CPG M2 CLINICAL MANAGEMENT OF BALANITIS GUIDELINE STATUS: FINAL 20/05/2008 REVIEW DATE: 20/05/2009 AUTHOR: MR BUSH, DM LEE SCOPE OF PRACTICE TARGET POPULATION • Male clients presenting with symptoms consistent with balanitis • Clients who present as asymptomatic with subsequent clinical findings of symptoms consistent with balanitis EXCLUSION CRITERIA • Clients with ongoing dermatological conditions such as lichen sclerosis, lichen planus, psoriasis, dermatitis, eczema, pre-malignant and malignant conditions, chronic skin conditions • Clients presenting with persistent symptoms post treatment • HIV positive clients who present with non STI associated dermatological symptoms GUIDELINE OBJECTIVES AND ANTICIPATED OUTCOMES • • • Provide treatment for symptomatic clients Identification of individual STI risk and provision of appropriate screening Identify public health risks to control infections by: • Provision of STI education and information • Identification and exploration of sexual risk taking behaviors • Partner notification and treatment as required • Test of reinfection/test of cure where appropriate • Monitoring antimicrobial resistance BACKGROUND CONDITION DESCRIPTION Balanitis is defined as inflammation of the glans penis, often involving the prepuce (balanoposthitis). It is not sexually transmitted but may occur after sexual contact. 1 Non specific balanitis is a common presentation. Inflammation has many possible causes, including irritation by environmental substances, physical trauma, and infection by a wide variety of pathogens, including bacteria, virus, or fungus, each of which require a particular treatment. Balanitis may be caused by candida, gardnerella and anaerobic infections. This condition typically causes pruritus and a red rash with white flat lesions on the glans penis, prepuce, coronal sulcus and shaft. 1,2 If inflammation continues, men may exhibit shallow ulcerations on the glans penis. 1,2,3 Candida balanitis occurs more frequently, and causes more symptoms in uncircumcised men. 1,2,3, 3 After unprotected intercourse with a woman who has Candida vaginitis, a man may experience transient erythema and burning of the glans penis. 2,4 Balanitis may cause oedema resulting in phimosis, or inability to retract the foreskin from the glans penis. Clinical Practice Guidelines for Sexual Health Nurse Practitioners Section M2 1 PRESENTING SYMPTOMS • Localised rash on glans and or prepuce • Pruritis • Soreness • Itch • Odour • Inability to retract foreskin • Discharge from the glans Table M2.1: Symptoms of Balanitis 1,2,3,4 (photos courtesy of MSHC) PRESENTING SIGNS • Erythema • Scaling • Ulceration • Fissuring • Crusting Exudate • Oedema • Leukoplakia • Sclerosis • Odour • Phimosis Table M2.2: Signs of Balanitis 1,2,3,4 (photos courtesy of MSHC) Predisposing factors such as HIV infection and diabetes should be considered. Clients with symptoms of diabetes, who are over 40 years of age, a family history of diabetes or recurrent candida balantitis should have a urine test to screen for glycosuria. 3,5,6 In diabetic clients the presentation may be more severe with oedema and fissuring of the foreskin present. 2,4 Recent use of oral antibiotics may also contribute to balanitis. 6 Candidal balanitis is considered the most common cause of balanitis usually caused by Candida albicans. 1,2 Other skin conditions may affect the glans penis, including • • • • • • • 2,3,4,5 Psoriasis Lichen planus Seborrheic dermatitis Phimosis Herpes simplex virus Malignant transformation Fixed drug reaction Clinical Practice Guidelines for Sexual Health Nurse Practitioners Section M2 2 INVESTIGATIONS AND DIAGNOSIS Diagnosis includes careful identification of the cause with the aid of a good history, swabs and cultures. Although the detection of aerobic and anaerobic bacteria does not always imply the cause of the balanitis, culture for bacteria can exclude an infective etiology and may be helpful. 3,5,6 • • • • • Sub preputial swab for Candida (Gonorrhoea Culture plate) and bacterial culture (Horse Blood Agar plate) may help to exclude an infective cause or super infection of a skin lesion. A swab for HSV PCR is warranted if ulceration is present Gram stain evaluation of sub preputial discharge if present Dark ground examination for spirochaetes and syphilis serology if ulcer is present and client’s history indicates epidemiological risk Screening for other STIs as indicated by the sexual history DIABETES SCREENING • Over 40 Years of age • Overweight • Family history of diabetes • History of recurrent balanitis • Symptoms of diabetes • Thirst/Frequent urination • Tiredness or lack of energy • Blurred vision • Infections • Weight loss (in type 1 diabetes) • Blood glucose or urine glucose as required Table M2.3: Diabetes screening CANDIDIAL BALANITIS • Symptoms include erythematous rash with soreness and or itch • Blotchy erythema with small papules or dull red areas with glazed appearance are seen on genital examination • A wet prep preparation of a skin scraping may reveal pseudohyphae or budding yeast • Microscopy and culture of area may reveal candida infection TREATMENT AND MANAGEMENT The aim of treatment is promotion of genital skin hygiene. Educating the client to keep the glans and foreskin clean and dry produces an environment where organisms are less likely to grow. GENITAL SKIN HYGIENE1,3,5,6 • Wash with water or a ‘soap alternative’ such as Sorbolene • Avoid soap • The area under the prepuce should be kept clean and dry (use hairdryer or fan) • After washing expose the glands to the air for 10 minutes • During urination avoid urine under foreskin • Wash penis as described above after sexual contact MANAGEMENT1,3,5,6 • Most causes should resolve within one to two weeks • Clients should avoid spermacides or lubricants if they are implicated as the cause of balanitis • Saline baths or Potassium permanganate wash may provide symptom relief • Avoiding sexual contact may promote resolution of balanitis • Recurrent or chronic balanitis requires a medical review Clinical Practice Guidelines for Sexual Health Nurse Practitioners Section M2 3 Treatment depends on the identified cause of balanitis. In the absence of an identifiable cause the diagnosis is nonspecific balanitis. In cases where candidal balanitis is suspected treatment with a topical imidazole is recommended. 1.4,6 Use of preparations containing 1% hydrocortisone is useful in clients with marked inflammation and preputial odema. 1,2. TREATMENT • CLOTRIMAZOLE CREAM 1% BD FOR 7-14 DAYS or • HYDROZOLE CREAM 1% BD FOR 7-14 DAYS and • POTASSIUM PERMANGANATE 1:8000 WASH • • • Advise about effect on condoms if antifungal creams are being used Potassium Permanganate 1: 8000 wash can be used for cleansing and deodorising MO review if symptoms continue post treatment Clinical Practice Guidelines for Sexual Health Nurse Practitioners Section M2 4 CLINICAL ALGORITHM Client attends with symptoms of balanitis Diabetes screening • >40 Years of age • Overweight • Family history of diabetes • History of recurrent balanitis • Symptoms of diabetes • • • • Symptom history Culture for pathogens STI screening Pathogen identified Other cause No pathogen identifies Candidal Balanitis Refer to appropriate CPG Non specific balanitis Clotrimazole cream 1% bd for 14 days Potassium permanganate wash and Hydrozole cream 1% bd for 14 days Genital skin Hygiene • No soap • Genital skin care • Dry glans post washing Improvement No further follow up No improvement MO review for further investigation Clinical Practice Guidelines for Sexual Health Nurse Practitioners Section M2 5 MEDICATION FORMULARY 8 DRUG INDICATIONS ROUTE DOSE FREQUENCY Clotrimazole Balanitis; balanoposthitis Topical 1% Apply small amount 2-3 times daily for 14 days Hydrozole Cream clotrimazole/ hydrocortisone Candidal infections Fungal infected dermatitis Tinea infections Topical 1% in 30g Apply small amount 2-3 times daily for 14 days THERAPEUTIC CLASS/ Poisons Schedule Topical antifungal A S3 Topical Antifungal A CONTRAINDICATIONS / INTERACTIONS Viral tuberculous skin infections, eye contact, occlusive dressings, severe circulation impairment PRECAUTIONS/ ADVERSE EFFECTS Latex products Local irritation, skin rash, urinary frequency, abdominal cramps Extensive use, non dermal fungal primary skin infections, Psoriasis, immunocompromised, pregnancy, lactation, children Dermatological effects Viral tuberculous skin infections, eye contact, occlusive dressings, severe circulation impairment Latex products Potassium permanganate 1:8000 Acute inflammatory dermatoses Topical 1:8000 b.d. prn Clinical Practice Guidelines for Sexual Health Nurse Practitioners N/A Section M2 N/A Persisting symptoms, recurrent infection, diabetes, pregnancy, lactation, adolescents Avoid menses N/A 6 REFERENCE 1. McMillan A, Ballard R C. Ulcers and other conditions of the external genitalia.. In: McMillan A, Young H, Ogilvie M M, Scott G R, editors. Clinical practice in sexually transmissible infections. London: Saunders; 2002. p 549-566. 2. Aitken S. Penile, epididymal, and testicular conditions. In: Russell D, Bradford D, and Fairley C, editors. Sexual health medicine. Melbourne: IP Communications; 2005. p. 167-183. 3. Denham I, Bowden F. Genital and sexually transmitted infections. In: Yung A , McDonald M, Spelmen D, Street A, Johnson P, Sorrell T, McCormack J, editors. Infectious diseases a clinical approach. 2nd ed. Melbourne: IP Communications; 2005. p. 372-387. 4. Edwards L. Genital dermatoses. In: Holmes K K, Sparling P F, Mardh P A, Lemon S M, Stamm W E, et al, editors. Sexually transmitted diseases. 3rd ed. New York: McGraw Hill; 1999. p. 893-902. 5. Marrazzo J, Ocbamichael N, Meegan A, Stamm WE, editors. The practitioner’s handbook for the management of STD’s. 4th ed. Washington: University of Washington; 2007. 6. Venereology Society of Victoria. National management guidelines for sexually transmissible infections. Melbourne: Venereology Society of Victoria; 2002. 7. Melbourne Sexual Health Centre. Treatment guidelines: Balanitis. Melbourne: Bayside Health; 2005. 8. Therapeutic Guidelines Limited. Therapeutic guidelines antibiotic version 13. Melbourne: Therapeutic Guidelines Limited; 2006. 9. Queensland Health. Queensland clinical practice guidelines for advanced sexual and reproductive health nursing officers. Public Health Service Branch. Queensland Government. 2007. Clinical Practice Guidelines for Sexual Health Nurse Practitioners Section M2 7
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