CET CONTINUING EDUCATION & TRAINING 1 FREE CET POINT Approved for: Optometrists 4 OT CET content supports Optometry Giving Sight Dispensing Opticians Having trouble signing in to take an exam? View CET FAQ Go to www.optometry.co.uk 4 Investigation and management of dry eyes increased hyperosmolarity of the surface, which causes rapid tear break up and increased shearing forces, due to reduced tear volume and reduced mucins at the ocular surface, resulting in inflammation ANTERIOR EYE AND OCULOPLASTICS PART 4 C-19306 O/D 44 hypersensitivity of the nerve endings. Amit Patel, MB BCh, FRCOphth When Sunil Shah, MBBS, FRCOphth, FRCS(Ed), FBCLA thorough The International Dry is Eye Workshop (DEWS) defines dry eyes as “a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the 27/07/12 CET at the ocular surface and ultimately tear film and inflammation of the ocular surface”. Dry eyes can have a profound effect on a patient’s comfort, vision and quality of life. Accurate diagnosis and classification of its severity is, therefore, important in developing an effective treatment plan, and this article discusses the optimal optometric approach. diagnosing history paramount dry from and eye, the a patient must include: •Frequency, severity and variation of symptoms •Medical history (eg rheumatoid arthritis, thyroid dysfunction) •Drug history (eg use of systemic antihistamines) •Environmental factors (eg exposure to air conditioning, contact lens wear) •Previous ocular surgery (eg refractive surgery) Incidence care Dry eye has long been recognised as a influenced their decision to use these common, and often chronic problem, • 63% of adults who use OTC eye professional Several questionnaires are available for symptoms dry eye evaluation in clinical practice Dry Eye Survey1 suggests the condition state that these are only “somewhat” (Table 1). While these are not a substitute may be more prevalent than previously or for history-taking, they serve as a useful survey found that: • 48% of adults experience one or “not at their Subjective tests drops The manage pharmacist particularly in older adults. The Allergan believed. to or •Lubricant use and frequency all” successful. tool to detect the presence of dry eyes and Diagnosis to evaluate the effects of therapy. Such vary questionnaires may be used in optometric considerably and may not always correlate practice prior to suggesting treatment and of with the diagnostic test results and clinical may also empower patients to monitor their symptoms signs. The symptoms reported by patients symptoms and adjust their own therapy. • 48% of adults who use over the include a foreign body sensation, burning, counter (OTC) eye drops to manage stinging, grittiness and blurred vision, Objective tests their symptoms state that their eye particularly notable when performing These more dry eye symptom(s) regularly • 43% of adults experience difficulty with reading their as dry a eye result Symptoms of dry Questionnaire Number of questions Source Ocular surface disease index 12 Schiffman et al.2 McMonnies dry eye questionnaire 14 McMonnies and Ho Dry eye questionnaire 23 CANDEES 13 3 Begley et al. 4 Doughty et al.5 Table 1 Dry eye questionnaires for subjective evaluation of symptoms eyes can tests evaluate the concentrated (quantity, quality and activities and of ocular and/ state the tears stability) surface. or when in dry Tear quantity is evaluated using the atmospheres. Schirmer Type 1 test and tear meniscus The cause height (TMH). The Schirmer type 1 test is unknown, but (without anaesthetic) involves using a could be due to 5x35mm strip of filter paper, which is the exact of anchored to the lower fornix and kept in nociceptive place for five minutes, at which point the nerve endings on length of wetting is measured. This measures the corneal surface. the basal and reflex tear production. The nerve endings Less than 5mm of wetting is considered are stimulated by diagnostic of aqueous tear deficiency. the activation Find out when CET points will be uploaded to Vantage at www.optometry.co.uk/cet/vantage-dates The Schirmer Type 2 test is performed lamp beam with cobalt blue filter looking established, after instilling a drop of anaesthetic and for evaporation of the tear film, which is will allow appropriate treatment to be measures only the basal tear secretion; the characterised by the appearance of black commenced. Dry eyes may be broadly presence of anaesthesia will prevent reflex spots. The tear film break-up time (TBUT) classified into aqueous deficiency dry tearing. There is evidence to suggest that is the interval between the last blink and eye (ADDE) or evaporative dry eye (EDE) the Type 2 test produces greater variability first appearance of a black spot. An average (Figure 1). The above diagnostic tests may and thus the Type 1 test is most commonly of three measurements is taken and a TBUT help determine which group the patient performed and utilised for diagnosis of of ≤10 seconds is indicative of dry eyes. falls into, eg a reduced Schirmer’s test is dry eyes.6 The TMH is a non-invasive The ocular surface evaluation includes indicative of ADDE, and reduced TBUT evaluation performed using the slit lamp. assessment of the lid margin, conjunctiva is indicative of EDE. In reality, however, A height of <0.2mm is associated with tear and cornea, notably grading these for both ADDE and EDE may co-exist. deficiency. In patients with dry eyes, the signs of dryness. The Oxford ocular Furthermore, both may give rise to similar tear meniscus is frequently reduced and surface grading system may be used to signs and symptoms. It is, therefore, has an irregular edge along the lid margin. document the location and severity of important to determine the individual surface damage. This is usually done components causing the dry eyes from the by assessing fluorescein and lissamine patient history, diagnostic tests, and ocular the osmolarity. A small sample is taken from the lower tear meniscus, such that reflex lacrimation is not induced. Using a microchip, the electrical conductivity of the tear sample is measured and this indicates the concentration of tear constituents; hyperosmolarity of the tear film is suggestive of dry eye due to reduced tear quality. One such device that indirectly measures tear osmolarity is the TearLab (TearLab Corp., San Diego, USA). A result of >316 mOsm/l is indicative of dry eyes. Tear film stability is assessed after instillation of fluorescein into the lower fornix and the patient is asked to blink 7 green staining of the bulbar conjunctiva and cornea. Lissamine green stains dead or devitalised cells, which occur as a result of dry eyes. Conjunctival injection is also noted and graded. Grading the severity of surface damage, usually on a scale of: 1 (none), 2 (mild), 3 (moderate) and 4 (severe), is useful for monitoring treatment effectiveness. Various other tests are also available, including evaluation of lysozyme, lactoferrin and matrix metalloproteinase-9 (MMP-9) levels in the tears, while impression cytology, brush cytology and lipid layer interferometry its cause surface evaluation, so that treatment can be targeted. For example, blepharitis is a common cause of dry eyes and the severity may not always correlate with the symptoms. It is characterised by crusting around the eyelashes, frothy tears, lid margin irregularity, vascular engorgement, plugging of the meibomian gland openings and displacement of the mucocutaneous junction. Grading the degree of blepharitis and conducting diagnostic tests of tear quality can then allow treatment to be targeted to alleviate symptoms. (LipiView, TearScience Inc., Morrisville, Management North Carolina, USA) may also be Management of dry eye disease is aimed at since drops may lead to excessive dying of employed. The latter allows practitioners the various components which contribute the tears and affect the quality of the test. to obtain digital images of the tear film to the symptoms. A very important, The tear film is scanned with a broad slit and grade it within about three minutes. and sometimes underrated, element of several times and then to refrain from doing so; a moistened fluorescein strip is preferred, 2 management is an explanation about the the cause(s), its aetiology and treatment, cut-off with emphasis that in the vast majority these of cases this is not a curable disease. tests, Simple measures relate to the external 3 environment, such as increasing humidity Table Diagnostic test Cut-off value for clinical dry eye summarises diagnostic Schirmer Type 1 ≤ 5 mm wetting in 5 minutes Tear break up time (TBUT) ≤ 10 seconds Tear meniscus height ≤ 0.2 mm Fluorescein staining > 3 (scale 0-15) Lissamine green staining > 3 (scale 0-15) Tear osmolarity > 316 mOsm/l Table 2 Cut-off values diagnostic of dry eyes for simple clinical tests values for diagnostic while Table indicates the grading and of different severities especially in windy conditions (in very of severe dry eye, wearing swimming goggles dry eyes. wearing protective spectacles, has been shown to provide symptomatic Causes relief). A review of systemic drugs is Once the diagnosis worthwhile as some drugs, eg beta-blockers and of and some psychotropic drugs (among dry eyes has been others), are known to cause dry eye and severity For the latest CET visit www.optometry.co.uk/cet 45 27/07/12 CET Tear quality is measured by assessing ascertaining CET CONTINUING EDUCATION & TRAINING 1 FREE CET POINT Approved for: Optometrists Dry Eye Severity 4 OT CET content supports Optometry Giving Sight Dispensing Opticians 1 Discomfort, severity and Mild and/or episodic; frequency occurs under environmental stress 27/07/12 CET 46 Having trouble signing in to take an exam? View CET FAQ Go to www.optometry.co.uk 4 2 3 4* Moderate, episodic, or chronic; stress or no stress Severe and/or frequent or constant; without stress Severe and/or disabling and constant Visual symptoms None or episodic with mild Annoying and/or activity limiting; episodic fatigue Annoying, chronic and/or constant; limiting activity Constant and/or possibly disabling Conjunctival injection None to mild None to mild None to mild Mild to severe Conjunctival staining None to mild Variable Moderate to severe Severe Corneal staining (severity/location) None to mild Variable Severe central Severe punctate erosions Corneal/tear signs None to mild Mild debris, reduced TMH Filamentary keratitis, mucous clumping, tear debris Filamentary keratitis, mucous clumping, increased tear debris, ulceration Lid/meibomian glands MGD variably present MGD variably present Frequent Trichiasis, keratinisation, symblepharon TBUT (sec) Variable ≤ 10 ≤5 Immediate Schirmer score (mm/5mins) Variable ≤ 10 ≤5 ≤2 Table 3 Dry eye severity grading scheme.8 TMH = Tear meniscus height; MGD = Meibomian gland dysfunction; TBUT = Tear break-up time. *Must have signs AND symptoms there may be an option to change them. Table 4 summarises the However, it should be noted that most been no large-scale, masked, comparative main ‘artificial tears’ do not actually mimic the clinical trials to evaluate the wide variety approaches which can be used to treat dry composition of natural tears and instead of ocular lubricants and the majority of eye according to the severity. These are contain active ingredients (eg demulcents, prescribing remains empirical or based discussed in turn in the sections below. emulsifiers, surfactants, and viscosity on patient self-reported preferences. The agents) and inactive additives (eg castor DEWS study9 reported that, although Lubrication oil and guar in Systane). However, it is ocular lubricants provide some protection The mainstay of dry eye treatment is very difficult to prove that the active of the ocular surface epithelium, there is tear supplementation with lubricants. ingredient is indeed ‘active’. There have no evidence to suggest that any agent is superior to another. Most clinical trials document some improvement but not resolution of subjective symptoms of dry eye and in some objective parameters. However, the improvements noted are not necessarily any better than those seen with non-preserved artificial lubricants. The elimination of preservatives and the development of newer, less toxic, preservatives have made ocular lubricants better tolerated by patients. Indeed, the ideal ‘artificial tears’ should be isotonic, preservative-free, contain the Figure 1 Classification of dry eye electrolyte composition of natural tears and have a mechanism that increases tear retention time. The main variables in the Find out when CET points will be uploaded to Vantage at www.optometry.co.uk/cet/vantage-dates formulation of ‘artificial tears’ are the Nutrition regulations surrounding blood products, concentration and choice of electrolytes, Omega-3 fish oils have been shown and therefore is not widely available. the osmolarity and the type of viscosity/ to help with dry eye syndrome, polymeric system, the presence (or either absence) preparations type of preservative. as commercially or as available flaxseed oil.10 Ultimately, the clinician has to decide Punctal plugs Punctal plugs are a simple and effective solution to treat dry eyes that have not on the severity of the dry eye and Antibiotics advise the patient on their options. Oral (eg above. Patients with lid margin disease Mild dry eye may not need any doxycycline and minocycline) have and ocular surface inflammation must treatment. If lubrication is needed, proven beneficial in cases of advanced have adequate treatment for this prior then hypromellose is cost effective. But meibomian dysfunction to considering the use of punctal plugs, advice as to frequency of use and long- (MGD).11 It is believed that these otherwise there will be retention of term maintenance is essential. A very drugs pro-inflammatory common problem is that frequency of bacterial lipases, which serve to alter on use is inappropriately low and therefore the consistency of the meibomian enhance damage to the ocular surface, patients feel that the therapy is ineffective. oils. In addition to their antibacterial accelerate For moderate to severe dry eye, it is action, tetracyclines are recognised therefore appropriate to suggest more viscous to anti-inflammatory Absorbable plugs are made from collagen preparations such as Viscotears, Gel agents, inhibiting the expression of or polymers and last for a few weeks, Tears or some of the newer preparations matrix metalloproteinases and other or months, prior to disintegrating. They such as Optive, Systane (Systane Ultra), cytokines. Therapeutic effects may are useful for short-term occlusion, eg Theratears or one of numerous hyaluronic be seen with low doses (typically post-refractive surgery or as a trial to acid preparations. In addition, one should 50-100mg Topical assess their effectiveness. Non-absorbable consider a preservative-free variety if azithromycin has recently been shown plugs are generally made from silicone using contact lenses or a high frequency of to be effective in the treatment of and instillation is required, eg Celluvisc 1% or blepharitis. these Vismed (some patients prefer Refresh or also exhibits anti-inflammatory effects, Plugs are available in various diameters Celluvisc 0.5% particularly with contact in addition to its antibacterial action. ranging from 0.2mm to 1.0mm. It is responded to simple measures described tetracycline gland inhibit be derivatives the potent once 12 production daily). of Like the tetracyclines, it lenses in situ). Some patients also benefit the ocular the components surface, disease produce although can tear which process, greater removed may and discomfort. considered be ‘permanent’ if required. important to select the correct size, as from night time ointments eg Simple Anti-inflammatory medication large plugs may be difficult to insert, may Eye Ointment, Lacrilube and VitA-Pos. Dry eye disease has a significant sit proud and irritate the ocular surface inflammatory component, therefore or fall off. Plugs which are smaller than Lid hygiene both topical steroids and topical the punctal opening may migrate into the Blepharitis is one of the commonest cyclosporine A canaliculus and prove difficult to remove. causes of dry eyes and eye lid hygiene breaking inflammatory is the mainstay treatment. Scrubbing the Dosage base of the lash follicles with a cotton severity and should be assessed in •Smart Plug (Medennium Inc., Irvine, bud dipped in dilute baby shampoo/ conjunction with all other measures. California, USA). This is a temperature- sodium bicarbonate solution, or dilute However, the preferred formulation sensitive tea tree oil, is effective, as are a variety for cyclosporine A is an emulsion, thermodynamic acrylic polymer. It is of commercially available lid wipes. For which is not available in the UK yet, thin and rigid (10.0mm long and 0.4mm meibomitis (posterior blepharitis), hot except from international pharmacies. in diameter) at room temperature and the depends are on useful the in cycle. disease New of innovative punctal plug plugs fabricated designs include: from a when inserted into a tear duct, the body compresses or commercial units like the ‘Eye Bag’ help to soften the inspissated Autologous serum temperature shortens and expands it, oils within the meibomian glands. This Autologous serum drops derived from transforming it into a soft gel-like glue which is followed by gentle massage of the the patient’s own blood have been fills the punctal space. Unlike traditional eyelids to express the oils. Selective shown to be highly effective in cases plugs, no part of the Smart Plug lies above gland expression or cannulation may of severe dry eye.13 However, it is the surface of the eyelid after insertion also be performed to unblock the glands. costly and difficult to obtain due to the and it is therefore instantly comfortable. For the latest CET visit www.optometry.co.uk/cet 47 27/07/12 CET and CET CONTINUING EDUCATION & TRAINING PEER REVIEWED 1 FREE CET POINT Approved for: Optometrists 4 OT CET content supports Optometry Giving Sight Dispensing Opticians 4 Having trouble signing in to take an exam? View CET FAQ Go to www.optometry.co.uk DRY EYE SEVERITY LEVELS 1 2 3 4* • Education and Environmental/ If Level 1 treatments are If Level 2 treatments are If Level 3 treatments are inadequate, add: inadequate, add: inadequate, add: • Anti-inflammatories • Autologous Serum • Systemic anti-inflammatory Dietary modifications • Elimination of offending systemic medications 48 • Tetracyclines (for meibomitis, acne • Contact lenses • Artificial tear substitutes, gels/ rosacea) ointments • Eye lid therapy agents • Permanent punctal occlusion • Surgery (lid surgery, • Punctal plugs tarsorrhaphy; mucus • Secretogogues membrane, salivary gland, • Moisture chamber spectacles amniotic membrane 27/07/12 CET transplantation) Table 4 Treatment recommendations for dry eye by severity of the disease. Modified from the International Task Force Guidelines for Dry Eye.8 Other measures level 2 severity of dry eye who are non- This Other measures for the treatment of dry respondent is a ‘one size fits all’ plug made eye include increasing room humidity with levels 3 and 4 severity should also of (eg be considered for referral to the HES. •FormFit Plug Glendora, California, hydrogel. (Oasis It Medical, USA). hydrates after commercially available radiator to treatment and those insertion to fill the punctal space. humidifiers), wearing swimming goggles to •Eagle Plugs retain moisture, moisture release eyewear, About the authors (EagleVision Inc, Memphis, Tennessee, and surgical options including tarsorrhaphy Mr USA). These are perforated plugs which and salivary gland auto-transplantation. ophthalmologist at the Heart of England Flow Controller are useful in patients who experience Amit Patel is a consultant NHS Trust and Midland Eye Institute in improvement with plugs, but where When to refer full occlusion results in epiphora. The initial management of dry eye does not in necessarily require referral to the hospital surgery. He is a treasurer of the British Other indications eye service (HES). In fact, it could be Society for Refractive Surgery (BSRS) Various factors may result in poor patient argued that primary care practitioners are and a council member of the Medical compliance in the use of drops, eg on the better placed to provide this management Contact grounds of cost, dementia, poor vision, than the HES, as they can recommend any Association or arthritis preventing adequate control one of several ocular lubrication products Shah is a consultant ophthalmologist at of the bottle. These patients may benefit available and even attempt the fitting of the Midland Eye Institute, Birmingham from punctal occlusion and may also punctal plugs. Indeed, the Allergan Dry Eye and Midland Eye Centre, and honorary benefit from residual longer retention Survey1 showed that eye care professionals consultant at Birmingham Children’s of any other therapeutic drops that they influenced a patient’s decision to use OTC Hospital. may be prescribed (eg for glaucoma). drops in a significant proportion of people. professor at The University of Ulster and People who experience dry eye as a result It is the experience of the authors that visiting professor at Aston University, of contact lens wear may also benefit from most patients seen in external eye disease Birmingham. He specialises in complex punctal plugs, provided that the lens fit clinics are not using lubrication more than corneal and refractive surgery. Professor is good, they are using adequate wetting three times daily and are intermittent in Shah is past president of the BSRS and solutions, and exercise good lens hygiene. their compliance (as admitted by patients). a specialist advisor to the National Other punctal In cases where the aetiology is in doubt, the Institute occlusion may yield some benefit include patient is symptomatic despite frequent corneal infiltrates, corneal abrasions, use of lubrication (and compliance is References recurrent corneal erosions, filamentary good) or there is concern about permanent See keratitis, keratitis, corneal damage, then onward referral Click on the article title and then trachoma and neurotrophic keratopathy. to the HES is appropriate. Patients with on conditions superior where limbic Birmingham. He has a special interest corneal, cataract Lens and and Ocular (MCLOSA). He for is refractive also Clinical Surface Prof an Sunil honorary Excellence. www.optometry.co.uk/clinical. ‘references’ to download. Find out when CET points will be uploaded to Vantage at www.optometry.co.uk/cet/vantage-dates CET CONTINUING EDUCATION & TRAINING PEER REVIEWED 1 FREE CET POINT Approved for: Optometrists 4 Dispensing Opticians OT CET content supports Optometry Giving Sight 4 Having trouble signing in to take an exam? View CET FAQ Go to www.optometry.co.uk PLEASE NOTE There is only one correct answer. All CET is now FREE. Enter online. Please complete online by midnight on September 7, 2012 – you will be unable to submit exams after this date. Answers to the module will be published on www.optometry.co.uk/cet/exam-archive. CET points for these exams will be uploaded to Vantage on September 17, 2012. Find out when CET points will be uploaded to Vantage at www.optometry.co.uk/cet/vantage-dates Module questions Course code: C-19306 O/D (P44-48) 54 1. Which of the following is NOT likely to cause dry eyes? a) Systemic antihistamines b) Increasing age c) Previous laser refractive surgery d) Frequent preservative free lubrication 4. What is the MOST appropriate first line treatment for dry eyes? a) Artificial tear substitutes b) Autologous serum eye drops c) Vitamin A therapy d) Tarsorrhaphy 2. Which of the following signs is NOT associated with dry eyes? a) Congestion of conjunctival vessels b) Filamentary keratitis c) Superficial punctate corneal erosions d) Cells in the anterior chamber 5. Which of the following statements regarding treatment of dry eyes is TRUE? a) Tetracyclines may be effective in treating meibomian gland dysfunction b) Preservative-free medication may exacerbate symptoms of dry eyes c) Dietary modification is not effective for treating dry eyes d) Autologous serum carries no risk as it is derived from the patient’s own blood 27/07/12 CET 3. Which of the following tests may be used in the diagnosis of dry eyes? a) Schirmers Type 1 and 2 b) Tear osmolarity c) Fluorescein and lissamine dye staining d) All of the above 6. Which of the following statements about punctal plugs is TRUE? a) They are used as a last resort in the treatment of dry eyes b) They are only placed in the lower eyelid punctae c)They can cause irritation of the ocular surface if not fitted correctly d) They are a first choice treatment for dry eyes caused by blepharitis Module questions Course code: C-19309 O/D 1. Which of the following is a common feature of cluster headaches? a) Bilateral eye pain b) Generalised headache c) Diplopia d) Red and watery eye 2. What should you do if a 75-year-old man develops an inferior visual field defect and complains of headaches? a) Enquire about scalp tenderness, jaw pain and loss of weight or malaise b) Perform fixation disparity testing and prescribe the full amount of prism c) Refer him routinely to ophthalmology for further testing (including blood tests) d) Reassure the patient that the headaches are likely to be migraines 3. Which of the following is NOT a common feature of carotid artery dissection? a) Unilateral limb weakness b) Visual field loss c) Colour vision defects d) Horner’s syndrome 4. Which of the following is most likely to be TRUE for a 42-year-old overweight woman who complains of recent onset diplopia and severe head pain? a) She is likely to have a sixth nerve palsy which warrants correction with prisms b) She is likely to have papilloedema and should be referred as an emergency c)There will be no other signs or symptom associated with this condition d) The underlying condition is likely to be benign and no further action is required 5. Which of the following is TRUE for a 35-year-old man who develops amaurosis fugax and neck pain on the left side, one week after a whiplash injury? a) He is likely to develop sudden onset occipital headaches b) He should be referred routinely to ophthalmology c) There could be a left Horner’s syndrome d) A visual field defect is unlikely to be present 6. Which of the following is MOST consistent with a headache due to refractive error or heterotropia? a) Thunderclap headache, which changes with different posture b) Headache worse in the morning, often waking up the patient c) Unilateral headache or pain around the eye with conjunctival redness and lacrimation d) Mild to moderate chronic / recurrent headache, worse in the evening, relieved by painkillers Find out when CET points will be uploaded to Vantage at www.optometry.co.uk/cet/vantage-dates
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