsiCo 70 Mountain Dew Code Red PepsiCo 55 Mountain Dew PepsiCo 55 Mello Yello Coca-Cola 51 Diet Coke Coca-Cola 45 Dr. Pepper Cadbury 41 Pepsi-Cola PepsiCo 38 7-Up 7-Up/Dr. Pepper 0 Commonly Misused Over-The-Counter (OTC) Drugs • Analgesics • • • • Cough Syrup • • • • • Aspirin Nonsteroidal AntiInflammatory Drugs Ibuprofen DXM Nasal Sprays Laxatives Eye Drops Sleep Aids Prescription Drugs Potential Complications Non-adherence Recurrent infections, serious medical complications, and emergency hospital treatment. Physical Side Effects Heart failure, heart attack, seizures, kidney and liver failure, severe blood disorders, birth defects, blindness, memory problems, and allergic reactions. Psychological Side Effects Depressive symptoms vs. agitation and anxiety. Drug Interactions OTC drugs, prescription drugs, alcohol, vitamins and minerals, and food components. Generic Drugs Have the same active ingredients as brand-name prescriptions, but their fillers and binders, which can affect the absorption of a drug, may be different. Prescription Drug Abuse Is Increasing Highest nonmedical use of prescription medication is among young adults age 18 to 25 Most widely abused medications are prescription stimulants and pain killers Key Terms Related to Drug Use • • • • • • • Psychoactive – “mind altering” Addiction - A behavioral pattern characterized by compulsion, loss of control, and continued repetition of a behavior or activity in spite of adverse consequences. Psychological Dependence - The emotional or mental attachment to the use of a drug. Physical Dependence - The physiological attachment to, and need for, a drug. Intoxication - Maladaptive behavioral, psychological, and physiologic changes that occur as a result of substance abuse. Withdrawal - Development of symptoms that cause significant psychological and physical distress when an individual reduces or stops drug use. Polyabuse - The misuse or abuse of more than one drug at a time. What Causes Drug Dependence and Abuse? The Biology of Dependence • Dopamine The Psychology of Vulnerability • Difficulty controlling impulses, a lack of values that may constrain drug use, low self-esteem, feelings of powerlessness, denial, anxiety, and depression. Early Influences • Lower socioeconomic backgrounds, family instability, a lack of realistic, rewarding alternatives and role models, and increased hopelessness. • Teen Drug Use • Early use of tobacco and alcohol is linked with a greater likelihood of marijuana use, which in turn increases the likelihood of other illegal drug use. The Biology of Dependence: Dopamine Levels For Cocaine Terminal of neuron Uptake pump Synapse Dopamine receptor Dendrite of adjacent neuron Dopamine Cocaine Fig. 12.2, p. 400 Drugs and Driving • Alcohol affects perception, coordination, and judgment. • Marijuana affects a wide range of motor skills. • Sedatives, hypnotics, and anti anxiety agents slow reaction time. • Amphetamines, after repeated use, impair coordination. • Hallucinogens distort judgment. Categories for Common Drugs Of Abuse Cannabis Club Drugs/ Designer Drugs Stimulants Depressants Hallucinogens Inhalants Marijuana MDMA, MDA, MDEA Amphetamines Benzodiazepines LSD Solvents Methamphetamine Rohypnol PCP Gases Cocaine Barbituates GHB Ketamine Nitrites Opioids (pain killers) Cannabis Marijuana and Hashish The Facts • Marijuana is the most widely used illegal drug in the United States (~12 million Americans). • Derived from the cannabis plant that contains the active ingredient THC. How Users Feel • A mild sense of euphoria, a sense of slowed time, a dreamy type of self-absorption, and some impairment in thinking and communicating. • The euphoria peaks within a half hour and usually lasts about three hours. • Potential for marijuana withdrawal syndrome. Negative Long-Term Effects Brain and central nervous system • Dulls sensory and cognitive skills • Impairs short-term memory • Alters motor coordination • Causes changes in brain chemistry • Leads to difficulty in concentration, attention to detail, and learning new, complex information Cardiovascular system • Increases heart rate • Increases blood pressure • Decreases blood flow to the limbs, which in extreme cases could require an amputation Respiratory system • Damages the lungs (50% more tar than tobacco) • May cause lung cancer • May damage throat from inhalation Reproductive system • In women, may impair ovulation and cause fetal abnormalities if used during pregnancy • In men, may suppress sexual functioning and may reduce the number, quality and mobility of sperm, possibly affecting fertility Positive Short-Term Therapeutic Effects for Patients Brain and central nervous system • May help minimize pain from the spread of cancer Vision • Reduces intraocular pressure, helping those afflicted with glaucoma Digestive system • Combats nausea from chemotherapy and helps minimize vomiting • Helps restore appetite in people who have lost weight from cancer or AIDS Muscular system • May help calm spasms from spinal-cord injury, multiple sclerosis, and possibly epilepsy Impact of Marijuana Fig. 12.3, p. 394 Common Names Of Club Drugs Ecstasy GHB Nitrites GBL Love drug hug Beans Herbal X Georgia home boy Cloud 9 Liquid Ecstasy Herbal bliss XTC G Grievous bodily harm Club Drugs (Designer Drugs) Ecstasy The Facts • Ecstasy is the common street name for methylene-dioxymethamphetamine (MDMA). • Has both stimulant and mildly hallucinogenic properties. Common Characteristics of Ecstasy Users • They are more likely to use marijuana, binge drink, spend more time socializing and less time studying, have more sexual partners, smoke cigarettes, rate parties as more important than academics, and view religion as less important. Club Drugs (Designer Drugs) GHB/GBL • • The Facts • GHB stimulates the release of human growth hormone, but has no known effects on muscle growth. • When GBL, an industrial solvent, is ingested it is converted to GHB. How Users Feel • Smaller doses induce euphoria and enhance sex due to a rise in dopamine in the brain. • Larger doses can cause individuals to pass out and possibly fall into a coma. The Risks of GHB/GBL Side Effects • Nausea, amnesia, hallucinations, decreased heart rate, convulsions, and sometimes blackouts/coma. Long Term Side Effects • Withdrawal reaction including rapid heartbeat, tremor, insomnia, anxiety, and occasionally hallucinations that last a few days to a week. • The danger is greatest when GHB is mixed with alcohol or opiates. Club Drugs Ketamine (K) The Facts • Ketamine is an anesthetic used by veterinarians. • K blocks chemical messengers in the brain that carry sensory input thereby leading to hallucinations. Side Effects • At high doses, K can cause delirium, amnesia, impaired motor function, high blood pressure, depression, and potentially fatal respiratory problems. Other Common Club Drugs Nitrites Herbal Ecstasy The Facts • Clear, amber-colored liquids especially abused in gay and bisexual men. • Used recreationally for a high feeling, a slowed sense of time, a carefree sense of wellbeing, and intensified sexual experiences. Side Effects • Headache, dizziness, a drop in blood pressure, changes in heart rate, increased pressure within the eye, and skin flushing. The Facts • A mixture of stimulants such as ephedrine, pseudosphedrine, and caffeine. • Sold as a “nautral” and safe alternative to ecstasy. Side Effects • Stroke, heart attack, and a disfiguring skin condition. Stimulants Amphetamines & Methamphetamine The Facts • • • Amphetamines trigger the release of epinephrine (adrenaline) which stimulates the central nervous system. Methamphetamine is a powerful addictive stimulant. Meth remains in the central nervous system and the body, producing prolonged stimulant effects. How Users Feel • Amphetamines produce a state of hyper-alertness and energy. • • High doses make users feel wired, talkative, excited, restless, irritable, anxious, and moody. Meth produces long-lasting toxic effects, including psychosis, violence, seizures, and cardiovascular abnormalities. Amphetamines & Methamphetamine Potential Side Effects • Binging and crashing. • Feelings of grandiosity, anxiety, tension, anger, agitation, paranoia, and impaired judgment. • Increased heart rate and blood pressure. Long Term Side Effects • Malnutrition, skin disorders, tooth loss, ulcers, insomnia, depression, vitamin deficiencies, sexual dysfunction, impaired concentration or memory, and, in some cases, brain damage. Prescription Stimulants • Abuse of stimulants prescribed for attention deficit/hyperactivity disorder (ADHD) has increased among young people, 18-25 years. • Most students who have tried stimulants so not feel that the drugs had a positive effect on their academic performance in the long run. Prescription Stimulant Abuse on Campus Stimulants (Cocaine) • Cocaine is a white crystalline powder extracted from the leaves of the South American coca plant. Routes of Administration • Sniffed/Snorted • Injected intravenously (speedballing) • Smoked (freebasing/crack) How Users Feel • Cocaine stimulates the central nervous system producing feelings of soaring well-being and boundless energy. • After a brief period of euphoria, users slump into depression. Central nervous system • Repeated use or high dosages may cause severe psychological problems • Suppresses desire for food, sex, and sleep • Can cause strokes, seizures, and neurological damage Some Effects Of Cocaine On The Body Nose • Damages mucous membrane Cardiovascular system • Increases blood pressure by constricting blood vessels • Causes irregular heartbeat • Damages heart tissue Respiratory system • Freebasing causes lung damage • Overdose can lead to respiratory arrest Reproductive system • In men, affects ability to maintain erections and ejaculate; also causes sperm abnormalities • In women, may affect ability to carry pregnancy to term Fig. 12.4, p. 403 Depressants Benzodiazepines and Barbiturates The Facts • Benzodiazepines are sedative-hypnotics and have largely replaced barbiturates. • Commonly prescribed for tension, muscular strain, sleep problems, anxiety, panic attacks, anesthesia, and in the treatment of alcohol withdrawal. • Rohypnol – date rape drug. How Users Feel • Low doses reduce or relieve tension, but may cause rapid mood changes, impaired judgment, and impaired social and occupational functioning. • High doses produce slurred speech, drowsiness, and stupor. Selected Benzodiazepines Generic Name Trade/Brand Name Medical Purpose alprazolam Xanax Tranquilizer chlordiazepoxide Librium Tranquilizer clonazepam Klonopin Anticonvulsant clorazepate Tranxene Tranquilizer diazepam Valium Tranquilizer slurazepam Dalmane Insomnia oxazepam Serax Tranquilizer triazolam Halcion Insomnia Dosages of these prescription drugs range from .5 mg to 30 mg Drug images taken from the DEA website Benzodiazepines and Barbiturates Side Effects • Physical and psychological dependence within two to four weeks. • Cross-tolerance. • Mood and behavior changes, slurred speech, poor coordination, unsteady gait, involuntary eye movements, impaired attention or memory, and stupor and coma. • Synergistic effect when used in combination with alcohol. Depressants Opioids (Narcotics: Opium, Morphine, Codeine, and Heroin) Prescription Opioids (Hydromorphine and Oxycodone) How Users Feel • All opioids relax the user, and impart feelings of euphoria while acting as powerful narcotics, or painkillers. Side Effects • Addiction, lethargy, weight loss, loss of sex drive, anxiety, insomnia and restlessness. • Overdose causes shock, coma, and depressed respiration. • Long Term Injection of Opioids: infections of the heart lining and valves, skin abscesses, and lung congestion. Treatment of Addiction Methadone Maintenance Hallucinogens Definition: a group of mind-altering drugs that affect the brain and nervous system bringing about changes in thought, self-awareness, emotion and sensation. Natural Sources Morning glories, jimsonweed, nutmeg, mace, of Hallucinogens peyote cactus, and psychedelic mushrooms Synthesized Hallucinogens LSD: lysergic acid diethylamide-24; a psychedelic drug that produces distorted reality. • PCP: an anesthetic that blocks nerve receptors from pain and temperature without producing numbness; angel dust, peace pill. • Inhalants Definition: drugs that produce vapors that cause psychoactive effects when inhaled or sniffed. Examples Potential Side Effects Model airplane glue, gasoline, paint thinner, transmission fluid, lighter fluid, liquid shoe polish, and fingernail polish remover. Gastroenteritis, depressed muscle tone, damage to the liver and kidneys, nervous system dysfunction, and bone marrow disorders. Inhalants – A Risk For Young People Only alcohol is more widely used than inhalants Slightly stimulated Effect Less inhibited Interference with thinking and impulse control Irritation of throat, lungs and nose Nausea and headache Risks Tolerance occurs Suffocation Cardiac arrhythmia Treating Drug Dependence and Abuse • • Recognize the reality of the problem. Consult a physician, counseling center, or local mental health clinic. Modes of Intervention • • • • Medical care Medication Detoxification Counseling • • • • Individual psychotherapy Marital and family therapy Behavior modification 12-step programs Stabilization and Self-Assessment Education Involvement of Significant Warning-sign Relapse-Prevention Planning Others Identification and Review of the Recovery Program Management Inventory Training Page 418 Choosing An Addiction Free Lifestyle • Set goals for getting help. • Participate in drug-free activities. • Educate yourself. • Choose friends with a future. The End This slide show was developed by: Richard C. Krejci, Ph.D. Professor of Public Health Columbia College of SC All Rights Reserved
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