1 Welcome!
On behalf of the Neuroblastoma Medulloblastoma Translational Research Consortium
(NMTRC), DELL, and the organizing committee, I would like to welcome you all to the 2015
NMTRC Annual Symposium. We are thankful to DELL for supporting us this year for what will
be a groundbreaking meeting. Once again we will be bringing together the experts in
these diseases, including physicians, researchers and parent advocates who work together
to accelerate the search for a cure. Our team will share our work uncovering the genomic
differences and targets in children’s cancers, sharing our advances in sequencing and
personalized medicine. This year we have combined this knowledge to target cancers at
diagnosis for better response rates with the targeting of cancer stem cells to prevent
children from relapsing. As a result, we will share our newest innovative protocol for children
with neuroblastoma for treatment at diagnosis. We welcome Dan Munro, an expert on the
interface between IT and healthcare from Forbes Magazine to help us in addressing the
transition and incorporation of genomics into clinical care and insurance reimbursement to
make this a reality for all patients in this year’s panel discussion.
Thank you for joining with us in our commitment to finding cures for patients with
Neuroblastoma and Medulloblastoma.
Sincerely,
Giselle Sholler, MD MSc.
Haworth Family Endowed Director of the Innovative Therapeutics Clinic
Head, Pediatric Oncology Translational Research Program
Chair, Neuroblastoma and Medulloblastoma Translational Research Consortium
(www.nmtrc.org)
Helen DeVos Children's Hospital
2 Agenda
MONDAY, MAY 4, 2015
HOTEL VALLEY HO
BREAKOUT SESSIONS – HOTEL VALLEY HO
10:00am – 5:00pm
PI Meetings – Tropicana Conference Room
(Closed Session)
1:00pm – 5:00pm
Site Coordinators Meeting – Dunes Conference Room
(Closed Session)
1:00pm – 5:00pm
Parent Advocates – Sands Conference Room
6:30pm
NMTRC Symposium Dinner – Palm Court Lawn
3 Agenda
TUESDAY, MAY 5, 2015
HOTEL VALLEY HO – SANDS
8:00 am
Registration/Breakfast
8:45 am
Welcome
Giselle Sholler, MD
Haworth Family Endowed Director of Innovative Therapeutics Clinic
Pediatric Oncology, Helen DeVos Children’s Hospital
Dennis Rosenthal
Parent Advocate
SESSION I MODERATED BY DON ESLIN, MD
9:00 am
NMTRC Year Update
Giselle Sholler, MD
Haworth Family Endowed Director of Innovative Therapeutics Clinic
Pediatric Oncology, Helen DeVos Children’s Hospital
9:15 am
Phase I Tolcapone Study Concept
Jessica Foley, MD and Maria Rich
Pediatric Hematology/Oncology
Helen DeVos Children’s Hospital
9:30 am
DFMO Study Updates
Giselle Sholler, MD and Deb Pankiewicz
Haworth Family Endowed Director of Innovative Therapeutics Clinic
Pediatric Oncology, Helen DeVos Children’s Hospital
10:15am
Break
11:00 am
Metronomic Therapy
Nicolas Andre, MD
Senior consultant, Pediatric Oncology AP-HM
Région de Marseille, France
11:20 am
Novartis Targeted Agents
Deanna Mitchell, MD
Pediatric Hematology/Oncology
Helen DeVos Children’s Hospital
4 11:40 am
Medulloblastoma Study with TB-403 Antibody
Edwin Spaans
PharmD, Clinical Pharmacologist
TB-403 Program Leader
Oncurious NV
12:00 pm
Lunch: Catered by the Hotel Valley Ho
SESSION II GENOMIC GUIDED THERAPY – MOVING INTO THE FUTURE
MODERATED BY WILLIAM FERGUSON, MD
1:15 pm
CAC2 – Pediatric Cancer Advocacy Movement
Andy Mikulak and Kyle Matthews
1:30 pm
Genomic Landscape of Pediatric Cancers
Will Hendricks, PhD and Pilar Ramos, PhD
Research Assistant Professors
Integrated Cancer Genomics, TGen
1:50 pm
Overview of New Upfront Neuroblastoma Study
PLAN-T (Precision Laboratory Advanced Neuroblastoma Therapy)
Giselle Sholler, MD
Haworth Family Endowed Director of Innovative Therapeutics Clinic
Pediatric Oncology, Helen DeVos Children’s Hospital
2:10 pm
NMTRC Portal, Future of Communication
William Burleson
KIDS Cloud Program Manager, Translational Genomics Research Institute (TGen)
Nehal Parikh, MD
Division of Hematology/Oncology
Connecticut Children's Medical Center
2:30 pm
Dell’s Vision: Legacy of Good
Wendy Wittington, MD, MMM
Dell | Services
3:00 pm
PANEL DISCUSSION: Moving Genomic Profiling to Clinical Care
MODERATED BY DAN MUNRO
Writer | Forbes Contributor | Author
Panel:
Jeffrey Trent, Ph.D.
President and Research Director, TGen
Professor of Genetic Basis of Human Disease Division
Head of Melanoma Therapeutics Lab
John Fox, MD
AVP, Medical Affairs
Executive Medical Director, Priority Health
Wendy Whittington, MD
Clinical Portfolio Leader at Dell,
Dell Computers
5 4:00 pm
Giselle Sholler, MD
Haworth Endowed Director of Innovative
Therapeutics Clinic Pediatric Oncology, Helen
DeVos Children’s Hospital Head, Pediatric
Oncology Translational Research Program,
Neuroblastoma Laboratory, HDVCH Chair,
Neuroblastoma and Medulloblastoma Translational
Research Consortium (www.NMTRC.org)
Jackie Kraveka, DO
Pediatric Hematology & Oncology
Medical Center of Medical University of South
Carolina
B. Melina Cimler, Ph.D.
Senior Vice President – Regulatory & Quality
Adaptive Biotechnologies Corporation
Jerry Conway, VP
VP of Payer Relations and Reimbursement
Foundation Medicine
TBD
Baylor University, Texas Children’s Hospital
Woody Thompson – Ronan Thompson Foundation
Parent Advocate
6 The Neuroblastoma and Medulloblastoma
Translational Research Consortium
Symposium 2015
With special thanks to our sponsors
who have helped make the symposium a success:
Presenting Sponsor:
The NMTRC would like to thank the Hotel Valley Ho and TGen for
hosting the symposium this year.
7 The Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC) is a group of
24 universities and children’s hospitals headquartered at Helen DeVos Children’s Hospital that offer a
national and international network of childhood cancer clinical trials. These trials are based on the
research from a group of closely collaborating investigators who are linked with laboratory programs
developing novel therapies for high-risk neuroblastoma and medulloblastoma.
Participating NMTRC Sites
William Ferguson, MD
Cardinal Glennon Children's Medical Center
Saint Louis University School of Medicine
1465 S. Grand Blvd.
Saint Louis, MO 63104
Phone: (314) 577-5638
Email: [email protected]
William Roberts, MD
Rady Children's Hospital San Diego
UCSD School of Medicine
3020 Children's Way
MC5035
San Diego, CA 92123-4282
Phone: (858) 966-5811
Email: [email protected]
8 Don Eslin, MD
Center for Children's Cancer and Blood
Disorders
Arnold Palmer Hospital for Children
92 West Miller St., MP318
Orlando, FL 32806
Phone: (321) 841-8588
Email: [email protected]
Jacqueline M. Kraveka, DO
Medical University of South Carolina
135 Rutledge Avenue, Room 480
MSC 558
Charleston, SC 29425
Phone: (843) 792-2957
Email: [email protected]
Javier Oesterheld, MD
Levine Children's Hospital
1001 Blythe Blvd
Charlotte, NC 28203
Phone: (704) 381-9900
Email: [email protected]
Giselle Sholler, MD and Deanna Mitchell, MD
Helen DeVos Children's Hospital
100 Michigan NE
Grand Rapids, MI 49503
Phone: (616) 391-2086
Email: [email protected]
Email: [email protected]
9 Nehal S. Parikh, MD
Connecticut Children's Medical Center
Division of Hematology/Oncology 2J
282 Washington Street
Hartford, CT 06106
Phone: (860) 545-9630
Email: [email protected] Kathleen A. Neville, MD, M.S.
Children's Mercy Hospitals
Divisions of Pediatric Clinical Pharmacology and
Pediatric Hematology/Oncology
2401 Gillham Road
Kansas City, MO 64108
Phone: (816) 234-3059
Email: [email protected]
Francis Eshun, MD
Center for Cancer and Blood Disorders
Phoenix Children's Hospital
1919 Thomas Road
Phoenix, AZ 85016
Phone: (602) 933-0920
Email: [email protected]
Virginia Harrod, MD, PhD
Pediatric Hematology Oncology
Dell Children's Blood and Cancer Center
1301 Barbara Jordan Blvd, Ste 401
Austin, Texas 78723
Phone: (512) 628-1900
Email: [email protected] 10 Mark Fluchel, MD
Primary Children's Hospital
Division of Pediatric Hematology/Oncology
100 North Mario Capecchi Drive, 4th Floor
Salt Lake City, UT 84113
Phone: (801) 662-4700
Email: [email protected]
Randy Wada, MD
Hawaii Pacific Health Research Institute
Kapiolani Medical Center for Women and
Children
Pediatric Hematology/Oncology
1319 Punahou Street
Honolulu, Hawai‘i 96826
Phone: (808) 983-6000
Email: [email protected]
Peter Zage, MD
Texas Children’s Hospital – Baylor University
6621 Fannin Street
Houston, Texas 77030
Phone: (832) 824-1000
Email: [email protected]
Devang Pastakia, MD
Vanderbilt University
Assistant Professor of Pediatrics
Division of Pediatric Hematology Oncology
Monroe Carell Jr. Children’s Hospital at Vanderbilt
200 Pierce Avenue | 397 PRB
Nashville, TN 37232-6310
Phone: (615) 936-1762
Email: [email protected]
11 Jawhar Rawwas, MD
Children’s Hospital and Clinics of MN
2525 Chicago Ave.
Minneapolis, MN 55404
Phone: (612) 813-5940
Email: [email protected]
Valerie Brown, MD, Ph.D.
Penn State Milton S. Hershey Medical Center
and Children’s Hospital
500 University Dr.
P.O. Box 850, MC H085
Hershey, PA 17033-0850
Phone: (717) 531-1042
Email: [email protected]
Ted Laetsch, MD
Children’s Medical Center
1935 Medical District Drive
Dallas, Texas 75235
Phone: (214) 456-7000
Email: [email protected]
Gregory Hale, MD
All Children’s Hospital
601 5th St S, Ste 302
St Petersburg, FL 33701
Phone: (727) 767-4176
Email: [email protected]
Raya Saab, MD
American University of Beirut Medical Center
AUBMC, DTS, 1st floor, John Kennedy Street, Beirut
Phone: +961-1-350000 ext. 8108
Email: [email protected]
Nilay Shah, MD
Nationwide Children’s Hospital
700 Children’s Dr.
Columbus, OH 43205
Phone (614) 722-3550
Email: [email protected]
12 Lars Wagner, MD
University of Kentucky HealthCare
2063 Norborne Dr.
Lexington, KY 40502
Phone: 859-257-1000
Email: [email protected] Jeffrey M. Trent, Ph.D.
Translational Genomics Research Institute
(TGen)
445 N 5th Street
Phoenix, AZ 85004
Phone: (602) 343-8419
www.tgen.org
Jeffrey P. Bond, Ph.D.
University of Vermont
Stafford Hall
95 Carrigan Drive
Burlington, VT 05405
Phone: (802) 656-4608
Email: [email protected]
André S. Bachmann, Ph.D.
Professor and Associate Chair for Research
Department of Pediatrics and Human
Development
College of Human Medicine
Michigan State University
Cook-DeVos Center for Health Sciences
301 Michigan Street, NE, Office 514
Grand Rapids, Michigan 49503, USA
Phone: 616-331-5982 (office); 616-331-5858 (lab)
Email: [email protected]
13 NMTRC Parent Advisory Board:
Kyle Matthews
Because of Ezra
becauseofezra.org
Dawn Burgess
SuperBub’s SuperHeroes
www.superbub.org
Andy Mikulak
Max’s Ring of Fire Foundation
www.maxsringoffire.org
Mayank Gala
Ishan Gala Foundation
www.ishangala.org
Patrick Lacey
Beat NB
www.beatnb.org
Lisa Riniolo
Melina’s White Lights
www.MelinasWhiteLight.org
14 Sponsor
Spotlight
About Dell
Dell Inc. (NASDAQ: DELL) listens to customers and delivers innovative technology
and services that give them the power to do more. Dell’s Powering the Possible
program is funded by the company’s pledge to contribute 1 percent of its
pre-tax profits to learning, pediatric cancer, innovative social entrepreneurship
and disaster relief initiatives that address unmet needs globally and enable
human potential. Information about Dell Powering the Possible is available at
www. dell.com/pediactriccancer. As the leading provider of healthcare IT
services in the world, Dell helps healthcare organizations harness the power of
information to simplify administration; coordinate and manage patient care;
transition from episodic care to prevention and wellness management and
ultimately to deliver personalized medicine.
About TGen
The Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based
non-profit organization dedicated to conducting groundbreaking research
for life changing results. Research at TGen is focused on helping patients with
diseases such as cancer, neurological disorders and diabetes. TGen is on the
cutting edge of translational research where investigators are able to unravel
the genetic components of common and complex diseases. Working with
collaborators in the scientific and medical communities, TGen believes it can
make a substantial contribution to the efficiency and effectiveness of the
translational process. TGen is affiliated with the Van Andel Research Institute in
Grand Rapids, Michigan. For more information, visit: www.tgen.org.
About NMTRC
The Neuroblastoma and Medulloblastoma Translational Research
Consortium (NMTRC) is a group of 24 universities and children’s hospitals
headquartered at the Helen DeVos Children’s Hospital that offer a
nationwide network of childhood cancer clinical trials. These trials are
based on the research from a group of closely collaborating investigators
who are linked with laboratory programs developing novel therapies for
high-risk neuroblastoma and medulloblastoma.
15 NMTRC Pediatric Cancer Heroes, Advocates, and
Supporters….THANK YOU!!!
The Swifty Foundation
16 Notes
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