Pan-American Research Day PARD 2015 May 2, 2015 Governor’s Square 14 & 15 Sheraton Denver Downtown Hotel Denver, Colorado This year’s Pan-American Research Day (PARD) is not to be missed. This exciting event is scheduled to take place on Saturday, May 2, 2015, from 12:30 – 6:00 pm at the Sheraton Denver Downtown Hotel, Denver, Colorado. This event is sponsored through a generous grant from Allergan. Over 90 speakers were chosen to present their ARVO accepted abstracts at this year’s meeting. There will be two keynote lectures: J. Bronwyn Bateman, MD (USA) – The ophthalmologist in the modern world of genetics Alfredo A. Sadun MD PhD (USA) – How a Giant Brazilian Pedigree Helped Solve 3 Great Mysteries in LHON A total of four travel awards and three research awards sponsored by industry leaders and private foundations will be awarded this year. Afterwards speakers and attendees can relax and discuss the business of the day at the wind-up cocktail party, which is immediately to follow. OVERVIEW 10:00 AM – Speaker Check in & Registration Opens 12:30 PM – Program Begins 12:35 PM – Keynote Speaker: J. Bronwyn Bateman MD 2:30 PM – 2:45 PM – Break – Governor’s Square 14 2:45 PM – 3:00 PM – Break – Governor’s Square 15 5:12 PM – Keynote Speaker: Alfredo A. Sadun MD PhD 5:20 PM – PAOF 5:30 PM – Awards Presentation 6:00 PM – Cocktail Reception Meeting Coordinator Paulo E.C. Dantas MD (Brazil), Chair Program Committee J. Fernando Arévalo MD (Saudi Arabia) Mauricio Maia MD (Brazil) Peter A. Quiros MD (USA) Lihteh Wu MD (Costa Rica) Thank you to all our partners who helped make this event possible: Allergan International ARVO David & Julianna Pyott Foundation Pan-American Ophthalmological Foundation Retina Research Foundation Sheraton Denver Downtown Hotel 1550 Court Place Denver, Colorado 80202 USA (303) 893-3333 1 Pan-American Research Day PARD 2015 May 2, 2015 Governor’s Square 14 & 15 Sheraton Denver Downtown Hotel Denver, Colorado Alfredo A. Sadun, MD PhD J. Bronwyn Bateman, MD Specialist in Genetics and Pediatric Ophthalmology Clinical Professor of Ophthalmology, David Geffen School of Medicine at UCLA Professor and Thornton Endowed Chair, Doheny Eye Institute Vice-Chair of Ophthalmology, Dept. Ophthalmology, UCLA. 12:38 PM – 12:50 PM Keynote talk: The ophthalmologist in the modern world of genetics 5:13 PM – 5:25 PM Keynote talk: How a Giant Brazilian Pedigree Helped Solve 3 Great Mysteries in LHON Dr. Bronwyn Bateman is a board-certified ophthalmologist who specializes in pediatric ophthalmology; she is also board-certified in clinical genetics. She attended the University of California, Berkeley for her undergraduate degree and moved on to the Columbia University College of Physicians and Surgeons for medical school. She did a residency in ophthalmology at the Jules Stein Eye Institute at UCLA and became a Professor of Ophthalmology and Pediatrics. She went to the University of Colorado School of Medicine in 1995 as Professor of Ophthalmology and Pediatrics, and Chair of Ophthalmology, the first woman in any department. Her research has been in the genetic bases of hereditary cataracts. She became the first woman President of the Association of University Professors of Ophthalmology. She has been President of the PanAmerican Association of Ophthalmology and is a member of the American Ophthalmological Society. She raised over $12 million to build the Rocky Mountain Lions Eye Institute and establish an endowed Chair. She is currently a Clinical Professor of Ophthalmology at the David Geffen School of Medicine, UCLA. Dr. Bateman has had a long-term interest in Nicaragua and serves as the Honorary Consul to the state of Colorado. Dr. Sadun graduated from MIT (1972) and after obtaining his Ph.D. and M.D., completed his residency in Ophthalmology at Harvard Medical School followed by a fellowship in Neuro-Ophthalmology. He joined the full-time faculty at Harvard, Department of Ophthalmology in 1983. He was recruited to USC/Doheny where he remained for 30 years. He helped lead Doheny in its transition to UCLA in 2014. His research has centered on the clinical, psychophysical and laboratory studies of diseases of the optic nerve. In the 1980’s, Dr. Sadun was one of the first to apply a new tract-tracing technique in order to establish nine anatomical pathways between the eye and the brain. He was the first to describe a human retinal projection to the hypothalamus that subserves the visual entrainment of the circadian rhythm. Dr. Sadun was the first to identify an optic neuropathy associated with Alzheimer’s disease. In 1993, he was selected and sponsored by the United Nations to lead an investigative team to determine the cause of an epidemic of optic neuropathy in Cuba. He is author of about 300 peer-reviewed publications (H-index: 47). 2 Pan-American Research Day Saturday, May 2, 2015 Sheraton Denver Downtown Hotel, (Plaza Building Concourse Level) Governor’s Square 14 (Posterior Segment & PotPourri) Governor’s Square 15 (Anterior Segment & PotPourri) Ana Luisa Hofling-Lima MD 12:30 PM 12:35 PM Welcome 12:35 PM 12:38 PM Introduction of keynote speaker 12:38 PM 12:50 PM Keynote talk: The ophthalmologist in the modern world of genetics 12:50 PM 1:00 PM 1:00 PM 1:05 PM Paulo E.C. Dantas MD J. Bronwyn Bateman MD BREAK / CHANGE ROOMS Moderators: Mauricio Maia MD, Peter Quiros MD, R.V. Paul Chan MD, Alfredo Sadun MD PhD Moderators: Paulo E.C. Dantas MD, Luis Izquierdo MD MMed PhD, Jorge Valdez MD, J. Bronwyn Bateman MD Rashi Arora MBBS MS MRCOphth Jesus Cabral Macías MD *Recipient 2015 Arno Habicht Award for Research Sciences* Multicolor imaging in Acute Macular Neuroretinopathy Novel TACSTD2 gene Nonsense Mutation in a Family with Gelatinous Drop-Like Corneal Dystrophy (GDLD) 1:05 PM 1:10 PM 1:10 PM 1:15 PM 1:15 PM 1:20 PM 1:20 PM 1:25 PM 1:25 PM 1:30 PM 1:30 PM 1:35 PM 1:35 PM 1:40 PM 1:40 PM 1:45 PM 1:45 PM 1:50 PM Gustavo Alfredo Ortiz David Islas MD Alpha-1-Antitrypsin Reduced IL-6 mRNA Levels in Human Microvascular Cells Exposed to a High Amount of Glucose Angular structure-assessment in children with congenital glaucoma and healthy controls using anterior segment optical coherence tomography. Catalina Hernández Sánchez PhD Andrew Gordon Olivo-Payne MD Proinsulin formulated in PLGA microspheres delays vision loss and activates survival pathways in the rd10 mouse model of retinitis pigmentosa. Small Incision Lenticule Extraction Performed by Residents: Experience and Safety María Dolores Pinazo Duran MD Adriana Margarita Caballero Acosta MD Differential profiles of miRNAs, homocystein, vitamin B12/folate levels and oxidative stress parameters in diabetic retinopathy Comparison of the efficacy of 5% or 10% povidone-iodine (PVI) irrigation in combination with moxifloxacin 0.5% as prophylaxis in patients undergoing cataract surgery Natalia Paulina Quiroz Casian MD Rossen M. Hazarbassanov MD PhD Genetic association of polymorphisms in the p53 and LTA genes with proliferative vitreoretinopathy after retinal detachment surgery in Mexican population Use of topical immunomodulator in the treatment of patients with aqueous deficient dry eye and evaporative dry eye Mohammed Qutub BSc(Med) MBBS Jaime D. Martinez MD Pericyte loss in vitrectomy samples is a sensitive and specific marker of diabetic retinopathy Iridocorneal Angle in Neonates Interoperator and Intraoperator Reliability using Spectral Domain Optical Coherence Tomography David Rivera De La Parra MD Verónica Elisa Castillo Benítez MD New Proposed Classification For Tomographic Posterior Vitreous Detachment (PVD), And High Prevalence Of Type 3 PVD In Diabetic Macular Edema Among Diabetic Patients. Detection of virulence factors with multiplex PCR Technique of Conjunctival Coagulase Negative-Staphylococcus (CNS) from patients undergoing cataract surgery Tânia Patrícia da Silva Borges MD Jesús Lozano Cárdenas MD Topographic distribution of ocular vascular lesions: a 20-year study Gene expression pattern comparison between pterygium and adipose cells Sultan Aldrees MBBS Denise Loya MD Gonadotropin releasing hormone receptor is expressed in retinoblastomas and a retinoblastoma cell line Outcomes of Sclero-Corneal Keratoplasty in Severe Corneal Perforations Dhariana Acon Ramírez MD Pamela Cepeda MD Long-Term Visual and Anatomical Outcomes of Patients with Macular Edema Secondary to Central Retinal Vein Occlusion Following Intravitreal Bevacizumab: Real World Experience from a Developing Country Control of intraocular pressure after Ahmed valve implant in patients with penetrating keratoplasty. A retrospective ten-year study. 1:50 PM 1:55 PM Eddie Liu Systematic review and meta-analysis on the efficacy of LipiFlow® device in the treatment of Meibomian Gland Dysfunction 3 Pan-American Research Day Saturday, May 2, 2015 Sheraton Denver Downtown Hotel, (Plaza Building Concourse Level) Governor’s Square 14 (Posterior Segment & PotPourri) 1:55 PM 2:00 PM 2:00 PM 2:05 PM 2:05 PM 2:10 PM 2:10 PM 2:15 PM 2:15 PM 2:20 PM 2:20 PM 2:25 PM 2:25 PM 2:30 PM Governor’s Square 15 (Anterior Segment & PotPourri) Rafael Bueno García MD Lorena Lam-Franco Screening of Diabetic Retinopathy: Our experience using telemedicine method in Mexican Population Evaluation of topographic indices in Hispanic patients with Keratoconus and Keratoconus suspects Gisela Barcat Angelelli MD Javier Cabrerizo MD Real-world visual acuity outcomes of ranibizumab treatment for retinal vein occlusion (RVO) in a well-defined region of the United Kingdom (UK). Changes in lipidomic profile of aqueous humor in Fuchs endothelial corneal dystrophy Christina Mastromonaco BS Alejandro Ibarra-Lozano MD Diagnosing pathological prognostic factors in retinoblastoma: correlation between traditional microscopy and digital slides Clinical and Microbiological Characteristics of Infectious Keratitis in Mexico Antonio Ferreras MD PhD Erick Hernández Bogantes MD Changes in the macular ganglion cell complex thickness associated to diseases of the vitreomacular interface Minor Ipsilateral Simple Limbal Epithelial Transplantation (MiniSLET) for Pterygium Treatment Alberto Miguel Hernández Pinto PhD Judith Zavala Arcos PhD PEDF-derived Peptides delay Photoreceptor Cell Death in two Experimental Models of Retinitis Pigmentosa. Inhibition of pterygium fibroblasts proliferation by Siempre viva plant (Sedum dendroideum) extracts (presented by Pedro Ramos) Rachel Bryant Marcos Ivo Ferreira Ríos MD Behavioural Validation of a Transgenic Mouse Modeling Specific Impairment of Detailed Vision Objective outcomes of AT LISA Tri IOL in Conde de Valenciana Matias Iglicki MD Pedro Mario González Madrigal MD Are the dyes enough for a complete peeling of the ILM or ERM and to distinguish the causes of the ERM ? : histopathological study.Up to Date. Pseudomonas aeruginosa Ocular Strains Resistant to Ceftazidime in Northeast of Mexico 2:30 PM 2:35 PM 2:35 PM 2:40 PM 2:40 PM 2:45 PM 2:45 PM 2:50 PM Brian Garrett BS Correlation of retroillumination photography analysis and clinical severity grading method in Fuchs Corneal Dystrophy Lauren Gabra COFFEE BREAK Comparing toricity ratios across leading toric IOL manufacturers Alejandro Eduardo Tamez Peña MD Micro-Monovision LASIK as a treatment for presbyopia Natalia Alpízar Alvarez MD *Recipient 2015 Allergan Latin America Research Incentive Awards in Retina* Long-Term Visual and Anatomical Outcomes of Patients with CME Secondary to BRVO Following Intravitreal Bevacizumab: Real World Experience from a Developing Country. 2:50 PM 2:55 PM 2:55 PM 3:00 PM 3:00 PM 3:05 PM Shireen Khattak Melanin Distribution in Intact Human and Minipig Eyes Detected by Photoacoustic Imaging COFFEE BREAK Jay Chhablani MD Validity of an automated algorithm for Choroidal Volume measurement Salvador López Rubio MD Non-mydriatic fundus photography vs. clinical ophthalmoscopy for diabetic retinopathy in patients with early diabetes diagnosis Mauricio Guzman *Recipient 2015 Allergan Latin America Research Incentive Awards in Cornea* Tear film hyperosmolarity breaks down the ocular surface’s immune tolerance: a role in initiating dry eye? 3:05 PM 3:10 PM 3:10 PM 3:15 PM 3:15 PM 3:20 PM Luiza Manhezi Oliveira MD Allister Gibbons Fell MD Explanted Scleral Buckle, a retrospective study Dry eye profiles in patients with a positive elevated surface matrix metallopeptidase 9 point of care test versus negative patients Damián Dorfman MD Juan Pablo Fernández MD Enriched environment protects from axoglial alterations of the optic pathway induced by experimental diabetes in adult rats Fuchs Syndrome: A cross sectional study in a tertiary university center in Argentina Aline Astorga MD Jeremías Gastón Galletti MD PhD *Recipient 2015 David & Juliana Pyott Foundation Travel Award * Chiasmal syndrome: clinical features in mexican patients, a 5 year review Corneal burn in one eye disrupts conjunctival immunological tolerance of the fellow eye 4 Pan-American Research Day Saturday, May 2, 2015 Sheraton Denver Downtown Hotel, (Plaza Building Concourse Level) Governor’s Square 14 (Posterior Segment & PotPourri) 3:20 PM 3:25 PM Governor’s Square 15 (Anterior Segment & PotPourri) Juliana Kato Etiology and susceptibility pattern of isolates in endophthalmitis over a 5-year period Romina Mayra Lasagni Vitar MSc *Recipient 2015 Arno Habicht Award for Research Sciences* Evaluation of redox status in human conjunctival epithelial cells exposed to diesel exhaust particles (DEP) 3:25 PM 3:30 PM 3:30 PM 3:35 PM 3:35 PM 3:40 PM 3:40 PM 3:45 PM Daniel Rangel O'Shea MD Nallely Ramos Betancourt MD Epidemiological characteristics of Vogt-Koyanagi-Harada syndrome in a mexican population Correlation between Infrared Meibography and Ocular Surface Disease signs and symptoms Rosalva Yasha Bobadilla Maryoquin MD Alexandra Arive Peña Velázquez MD Clinical features of syphilitic uveitis in an ophthalmologic reference center in Mexico City Combined Therapy with Verteporfin and Ranibizumab for Corneal Neovascularization Cristhian A. Urzúa Salinas MD MSc Juan Carlos Serna Ojeda MD Expression kinetics of Glucocorticoid Receptor Isoforms Predicts Treatment Response to Glucocorticoids in Uveitis patients Herpes simplex virus disease of the anterior segment in children Mariana Ingolotti MD Ricardo Yuji Abe MD *Recipient 2015 Arno Habicht Award for Research Sciences* Hypertension in uveitis: a case series study. Detecting Functional Loss in Glaucoma with the Performance Centered Portable Test (PERCEPT) 3:45 PM 3:50 PM 3:50 PM 3:55 PM Beatriz Valadez Blanco MD Maria V.C. Pereira da Silva MD PhD Pediatric uveitis in a reference Centre in Mexico. Detection of Human herpes virus 1 (HHV-1) in graft failure corneas: a study of 24 cases using polymerase chain reaction (PCR) Carlos Eduardo Estrada MD Augusto Paranhos Jr. MD PhD *Recipient 2015 Allergan Latin America Research Incentive Awards in Glaucoma* Triple therapy for Choroidal Hemangioma: Experience in an Ophthalmology Institute of Mexico City. Intrinsically photosensitive retinal ganglion cell activity is associated with decreased sleep quality in glaucoma patients 3:55 PM 4:00 PM 4:00 PM 4:05 PM 4:05 PM 4:10 PM 4:10 PM 4:15 PM 4:15 PM 4:20 PM 4:20 PM 4:25 PM 4:25 PM 4:30 PM 4:30 PM 4:35 PM 4:35 PM 4:40 PM 4:40 PM 4:45 PM Patrick Logan MSc PhD Sandra María Ferreira PhD Evaluating the in vivo efficacy of a novel first in class drug for the treatment of primary uveal melanoma Changes in the antioxidant status of brain structures in a rat model of glaucoma. Dalia Consuelo Guadarrama Vallejo MD María de los Angeles Ramos Cadena MD Identification of RB1 gene germline mutations in Mexican patients with sporadic unilateral retinoblastoma Open-angle glaucoma Mexican patients treated with Canaloplasty: first 6-month post-operative report from a 5-year follow-up. Laura Andrea Torrado Cobian MD Fauze Abdulmassih Gonçalves MD Adenoma of the nonpigmented ciliary body and iris epithelium in Mexican mestizo patients (presented by Juan Carlos Serna Ojeda) Correlation and agreement between the diurnal tension curve, the water-drinking test and the postural-change test in glaucoma patients Nadine Marques Olegario Iván Castro Vite MD PAR-1 and Maspin expression in Retinoblastoma and their correlation with histopathological prognostic features Ocular complications of pediatric uveitis at a reference center in Mexico city Vasco Torres Fernandes Bravo Filho MD Effects of ranibizumab and amfenac on the functional abilities of uveal melanoma cells Pablo J. Guzmán Salas MD Surgical and visual outcomes in traumatic cataract following phacoemulsification, in a mexican pediatric population. Paulina Núñez Rivera MD Erica De Abreu Borges MD Thyroid-associated ophthalmopathy: Epidemiologic characteristics in a reference institution in Mexico City. Comparison of Daily Curve of Intraocular Pressure Using Measurements at 6 am and at 8 am in Glaucoma Alberto Carlos Abdala Figuerola MD María Angelica Moussalli MD Systemic and Immune Thyroid Status in Hispanic Patients with Recently Diagnosed Thyroid Eye Disease at the Conde Valenciana Institute of Ophthalmology – Mexico City. A 7 year review. Evaluation of knowledge of patients with Glaucoma.Author Moussalli María A Coauthor Montañez N,Tapia C, Echeverría B,Burchakchi A Glaucoma Unit: Hospital Italiano de BsAs César Miguel Portilla Espinosa MD Richard Filek BMSc Congenital Blepharoptosis: Clinical Characteristics and Surgical Outcomes in Mexican Population Visual Field Indices as the Primary outcome for New Glaucoma Drug Testing: A Systematic Review Oscar Francisco Chacón Camacho MD Adrián Aldrete MD Exome sequencing in Nasopalpebral-Lipoma-Coloboma Syndrome identifies a pathogenic mutation in an imprinted locus RETCAM 3 Calculated Cup/Disc Ratio of Preterm Newborn Optic Nerves in a Mexican Population 5 Pan-American Research Day Saturday, May 2, 2015 Sheraton Denver Downtown Hotel, (Plaza Building Concourse Level) Governor’s Square 14 (Posterior Segment & PotPourri) 4:45 PM 4:50 PM 4:50 PM 4:55 PM 4:55 PM 5:00 PM 5:00 PM - Governor’s Square 15 (Anterior Segment & PotPourri) Cristina Fonseca MD MSc Sebastião Cronemberger MD PhD A large series of blind painful eyes: potential causes and associated histopathological features Effects of age, gender, race, biometric parameters and refractive error on retinal nerve fiber layer of acute primary angle closure and fellow eyes Mariana Flores MD Matheus Iván Schmitz Vieira MD Risk factors associated with nonarteritic anterior ischemic optic neuropathy in young patients at a reference center in Mexico City SECTION: Eye Movements/Strabismus/Amblyopia/Neuroophthalmology (EY) Anterior Segment Evaluation in healthy Brazilian children with Scheimpflug topography Givago Da Silva Souza PhD Valentina Franco Cardenas MD Visual evoked cortical potential (VECP) elicited by pseudoisochromatic stimuli Decadelong Gender Presence in Editorials of Ophthalmic Literature Move to Governor’s Square 14 for Keynote talk and Awards Ceremony BREAK / CHANGE ROOMS 5:10 PM 5:13 PM Introduction of Keynote Speaker 5:13 PM 5:25 PM Keynote talk: How a Giant Brazilian Pedigree Helped Solve 3 Great Mysteries in LHON 5:25 PM 5:30 PM PAOF 5:30 PM 6:00 PM 6:00 PM 8:00 PM Peter A. Quiros MD Alfredo A. Sadun MD PhD Mark J. Mannis MD Awards Ceremony - Arno Habicht Awards for Research Sciences ... Romina Mayra Lasagni Vitar MSc ... Ricardo Yuji Abe MD ... Jesus Cabral Macías MD - David & Juliana Pyott Foundation Travel Award ... Jeremías Gastón Galletti MD PhD - Allergan Latin America Research Incentive Awards in Glaucoma ... Augusto Paranhos Jr. MD PhD - Allergan Latin America Research Incentive Awards in Cornea ... Mauricio Guzman - Allergan Latin America Research Incentive Awards in Retina ... Natalia Alpízar Alvarez MD Cocktail Reception, sponsored by Allergan Windows Room (Tower Building Second Level) ** Must be registered for PARD (with badge) to attend ** 6
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